Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids
Identifieur interne : 001E48 ( Istex/Corpus ); précédent : 001E47; suivant : 001E49Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids
Auteurs : Richard Bandler ; Antoine Depaulis ; Marguerite VergnesSource :
- Behavioural Brain Research [ 0166-4328 ] ; 1985.
English descriptors
- KwdEn :
- Acid, Acid injections, Acid microinjections, Aggressive behavior, Alert immobility, Arterial pressure, Aspartate, Bandler, Behaviour, Behavioural, Behavioural effect, Behavioural effects, Behavioural reaction, Behavioural reactions, Behavioural response, Behavioural responses, Behavioural states, Bicc, Bicc injection, Bicuculline, Bicuculline methiodide, Body contralateral, Cannula, Catheter tubing, Caudal, Caudal half, Cell bodies, Cell group, Contralateral, Contralateral side, Defence, Defence reaction, Defensive behaviour, Defensive reactions, Depolarization block, Effective spread, Electrical stimulation, Excitation, Excitatory, Explosive jumps, First jump, Frontal plane, Gaba, Gaba antagonist, Glutamate, Glutamic acid, Guide cannula, Initial period, Injection, Injection cannula, Injection cannulae, Injection site, Injection sites, Interaural level, Ipsilateral, Ipsilateral side, Locomotor activity, Medulla, Microinjections, Midbrain, Midbrain neurones, Midbrain periaqueductal, Multiple jumps, Neurones, Numerical score, Other sites, Periaqueductal, Periventricular structures, Physiol, Previous studies, Rat, Raven press, Rearing, Repetitive, Same midbrain site, Same midbrain sites, Same reaction, Same reactions, Same site, Same sites, Sensorimotor activity, Sensorimotor responsiveness, Sensory control, Sensory stimuli, Snout, Snout contralateral, Stainless steel tubing, Such behaviour, Such neurones, Such sites, Superior colliculus, Surgical isolation, Tactile stimulus, Tegmental injection sites, Test cage, Unilateral microinjections, Ventrolateral medulla.
- Teeft :
- Acid, Acid injections, Acid microinjections, Aggressive behavior, Alert immobility, Arterial pressure, Aspartate, Bandler, Behaviour, Behavioural, Behavioural effect, Behavioural effects, Behavioural reaction, Behavioural reactions, Behavioural response, Behavioural responses, Behavioural states, Bicc, Bicc injection, Bicuculline, Bicuculline methiodide, Body contralateral, Cannula, Catheter tubing, Caudal, Caudal half, Cell bodies, Cell group, Contralateral, Contralateral side, Defence, Defence reaction, Defensive behaviour, Defensive reactions, Depolarization block, Effective spread, Electrical stimulation, Excitation, Excitatory, Explosive jumps, First jump, Frontal plane, Gaba, Gaba antagonist, Glutamate, Glutamic acid, Guide cannula, Initial period, Injection, Injection cannula, Injection cannulae, Injection site, Injection sites, Interaural level, Ipsilateral, Ipsilateral side, Locomotor activity, Medulla, Microinjections, Midbrain, Midbrain neurones, Midbrain periaqueductal, Multiple jumps, Neurones, Numerical score, Other sites, Periaqueductal, Periventricular structures, Physiol, Previous studies, Rat, Raven press, Rearing, Repetitive, Same midbrain site, Same midbrain sites, Same reaction, Same reactions, Same site, Same sites, Sensorimotor activity, Sensorimotor responsiveness, Sensory control, Sensory stimuli, Snout, Snout contralateral, Stainless steel tubing, Such behaviour, Such neurones, Such sites, Superior colliculus, Surgical isolation, Tactile stimulus, Tegmental injection sites, Test cage, Unilateral microinjections, Ventrolateral medulla.
