Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning
Identifieur interne : 001873 ( Istex/Corpus ); précédent : 001872; suivant : 001874Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning
Auteurs : Knut Arvid Kirkeböen ; Gunnar Aksnes ; Arnfinn IlebekkSource :
- Cardiovascular Research [ 1755-3245 ] ; 1990-12.
Abstract
Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p<0.01), duration of hyperaemia by 44% (p<0.001), volume of hyperaemia by 53% (p<0.001), and repayment of flow debt by 43% (p<0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning. Conclusions – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.
Url:
DOI: 10.1093/cvr/24.12.998
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ISTEX:19912D7DB4CB4175ADEC6E0716A93B5A209175FDLe document en format XML
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Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p<0.01), duration of hyperaemia by 44% (p<0.001), volume of hyperaemia by 53% (p<0.001), and repayment of flow debt by 43% (p<0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning. Conclusions – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Knut Arvid Kirkeböen</name><affiliations><json:string>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</json:string></affiliations></json:item><json:item><name>Gunnar Aksnes</name><affiliations><json:string>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</json:string></affiliations></json:item><json:item><name>Arnfinn Ilebekk</name><affiliations><json:string>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</json:string></affiliations></json:item></author><subject><json:item><value>adenosine</value></json:item><json:item><value>ADP</value></json:item><json:item><value>endothelium dependent vasodilatation</value></json:item><json:item><value>endothelium independent vasodilatation</value></json:item><json:item><value>myocardial ischaemia</value></json:item><json:item><value>myocardial stunning</value></json:item><json:item><value>pig</value></json:item><json:item><value>preconditioning</value></json:item><json:item><value>reactive hyperaemia</value></json:item></subject><articleId><json:string>24-12-998</json:string></articleId><language><json:string>unknown</json:string></language><originalGenre><json:string>review-article</json:string></originalGenre><abstract>Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p>0.01), duration of hyperaemia by 44% (p>0.001), volume of hyperaemia by 53% (p>0.001), and repayment of flow debt by 43% (p>0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning. Conclusions – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.</abstract><qualityIndicators><score>9.508</score><pdfWordCount>5094</pdfWordCount><pdfCharCount>35068</pdfCharCount><pdfVersion>1.3</pdfVersion><pdfPageCount>10</pdfPageCount><pdfPageSize>540 x 756 pts</pdfPageSize><refBibsNative>false</refBibsNative><abstractWordCount>209</abstractWordCount><abstractCharCount>1438</abstractCharCount><keywordCount>9</keywordCount></qualityIndicators><title>Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning</title><genre><json:string>review-article</json:string></genre><host><title>Cardiovascular Research</title><language><json:string>unknown</json:string></language><eissn><json:string>1755-3245</json:string></eissn><publisherId><json:string>cardiovascres</json:string></publisherId><volume>24</volume><issue>12</issue><pages><first>998</first><last>1007</last></pages><genre><json:string>journal</json:string></genre></host><publicationDate>1990</publicationDate><copyrightDate>1990</copyrightDate><doi><json:string>10.1093/cvr/24.12.998</json:string></doi><id>19912D7DB4CB4175ADEC6E0716A93B5A209175FD</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/19912D7DB4CB4175ADEC6E0716A93B5A209175FD/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/19912D7DB4CB4175ADEC6E0716A93B5A209175FD/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/19912D7DB4CB4175ADEC6E0716A93B5A209175FD/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher scheme="https://publisher-list.data.istex.fr">Oxford University Press</publisher><availability><licence><p>Copyright © 1990, European Society of Cardiology</p></licence><p scheme="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</p></availability><date>1990</date></publicationStmt><notesStmt><note type="review-article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</note><note type="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note><note>Correspondence to: Dr Kirkeböen</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning</title><author xml:id="author-0000"><persName><forename type="first">Knut Arvid</forename><surname>Kirkeböen</surname></persName><affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Gunnar</forename><surname>Aksnes</surname></persName><affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Arnfinn</forename><surname>Ilebekk</surname></persName><affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</affiliation></author><idno type="istex">19912D7DB4CB4175ADEC6E0716A93B5A209175FD</idno><idno type="ark">ark:/67375/HXZ-J2476CS6-N</idno><idno type="DOI">10.1093/cvr/24.12.998</idno><idno type="article-id">24-12-998</idno></analytic><monogr><title level="j">Cardiovascular Research</title><idno type="eISSN">1755-3245</idno><idno type="publisher-id">cardiovascres</idno><idno type="PublisherID-hwp">cardiovascres</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="1990-12"></date><biblScope unit="volume">24</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="998">998</biblScope><biblScope unit="page" to="1007">1007</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990</date></creation><abstract><p>Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p<0.01), duration of hyperaemia by 44% (p<0.001), volume of hyperaemia by 53% (p<0.001), and repayment of flow debt by 43% (p<0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning. Conclusions – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.</p></abstract><textClass><keywords scheme="keyword"><list><head>Key words</head><item><term>adenosine</term></item><item><term>ADP</term></item><item><term>endothelium dependent vasodilatation</term></item><item><term>endothelium independent vasodilatation</term></item><item><term>myocardial ischaemia</term></item><item><term>myocardial stunning</term></item><item><term>pig</term></item><item><term>preconditioning</term></item><item><term>reactive hyperaemia</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-12">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-10-5">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/19912D7DB4CB4175ADEC6E0716A93B5A209175FD/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="review-article">
