Constant flowrate blocking laws and an example of their application to dead-end microfiltration of protein solutions
Identifieur interne : 000133 ( Istex/Corpus ); précédent : 000132; suivant : 000134Constant flowrate blocking laws and an example of their application to dead-end microfiltration of protein solutions
Auteurs : M. Hlavacek ; F. BouchetSource :
- Journal of Membrane Science [ 0376-7388 ] ; 1993.
English descriptors
- KwdEn :
- Bouchet, Bovine serum albumin, Cake filtration, Constant flowrate, Constant pressure, Constant pressure experiments, Crossflow microfiltration, Different conditions, Different laws, Different membranes, Electrical attraction, Electrical charge, Electrical repulsion, Electron micrographs, Elsevier science publishers, Experimental results, Filtrate, Filtrate volume, Filtration, Flow regime, Flowrate, Flux decline, Fouling, Fouling ability, Fouling rate, Free pore radius, Free surface, General equation, General expression, Good agreement, Gvhp, Gvwp, Hlavacek, Hydraulic resistance, Hydrophilic millipore gswp, Instantaneous resistance, Ionic strength, Isoelectric point, Linear regression, Linearized form, Membrane, Membrane area, Membrane fouling, Membrane pore size, Membrane surface, Microfiltration, Microporous membranes, Millipore, Millipore gswp, Millipore gvhp, Millipore gvwp, Millipore membranes, Nominal pore size, Nuclepore, Nuclepore membrane, Nuclepore membranes, Other hand, Pore, Porosity, Pressure curves, Pressure drop, Pressure transducer, Protein aggregates, Protein molecules, Protein solutions, Several times, Shear conditions, Slow increase, Surface deposit, Ultrafiltration.
- Teeft :
- Bouchet, Bovine serum albumin, Cake filtration, Constant flowrate, Constant pressure, Constant pressure experiments, Crossflow microfiltration, Different conditions, Different laws, Different membranes, Electrical attraction, Electrical charge, Electrical repulsion, Electron micrographs, Elsevier science publishers, Experimental results, Filtrate, Filtrate volume, Filtration, Flow regime, Flowrate, Flux decline, Fouling, Fouling ability, Fouling rate, Free pore radius, Free surface, General equation, General expression, Good agreement, Gvhp, Gvwp, Hlavacek, Hydraulic resistance, Hydrophilic millipore gswp, Instantaneous resistance, Ionic strength, Isoelectric point, Linear regression, Linearized form, Membrane, Membrane area, Membrane fouling, Membrane pore size, Membrane surface, Microfiltration, Microporous membranes, Millipore, Millipore gswp, Millipore gvhp, Millipore gvwp, Millipore membranes, Nominal pore size, Nuclepore, Nuclepore membrane, Nuclepore membranes, Other hand, Pore, Porosity, Pressure curves, Pressure drop, Pressure transducer, Protein aggregates, Protein molecules, Protein solutions, Several times, Shear conditions, Slow increase, Surface deposit, Ultrafiltration.
Abstract
Abstract: We developed equations for the blocking laws (complete, standard and intermediate) at a constant flowrate and we derive a general expression related to the instantaneous hydraulic permeability of the deposit dt/(ΔP). Microfiltration of BSA solutions is carried out at a constant flowrate and shows that both the type of membrane and physico-chemical conditions influence the pressure drop. The curves of pressure as a function of time are fitted by the intermediate law that enables one to determine the clogging coefficient of the solution σ and quantify the fouling through the ratio (σ/gE) of the clogging coefficient σ and the porosity ϵ. The intermediate law predicts that the increase in pressure drop is inversely proportional to the membrane porosity. The experimental results are in reasonably good agreement with the theory as track-etched Nuclepore membranes (ϵ=8%) foul 5 to 10 times more rapidly than microporous Millipore membranes (ϵ=80%). Fouling is more apparent at pH 3.6 than at pH 4.6 and pH 5.6. This is explained by electrical protein-membrane attraction at pH 3.6. Scanning electron micrographs show that the fouling is mostly a surface deposit made up of protein aggregates. The deposit turns to be thicker at pH 5.6 (3–5μm) than at pH 4.6 (0.5–1 μm). At pH 3.6, the deposit slightly penetrates the membrane and is entangled with membrane fibers on the upstream side.