Abstract
Abstract: Unilateral microinjections (0.20 μl) of excitatory amino acids were made into the midbrain of freely moving rats. Injections made within the midbrain periaqueductal grey matter (PAG) consistently elicited reactions characteristic of defensive behaviour (i.e. explosive jumps, freezing, upright postures), whereas injections made in the tegmentum bordering the PAG did not as reliably elicit such behaviour. As injections of excitatory amino acids depolarize cell bodies but not axons, the results suggest that a population of neurones whose excitation elicits these reactions is found primarily within the midbrain PAG of the rat. Furthermore, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG. Injections of the GABA antagonist, bicuculline methiodide, at many of the same midbrain sites produced behaviour similar to that elicited by excitatory amino acids indicating a possible GABAergic modulation of these same PAG-mediated reactions. It also was observed following unilateral injection into the PAG, of either the excitatory amino acid, l-aspartic acid or bicuculline, that defensive behaviour was elicited by touching the rat on the body or snout contralateral but not ipsilateral to the injection site. This suggests that the induction of defensive behaviour by unilateral PAG stimulation is due, at least in part, to lateralized alterations in sensorimotor responsiveness.
Url:
DOI: 10.1016/0166-4328(85)90058-0
Links to Exploration step
ISTEX:A0EB58B49E9955ED827C5613DB9CC91258D0DEE2Le document en format XML
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medulla</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Unilateral microinjections (0.20 μl) of excitatory amino acids were made into the midbrain of freely moving rats. Injections made within the midbrain periaqueductal grey matter (PAG) consistently elicited reactions characteristic of defensive behaviour (i.e. explosive jumps, freezing, upright postures), whereas injections made in the tegmentum bordering the PAG did not as reliably elicit such behaviour. As injections of excitatory amino acids depolarize cell bodies but not axons, the results suggest that a population of neurones whose excitation elicits these reactions is found primarily within the midbrain PAG of the rat. Furthermore, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG. Injections of the GABA antagonist, bicuculline methiodide, at many of the same midbrain sites produced behaviour similar to that elicited by excitatory amino acids indicating a possible GABAergic modulation of these same PAG-mediated reactions. It also was observed following unilateral injection into the PAG, of either the excitatory amino acid, l-aspartic acid or bicuculline, that defensive behaviour was elicited by touching the rat on the body or snout contralateral but not ipsilateral to the injection site. This suggests that the induction of defensive behaviour by unilateral PAG stimulation is due, at least in part, to lateralized alterations in sensorimotor responsiveness.</div></front></TEI><istex><corpusName>elsevier</corpusName><keywords><teeft><json:string>midbrain</json:string><json:string>behavioural</json:string><json:string>neurones</json:string><json:string>microinjections</json:string><json:string>cannula</json:string><json:string>bicc</json:string><json:string>bicuculline</json:string><json:string>periaqueductal</json:string><json:string>behavioural reactions</json:string><json:string>contralateral</json:string><json:string>defensive behaviour</json:string><json:string>caudal</json:string><json:string>glutamate</json:string><json:string>excitation</json:string><json:string>aspartate</json:string><json:string>injection</json:string><json:string>guide cannula</json:string><json:string>gaba</json:string><json:string>injection 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responsiveness</json:string><json:string>interaural level</json:string><json:string>snout contralateral</json:string><json:string>behavioural effects</json:string><json:string>same reactions</json:string><json:string>same midbrain sites</json:string><json:string>tegmental injection sites</json:string><json:string>gaba antagonist</json:string><json:string>such sites</json:string><json:string>behavioural responses</json:string><json:string>first jump</json:string><json:string>same reaction</json:string><json:string>caudal half</json:string><json:string>same sites</json:string><json:string>same site</json:string><json:string>such neurones</json:string><json:string>depolarization