Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids
Identifieur interne : 001E48 ( Istex/Curation ); précédent : 001E47; suivant : 001E49Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids
Auteurs : Richard Bandler [Australie] ; Antoine Depaulis [France] ; Marguerite Vergnes [France]Source :
- Behavioural Brain Research [ 0166-4328 ] ; 1985.
Descripteurs français
- Wicri :
- topic : Acide.
English descriptors
- KwdEn :
- Acid, Acid injections, Acid microinjections, Aggressive behavior, Alert immobility, Arterial pressure, Aspartate, Bandler, Behaviour, Behavioural, Behavioural effect, Behavioural effects, Behavioural reaction, Behavioural reactions, Behavioural response, Behavioural responses, Behavioural states, Bicc, Bicc injection, Bicuculline, Bicuculline methiodide, Body contralateral, Cannula, Catheter tubing, Caudal, Caudal half, Cell bodies, Cell group, Contralateral, Contralateral side, Defence, Defence reaction, Defensive behaviour, Defensive reactions, Depolarization block, Effective spread, Electrical stimulation, Excitation, Excitatory, Explosive jumps, First jump, Frontal plane, Gaba, Gaba antagonist, Glutamate, Glutamic acid, Guide cannula, Initial period, Injection, Injection cannula, Injection cannulae, Injection site, Injection sites, Interaural level, Ipsilateral, Ipsilateral side, Locomotor activity, Medulla, Microinjections, Midbrain, Midbrain neurones, Midbrain periaqueductal, Multiple jumps, Neurones, Numerical score, Other sites, Periaqueductal, Periventricular structures, Physiol, Previous studies, Rat, Raven press, Rearing, Repetitive, Same midbrain site, Same midbrain sites, Same reaction, Same reactions, Same site, Same sites, Sensorimotor activity, Sensorimotor responsiveness, Sensory control, Sensory stimuli, Snout, Snout contralateral, Stainless steel tubing, Such behaviour, Such neurones, Such sites, Superior colliculus, Surgical isolation, Tactile stimulus, Tegmental injection sites, Test cage, Unilateral microinjections, Ventrolateral medulla.
- Teeft :
- Acid, Acid injections, Acid microinjections, Aggressive behavior, Alert immobility, Arterial pressure, Aspartate, Bandler, Behaviour, Behavioural, Behavioural effect, Behavioural effects, Behavioural reaction, Behavioural reactions, Behavioural response, Behavioural responses, Behavioural states, Bicc, Bicc injection, Bicuculline, Bicuculline methiodide, Body contralateral, Cannula, Catheter tubing, Caudal, Caudal half, Cell bodies, Cell group, Contralateral, Contralateral side, Defence, Defence reaction, Defensive behaviour, Defensive reactions, Depolarization block, Effective spread, Electrical stimulation, Excitation, Excitatory, Explosive jumps, First jump, Frontal plane, Gaba, Gaba antagonist, Glutamate, Glutamic acid, Guide cannula, Initial period, Injection, Injection cannula, Injection cannulae, Injection site, Injection sites, Interaural level, Ipsilateral, Ipsilateral side, Locomotor activity, Medulla, Microinjections, Midbrain, Midbrain neurones, Midbrain periaqueductal, Multiple jumps, Neurones, Numerical score, Other sites, Periaqueductal, Periventricular structures, Physiol, Previous studies, Rat, Raven press, Rearing, Repetitive, Same midbrain site, Same midbrain sites, Same reaction, Same reactions, Same site, Same sites, Sensorimotor activity, Sensorimotor responsiveness, Sensory control, Sensory stimuli, Snout, Snout contralateral, Stainless steel tubing, Such behaviour, Such neurones, Such sites, Superior colliculus, Surgical isolation, Tactile stimulus, Tegmental injection sites, Test cage, Unilateral microinjections, Ventrolateral medulla.
