Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions
Identifieur interne : 000649 ( Istex/Corpus ); précédent : 000648; suivant : 000650Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions
Auteurs : M. Leonard ; M. Rastello De Boisseson ; P. Hubert ; E. DellacherieSource :
- Journal of Biomedical Materials Research Part A [ 1549-3296 ] ; 2004-02-01.
English descriptors
- KwdEn :
- Alginate, Alginate beads, Alginate derivatives, Alginate microparticles, Alginate particles, Alkyl, Alkyl chain, Alkyl chain substitution ratio, Alkyl chains, Amphiphilic, Amphiphilic derivatives, Aqueous solution, Aqueous solutions, Bioadhesive microspheres, Biomed mater, Cacl2, Cacl2 concentration, Current article, Dellacherie, Dellacherie figure, Derivative, Different stages, Dispersion, Dispersion phase, Distribution curve, Divalent cations, Dodecyl chains, Drug delivery, Encapsulated, Encapsulation, Experimental conditions, Experimental section, Hydrogel, Microparticle, Microparticle size distribution, Microparticles, Microspheres, Nacl, Nacl concentration, Nacl solutions, Nongelling cations, Oral administration, Other conditions, Particle size, Particle size distribution, Particle stability, Pharm, Pharm pharmacol, Polycationic polymers, Polymer, Polymer concentration, Polymer solutions, Polysaccharide, Polysaccharide backbone, Polysaccharidic hydrogel microparticles, Pregel, Preliminary assays, Protein release, Rheological, Rheological moduli, Rheological properties, Salt concentration, Shear rate, Size distribution, Size distribution curves, Small particles, Sodium alginate, Sodium citrate, Substitution, Substitution ratio, Substitution ratios, Ultraturrax, Various ultraturrax, Wiley periodicals.
- Teeft :
- Alginate, Alginate beads, Alginate derivatives, Alginate microparticles, Alginate particles, Alkyl, Alkyl chain, Alkyl chain substitution ratio, Alkyl chains, Amphiphilic, Amphiphilic derivatives, Aqueous solution, Aqueous solutions, Bioadhesive microspheres, Biomed mater, Cacl2, Cacl2 concentration, Current article, Dellacherie, Dellacherie figure, Derivative, Different stages, Dispersion, Dispersion phase, Distribution curve, Divalent cations, Dodecyl chains, Drug delivery, Encapsulated, Encapsulation, Experimental conditions, Experimental section, Hydrogel, Microparticle, Microparticle size distribution, Microparticles, Microspheres, Nacl, Nacl concentration, Nacl solutions, Nongelling cations, Oral administration, Other conditions, Particle size, Particle size distribution, Particle stability, Pharm, Pharm pharmacol, Polycationic polymers, Polymer, Polymer concentration, Polymer solutions, Polysaccharide, Polysaccharide backbone, Polysaccharidic hydrogel microparticles, Pregel, Preliminary assays, Protein release, Rheological, Rheological moduli, Rheological properties, Salt concentration, Shear rate, Size distribution, Size distribution curves, Small particles, Sodium alginate, Sodium citrate, Substitution, Substitution ratio, Substitution ratios, Ultraturrax, Various ultraturrax, Wiley periodicals.