block</json:string><json:string>injection cannulae</json:string><json:string>ventrolateral medulla</json:string><json:string>arterial pressure</json:string><json:string>cell group</json:string><json:string>acid microinjections</json:string><json:string>sensory control</json:string><json:string>unilateral microinjections</json:string><json:string>contralateral side</json:string><json:string>sensorimotor activity</json:string><json:string>behavioural states</json:string><json:string>initial period</json:string><json:string>periventricular structures</json:string><json:string>aggressive behavior</json:string><json:string>raven press</json:string></teeft></keywords><author><json:item><name>Richard Bandler</name><affiliations><json:string>Brain-Behaviour Laboratory, Department of Anatomy, University of Sydney, N.S.W. 2006 Australia</json:string></affiliations></json:item><json:item><name>Antoine Depaulis</name><affiliations><json:string>Laboratoire de Neurophysiologie, Centre de Neurochimie du CNRS, 67084 Strasbourg France</json:string></affiliations></json:item><json:item><name>Marguerite Vergnes</name><affiliations><json:string>Laboratoire de Neurophysiologie, Centre de Neurochimie du CNRS, 67084 Strasbourg France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>defensive behaviour</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>midbrain periaqueductal grey region</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>aspartate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>glutamate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>bicuculline</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>excitatory amino acids</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>rat</value></json:item></subject><arkIstex>ark:/67375/6H6-NQ9FBR6C-S</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Abstract: Unilateral microinjections (0.20 μl) of excitatory amino acids were made into the midbrain of freely moving rats. Injections made within the midbrain periaqueductal grey matter (PAG) consistently elicited reactions characteristic of defensive behaviour (i.e. explosive jumps, freezing, upright postures), whereas injections made in the tegmentum bordering the PAG did not as reliably elicit such behaviour. As injections of excitatory amino acids depolarize cell bodies but not axons, the results suggest that a population of neurones whose excitation elicits these reactions is found primarily within the midbrain PAG of the rat. Furthermore, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG. Injections of the GABA antagonist, bicuculline methiodide, at many of the same midbrain sites produced behaviour similar to that elicited by excitatory amino acids indicating a possible GABAergic modulation of these same PAG-mediated reactions. It also was observed following unilateral injection into the PAG, of either the excitatory amino acid, l-aspartic acid or bicuculline, that defensive behaviour was elicited by touching the rat on the body or snout contralateral but not ipsilateral to the injection site. This suggests that the induction of defensive behaviour by unilateral PAG stimulation is due, at least in part, to lateralized alterations in sensorimotor responsiveness.</abstract><qualityIndicators><score>9.52</score><pdfWordCount>6849</pdfWordCount><pdfCharCount>39949</pdfCharCount><pdfVersion>1.4</pdfVersion><pdfPageCount>13</pdfPageCount><pdfPageSize>548 x 749 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractWordCount>210</abstractWordCount><abstractCharCount>1454</abstractCharCount><keywordCount>7</keywordCount></qualityIndicators><title>Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids</title><pmid><json:string>2859869</json:string></pmid><pii><json:string>0166-4328(85)90058-0</json:string></pii><genre><json:string>research-article</json:string></genre><host><title>Behavioural Brain Research</title><language><json:string>unknown</json:string></language><publicationDate>1985</publicationDate><issn><json:string>0166-4328</json:string></issn><pii><json:string>S0166-4328(00)X0151-9</json:string></pii><volume>15</volume><issue>2</issue><pages><first>107</first><last>119</last></pages><genre><json:string>journal</json:string></genre></host><namedEntities><unitex><date><json:string>2s</json:string><json:string>1985</json:string></date><geogName></geogName><orgName><json:string>Brain-Behaviour Laboratory, Department of Anatomy, University of Sydney</json:string><json:string>Medical Research