Url:
DOI: 10.1016/0376-7388(93)85193-Z
Links to Exploration step
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<front><div type="abstract" xml:lang="en">Abstract: We developed equations for the blocking laws (complete, standard and intermediate) at a constant flowrate and we derive a general expression related to the instantaneous hydraulic permeability of the deposit dt/(ΔP). Microfiltration of BSA solutions is carried out at a constant flowrate and shows that both the type of membrane and physico-chemical conditions influence the pressure drop. The curves of pressure as a function of time are fitted by the intermediate law that enables one to determine the clogging coefficient of the solution σ and quantify the fouling through the ratio (σ/gE) of the clogging coefficient σ and the porosity ϵ. The intermediate law predicts that the increase in pressure drop is inversely proportional to the membrane porosity. The experimental results are in reasonably good agreement with the theory as track-etched Nuclepore membranes (ϵ=8%) foul 5 to 10 times more rapidly than microporous Millipore membranes (ϵ=80%). Fouling is more apparent at pH 3.6 than at pH 4.6 and pH 5.6. This is explained by electrical protein-membrane attraction at pH 3.6. Scanning electron micrographs show that the fouling is mostly a surface deposit made up of protein aggregates. The deposit turns to be thicker at pH 5.6 (3–5μm) than at pH 4.6 (0.5–1 μm). At pH 3.6, the deposit slightly penetrates the membrane and is entangled with membrane fibers on the upstream side.</div>
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<abstract xml:lang="en"><p>We developed equations for the blocking laws (complete, standard and intermediate) at a constant flowrate and we derive a general expression related to the instantaneous hydraulic permeability of the deposit dt/(ΔP). Microfiltration of BSA solutions is carried out at a constant flowrate and shows that both the type of membrane and physico-chemical conditions influence the pressure drop. The curves of pressure as a function of time are fitted by the intermediate law that enables one to determine the clogging coefficient of the solution σ and quantify the fouling through the ratio (σ/gE) of the clogging coefficient σ and the porosity ϵ. The intermediate law predicts that the increase in pressure drop is inversely proportional to the membrane porosity. The experimental results are in reasonably good agreement with the theory as track-etched Nuclepore membranes (ϵ=8%) foul 5 to 10 times more rapidly than microporous Millipore membranes (ϵ=80%). Fouling is more apparent at pH 3.6 than at pH 4.6 and pH 5.6. This is explained by electrical protein-membrane attraction at pH 3.6. Scanning electron micrographs show that the fouling is mostly a surface deposit made up of protein aggregates. The deposit turns to be thicker at pH 5.6 (3–5μm) than at pH 4.6 (0.5–1 μm). At pH 3.6, the deposit slightly penetrates the membrane and is entangled with membrane fibers on the upstream side.</p>
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<item><term>microfiltration, dead-end</term>
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<head><ce:title>Constant flowrate blocking laws and an example of their application to dead-end microfiltration of protein solutions</ce:title>
<ce:author-group><ce:author><ce:given-name>M.</ce:given-name>
<ce:surname>Hlavacek</ce:surname>
<ce:cross-ref refid="COR1"><ce:sup>∗</ce:sup>
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<ce:author><ce:given-name>F.</ce:given-name>
<ce:surname>Bouchet</ce:surname>
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<ce:affiliation><ce:textfn>LSGC-CNRS-ENSIC, 1 rue Grandville, BP 451, 54001 Nancy Cedex France</ce:textfn>
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<ce:correspondence id="COR1"><ce:label>*</ce:label>
<ce:text>To whom correspondence should be addressed. Present address: School of Chemical Engineering, University of New South Wales, P.O. Box 1, Kensington 2033, N.S.W., Australia.</ce:text>
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<ce:abstract><ce:section-title>Abstract</ce:section-title>
<ce:abstract-sec><ce:simple-para>We developed equations for the blocking laws (complete, standard and intermediate) at a constant flowrate and we derive a general expression related to the instantaneous hydraulic permeability of the deposit d<ce:italic>t</ce:italic>
/(Δ<ce:italic>P</ce:italic>
). Microfiltration of BSA solutions is carried out at a constant flowrate and shows that both the type of membrane and physico-chemical conditions influence the pressure drop. The curves of pressure as a function of time are fitted by the intermediate law that enables one to determine the clogging coefficient of the solution σ and quantify the fouling through the ratio (σ/gE) of the clogging coefficient σ and the porosity ϵ. The intermediate law predicts that the increase in pressure drop is inversely proportional to the membrane porosity. The experimental results are in reasonably good agreement with the theory as track-etched Nuclepore membranes (ϵ=8%) foul 5 to 10 times more rapidly than microporous Millipore membranes (ϵ=80%). Fouling is more apparent at pH 3.6 than at pH 4.6 and pH 5.6. This is explained by electrical protein-membrane attraction at pH 3.6. Scanning electron micrographs show that the fouling is mostly a surface deposit made up of protein aggregates. The deposit turns to be thicker at pH 5.6 (3–5μm) than at pH 4.6 (0.5–1 μm). At pH 3.6, the deposit slightly penetrates the membrane and is entangled with membrane fibers on the upstream side.</ce:simple-para>
</ce:abstract-sec>
</ce:abstract>
<ce:keywords><ce:section-title>Keywords</ce:section-title>
<ce:keyword><ce:text>blocking laws</ce:text>
</ce:keyword>
<ce:keyword><ce:text>bovine serum albumin</ce:text>
</ce:keyword>
<ce:keyword><ce:text>flowrate</ce:text>
</ce:keyword>
<ce:keyword><ce:text>microfiltration, dead-end</ce:text>
</ce:keyword>
<ce:keyword><ce:text>fouling</ce:text>
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<abstract lang="en">Abstract: We developed equations for the blocking laws (complete, standard and intermediate) at a constant flowrate and we derive a general expression related to the instantaneous hydraulic permeability of the deposit dt/(ΔP). Microfiltration of BSA solutions is carried out at a constant flowrate and shows that both the type of membrane and physico-chemical conditions influence the pressure drop. The curves of pressure as a function of time are fitted by the intermediate law that enables one to determine the clogging coefficient of the solution σ and quantify the fouling through the ratio (σ/gE) of the clogging coefficient σ and the porosity ϵ. The intermediate law predicts that the increase in pressure drop is inversely proportional to the membrane porosity. The experimental results are in reasonably good agreement with the theory as track-etched Nuclepore membranes (ϵ=8%) foul 5 to 10 times more rapidly than microporous Millipore membranes (ϵ=80%). Fouling is more apparent at pH 3.6 than at pH 4.6 and pH 5.6. This is explained by electrical protein-membrane attraction at pH 3.6. Scanning electron micrographs show that the fouling is mostly a surface deposit made up of protein aggregates. The deposit turns to be thicker at pH 5.6 (3–5μm) than at pH 4.6 (0.5–1 μm). At pH 3.6, the deposit slightly penetrates the membrane and is entangled with membrane fibers on the upstream side.</abstract>
<subject><genre>Keywords</genre>
<topic>blocking laws</topic>
<topic>bovine serum albumin</topic>
<topic>flowrate</topic>
<topic>microfiltration, dead-end</topic>
<topic>fouling</topic>
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