Abstract
A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca2+‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004
Url:
DOI: 10.1002/jbm.a.20006
Links to Exploration step
ISTEX:84961DE1F34AF0F8E4D5F992A7A54FDF179F12BBLe document en format XML
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Leonard</name><affiliation><mods:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: mleonard@ensic.inpl‐nancy.fr</mods:affiliation></affiliation><affiliation><mods:affiliation>Correspondence address: Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Rastello De Boisseson, M" sort="Rastello De Boisseson, M" uniqKey="Rastello De Boisseson M" first="M." last="Rastello De Boisseson">M. Rastello De Boisseson</name><affiliation><mods:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation></affiliation></author><author><name sortKey="Hubert, P" sort="Hubert, P" uniqKey="Hubert P" first="P." last="Hubert">P. 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Dellacherie</name><affiliation><mods:affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of Biomedical Materials Research Part A</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A</title><idno type="ISSN">1549-3296</idno><idno type="eISSN">1552-4965</idno><imprint><biblScope unit="vol">68A</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="335">335</biblScope><biblScope unit="page" to="342">342</biblScope><biblScope unit="page-count">8</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-02-01">2004-02-01</date></imprint><idno type="ISSN">1549-3296</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1549-3296</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alginate</term><term>Alginate beads</term><term>Alginate derivatives</term><term>Alginate microparticles</term><term>Alginate particles</term><term>Alkyl</term><term>Alkyl chain</term><term>Alkyl chain substitution ratio</term><term>Alkyl chains</term><term>Amphiphilic</term><term>Amphiphilic derivatives</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bioadhesive microspheres</term><term>Biomed mater</term><term>Cacl2</term><term>Cacl2 concentration</term><term>Current article</term><term>Dellacherie</term><term>Dellacherie figure</term><term>Derivative</term><term>Different stages</term><term>Dispersion</term><term>Dispersion phase</term><term>Distribution curve</term><term>Divalent cations</term><term>Dodecyl chains</term><term>Drug delivery</term><term>Encapsulated</term><term>Encapsulation</term><term>Experimental conditions</term><term>Experimental section</term><term>Hydrogel</term><term>Microparticle</term><term>Microparticle size distribution</term><term>Microparticles</term><term>Microspheres</term><term>Nacl</term><term>Nacl concentration</term><term>Nacl solutions</term><term>Nongelling cations</term><term>Oral administration</term><term>Other conditions</term><term>Particle size</term><term>Particle size distribution</term><term>Particle stability</term><term>Pharm</term><term>Pharm pharmacol</term><term>Polycationic polymers</term><term>Polymer</term><term>Polymer concentration</term><term>Polymer solutions</term><term>Polysaccharide</term><term>Polysaccharide backbone</term><term>Polysaccharidic hydrogel microparticles</term><term>Pregel</term><term>Preliminary assays</term><term>Protein release</term><term>Rheological</term><term>Rheological moduli</term><term>Rheological properties</term><term>Salt concentration</term><term>Shear rate</term><term>Size distribution</term><term>Size distribution curves</term><term>Small particles</term><term>Sodium alginate</term><term>Sodium citrate</term><term>Substitution</term><term>Substitution ratio</term><term>Substitution ratios</term><term>Ultraturrax</term><term>Various ultraturrax</term><term>Wiley periodicals</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Alginate</term><term>Alginate beads</term><term>Alginate derivatives</term><term>Alginate microparticles</term><term>Alginate particles</term><term>Alkyl</term><term>Alkyl chain</term><term>Alkyl chain substitution ratio</term><term>Alkyl chains</term><term>Amphiphilic</term><term>Amphiphilic derivatives</term><term>Aqueous solution</term><term>Aqueous solutions</term><term>Bioadhesive microspheres</term><term>Biomed mater</term><term>Cacl2</term><term>Cacl2 concentration</term><term>Current article</term><term>Dellacherie</term><term>Dellacherie figure</term><term>Derivative</term><term>Different stages</term><term>Dispersion</term><term>Dispersion phase</term><term>Distribution curve</term><term>Divalent cations</term><term>Dodecyl chains</term><term>Drug delivery</term><term>Encapsulated</term><term>Encapsulation</term><term>Experimental conditions</term><term>Experimental section</term><term>Hydrogel</term><term>Microparticle</term><term>Microparticle size distribution</term><term>Microparticles</term><term>Microspheres</term><term>Nacl</term><term>Nacl concentration</term><term>Nacl solutions</term><term>Nongelling cations</term><term>Oral administration</term><term>Other conditions</term><term>Particle size</term><term>Particle size distribution</term><term>Particle