Abstract
Abstract: Unilateral microinjections (0.20 μl) of excitatory amino acids were made into the midbrain of freely moving rats. Injections made within the midbrain periaqueductal grey matter (PAG) consistently elicited reactions characteristic of defensive behaviour (i.e. explosive jumps, freezing, upright postures), whereas injections made in the tegmentum bordering the PAG did not as reliably elicit such behaviour. As injections of excitatory amino acids depolarize cell bodies but not axons, the results suggest that a population of neurones whose excitation elicits these reactions is found primarily within the midbrain PAG of the rat. Furthermore, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG. Injections of the GABA antagonist, bicuculline methiodide, at many of the same midbrain sites produced behaviour similar to that elicited by excitatory amino acids indicating a possible GABAergic modulation of these same PAG-mediated reactions. It also was observed following unilateral injection into the PAG, of either the excitatory amino acid, l-aspartic acid or bicuculline, that defensive behaviour was elicited by touching the rat on the body or snout contralateral but not ipsilateral to the injection site. This suggests that the induction of defensive behaviour by unilateral PAG stimulation is due, at least in part, to lateralized alterations in sensorimotor responsiveness.
Url:
DOI: 10.1016/0166-4328(85)90058-0
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states</term><term>Bicc</term><term>Bicc injection</term><term>Bicuculline</term><term>Bicuculline methiodide</term><term>Body contralateral</term><term>Cannula</term><term>Catheter tubing</term><term>Caudal</term><term>Caudal half</term><term>Cell bodies</term><term>Cell group</term><term>Contralateral</term><term>Contralateral side</term><term>Defence</term><term>Defence reaction</term><term>Defensive behaviour</term><term>Defensive reactions</term><term>Depolarization block</term><term>Effective spread</term><term>Electrical stimulation</term><term>Excitation</term><term>Excitatory</term><term>Explosive jumps</term><term>First jump</term><term>Frontal plane</term><term>Gaba</term><term>Gaba antagonist</term><term>Glutamate</term><term>Glutamic acid</term><term>Guide cannula</term><term>Initial period</term><term>Injection</term><term>Injection cannula</term><term>Injection cannulae</term><term>Injection site</term><term>Injection sites</term><term>Interaural level</term><term>Ipsilateral</term><term>Ipsilateral side</term><term>Locomotor activity</term><term>Medulla</term><term>Microinjections</term><term>Midbrain</term><term>Midbrain neurones</term><term>Midbrain periaqueductal</term><term>Multiple jumps</term><term>Neurones</term><term>Numerical score</term><term>Other sites</term><term>Periaqueductal</term><term>Periventricular structures</term><term>Physiol</term><term>Previous studies</term><term>Rat</term><term>Raven press</term><term>Rearing</term><term>Repetitive</term><term>Same midbrain site</term><term>Same midbrain sites</term><term>Same reaction</term><term>Same reactions</term><term>Same site</term><term>Same sites</term><term>Sensorimotor activity</term><term>Sensorimotor responsiveness</term><term>Sensory control</term><term>Sensory stimuli</term><term>Snout</term><term>Snout contralateral</term><term>Stainless steel tubing</term><term>Such behaviour</term><term>Such neurones</term><term>Such sites</term><term>Superior 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type="topic" xml:lang="fr"><term>Acide</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Unilateral microinjections (0.20 μl) of excitatory amino acids were made into the midbrain of freely moving rats. Injections made within the midbrain periaqueductal grey matter (PAG) consistently elicited reactions characteristic of defensive behaviour (i.e. explosive jumps, freezing, upright postures), whereas injections made in the tegmentum bordering the PAG did not as reliably elicit such behaviour. As injections of excitatory amino acids depolarize cell bodies but not axons, the results suggest that a population of neurones whose excitation elicits these reactions is found primarily within the midbrain PAG of the rat. Furthermore, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG. Injections of the GABA antagonist, bicuculline methiodide, at many of the same midbrain sites produced behaviour similar to that elicited by excitatory amino acids indicating a possible GABAergic modulation of these same PAG-mediated reactions. It also was observed following unilateral injection into the PAG, of either the excitatory amino acid, l-aspartic acid or bicuculline, that defensive behaviour was elicited by touching the rat on the body or snout contralateral but not ipsilateral to the injection site. This suggests that the induction of defensive behaviour by unilateral PAG stimulation is due, at least in part, to lateralized alterations in sensorimotor responsiveness.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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