Studies in Down's syndrome
Identifieur interne : 001619 ( Istex/Curation ); précédent : 001618; suivant : 001620Studies in Down's syndrome
Auteurs : Ch. Rittner [Allemagne] ; E. Schwinger [Allemagne]Source :
- Clinical Genetics [ 0009-9163 ] ; 1973-09.
English descriptors
- KwdEn :
- Antigen carriers, Association studies, Auish, Auish antigen, Control group, Control groups, Different subsamples, Differential viability, Environmental factors, Enzyme groups, Handicapped patients, Haptoglobin distributions, Highest incidence, Lower rhine area, Negative results, Normal controls, Older patients, Patients group, Phenotype, Positive individuals, Possible association, Possible associations, Previous paper, Retarded patients, Rittner, Second group, Second series, Significant result, Statistical significance, Syndrome, Syndrome patients.
- Teeft :
- Antigen carriers, Association studies, Auish, Auish antigen, Control group, Control groups, Different subsamples, Differential viability, Environmental factors, Enzyme groups, Handicapped patients, Haptoglobin distributions, Highest incidence, Lower rhine area, Negative results, Normal controls, Older patients, Patients group, Phenotype, Positive individuals, Possible association, Possible associations, Previous paper, Retarded patients, Rittner, Second group, Second series, Significant result, Statistical significance, Syndrome, Syndrome patients.
Abstract
Two series of 88 and 53 patients with Down's syndrome and 91 other mentally retarded patients were investigated for various blood, serum and enzyme groups. No association of trisomy 21 and the following systems and factors was found: ABO, Rh(D), MNSs, K, P, Fy(a, b), Jk(a, b), Gm, (1,2), InV(1), Ag (x), Lp(a), Tf, C3, acP, PGM1 and GPT. None of these markers was associated with age or the presence or absence of the Au/SH antigen in Down's syndrome or other mentally handicapped patients. Gm(+1) individuals were more frequent among Down and other mentally retarded patients than in normal controls. A decrease of Hp2 individuals with age was found in the first, but not in the second group of Down patients. A possible association of Au/SH positive and tic 1‐1 individuals was found in the first. but not confirmed in the second series of patients with Down's syndrome. The control group of other mentally retarded patients exhibited a helerogeneity according to sex and age in the distribution of Gc phenotypes.
Url:
DOI: 10.1111/j.1399-0004.1973.tb01166.x
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<term>Control groups</term>
<term>Different subsamples</term>
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<term>Environmental factors</term>
<term>Enzyme groups</term>
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<term>Haptoglobin distributions</term>
<term>Highest incidence</term>
<term>Lower rhine area</term>
<term>Negative results</term>
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<term>Older patients</term>
<term>Patients group</term>
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<term>Positive individuals</term>
<term>Possible association</term>
<term>Possible associations</term>
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<term>Rittner</term>
<term>Second group</term>
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<term>Different subsamples</term>
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<term>Enzyme groups</term>
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<term>Positive individuals</term>
<term>Possible association</term>
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<term>Rittner</term>
<term>Second group</term>
<term>Second series</term>
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<front><div type="abstract" xml:lang="en">Two series of 88 and 53 patients with Down's syndrome and 91 other mentally retarded patients were investigated for various blood, serum and enzyme groups. No association of trisomy 21 and the following systems and factors was found: ABO, Rh(D), MNSs, K, P, Fy(a, b), Jk(a, b), Gm, (1,2), InV(1), Ag (x), Lp(a), Tf, C3, acP, PGM1 and GPT. None of these markers was associated with age or the presence or absence of the Au/SH antigen in Down's syndrome or other mentally handicapped patients. Gm(+1) individuals were more frequent among Down and other mentally retarded patients than in normal controls. A decrease of Hp2 individuals with age was found in the first, but not in the second group of Down patients. A possible association of Au/SH positive and tic 1‐1 individuals was found in the first. but not confirmed in the second series of patients with Down's syndrome. The control group of other mentally retarded patients exhibited a helerogeneity according to sex and age in the distribution of Gc phenotypes.</div>
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