stability</term><term>Pharm</term><term>Pharm pharmacol</term><term>Polycationic polymers</term><term>Polymer</term><term>Polymer concentration</term><term>Polymer solutions</term><term>Polysaccharide</term><term>Polysaccharide backbone</term><term>Polysaccharidic hydrogel microparticles</term><term>Pregel</term><term>Preliminary assays</term><term>Protein release</term><term>Rheological</term><term>Rheological moduli</term><term>Rheological properties</term><term>Salt concentration</term><term>Shear rate</term><term>Size distribution</term><term>Size distribution curves</term><term>Small particles</term><term>Sodium alginate</term><term>Sodium citrate</term><term>Substitution</term><term>Substitution ratio</term><term>Substitution ratios</term><term>Ultraturrax</term><term>Various ultraturrax</term><term>Wiley periodicals</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca2+‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>alginate</json:string><json:string>nacl</json:string><json:string>microparticles</json:string><json:string>hydrogel</json:string><json:string>cacl2</json:string><json:string>microspheres</json:string><json:string>dellacherie</json:string><json:string>alkyl</json:string><json:string>polysaccharide</json:string><json:string>pharm</json:string><json:string>ultraturrax</json:string><json:string>derivative</json:string><json:string>encapsulation</json:string><json:string>amphiphilic</json:string><json:string>rheological</json:string><json:string>pregel</json:string><json:string>microparticle</json:string><json:string>encapsulated</json:string><json:string>polymer</json:string><json:string>substitution ratio</json:string><json:string>aqueous solution</json:string><json:string>dispersion phase</json:string><json:string>nacl concentration</json:string><json:string>particle size distribution</json:string><json:string>alginate derivatives</json:string><json:string>drug delivery</json:string><json:string>cacl2 concentration</json:string><json:string>substitution</json:string><json:string>biomed mater</json:string><json:string>amphiphilic derivatives</json:string><json:string>distribution curve</json:string><json:string>dodecyl chains</json:string><json:string>nacl solutions</json:string><json:string>sodium alginate</json:string><json:string>alkyl chain substitution ratio</json:string><json:string>polymer concentration</json:string><json:string>microparticle size distribution</json:string><json:string>other conditions</json:string><json:string>shear rate</json:string><json:string>dispersion</json:string><json:string>polymer solutions</json:string><json:string>alginate particles</json:string><json:string>salt concentration</json:string><json:string>current article</json:string><json:string>rheological moduli</json:string><json:string>preliminary assays</json:string><json:string>aqueous solutions</json:string><json:string>divalent cations</json:string><json:string>dellacherie figure</json:string><json:string>different stages</json:string><json:string>alkyl chains</json:string><json:string>nongelling cations</json:string><json:string>wiley periodicals</json:string><json:string>polysaccharide backbone</json:string><json:string>size distribution curves</json:string><json:string>various ultraturrax</json:string><json:string>particle size</json:string><json:string>substitution ratios</json:string><json:string>alkyl chain</json:string><json:string>alginate beads</json:string><json:string>size distribution</json:string><json:string>small particles</json:string><json:string>rheological properties</json:string><json:string>polycationic polymers</json:string><json:string>experimental section</json:string><json:string>particle stability</json:string><json:string>sodium citrate</json:string><json:string>polysaccharidic hydrogel microparticles</json:string><json:string>pharm pharmacol</json:string><json:string>bioadhesive microspheres</json:string><json:string>protein release</json:string><json:string>oral administration</json:string><json:string>experimental conditions</json:string><json:string>alginate microparticles</json:string></teeft></keywords><author><json:item><name>M. Leonard</name><affiliations><json:string>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</json:string><json:string>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</json:string></affiliations></json:item><json:item><name>M. Rastello de Boisseson</name><affiliations><json:string>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</json:string></affiliations></json:item><json:item><name>P. Hubert</name><affiliations><json:string>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</json:string></affiliations></json:item><json:item><name>E. Dellacherie</name><affiliations><json:string>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>associative alginate</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>hydrogels</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>microparticles</value></json:item></subject><articleId><json:string>JBM20006</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca2+‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. 