Council</json:string><json:string>INSERM</json:string><json:string>Australian National Health</json:string></orgName><orgName_funder><json:string>Medical Research Council</json:string><json:string>INSERM</json:string><json:string>Australian National Health</json:string></orgName_funder><orgName_provider></orgName_provider><persName><json:string>A. Boehrer</json:string><json:string>J. McCall</json:string><json:string>Murray</json:string><json:string>P. Schmitt</json:string><json:string>J. Engel</json:string><json:string>The</json:string><json:string>I. Drawings</json:string><json:string>R. Bandler</json:string></persName><placeName><json:string>Australia</json:string><json:string>Strasbourg</json:string><json:string>France</json:string></placeName><ref_url></ref_url><ref_bibl><json:string>Accepted January 21st, 1985</json:string><json:string>Revised version received January 17th, 1985</json:string><json:string>Received October 3rd, 1984</json:string></ref_bibl><bibl></bibl></unitex></namedEntities><ark><json:string>ark:/67375/6H6-NQ9FBR6C-S</json:string></ark><categories><wos><json:string>1 - science</json:string><json:string>2 - neurosciences</json:string><json:string>2 - behavioral sciences</json:string></wos><scienceMetrix><json:string>1 - health sciences</json:string><json:string>2 - clinical medicine</json:string><json:string>3 - neurology & neurosurgery</json:string></scienceMetrix><scopus><json:string>1 - Life Sciences</json:string><json:string>2 - Neuroscience</json:string><json:string>3 - Behavioral Neuroscience</json:string></scopus><inist><json:string>1 - sciences appliquees, technologies et medecines</json:string><json:string>2 - sciences biologiques et medicales</json:string><json:string>3 - sciences biologiques fondamentales et appliquees. psychologie</json:string></inist></categories><publicationDate>1985</publicationDate><copyrightDate>1985</copyrightDate><doi><json:string>10.1016/0166-4328(85)90058-0</json:string></doi><id>A0EB58B49E9955ED827C5613DB9CC91258D0DEE2</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/A0EB58B49E9955ED827C5613DB9CC91258D0DEE2/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/A0EB58B49E9955ED827C5613DB9CC91258D0DEE2/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/A0EB58B49E9955ED827C5613DB9CC91258D0DEE2/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1985</date></publicationStmt><notesStmt><note type="content">Section title: Research report</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids</title><author xml:id="author-0000"><persName><forename type="first">Richard</forename><surname>Bandler</surname></persName><note type="correspondence"><p>Correspondence: R. Bandler, Brain-Behaviour Laboratory, Department of Anatomy, University of Sydney, N.S.W., Australia 2006.</p></note><affiliation>Brain-Behaviour Laboratory, Department of Anatomy, University of Sydney, N.S.W. 2006 Australia</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Antoine</forename><surname>Depaulis</surname></persName><affiliation>Laboratoire de Neurophysiologie, Centre de Neurochimie du CNRS, 67084 Strasbourg France</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Marguerite</forename><surname>Vergnes</surname></persName><affiliation>Laboratoire de Neurophysiologie, Centre de Neurochimie du CNRS, 67084 Strasbourg France</affiliation></author><idno type="istex">A0EB58B49E9955ED827C5613DB9CC91258D0DEE2</idno><idno type="DOI">10.1016/0166-4328(85)90058-0</idno><idno type="PII">0166-4328(85)90058-0</idno></analytic><monogr><title level="j">Behavioural Brain Research</title><title level="j" type="abbrev">BBR</title><idno type="pISSN">0166-4328</idno><idno type="PII">S0166-4328(00)X0151-9</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985"></date><biblScope unit="volume">15</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="107">107</biblScope><biblScope unit="page" to="119">119</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1985</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Unilateral microinjections (0.20 μl) of excitatory amino acids were made into the midbrain of freely moving rats. Injections made within the midbrain periaqueductal grey matter (PAG) consistently elicited reactions characteristic of defensive behaviour (i.e. explosive jumps, freezing, upright postures), whereas injections made in the tegmentum bordering the PAG did not as reliably elicit such behaviour. As injections of excitatory amino acids depolarize cell bodies but not axons, the results suggest that a population of neurones whose