Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.
Identifieur interne : 000018 ( PubMed/Checkpoint ); précédent : 000017; suivant : 000019Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.
Auteurs : Béatrice Brembilla-Perrot [France] ; Arnaud Olivier [France] ; Jean-Marc Sellal [France] ; Vladimir Manenti [France] ; Alice Brembilla [France] ; Thibaut Villemin [France] ; Philippe Admant [France] ; Daniel Beurrier [France] ; Erwan Bozec [France] ; Nicolas Girerd [France]Source :
- BMJ open [ 2044-6055 ] ; 2016.
Abstract
There are very little data on pre-excitation syndrome (PS) in the elderly. We investigated the influence of advancing age on clinical presentation, treatment and long-term outcome of PS.
DOI: 10.1136/bmjopen-2015-010520
PubMed: 27188807
Affiliations:
- France
- Bourgogne-Franche-Comté, Franche-Comté, Grand Est, Lorraine (région)
- Besançon, Nancy, Vandœuvre-lès-Nancy, Épinal
- Université de Lorraine
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.</title><author><name sortKey="Brembilla Perrot, Beatrice" sort="Brembilla Perrot, Beatrice" uniqKey="Brembilla Perrot B" first="Béatrice" last="Brembilla-Perrot">Béatrice Brembilla-Perrot</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Olivier, Arnaud" sort="Olivier, Arnaud" uniqKey="Olivier A" first="Arnaud" last="Olivier">Arnaud Olivier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Sellal, Jean Marc" sort="Sellal, Jean Marc" uniqKey="Sellal J" first="Jean-Marc" last="Sellal">Jean-Marc Sellal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Manenti, Vladimir" sort="Manenti, Vladimir" uniqKey="Manenti V" first="Vladimir" last="Manenti">Vladimir Manenti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement 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France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Admant, Philippe" sort="Admant, Philippe" uniqKey="Admant P" first="Philippe" last="Admant">Philippe Admant</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CH of Epinal, Épinal, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CH of Epinal, Épinal</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Épinal</settlement></placeName></affiliation></author><author><name sortKey="Beurrier, Daniel" sort="Beurrier, Daniel" uniqKey="Beurrier D" first="Daniel" last="Beurrier">Daniel Beurrier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Bozec, Erwan" sort="Bozec, Erwan" uniqKey="Bozec E" first="Erwan" last="Bozec">Erwan Bozec</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno 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last="Brembilla-Perrot">Béatrice Brembilla-Perrot</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Olivier, Arnaud" sort="Olivier, Arnaud" uniqKey="Olivier A" first="Arnaud" last="Olivier">Arnaud Olivier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Sellal, Jean Marc" sort="Sellal, Jean Marc" uniqKey="Sellal J" first="Jean-Marc" last="Sellal">Jean-Marc Sellal</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Manenti, Vladimir" sort="Manenti, Vladimir" uniqKey="Manenti V" first="Vladimir" last="Manenti">Vladimir Manenti</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Brembilla, Alice" sort="Brembilla, Alice" uniqKey="Brembilla A" first="Alice" last="Brembilla">Alice Brembilla</name><affiliation wicri:level="3"><nlm:affiliation>Department of Epidemiology, CHU of Besançon, Besançon, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Epidemiology, CHU of Besançon, Besançon</wicri:regionArea><placeName><region type="region">Bourgogne-Franche-Comté</region><region type="old region">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Villemin, Thibaut" sort="Villemin, Thibaut" uniqKey="Villemin T" first="Thibaut" last="Villemin">Thibaut Villemin</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Admant, Philippe" sort="Admant, Philippe" uniqKey="Admant P" first="Philippe" last="Admant">Philippe Admant</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CH of Epinal, Épinal, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CH of Epinal, Épinal</wicri:regionArea><placeName><region type="region">Grand Est</region><region type="old region">Lorraine (région)</region><settlement type="city">Épinal</settlement></placeName></affiliation></author><author><name sortKey="Beurrier, Daniel" sort="Beurrier, Daniel" uniqKey="Beurrier D" first="Daniel" last="Beurrier">Daniel Beurrier</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName></affiliation></author><author><name sortKey="Bozec, Erwan" sort="Bozec, Erwan" uniqKey="Bozec E" first="Erwan" last="Bozec">Erwan Bozec</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><affiliation wicri:level="4"><nlm:affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy</wicri:regionArea><placeName><region type="region" nuts="2">Grand Est</region><region type="old region" nuts="2">Lorraine (région)</region><settlement type="city">Vandœuvre-lès-Nancy</settlement><settlement type="city" wicri:auto="agglo">Nancy</settlement></placeName><orgName type="university">Université de Lorraine</orgName></affiliation></author></analytic><series><title level="j">BMJ open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are very little data on pre-excitation syndrome (PS) in the elderly. We investigated the influence of advancing age on clinical presentation, treatment and long-term outcome of PS.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Data-Review"><PMID Version="1">27188807</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>18</Day></DateCreated><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2044-6055</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>5</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>BMJ open</Title><ISOAbbreviation>BMJ Open</ISOAbbreviation></Journal><ArticleTitle>Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.