LrgpV1, Istex, Corpus, bibRecord, 001308

A General Approach to (Trifluoromethoxy)pyridines: First X‐ray Structure Determinations and Quantum Chemistry Studies

Identifieur interne : 001308 ( Istex/Corpus ); précédent : 001307; suivant : 001309

A General Approach to (Trifluoromethoxy)pyridines: First X‐ray Structure Determinations and Quantum Chemistry Studies

Auteurs : Baptiste Manteau ; Pierre Genix ; Lydia Brelot ; Jean-Pierre Vors ; Sergiy Pazenok ; Florence Giornal ; Charlotte Leuenberger ; Frédéric R. Leroux

Source :

European Journal of Organic Chemistry [ 1434-193X ] ; 2010-11.

RBID : ISTEX:A471E7D4C151D5F3D7577A8EC716C0E331E2B0D5

English descriptors

KwdEn :
- Ammonium, Ammonium formate, Aqueous layer, Aqueous sodium hydrogen carbonate, Aqueous sodium hydroxide, Aqueous solution, Azide, Benzenesulfonyl, Benzenesulfonyl azide, Butyllithium, Calcd, Carbonate, Carboxylation, Cd3od, Cdcl3, Chem, Chloroform, Citric acid, Colorless, Colorless needles, Colorless powder, Cooh, Crude product, Cyclohexane, Dichloromethane, Diethyl, Diethyl ether, Dihedral angle, Diisopropylamine, Dropwise, Dropwise addition, Eluent, Equiv, Ether, Ethyl, Ethyl acetate, Excess chlorine, Filtrate, Fluorine chem, Formate, Full paper, Gmbh, Hexane, Hrms, Hydrochloric, Hydrochloric acid, Hydroxide, Kgaa, Leroux, Mbar, Methanol, Methoxy, Methoxy group, Mmol, Occl3, Ocf2cl, Ocf2cl byproduct, Ocf3, Ocf3 group, Organic layers, Propionitrile, Pure acid, Pure product, Pyridine, Pyridine ring, Reaction mixture, Reflux, Sbcl5, Sbf3, Schlosser, Sodium hydroxide, Sodium sulfate, Sulfate, Tetrabutylammonium fluoride, Thiophosgene, Toluene, Trifluoromethoxy, Verlag, Verlag gmbh, Weinheim, White powder, Yellow solution.
Teeft :
- Ammonium, Ammonium formate, Aqueous layer, Aqueous sodium hydrogen carbonate, Aqueous sodium hydroxide, Aqueous solution, Azide, Benzenesulfonyl, Benzenesulfonyl azide, Butyllithium, Calcd, Carbonate, Carboxylation, Cd3od, Cdcl3, Chem, Chloroform, Citric acid, Colorless, Colorless needles, Colorless powder, Cooh, Crude product, Cyclohexane, Dichloromethane, Diethyl, Diethyl ether, Dihedral angle, Diisopropylamine, Dropwise, Dropwise addition, Eluent, Equiv, Ether, Ethyl, Ethyl acetate, Excess chlorine, Filtrate, Fluorine chem, Formate, Full paper, Gmbh, Hexane, Hrms, Hydrochloric, Hydrochloric acid, Hydroxide, Kgaa, Leroux, Mbar, Methanol, Methoxy, Methoxy group, Mmol, Occl3, Ocf2cl, Ocf2cl byproduct, Ocf3, Ocf3 group, Organic layers, Propionitrile, Pure acid, Pure product, Pyridine, Pyridine ring, Reaction mixture, Reflux, Sbcl5, Sbf3, Schlosser, Sodium hydroxide, Sodium sulfate, Sulfate, Tetrabutylammonium fluoride, Thiophosgene, Toluene, Trifluoromethoxy, Verlag, Verlag gmbh, Weinheim, White powder, Yellow solution.

Abstract

The previously unknown 2‐, 3‐, and 4‐(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large‐scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life‐sciences‐oriented research. In addition, the first X‐ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest‐energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies.

Url:

https://api.istex.fr/document/A471E7D4C151D5F3D7577A8EC716C0E331E2B0D5/fulltext/pdf

DOI: 10.1002/ejoc.201000958

Links to Exploration step

ISTEX:A471E7D4C151D5F3D7577A8EC716C0E331E2B0D5

Le document en format XML

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<front><div type="abstract" xml:lang="en">The previously unknown 2‐, 3‐, and 4‐(trifluoromethoxy)pyridines have now become readily accessible by means of an efficient and straightforward large‐scale synthesis. Their regioselective functionalization by organometallic methods has been studied and has afforded new and highly important building blocks for life‐sciences‐oriented research. In addition, the first X‐ray crystallographic structure determinations of (trifluoromethoxy)pyridines have been performed. Lowest‐energy conformations of (trifluoromethoxy)pyridines and (trifluoromethoxy)pyridinium cations were determined by in silico studies.</div>
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A General Approach to (Trifluoromethoxy)pyridines: First X‐ray Structure Determinations and Quantum Chemistry Studies

A General Approach to (Trifluoromethoxy)pyridines: First X‐ray Structure Determinations and Quantum Chemistry Studies

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