excitation elicits these reactions is found primarily within the midbrain PAG of the rat. Furthermore, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG. Injections of the GABA antagonist, bicuculline methiodide, at many of the same midbrain sites produced behaviour similar to that elicited by excitatory amino acids indicating a possible GABAergic modulation of these same PAG-mediated reactions. It also was observed following unilateral injection into the PAG, of either the excitatory amino acid, l-aspartic acid or bicuculline, that defensive behaviour was elicited by touching the rat on the body or snout contralateral but not ipsilateral to the injection site. This suggests that the induction of defensive behaviour by unilateral PAG stimulation is due, at least in part, to lateralized alterations in sensorimotor responsiveness.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>defensive behaviour</term></item><item><term>midbrain periaqueductal grey region</term></item><item><term>aspartate</term></item><item><term>glutamate</term></item><item><term>bicuculline</term></item><item><term>excitatory amino acids</term></item><item><term>rat</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1985-01-17">Modified</change><change when="1985">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/A0EB58B49E9955ED827C5613DB9CC91258D0DEE2/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>BBR</jid><aid>85900580</aid><ce:pii>0166-4328(85)90058-0</ce:pii><ce:doi>10.1016/0166-4328(85)90058-0</ce:doi><ce:copyright type="unknown" year="1985"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Research report</ce:textfn></ce:dochead><ce:title>Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids</ce:title><ce:author-group><ce:author><ce:given-name>Richard</ce:given-name><ce:surname>Bandler</ce:surname><ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup></ce:cross-ref><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Antoine</ce:given-name><ce:surname>Depaulis</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>Marguerite</ce:given-name><ce:surname>Vergnes</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>a</ce:label><ce:textfn>Brain-Behaviour Laboratory, Department of Anatomy, University of Sydney, N.S.W. 2006 Australia</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>b</ce:label><ce:textfn>Laboratoire de Neurophysiologie, Centre de Neurochimie du CNRS, 67084 Strasbourg France</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>∗</ce:label><ce:text>Correspondence: R. Bandler, Brain-Behaviour Laboratory, Department of Anatomy, University of Sydney, N.S.W., Australia 2006.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="3" month="10" year="1984"></ce:date-received><ce:date-revised day="17" month="1" year="1985"></ce:date-revised><ce:date-accepted day="21" month="1" year="1985"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Unilateral microinjections (0.20 μl) of excitatory amino acids were made into the midbrain of freely moving rats. Injections made within the midbrain periaqueductal grey matter (PAG) consistently elicited reactions characteristic of defensive behaviour (i.e. explosive jumps, freezing, upright postures), whereas injections made in the tegmentum bordering the PAG did not as reliably elicit such behaviour. As injections of excitatory amino acids depolarize cell bodies but not axons, the results suggest that a population of neurones whose excitation elicits these reactions is found primarily within the midbrain PAG of the rat. Furthermore, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG. Injections of the GABA antagonist, bicuculline methiodide, at many of the same midbrain sites produced behaviour similar to that elicited by excitatory amino acids indicating a possible GABAergic modulation of these same PAG-mediated reactions. It also was observed following unilateral injection into the PAG, of either the excitatory amino acid, <ce:small-caps>l</ce:small-caps>-aspartic acid or bicuculline, that defensive behaviour was elicited by touching the rat on the body or snout contralateral but not ipsilateral to the injection site. This suggests that the induction of defensive behaviour by unilateral PAG stimulation is due, at least in part, to lateralized alterations in sensorimotor responsiveness.