Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.
Identifieur interne : 000000 ( PubMed/Corpus ); suivant : 000001Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.
Auteurs : Béatrice Brembilla-Perrot ; Arnaud Olivier ; Jean-Marc Sellal ; Vladimir Manenti ; Alice Brembilla ; Thibaut Villemin ; Philippe Admant ; Daniel Beurrier ; Erwan Bozec ; Nicolas GirerdSource :
- BMJ open [ 2044-6055 ] ; 2016.
Abstract
There are very little data on pre-excitation syndrome (PS) in the elderly. We investigated the influence of advancing age on clinical presentation, treatment and long-term outcome of PS.
DOI: 10.1136/bmjopen-2015-010520
PubMed: 27188807
Links to Exploration step
pubmed:27188807Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.</title><author><name sortKey="Brembilla Perrot, Beatrice" sort="Brembilla Perrot, Beatrice" uniqKey="Brembilla Perrot B" first="Béatrice" last="Brembilla-Perrot">Béatrice Brembilla-Perrot</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Olivier, Arnaud" sort="Olivier, Arnaud" uniqKey="Olivier A" first="Arnaud" last="Olivier">Arnaud Olivier</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sellal, Jean Marc" sort="Sellal, Jean Marc" uniqKey="Sellal J" first="Jean-Marc" last="Sellal">Jean-Marc Sellal</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Manenti, Vladimir" sort="Manenti, Vladimir" uniqKey="Manenti V" first="Vladimir" last="Manenti">Vladimir Manenti</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brembilla, Alice" sort="Brembilla, Alice" uniqKey="Brembilla A" first="Alice" last="Brembilla">Alice Brembilla</name><affiliation><nlm:affiliation>Department of Epidemiology, CHU of Besançon, Besançon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Villemin, Thibaut" sort="Villemin, Thibaut" uniqKey="Villemin T" first="Thibaut" last="Villemin">Thibaut Villemin</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Admant, Philippe" sort="Admant, Philippe" uniqKey="Admant P" first="Philippe" last="Admant">Philippe Admant</name><affiliation><nlm:affiliation>Department of Cardiology, CH of Epinal, Épinal, France.</nlm:affiliation></affiliation></author><author><name sortKey="Beurrier, Daniel" sort="Beurrier, Daniel" uniqKey="Beurrier D" first="Daniel" last="Beurrier">Daniel Beurrier</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bozec, Erwan" sort="Bozec, Erwan" uniqKey="Bozec E" first="Erwan" last="Bozec">Erwan Bozec</name><affiliation><nlm:affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><affiliation><nlm:affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="doi">10.1136/bmjopen-2015-010520</idno><idno type="RBID">pubmed:27188807</idno><idno type="pmid">27188807</idno><idno type="wicri:Area/PubMed/Corpus">000000</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000000</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.</title><author><name sortKey="Brembilla Perrot, Beatrice" sort="Brembilla Perrot, Beatrice" uniqKey="Brembilla Perrot B" first="Béatrice" last="Brembilla-Perrot">Béatrice Brembilla-Perrot</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Olivier, Arnaud" sort="Olivier, Arnaud" uniqKey="Olivier A" first="Arnaud" last="Olivier">Arnaud Olivier</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Sellal, Jean Marc" sort="Sellal, Jean Marc" uniqKey="Sellal J" first="Jean-Marc" last="Sellal">Jean-Marc Sellal</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Manenti, Vladimir" sort="Manenti, Vladimir" uniqKey="Manenti V" first="Vladimir" last="Manenti">Vladimir Manenti</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Brembilla, Alice" sort="Brembilla, Alice" uniqKey="Brembilla A" first="Alice" last="Brembilla">Alice Brembilla</name><affiliation><nlm:affiliation>Department of Epidemiology, CHU of Besançon, Besançon, France.</nlm:affiliation></affiliation></author><author><name sortKey="Villemin, Thibaut" sort="Villemin, Thibaut" uniqKey="Villemin T" first="Thibaut" last="Villemin">Thibaut Villemin</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Admant, Philippe" sort="Admant, Philippe" uniqKey="Admant P" first="Philippe" last="Admant">Philippe Admant</name><affiliation><nlm:affiliation>Department of Cardiology, CH of Epinal, Épinal, France.</nlm:affiliation></affiliation></author><author><name sortKey="Beurrier, Daniel" sort="Beurrier, Daniel" uniqKey="Beurrier D" first="Daniel" last="Beurrier">Daniel Beurrier</name><affiliation><nlm:affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Bozec, Erwan" sort="Bozec, Erwan" uniqKey="Bozec E" first="Erwan" last="Bozec">Erwan Bozec</name><affiliation><nlm:affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author><author><name sortKey="Girerd, Nicolas" sort="Girerd, Nicolas" uniqKey="Girerd N" first="Nicolas" last="Girerd">Nicolas Girerd</name><affiliation><nlm:affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</nlm:affiliation></affiliation></author></analytic><series><title level="j">BMJ open</title><idno type="eISSN">2044-6055</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">There are very little data on pre-excitation syndrome (PS) in the elderly. We investigated the influence of advancing age on clinical presentation, treatment and long-term outcome of PS.</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="In-Data-Review"><PMID Version="1">27188807</PMID><DateCreated><Year>2016</Year><Month>05</Month><Day>18</Day></DateCreated><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">2044-6055</ISSN><JournalIssue CitedMedium="Internet"><Volume>6</Volume><Issue>5</Issue><PubDate><Year>2016</Year></PubDate></JournalIssue><Title>BMJ open</Title><ISOAbbreviation>BMJ Open</ISOAbbreviation></Journal><ArticleTitle>Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.