Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.
Identifieur interne : 000210 ( PubMed/Checkpoint ); précédent : 000209; suivant : 000211Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.
Auteurs : C. Rouzes [France] ; R. Gref ; M. Leonard ; A. De Sousa Delgado ; Édith Dellacherie [France]Source :
- Journal of biomedical materials research [ 0021-9304 ] ; 2000.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Lactic Acid, Polymers.
- chemical : Dextrans, Emulsions, Serum Albumin, Bovine.
- Adsorption, Animals, Calorimetry, Differential Scanning, Cattle, Drug Delivery Systems, Drug Stability, Electron Probe Microanalysis, Microscopy, Atomic Force, Surface Properties.
Abstract
Sterically stabilized biocompatible poly(lactic acid) (PLA) nanospheres were prepared by an o/w emulsion/evaporation technique, using hydrophobically modified dextrans (DexP) as the emulsion stabilizer. Photon correlation spectroscopy, zetametry, and differential scanning calorimetry studies corroborated that interfacial adhesion between immiscible dextran and PLA chains was achieved by compatibilization of polymer segments via hydrophobic groups grafted onto dextran and thus leading to the formation of entanglements between the hydrophobic dextran parts and the PLA matrix. The presence of dextran exposed at the particle surface was confirmed by X-ray photoelectron spectroscopy and by the fact that the suspensions showed an increased stability in concentrated NaCl solutions and a reduction of bovine serum albumin adsorption compared to uncoated PLA nanoparticles. A comparison of the characteristics of PLA nanospheres DexP-coated via the emulsion procedure (NS(em)) with those of PLA particles coated by DexP adsorption (NS(ad)) suggests that the conformation of the polymer in the superficial layers may be different. However, both DexP layers behave similarly in terms of stability and protein adsorption.
PubMed: 10756314
Affiliations:
- France
- Grand Est, Lorraine (région)
- Nancy
- Centre national de la recherche scientifique, Laboratoire réactions et génie des procédés, Université de Lorraine
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pubmed:10756314Le document en format XML
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<term>Calorimetry, Differential Scanning</term>
<term>Cattle</term>
<term>Dextrans</term>
<term>Drug Delivery Systems</term>
<term>Drug Stability</term>
<term>Electron Probe Microanalysis</term>
<term>Emulsions</term>
<term>Lactic Acid (chemistry)</term>
<term>Microscopy, Atomic Force</term>
<term>Polymers (chemistry)</term>
<term>Serum Albumin, Bovine</term>
<term>Surface Properties</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Acide lactique ()</term>
<term>Adsorption</term>
<term>Animaux</term>
<term>Bovins</term>
<term>Calorimétrie différentielle à balayage</term>
<term>Dextrane</term>
<term>Microanalyse par sonde électronique</term>
<term>Microscopie à force atomique</term>
<term>Polymères ()</term>
<term>Propriétés de surface</term>
<term>Stabilité de médicament</term>
<term>Systèmes de délivrance de médicaments</term>
<term>Sérumalbumine bovine</term>
<term>Émulsions</term>
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<keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Lactic Acid</term>
<term>Polymers</term>
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<term>Emulsions</term>
<term>Serum Albumin, Bovine</term>
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<term>Calorimetry, Differential Scanning</term>
<term>Cattle</term>
<term>Drug Delivery Systems</term>
<term>Drug Stability</term>
<term>Electron Probe Microanalysis</term>
<term>Microscopy, Atomic Force</term>
<term>Surface Properties</term>
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<term>Adsorption</term>
<term>Animaux</term>
<term>Bovins</term>
<term>Calorimétrie différentielle à balayage</term>
<term>Dextrane</term>
<term>Microanalyse par sonde électronique</term>
<term>Microscopie à force atomique</term>
<term>Polymères</term>
<term>Propriétés de surface</term>
<term>Stabilité de médicament</term>
<term>Systèmes de délivrance de médicaments</term>
<term>Sérumalbumine bovine</term>
<term>Émulsions</term>
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<front><div type="abstract" xml:lang="en">Sterically stabilized biocompatible poly(lactic acid) (PLA) nanospheres were prepared by an o/w emulsion/evaporation technique, using hydrophobically modified dextrans (DexP) as the emulsion stabilizer. Photon correlation spectroscopy, zetametry, and differential scanning calorimetry studies corroborated that interfacial adhesion between immiscible dextran and PLA chains was achieved by compatibilization of polymer segments via hydrophobic groups grafted onto dextran and thus leading to the formation of entanglements between the hydrophobic dextran parts and the PLA matrix. The presence of dextran exposed at the particle surface was confirmed by X-ray photoelectron spectroscopy and by the fact that the suspensions showed an increased stability in concentrated NaCl solutions and a reduction of bovine serum albumin adsorption compared to uncoated PLA nanoparticles. A comparison of the characteristics of PLA nanospheres DexP-coated via the emulsion procedure (NS(em)) with those of PLA particles coated by DexP adsorption (NS(ad)) suggests that the conformation of the polymer in the superficial layers may be different. However, both DexP layers behave similarly in terms of stability and protein adsorption.</div>
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<Abstract><AbstractText>Sterically stabilized biocompatible poly(lactic acid) (PLA) nanospheres were prepared by an o/w emulsion/evaporation technique, using hydrophobically modified dextrans (DexP) as the emulsion stabilizer. Photon correlation spectroscopy, zetametry, and differential scanning calorimetry studies corroborated that interfacial adhesion between immiscible dextran and PLA chains was achieved by compatibilization of polymer segments via hydrophobic groups grafted onto dextran and thus leading to the formation of entanglements between the hydrophobic dextran parts and the PLA matrix. The presence of dextran exposed at the particle surface was confirmed by X-ray photoelectron spectroscopy and by the fact that the suspensions showed an increased stability in concentrated NaCl solutions and a reduction of bovine serum albumin adsorption compared to uncoated PLA nanoparticles. A comparison of the characteristics of PLA nanospheres DexP-coated via the emulsion procedure (NS(em)) with those of PLA particles coated by DexP adsorption (NS(ad)) suggests that the conformation of the polymer in the superficial layers may be different. However, both DexP layers behave similarly in terms of stability and protein adsorption.</AbstractText>
<CopyrightInformation>Copyright 2000 John Wiley & Sons, Inc.</CopyrightInformation>
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