LrgpV1, PubMed, Corpus, bibRecord, 000228

Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.

Identifieur interne : 000228 ( PubMed/Corpus ); précédent : 000227; suivant : 000229

Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.

Auteurs : C. Rouzes ; R. Gref ; M. Leonard ; A. De Sousa Delgado ; E. Dellacherie

Source :

Journal of biomedical materials research [ 0021-9304 ] ; 2000.

RBID : pubmed:10756314

English descriptors

KwdEn :
- Adsorption, Animals, Calorimetry, Differential Scanning, Cattle, Dextrans, Drug Delivery Systems, Drug Stability, Electron Probe Microanalysis, Emulsions, Lactic Acid (chemistry), Microscopy, Atomic Force, Polymers (chemistry), Serum Albumin, Bovine, Surface Properties.
MESH :
- chemical , chemistry : Lactic Acid, Polymers.
- chemical : Dextrans, Emulsions, Serum Albumin, Bovine.
- Adsorption, Animals, Calorimetry, Differential Scanning, Cattle, Drug Delivery Systems, Drug Stability, Electron Probe Microanalysis, Microscopy, Atomic Force, Surface Properties.

Abstract

Sterically stabilized biocompatible poly(lactic acid) (PLA) nanospheres were prepared by an o/w emulsion/evaporation technique, using hydrophobically modified dextrans (DexP) as the emulsion stabilizer. Photon correlation spectroscopy, zetametry, and differential scanning calorimetry studies corroborated that interfacial adhesion between immiscible dextran and PLA chains was achieved by compatibilization of polymer segments via hydrophobic groups grafted onto dextran and thus leading to the formation of entanglements between the hydrophobic dextran parts and the PLA matrix. The presence of dextran exposed at the particle surface was confirmed by X-ray photoelectron spectroscopy and by the fact that the suspensions showed an increased stability in concentrated NaCl solutions and a reduction of bovine serum albumin adsorption compared to uncoated PLA nanoparticles. A comparison of the characteristics of PLA nanospheres DexP-coated via the emulsion procedure (NS(em)) with those of PLA particles coated by DexP adsorption (NS(ad)) suggests that the conformation of the polymer in the superficial layers may be different. However, both DexP layers behave similarly in terms of stability and protein adsorption.

PubMed: 10756314

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pubmed:10756314

Le document en format XML

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<author><name sortKey="Rouzes, C" sort="Rouzes, C" uniqKey="Rouzes C" first="C" last="Rouzes">C. Rouzes</name>
<affiliation><nlm:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS-INPL 7568, Groupe ENSIC, 1 rue Grandville, BP 451, F-54001 Nancy Cedex, France.</nlm:affiliation>
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<author><name sortKey="Gref, R" sort="Gref, R" uniqKey="Gref R" first="R" last="Gref">R. Gref</name>
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<author><name sortKey="Leonard, M" sort="Leonard, M" uniqKey="Leonard M" first="M" last="Leonard">M. Leonard</name>
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<author><name sortKey="De Sousa Delgado, A" sort="De Sousa Delgado, A" uniqKey="De Sousa Delgado A" first="A" last="De Sousa Delgado">A. De Sousa Delgado</name>
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<author><name sortKey="Dellacherie, E" sort="Dellacherie, E" uniqKey="Dellacherie E" first="E" last="Dellacherie">E. Dellacherie</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.</title>
<author><name sortKey="Rouzes, C" sort="Rouzes, C" uniqKey="Rouzes C" first="C" last="Rouzes">C. Rouzes</name>
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<term>Animals</term>
<term>Calorimetry, Differential Scanning</term>
<term>Cattle</term>
<term>Dextrans</term>
<term>Drug Delivery Systems</term>
<term>Drug Stability</term>
<term>Electron Probe Microanalysis</term>
<term>Emulsions</term>
<term>Lactic Acid (chemistry)</term>
<term>Microscopy, Atomic Force</term>
<term>Polymers (chemistry)</term>
<term>Serum Albumin, Bovine</term>
<term>Surface Properties</term>
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<term>Polymers</term>
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<term>Emulsions</term>
<term>Serum Albumin, Bovine</term>
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<term>Animals</term>
<term>Calorimetry, Differential Scanning</term>
<term>Cattle</term>
<term>Drug Delivery Systems</term>
<term>Drug Stability</term>
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<front><div type="abstract" xml:lang="en">Sterically stabilized biocompatible poly(lactic acid) (PLA) nanospheres were prepared by an o/w emulsion/evaporation technique, using hydrophobically modified dextrans (DexP) as the emulsion stabilizer. Photon correlation spectroscopy, zetametry, and differential scanning calorimetry studies corroborated that interfacial adhesion between immiscible dextran and PLA chains was achieved by compatibilization of polymer segments via hydrophobic groups grafted onto dextran and thus leading to the formation of entanglements between the hydrophobic dextran parts and the PLA matrix. The presence of dextran exposed at the particle surface was confirmed by X-ray photoelectron spectroscopy and by the fact that the suspensions showed an increased stability in concentrated NaCl solutions and a reduction of bovine serum albumin adsorption compared to uncoated PLA nanoparticles. A comparison of the characteristics of PLA nanospheres DexP-coated via the emulsion procedure (NS(em)) with those of PLA particles coated by DexP adsorption (NS(ad)) suggests that the conformation of the polymer in the superficial layers may be different. However, both DexP layers behave similarly in terms of stability and protein adsorption.</div>
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<ArticleTitle>Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.</ArticleTitle>
<Pagination><MedlinePgn>557-65</MedlinePgn>
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<Abstract><AbstractText>Sterically stabilized biocompatible poly(lactic acid) (PLA) nanospheres were prepared by an o/w emulsion/evaporation technique, using hydrophobically modified dextrans (DexP) as the emulsion stabilizer. Photon correlation spectroscopy, zetametry, and differential scanning calorimetry studies corroborated that interfacial adhesion between immiscible dextran and PLA chains was achieved by compatibilization of polymer segments via hydrophobic groups grafted onto dextran and thus leading to the formation of entanglements between the hydrophobic dextran parts and the PLA matrix. The presence of dextran exposed at the particle surface was confirmed by X-ray photoelectron spectroscopy and by the fact that the suspensions showed an increased stability in concentrated NaCl solutions and a reduction of bovine serum albumin adsorption compared to uncoated PLA nanoparticles. A comparison of the characteristics of PLA nanospheres DexP-coated via the emulsion procedure (NS(em)) with those of PLA particles coated by DexP adsorption (NS(ad)) suggests that the conformation of the polymer in the superficial layers may be different. However, both DexP layers behave similarly in terms of stability and protein adsorption.</AbstractText>
<CopyrightInformation>Copyright 2000 John Wiley & Sons, Inc.</CopyrightInformation>
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Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.

Surface modification of poly(lactic acid) nanospheres using hydrophobically modified dextrans as stabilizers in an o/w emulsion/evaporation technique.

Source :

English descriptors

Abstract

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