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>defensive behaviour</ce:text></ce:keyword><ce:keyword><ce:text>midbrain periaqueductal grey region</ce:text></ce:keyword><ce:keyword><ce:text>aspartate</ce:text></ce:keyword><ce:keyword><ce:text>glutamate</ce:text></ce:keyword><ce:keyword><ce:text>bicuculline</ce:text></ce:keyword><ce:keyword><ce:text>excitatory amino acids</ce:text></ce:keyword><ce:keyword><ce:text>rat</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Indentification of midbrain neurones mediating defensive behaviour in the rat by microinjections of excitatory amino acids</title></titleInfo><name type="personal"><namePart type="given">Richard</namePart><namePart type="family">Bandler</namePart><affiliation>Brain-Behaviour Laboratory, Department of Anatomy, University of Sydney, N.S.W. 2006 Australia</affiliation><description>Correspondence: R. Bandler, Brain-Behaviour Laboratory, Department of Anatomy, University of Sydney, N.S.W., Australia 2006.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Antoine</namePart><namePart type="family">Depaulis</namePart><affiliation>Laboratoire de Neurophysiologie, Centre de Neurochimie du CNRS, 67084 Strasbourg France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Marguerite</namePart><namePart type="family">Vergnes</namePart><affiliation>Laboratoire de Neurophysiologie, Centre de Neurochimie du CNRS, 67084 Strasbourg France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-1JC4F85T-7">research-article</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1985</dateIssued><dateModified encoding="w3cdtf">1985-01-17</dateModified><copyrightDate encoding="w3cdtf">1985</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><abstract lang="en">Abstract: Unilateral microinjections (0.20 μl) of excitatory amino acids were made into the midbrain of freely moving rats. Injections made within the midbrain periaqueductal grey matter (PAG) consistently elicited reactions characteristic of defensive behaviour (i.e. explosive jumps, freezing, upright postures), whereas injections made in the tegmentum bordering the PAG did not as reliably elicit such behaviour. As injections of excitatory amino acids depolarize cell bodies but not axons, the results suggest that a population of neurones whose excitation elicits these reactions is found primarily within the midbrain PAG of the rat. Furthermore, the data suggested that such neurones may be localized preferentially within the caudal half of the midbrain PAG. Injections of the GABA antagonist, bicuculline methiodide, at many of the same midbrain sites produced behaviour similar to that elicited by excitatory amino acids indicating a possible GABAergic modulation of these same PAG-mediated reactions. It also was observed following unilateral injection into the PAG, of either the excitatory amino acid, l-aspartic acid or bicuculline, that defensive behaviour was elicited by touching the rat on the body or snout contralateral but not ipsilateral to the injection site. This suggests that the induction of defensive behaviour by unilateral PAG stimulation is due, at least in part, to lateralized alterations in sensorimotor responsiveness.</abstract><note type="content">Section title: Research report</note><subject><genre>Keywords</genre><topic>defensive behaviour</topic><topic>midbrain periaqueductal grey region</topic><topic>aspartate</topic><topic>glutamate</topic><topic>bicuculline</topic><topic>excitatory amino acids</topic><topic>rat</topic></subject><relatedItem type="host"><titleInfo><title>Behavioural Brain Research</title></titleInfo><titleInfo type="abbreviated"><title>BBR</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">198504</dateIssued></originInfo><identifier type="ISSN">0166-4328</identifier><identifier type="PII">S0166-4328(00)X0151-9</identifier><part><date>198504</date><detail type="volume"><number>15</number><caption>vol.</caption></detail><detail type="issue"><number>2</number><caption>no.</caption></detail><extent unit="issue-pages"><start>75</start><end>176</end></extent><extent unit="pages"><start>107</start><end>119</end></extent></part></relatedItem><identifier type="istex">A0EB58B49E9955ED827C5613DB9CC91258D0DEE2</identifier><identifier type="ark">ark:/67375/6H6-NQ9FBR6C-S</identifier><identifier type="DOI">10.1016/0166-4328(85)90058-0</identifier><identifier type="PII">0166-4328(85)90058-0</identifier><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-HKKZVM7B-M">elsevier</recordContentSource></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/A0EB58B49E9955ED827C5613DB9CC91258D0DEE2/metadata/json</uri></json:item></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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