Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning
Identifieur interne : 001873 ( Istex/Curation ); précédent : 001872; suivant : 001874Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning
Auteurs : Knut Arvid Kirkeböen [Norvège] ; Gunnar Aksnes [Norvège] ; Arnfinn Ilebekk [Norvège]Source :
- Cardiovascular Research [ 1755-3245 ] ; 1990-12.
Abstract
Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p<0.01), duration of hyperaemia by 44% (p<0.001), volume of hyperaemia by 53% (p<0.001), and repayment of flow debt by 43% (p<0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning. Conclusions – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.
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DOI: 10.1093/cvr/24.12.998
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning</title><author><name sortKey="Kirkeboen, Knut Arvid" sort="Kirkeboen, Knut Arvid" uniqKey="Kirkeboen K" first="Knut Arvid" last="Kirkeböen">Knut Arvid Kirkeböen</name><affiliation wicri:level="1"><mods:affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4</wicri:regionArea></affiliation></author><author><name sortKey="Aksnes, Gunnar" sort="Aksnes, Gunnar" uniqKey="Aksnes G" first="Gunnar" last="Aksnes">Gunnar Aksnes</name><affiliation wicri:level="1"><mods:affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4</wicri:regionArea></affiliation></author><author><name sortKey="Ilebekk, Arnfinn" sort="Ilebekk, Arnfinn" uniqKey="Ilebekk A" first="Arnfinn" last="Ilebekk">Arnfinn Ilebekk</name><affiliation wicri:level="1"><mods:affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:19912D7DB4CB4175ADEC6E0716A93B5A209175FD</idno><date when="1990" year="1990">1990</date><idno type="doi">10.1093/cvr/24.12.998</idno><idno type="url">https://api.istex.fr/document/19912D7DB4CB4175ADEC6E0716A93B5A209175FD/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001873</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001873</idno><idno type="wicri:Area/Istex/Curation">001873</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning</title><author><name sortKey="Kirkeboen, Knut Arvid" sort="Kirkeboen, Knut Arvid" uniqKey="Kirkeboen K" first="Knut Arvid" last="Kirkeböen">Knut Arvid Kirkeböen</name><affiliation wicri:level="1"><mods:affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4</wicri:regionArea></affiliation></author><author><name sortKey="Aksnes, Gunnar" sort="Aksnes, Gunnar" uniqKey="Aksnes G" first="Gunnar" last="Aksnes">Gunnar Aksnes</name><affiliation wicri:level="1"><mods:affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4</wicri:regionArea></affiliation></author><author><name sortKey="Ilebekk, Arnfinn" sort="Ilebekk, Arnfinn" uniqKey="Ilebekk A" first="Arnfinn" last="Ilebekk">Arnfinn Ilebekk</name><affiliation wicri:level="1"><mods:affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</mods:affiliation><country xml:lang="fr">Norvège</country><wicri:regionArea>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Cardiovascular Research</title><idno type="eISSN">1755-3245</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1990-12">1990-12</date><biblScope unit="volume">24</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="998">998</biblScope><biblScope unit="page" to="1007">1007</biblScope></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p<0.01), duration of hyperaemia by 44% (p<0.001), volume of hyperaemia by 53% (p<0.001), and repayment of flow debt by 43% (p<0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning. Conclusions – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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