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role="corresp"><persName><forename type="first">M.</forename><surname>Leonard</surname></persName><email>mleonard@ensic.inpl‐nancy.fr</email><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France<address><country key="FR"></country></address></affiliation><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</affiliation></author><author xml:id="author-0001"><persName><forename type="first">M.</forename><surname>Rastello de Boisseson</surname></persName><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">P.</forename><surname>Hubert</surname></persName><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France<address><country key="FR"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">E.</forename><surname>Dellacherie</surname></persName><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France<address><country key="FR"></country></address></affiliation></author><idno type="istex">84961DE1F34AF0F8E4D5F992A7A54FDF179F12BB</idno><idno type="ark">ark:/67375/WNG-RH0XTFKB-C</idno><idno type="DOI">10.1002/jbm.a.20006</idno><idno type="unit">JBM20006</idno><idno type="toTypesetVersion">file:JBM.JBM20006.pdf</idno></analytic><monogr><title level="j" type="main">Journal of Biomedical Materials Research Part A</title><title level="j" type="alt">JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A</title><idno type="pISSN">1549-3296</idno><idno type="eISSN">1552-4965</idno><idno type="book-DOI">10.1002/(ISSN)1552-4965</idno><idno type="book-part-DOI">10.1002/jbm.a.v68a:2</idno><idno type="product">JBM</idno><imprint><biblScope unit="vol">68A</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="335">335</biblScope><biblScope unit="page" to="342">342</biblScope><biblScope unit="page-count">8</biblScope><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>Hoboken</pubPlace><date type="published" when="2004-02-01"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p>A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca<hi rend="superscript">2+</hi>‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004</p></abstract><textClass><keywords xml:lang="en"><term xml:id="kwd1">associative alginate</term><term xml:id="kwd2">hydrogels</term><term xml:id="kwd3">microparticles</term></keywords><keywords rend="articleCategory"><term>Research Article</term></keywords><keywords rend="tocHeading1"><term>Research Articles</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/84961DE1F34AF0F8E4D5F992A7A54FDF179F12BB/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Wiley Subscription Services, Inc., A Wiley Company</publisherName><publisherLoc>Hoboken</publisherLoc></publisherInfo><doi registered="yes">10.1002/(ISSN)1552-4965</doi><issn type="print">1549-3296</issn><issn type="electronic">1552-4965</issn><idGroup><id type="product" value="JBM"></id></idGroup><titleGroup><title type="main" xml:lang="en" sort="JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A">Journal of Biomedical Materials Research Part A</title><title type="subtitle">An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials</title><title type="short">J. Biomed. Mater. Res.</title></titleGroup><selfCitationGroup><citation type="ancestor" xml:id="cit1"><journalTitle>Journal of Applied Biomaterials</journalTitle><accessionId ref="info:x-wiley/issn/10454861">1045-4861</accessionId><pubYear year="1995">1995</pubYear><vol>6</vol><issue>4</issue></citation></selfCitationGroup></publicationMeta><publicationMeta level="part" position="20"><doi origin="wiley" registered="yes">10.1002/jbm.a.v68a:2</doi><idGroup><id type="focusSection" value="0"></id></idGroup><titleGroup><title type="focusSection" xml:lang="en">Journal of Biomedical Materials Research Part A</title></titleGroup><numberingGroup><numbering type="journalVolume" number="68">68A</numbering><numbering type="journalIssue">2</numbering></numberingGroup><coverDate startDate="2004-02-01">1 February 2004</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="150" status="forIssue"><doi origin="wiley" registered="yes">10.1002/jbm.a.20006</doi><idGroup><id type="unit" value="JBM20006"></id></idGroup><countGroup><count type="pageTotal" number="8"></count></countGroup><titleGroup><title type="articleCategory">Research Article</title><title type="tocHeading1">Research Articles</title></titleGroup><copyright ownership="publisher">Copyright © 2003 Wiley Periodicals, Inc.</copyright><eventGroup><event type="manuscriptReceived" date="2003-06-11"></event><event type="manuscriptRevised" date="2003-07-18"></event><event type="manuscriptAccepted" date="2003-08-06"></event><event type="firstOnline" date="2003-12-18"></event><event type="publishedOnlineFinalForm" date="2003-12-18"></event><event type="xmlConverted" agent="Converter:JWSART34_TO_WML3G version:2.3.6 mode:FullText source:FullText result:FullText" date="2010-05-10"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-01-28"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-23"></event></eventGroup><numberingGroup><numbering type="pageFirst">335</numbering><numbering type="pageLast">342</numbering></numberingGroup><correspondenceTo>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JBM.JBM20006.