</ArticleTitle><Pagination><MedlinePgn>e010520</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjopen-2015-010520</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">There are very little data on pre-excitation syndrome (PS) in the elderly. We investigated the influence of advancing age on clinical presentation, treatment and long-term outcome of PS.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Single-centre retrospective study of patient files.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">In all, 961 patients (72 patients ≥60 years (mean 68.5±6), 889 patients <60 years (mean 30.5±14)) referred for overt pre-excitation and indication for electrophysiological study (EPS) were followed for 5.3±5 years. Usual care included 24 h Holter monitoring, echocardiography and EPS. Patients underwent accessory pathway (AP) ablation if necessary.</AbstractText><AbstractText Label="PRIMARY AND SECONDARY OUTCOME MEASURES" NlmCategory="METHODS">Occurrence of atrial fibrillation (AF) or procedure-induced adverse event.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Electrophysiological data and recourse to AP ablation (43% vs 48.5%, p=0.375) did not significantly differ between the groups. Older patients more often had symptomatic forms (81% vs 63%, p=0.003), history of spontaneous AF (8% vs 3%, p=0.01) or adverse presentation (poorly tolerated arrhythmias: 18% vs 7%, p=0.0009). In multivariable analysis, patients ≥60 years had a significantly higher risk of history of AF (OR=4.2, 2.1 to 8.3, p=0.001) and poorly tolerated arrhythmias (OR=3.8, 1.8 to 8.1, p=0.001). Age ≥60 years was associated with an increased major AP ablation complication risk (10% vs 1.9%, p=0.006). During follow-up, occurrence of AF (13.9% vs 3.6%, p<0.001) and incidence of poorly tolerated tachycardia (4.2% vs 0.6%, p=0.001) were more frequent in patients ≥60 years, although frequency of ablation failure or recurrence was similar (20% vs 15.5%, p=0.52). In multivariable analysis, patients ≥60 years had a significantly higher risk of AF (OR=2.9, 1.2 to 6.8, p≤0.01).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In this retrospective monocentre study, patients ≥60 years referred for PS work up appeared at higher risk of AF and adverse presentation, both prior and after the work up. These results suggest that, in elderly patients, the decision for EPS and AP ablation should be discussed in light of their suspected higher risk of events and ablation complications. However, these findings should be further validated in future prospective multicentre studies.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brembilla-Perrot</LastName><ForeName>Béatrice</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olivier</LastName><ForeName>Arnaud</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sellal</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manenti</LastName><ForeName>Vladimir</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brembilla</LastName><ForeName>Alice</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, CHU of Besançon, Besançon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villemin</LastName><ForeName>Thibaut</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Admant</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CH of Epinal, Épinal, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beurrier</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bozec</LastName><ForeName>Erwan</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girerd</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>05</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMJ Open</MedlineTA><NlmUniqueID>101552874</NlmUniqueID></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">atrial fibrillation</Keyword><Keyword MajorTopicYN="N">elderly</Keyword><Keyword MajorTopicYN="N">electrophysiological study</Keyword><Keyword MajorTopicYN="N">pre-excitation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">bmjopen-2015-010520</ArticleId><ArticleId IdType="doi">10.1136/bmjopen-2015-010520</ArticleId><ArticleId IdType="pubmed">27188807</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>France</li></country><region><li>Bourgogne-Franche-Comté</li><li>Franche-Comté</li><li>Grand Est</li><li>Lorraine (région)</li></region><settlement><li>Besançon</li><li>Nancy</li><li>Vandœuvre-lès-Nancy</li><li>Épinal</li></settlement><orgName><li>Université de Lorraine</li></orgName></list><tree><country name="France"><region name="Grand Est"><name sortKey="Brembilla Perrot, Beatrice" sort="Brembilla Perrot, Beatrice" uniqKey="Brembilla Perrot B" first="Béatrice" last="Brembilla-Perrot">Béatrice Brembilla-Perrot</name></region><name sortKey="Admant, Philippe" sort="Admant, Philippe" uniqKey="Admant P" first="Philippe" last="Admant">Philippe Admant</name><name sortKey="Beurrier, Daniel" sort="Beurrier, Daniel" uniqKey="Beurrier D" first="Daniel" last="Beurrier">Daniel Beurrier</name><name sortKey="Bozec, Erwan" sort="Bozec, Erwan" uniqKey="Bozec E" first="Erwan" last="Bozec">Erwan Bozec</name><name sortKey="Brembilla, Alice" sort="Brembilla, Alice" uniqKey="Brembilla A" first="Alice" last="Brembilla">Alice Brembilla</name><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><name sortKey="Manenti, Vladimir" sort="Manenti, Vladimir" uniqKey="Manenti V" first="Vladimir" last="Manenti">Vladimir Manenti</name><name sortKey="Olivier, Arnaud" sort="Olivier, Arnaud" uniqKey="Olivier A" first="Arnaud" last="Olivier">Arnaud Olivier</name><name sortKey="Sellal, Jean Marc" sort="Sellal, Jean Marc" uniqKey="Sellal J" first="Jean-Marc" last="Sellal">Jean-Marc Sellal</name><name sortKey="Villemin, Thibaut" sort="Villemin, Thibaut" uniqKey="Villemin T" first="Thibaut" last="Villemin">Thibaut Villemin</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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