</ArticleTitle><Pagination><MedlinePgn>e010520</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1136/bmjopen-2015-010520</ELocationID><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">There are very little data on pre-excitation syndrome (PS) in the elderly. We investigated the influence of advancing age on clinical presentation, treatment and long-term outcome of PS.</AbstractText><AbstractText Label="SETTING" NlmCategory="METHODS">Single-centre retrospective study of patient files.</AbstractText><AbstractText Label="PARTICIPANTS" NlmCategory="METHODS">In all, 961 patients (72 patients ≥60 years (mean 68.5±6), 889 patients <60 years (mean 30.5±14)) referred for overt pre-excitation and indication for electrophysiological study (EPS) were followed for 5.3±5 years. Usual care included 24 h Holter monitoring, echocardiography and EPS. Patients underwent accessory pathway (AP) ablation if necessary.</AbstractText><AbstractText Label="PRIMARY AND SECONDARY OUTCOME MEASURES" NlmCategory="METHODS">Occurrence of atrial fibrillation (AF) or procedure-induced adverse event.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Electrophysiological data and recourse to AP ablation (43% vs 48.5%, p=0.375) did not significantly differ between the groups. Older patients more often had symptomatic forms (81% vs 63%, p=0.003), history of spontaneous AF (8% vs 3%, p=0.01) or adverse presentation (poorly tolerated arrhythmias: 18% vs 7%, p=0.0009). In multivariable analysis, patients ≥60 years had a significantly higher risk of history of AF (OR=4.2, 2.1 to 8.3, p=0.001) and poorly tolerated arrhythmias (OR=3.8, 1.8 to 8.1, p=0.001). Age ≥60 years was associated with an increased major AP ablation complication risk (10% vs 1.9%, p=0.006). During follow-up, occurrence of AF (13.9% vs 3.6%, p<0.001) and incidence of poorly tolerated tachycardia (4.2% vs 0.6%, p=0.001) were more frequent in patients ≥60 years, although frequency of ablation failure or recurrence was similar (20% vs 15.5%, p=0.52). In multivariable analysis, patients ≥60 years had a significantly higher risk of AF (OR=2.9, 1.2 to 6.8, p≤0.01).</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">In this retrospective monocentre study, patients ≥60 years referred for PS work up appeared at higher risk of AF and adverse presentation, both prior and after the work up. These results suggest that, in elderly patients, the decision for EPS and AP ablation should be discussed in light of their suspected higher risk of events and ablation complications. However, these findings should be further validated in future prospective multicentre studies.</AbstractText><CopyrightInformation>Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://www.bmj.com/company/products-services/rights-and-licensing/</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Brembilla-Perrot</LastName><ForeName>Béatrice</ForeName><Initials>B</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Olivier</LastName><ForeName>Arnaud</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sellal</LastName><ForeName>Jean-Marc</ForeName><Initials>JM</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Manenti</LastName><ForeName>Vladimir</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Brembilla</LastName><ForeName>Alice</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Epidemiology, CHU of Besançon, Besançon, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Villemin</LastName><ForeName>Thibaut</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Admant</LastName><ForeName>Philippe</ForeName><Initials>P</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CH of Epinal, Épinal, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Beurrier</LastName><ForeName>Daniel</ForeName><Initials>D</Initials><AffiliationInfo><Affiliation>Department of Cardiology, CHU de Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Bozec</LastName><ForeName>Erwan</ForeName><Initials>E</Initials><AffiliationInfo><Affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Girerd</LastName><ForeName>Nicolas</ForeName><Initials>N</Initials><AffiliationInfo><Affiliation>INSERM, Centre d'Investigations Cliniques 1433, Université de Lorraine, CHU de Nancy, Institut Lorrain du cœur et des vaisseaux and INI-CRCT (Cardiovascular and Renal Clinical Trialists) F-CRIN network, Nancy, Vandoeuvre-lès-Nancy, France.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>05</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>BMJ Open</MedlineTA><NlmUniqueID>101552874</NlmUniqueID></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">atrial fibrillation</Keyword><Keyword MajorTopicYN="N">elderly</Keyword><Keyword MajorTopicYN="N">electrophysiological study</Keyword><Keyword MajorTopicYN="N">pre-excitation</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>5</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>5</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pii">bmjopen-2015-010520</ArticleId><ArticleId IdType="doi">10.1136/bmjopen-2015-010520</ArticleId><ArticleId IdType="pubmed">27188807</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Lorraine/explor/InforLorV4/Data/PubMed/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000000 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd -nk 000000 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Lorraine
|area= InforLorV4
|flux= PubMed
|étape= Corpus
|type= RBID
|clé= pubmed:27188807
|texte= Influence of advancing age on clinical presentation, treatment efficacy and safety, and long-term outcome of pre-excitation syndromes: a retrospective cohort study of 961 patients included over a 25-year period.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/PubMed/Corpus/RBID.i -Sk "pubmed:27188807" \
| HfdSelect -Kh $EXPLOR_AREA/Data/PubMed/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a InforLorV4
| This area was generated with Dilib version V0.6.33. |  |