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="10"></count><count type="tableTotal" number="1"></count><count type="referenceTotal" number="41"></count><count type="wordTotal" number="4444"></count></countGroup><titleGroup><title type="main" xml:lang="en">Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions</title><title type="short" xml:lang="en">Microspheres and Alginate Derivatives</title></titleGroup><creators><creator xml:id="au1" creatorRole="author" affiliationRef="#af1" corresponding="yes"><personName><givenNames>M.</givenNames><familyName>Leonard</familyName></personName><contactDetails><email normalForm="mleonard@ensic.inpl-nancy.fr">mleonard@ensic.inpl‐nancy.fr</email></contactDetails></creator><creator xml:id="au2" creatorRole="author" affiliationRef="#af1"><personName><givenNames>M.</givenNames><familyName>Rastello de Boisseson</familyName></personName></creator><creator xml:id="au3" creatorRole="author" affiliationRef="#af1"><personName><givenNames>P.</givenNames><familyName>Hubert</familyName></personName></creator><creator xml:id="au4" creatorRole="author" affiliationRef="#af1"><personName><givenNames>E.</givenNames><familyName>Dellacherie</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="af1" countryCode="FR" type="organization"><unparsedAffiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en" type="author"><keyword xml:id="kwd1">associative alginate</keyword><keyword xml:id="kwd2">hydrogels</keyword><keyword xml:id="kwd3">microparticles</keyword></keywordGroup><fundingInfo><fundingAgency>CNRS</fundingAgency></fundingInfo><fundingInfo><fundingAgency>Rhône‐Poulenc Industrialisation/Rhodia</fundingAgency></fundingInfo><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca<sup>2+</sup>‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Microspheres and Alginate Derivatives</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Production of microspheres based on hydrophobically associating alginate derivatives by dispersion/gelation in aqueous sodium chloride solutions</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Leonard</namePart><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</affiliation><affiliation>E-mail: mleonard@ensic.inpl‐nancy.fr</affiliation><affiliation>Correspondence address: Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Rastello de Boisseson</namePart><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">P.</namePart><namePart type="family">Hubert</namePart><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Dellacherie</namePart><affiliation>Laboratoire de Chimie Physique Macromoléculaire, UMR CNRS‐INPL 7568, Groupe ENSIC, BP 451, 54001 Nancy Cedex, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><place><placeTerm type="text">Hoboken</placeTerm></place><dateIssued encoding="w3cdtf">2004-02-01</dateIssued><dateCaptured encoding="w3cdtf">2003-06-11</dateCaptured><dateValid encoding="w3cdtf">2003-08-06</dateValid><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">10</extent><extent unit="tables">1</extent><extent unit="references">41</extent><extent unit="words">4444</extent></physicalDescription><abstract lang="en">A new “all aqueous” procedure for the preparation of stable polysaccharide microparticles was developed. The method consists of dispersing a water solution of an amphiphilic alginate derivative (in the current work, alginate substituted with low amounts of dodecyl chains) first fluidified under mechanical stress, into an NaCl solution. The procedure exploits the ability of amphiphilic associative derivatives to form strong hydrogels in the presence of nonchaotropic salts and their shear‐thinning/thixotropic properties. Depending on the experimental conditions, the size of the microparticles can be varied from 10 μm to several hundred micrometers. Their mechanical properties can eventually be reinforced by addition of low concentrations of calcium chloride. The resulting microparticles exhibit a better stability than that of plain Ca2+‐alginate particles, as they are not disrupted when nongelling cations or calcium‐sequestering agents are added to the solution. In addition, the particles can be easily redispersed after being centrifuged or freeze‐dried. © 2003 Wiley Periodicals, Inc. J Biomed Mater Res 68A: 335–342, 2004</abstract><note type="funding">CNRS</note><note type="funding">Rhône‐Poulenc Industrialisation/Rhodia</note><subject lang="en"><genre>keywords</genre><topic>associative alginate</topic><topic>hydrogels</topic><topic>microparticles</topic></subject><relatedItem type="host"><titleInfo><title>Journal of Biomedical Materials Research Part A</title><subTitle>An Official Journal of The Society for Biomaterials, The Japanese Society for Biomaterials, and The Australian Society for Biomaterials and the Korean Society for Biomaterials</subTitle></titleInfo><titleInfo type="abbreviated"><title>J. Biomed. Mater. 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