<front>
<journal-meta>
<journal-id journal-id-type="hwp">cardiovascres</journal-id>
<journal-id journal-id-type="publisher-id">cardiovascres</journal-id>
<journal-title>Cardiovascular Research</journal-title>
<issn pub-type="epub">1755-3245</issn>
<publisher>
<publisher-name>Oxford University Press</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1093/cvr/24.12.998</article-id>
<article-id pub-id-type="publisher-id">24-12-998</article-id>
<title-group>
<article-title>Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Kirkeböen</surname>
<given-names>Knut Arvid</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Aksnes</surname>
<given-names>Gunnar</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Ilebekk</surname>
<given-names>Arnfinn</given-names>
</name>
</contrib>
</contrib-group>
<aff>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</aff>
<author-notes>
<corresp>Correspondence to: Dr Kirkeböen</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>12</month>
<year>1990</year>
</pub-date>
<volume>24</volume>
<issue>12</issue>
<fpage>998</fpage>
<lpage>1007</lpage>
<history>
<date date-type="accepted">
<day>28</day>
<month>6</month>
<year>1990</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 1990, European Society of Cardiology</copyright-statement>
<copyright-year>1990</copyright-year>
</permissions>
<abstract>
<p><italic>Study objective</italic> – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium.</p>
<p><italic>Design</italic> – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe.</p>
<p><italic>Experimental material</italic> – 11 domestic pigs, weight 25-36 kg, were used.</p>
<p><italic>Measurements and main results</italic> – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p<0.01), duration of hyperaemia by 44% (p<0.001), volume of hyperaemia by 53% (p<0.001), and repayment of flow debt by 43% (p<0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning.</p>
<p><italic>Conclusions</italic> – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.</p>
</abstract>
<kwd-group>
<title>Key words</title>
<kwd>adenosine</kwd>
<kwd>ADP</kwd>
<kwd>endothelium dependent vasodilatation</kwd>
<kwd>endothelium independent vasodilatation</kwd>
<kwd>myocardial ischaemia</kwd>
<kwd>myocardial stunning</kwd>
<kwd>pig</kwd>
<kwd>preconditioning</kwd>
<kwd>reactive hyperaemia</kwd>
</kwd-group>
</article-meta>
</front>
</article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Coronary reactivity in the porcine heart after short lasting myocardial ischaemia: effects of duration of ischaemia and myocardial stunning</title></titleInfo><name type="personal"><namePart type="given">Knut Arvid</namePart><namePart type="family">Kirkeböen</namePart><affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gunnar</namePart><namePart type="family">Aksnes</namePart><affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Arnfinn</namePart><namePart type="family">Ilebekk</namePart><affiliation>University of Oslo, Institute for Experimental Medical Research, Ullevål Hospital, 0407 Oslo 4, Norway</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="review-article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-L5L7X3NF-P">review-article</genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">1990-12</dateIssued><copyrightDate encoding="w3cdtf">1990</copyrightDate></originInfo><abstract>Study objective – The aim was to characterise reactive hyperaemia and endothelium dependent (ADP) and independent (adenosine) vasodilatation after ischaemic periods of increasing duration, and in the stunned myocardium. Design – The left anterior descending coronary artery was occluded 5-7 cm distal from its origin for consecutive periods of 2, 2, 5, 10, and 2 min separated by 30 min of reperfusion. Coronary flow was continuously measured by Doppler flowmetry proximal to the occlusion site. ADP and adenosine were infused into the left coronary artery proximal to the flowprobe. Experimental material – 11 domestic pigs, weight 25-36 kg, were used. Measurements and main results – In the stunned myocardium maximal reactive hyperaemia after 2 min of ischaemia was preserved, whereas all other variables describing reactive hyperaemia were diminished: time to maximal hyperaemia by 40% (p<0.01), duration of hyperaemia by 44% (p<0.001), volume of hyperaemia by 53% (p<0.001), and repayment of flow debt by 43% (p<0.001). The vasodilating effects of ADP and adenosine (dose-response curves) were not altered after development of stunning. Conclusions – Preserved maximal hyperaemia and vasodilatation during ADP and adenosine infusion, but reduced volume of hyperaemia, indicate normal coronary reactivity but diminished release in the stunned myocardium of the vasodilator(s) responsible for the prolonged postischaemic flow increase.</abstract><note type="author-notes">Correspondence to: Dr Kirkeböen</note><subject><genre>Key words</genre><topic>adenosine</topic><topic>ADP</topic><topic>endothelium dependent vasodilatation</topic><topic>endothelium independent vasodilatation</topic><topic>myocardial ischaemia</topic><topic>myocardial stunning</topic><topic>pig</topic><topic>preconditioning</topic><topic>reactive hyperaemia</topic></subject><relatedItem type="host"><titleInfo><title>Cardiovascular Research</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="eISSN">1755-3245</identifier><identifier type="PublisherID">cardiovascres</identifier><identifier type="PublisherID-hwp">cardiovascres</identifier><part><date>1990</date><detail type="volume"><caption>vol.</caption><number>24</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>998</start><end>1007</end></extent></part></relatedItem><identifier type="istex">19912D7DB4CB4175ADEC6E0716A93B5A209175FD</identifier><identifier type="DOI">10.1093/cvr/24.12.998</identifier><identifier type="ArticleID">24-12-998</identifier><accessCondition type="use and reproduction" contentType="copyright">Copyright © 1990, European Society of Cardiology</accessCondition><recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-GTWS0RDP-M">oup</recordContentSource><recordOrigin>Copyright © 1990, European Society of Cardiology</recordOrigin></recordInfo></mods><json:item><extension>json</extension><original>false</original><mimetype>application/json</mimetype><uri>https://api.istex.fr/document/19912D7DB4CB4175ADEC6E0716A93B5A209175FD/metadata/json</uri></json:item></metadata><annexes><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/19912D7DB4CB4175ADEC6E0716A93B5A209175FD/annexes/pdf</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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