Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations.
Identifieur interne : 001494 ( PubMed/Corpus ); précédent : 001493; suivant : 001495Local dose enhancement of proton therapy by ceramic oxide nanoparticles investigated with Geant4 simulations.
Auteurs : Sally Mckinnon ; Susanna Guatelli ; Sebastien Incerti ; Vladimir Ivanchenko ; Konstantin Konstantinov ; Stéphanie Corde ; Michael Lerch ; Moeava Tehei ; Anatoly RosenfeldSource :
- Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) [ 1724-191X ] ; 2016.
English descriptors
- KwdEn :
- Cerium (chemistry), Cerium (pharmacology), Gold (chemistry), Humans, Male, Metal Nanoparticles (chemistry), Monte Carlo Method, Nanoparticles, Oxides (chemistry), Oxides (pharmacology), Prostatic Neoplasms (radiotherapy), Proton Therapy (methods), Radiation Dosage, Radiotherapy Dosage, Tantalum (chemistry), Tantalum (pharmacology).
- MESH :
- chemical , chemistry : Cerium, Gold, Oxides, Tantalum.
- chemical , pharmacology : Cerium, Oxides, Tantalum.
- chemistry : Metal Nanoparticles.
- methods : Proton Therapy.
- radiotherapy : Prostatic Neoplasms.
- Humans, Male, Monte Carlo Method, Nanoparticles, Radiation Dosage, Radiotherapy Dosage.
Abstract
Nanoparticles (NPs) have been shown to enhance X-ray radiotherapy and proton therapy of cancer. The effectiveness of radiation damage is enhanced in the presence of high atomic number (high-Z) NPs due to increased production of low energy, higher linear energy transfer (LET) secondary electrons when NPs are selectively internalized by tumour cells. This work quantifies the local dose enhancement produced by the high-Z ceramic oxide NPs Ta2O5 and CeO2, in the target tumour, for the first time in proton therapy, by means of Geant4 simulations. The dose enhancement produced by the ceramic oxides is compared against gold NPs. The energy deposition on a nanoscale around a single nanoparticle of 100nm diameter is investigated using the Geant4-DNA extension to model particle interactions in the water medium. Enhancement of energy deposition in nano-sized shells of water, local to the NP boundary, ranging between 14% and 27% was observed for proton energies of 5MeV and 50MeV, depending on the NP material. Enhancement of electron production and energy deposition can be correlated to the direct DNA damage mechanism if the NP is in close proximity to the nucleus.
DOI: 10.1016/j.ejmp.2016.11.112
PubMed: 27916516
Links to Exploration step
pubmed:27916516Le document en format XML
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<front><div type="abstract" xml:lang="en">Nanoparticles (NPs) have been shown to enhance X-ray radiotherapy and proton therapy of cancer. The effectiveness of radiation damage is enhanced in the presence of high atomic number (high-Z) NPs due to increased production of low energy, higher linear energy transfer (LET) secondary electrons when NPs are selectively internalized by tumour cells. This work quantifies the local dose enhancement produced by the high-Z ceramic oxide NPs Ta2O5 and CeO2, in the target tumour, for the first time in proton therapy, by means of Geant4 simulations. The dose enhancement produced by the ceramic oxides is compared against gold NPs. The energy deposition on a nanoscale around a single nanoparticle of 100nm diameter is investigated using the Geant4-DNA extension to model particle interactions in the water medium. Enhancement of energy deposition in nano-sized shells of water, local to the NP boundary, ranging between 14% and 27% was observed for proton energies of 5MeV and 50MeV, depending on the NP material. Enhancement of electron production and energy deposition can be correlated to the direct DNA damage mechanism if the NP is in close proximity to the nucleus.</div>
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