Studies in Down's syndrome
Identifieur interne : 003621 ( Main/Curation ); précédent : 003620; suivant : 003622Studies in Down's syndrome
Auteurs : Ch. Rittner [Allemagne] ; E. Schwinger [Allemagne]Source :
- Clinical Genetics [ 0009-9163 ] ; 1973-09.
English descriptors
- KwdEn :
- Antigen carriers, Association studies, Auish, Auish antigen, Control group, Control groups, Different subsamples, Differential viability, Environmental factors, Enzyme groups, Handicapped patients, Haptoglobin distributions, Highest incidence, Lower rhine area, Negative results, Normal controls, Older patients, Patients group, Phenotype, Positive individuals, Possible association, Possible associations, Previous paper, Retarded patients, Rittner, Second group, Second series, Significant result, Statistical significance, Syndrome, Syndrome patients.
- Teeft :
- Antigen carriers, Association studies, Auish, Auish antigen, Control group, Control groups, Different subsamples, Differential viability, Environmental factors, Enzyme groups, Handicapped patients, Haptoglobin distributions, Highest incidence, Lower rhine area, Negative results, Normal controls, Older patients, Patients group, Phenotype, Positive individuals, Possible association, Possible associations, Previous paper, Retarded patients, Rittner, Second group, Second series, Significant result, Statistical significance, Syndrome, Syndrome patients.
Abstract
Two series of 88 and 53 patients with Down's syndrome and 91 other mentally retarded patients were investigated for various blood, serum and enzyme groups. No association of trisomy 21 and the following systems and factors was found: ABO, Rh(D), MNSs, K, P, Fy(a, b), Jk(a, b), Gm, (1,2), InV(1), Ag (x), Lp(a), Tf, C3, acP, PGM1 and GPT. None of these markers was associated with age or the presence or absence of the Au/SH antigen in Down's syndrome or other mentally handicapped patients. Gm(+1) individuals were more frequent among Down and other mentally retarded patients than in normal controls. A decrease of Hp2 individuals with age was found in the first, but not in the second group of Down patients. A possible association of Au/SH positive and tic 1‐1 individuals was found in the first. but not confirmed in the second series of patients with Down's syndrome. The control group of other mentally retarded patients exhibited a helerogeneity according to sex and age in the distribution of Gc phenotypes.
Url:
DOI: 10.1111/j.1399-0004.1973.tb01166.x
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Rittner</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Forensic Medicine, University of Bonn</wicri:regionArea><wicri:noRegion>University of Bonn</wicri:noRegion><wicri:noRegion>University of Bonn</wicri:noRegion></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Correspondence address: Institute of Forensic Medicine University of Bonn</wicri:regionArea></affiliation></author><author><name sortKey="Schwinger, E" sort="Schwinger, E" uniqKey="Schwinger E" first="E." last="Schwinger">E. Schwinger</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Forensic Medicine, University of Bonn</wicri:regionArea><wicri:noRegion>University of Bonn</wicri:noRegion><wicri:noRegion>University of Bonn</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Clinical Genetics</title><title level="j" type="alt">CLINICAL GENETICS</title><idno type="ISSN">0009-9163</idno><idno type="eISSN">1399-0004</idno><imprint><biblScope unit="vol">4</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="398">398</biblScope><biblScope unit="page" to="406">406</biblScope><biblScope unit="page-count">9</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1973-09">1973-09</date></imprint><idno type="ISSN">0009-9163</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0009-9163</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antigen carriers</term><term>Association studies</term><term>Auish</term><term>Auish antigen</term><term>Control group</term><term>Control groups</term><term>Different subsamples</term><term>Differential viability</term><term>Environmental factors</term><term>Enzyme groups</term><term>Handicapped patients</term><term>Haptoglobin distributions</term><term>Highest incidence</term><term>Lower rhine area</term><term>Negative results</term><term>Normal controls</term><term>Older patients</term><term>Patients group</term><term>Phenotype</term><term>Positive individuals</term><term>Possible association</term><term>Possible associations</term><term>Previous paper</term><term>Retarded patients</term><term>Rittner</term><term>Second group</term><term>Second series</term><term>Significant result</term><term>Statistical significance</term><term>Syndrome</term><term>Syndrome patients</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Antigen carriers</term><term>Association studies</term><term>Auish</term><term>Auish antigen</term><term>Control group</term><term>Control groups</term><term>Different subsamples</term><term>Differential viability</term><term>Environmental factors</term><term>Enzyme groups</term><term>Handicapped patients</term><term>Haptoglobin distributions</term><term>Highest incidence</term><term>Lower rhine area</term><term>Negative results</term><term>Normal controls</term><term>Older patients</term><term>Patients group</term><term>Phenotype</term><term>Positive individuals</term><term>Possible association</term><term>Possible associations</term><term>Previous paper</term><term>Retarded patients</term><term>Rittner</term><term>Second group</term><term>Second series</term><term>Significant result</term><term>Statistical significance</term><term>Syndrome</term><term>Syndrome patients</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Two series of 88 and 53 patients with Down's syndrome and 91 other mentally retarded patients were investigated for various blood, serum and enzyme groups. No association of trisomy 21 and the following systems and factors was found: ABO, Rh(D), MNSs, K, P, Fy(a, b), Jk(a, b), Gm, (1,2), InV(1), Ag (x), Lp(a), Tf, C3, acP, PGM1 and GPT. None of these markers was associated with age or the presence or absence of the Au/SH antigen in Down's syndrome or other mentally handicapped patients. Gm(+1) individuals were more frequent among Down and other mentally retarded patients than in normal controls. A decrease of Hp2 individuals with age was found in the first, but not in the second group of Down patients. A possible association of Au/SH positive and tic 1‐1 individuals was found in the first. but not confirmed in the second series of patients with Down's syndrome. The control group of other mentally retarded patients exhibited a helerogeneity according to sex and age in the distribution of Gc phenotypes.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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