Mathematical modelling of ICAN-mediated persistent firing in hippocampal neurons
Identifieur interne : 000032 ( Pmc/Corpus ); précédent : 000031; suivant : 000033Mathematical modelling of ICAN-mediated persistent firing in hippocampal neurons
Auteurs : Francesco Giovannini ; Motoharu Yoshida ; Laure BuhrySource :
- BMC Neuroscience [ 1471-2202 ] ; 2015.
Url:
DOI: 10.1186/1471-2202-16-S1-P292
PubMed: NONE
PubMed Central: 4699106
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Mathematical modelling of ICAN-mediated persistent firing in hippocampal neurons</title><author><name sortKey="Giovannini, Francesco" sort="Giovannini, Francesco" uniqKey="Giovannini F" first="Francesco" last="Giovannini">Francesco Giovannini</name><affiliation><nlm:aff id="I1">Neurosys Team, INRIA, LORIA UMR 7503, CNRS, Université de Lorraine, Villers-lès-Nancy, F-54600, France</nlm:aff></affiliation></author><author><name sortKey="Yoshida, Motoharu" sort="Yoshida, Motoharu" uniqKey="Yoshida M" first="Motoharu" last="Yoshida">Motoharu Yoshida</name><affiliation><nlm:aff id="I2">Faculty of Psychology, Mercator Research Group - Structure of Memory, Ruhr-University, Bochum, 44801, Germany</nlm:aff></affiliation></author><author><name sortKey="Buhry, Laure" sort="Buhry, Laure" uniqKey="Buhry L" first="Laure" last="Buhry">Laure Buhry</name><affiliation><nlm:aff id="I1">Neurosys Team, INRIA, LORIA UMR 7503, CNRS, Université de Lorraine, Villers-lès-Nancy, F-54600, France</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">4699106</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4699106</idno><idno type="RBID">PMC:4699106</idno><idno type="doi">10.1186/1471-2202-16-S1-P292</idno><idno type="pmid">NONE</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000032</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000032</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mathematical modelling of ICAN-mediated persistent firing in hippocampal neurons</title><author><name sortKey="Giovannini, Francesco" sort="Giovannini, Francesco" uniqKey="Giovannini F" first="Francesco" last="Giovannini">Francesco Giovannini</name><affiliation><nlm:aff id="I1">Neurosys Team, INRIA, LORIA UMR 7503, CNRS, Université de Lorraine, Villers-lès-Nancy, F-54600, France</nlm:aff></affiliation></author><author><name sortKey="Yoshida, Motoharu" sort="Yoshida, Motoharu" uniqKey="Yoshida M" first="Motoharu" last="Yoshida">Motoharu Yoshida</name><affiliation><nlm:aff id="I2">Faculty of Psychology, Mercator Research Group - Structure of Memory, Ruhr-University, Bochum, 44801, Germany</nlm:aff></affiliation></author><author><name sortKey="Buhry, Laure" sort="Buhry, Laure" uniqKey="Buhry L" first="Laure" last="Buhry">Laure Buhry</name><affiliation><nlm:aff id="I1">Neurosys Team, INRIA, LORIA UMR 7503, CNRS, Université de Lorraine, Villers-lès-Nancy, F-54600, France</nlm:aff></affiliation></author></analytic><series><title level="j">BMC Neuroscience</title><idno type="eISSN">1471-2202</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Fuster, J" uniqKey="Fuster J">J Fuster</name></author><author><name sortKey="Alexander, Ge" uniqKey="Alexander G">GE Alexander</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, X J" uniqKey="Wang X">X-J Wang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Amaral, Dg" uniqKey="Amaral D">DG Amaral</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Knauer, B" uniqKey="Knauer B">B Knauer</name></author><author><name sortKey="Jochems, A" uniqKey="Jochems A">A Jochems</name></author><author><name sortKey="Valero Aracama, Mj" uniqKey="Valero Aracama M">MJ Valero-Aracama</name></author><author><name sortKey="Yoshida, M" uniqKey="Yoshida M">M Yoshida</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Destexhe, A" uniqKey="Destexhe A">A Destexhe</name></author><author><name sortKey="Contreras, D" uniqKey="Contreras D">D Contreras</name></author><author><name sortKey="Sejnowski, Tj" uniqKey="Sejnowski T">TJ Sejnowski</name></author><author><name sortKey="Steriade, M" uniqKey="Steriade M">M Steriade</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Partridge, Ld" uniqKey="Partridge L">LD Partridge</name></author><author><name sortKey="Swandulla, D" uniqKey="Swandulla D">D Swandulla</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="abstract" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">BMC Neurosci</journal-id><journal-title-group><journal-title>BMC Neuroscience</journal-title></journal-title-group><issn pub-type="epub">1471-2202</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">4699106</article-id><article-id pub-id-type="publisher-id">1471-2202-16-S1-P292</article-id><article-id pub-id-type="doi">10.1186/1471-2202-16-S1-P292</article-id><article-categories><subj-group subj-group-type="heading"><subject>Poster Presentation</subject></subj-group></article-categories><title-group><article-title>Mathematical modelling of ICAN-mediated persistent firing in hippocampal neurons</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Giovannini</surname><given-names>Francesco</given-names></name><xref ref-type="aff" rid="I1">1</xref><email>francesco.giovannini@inria.fr</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Yoshida</surname><given-names>Motoharu</given-names></name><xref ref-type="aff" rid="I2">2</xref></contrib><contrib contrib-type="author" id="A3"><name><surname>Buhry</surname><given-names>Laure</given-names></name><xref ref-type="aff" rid="I1">1</xref></contrib></contrib-group><aff id="I1"><label>1</label>Neurosys Team, INRIA, LORIA UMR 7503, CNRS, Université de Lorraine, Villers-lès-Nancy, F-54600, France</aff><aff id="I2"><label>2</label>Faculty of Psychology, Mercator Research Group - Structure of Memory, Ruhr-University, Bochum, 44801, Germany</aff><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>18</day><month>12</month><year>2015</year></pub-date><volume>16</volume><issue>Suppl 1</issue><supplement><named-content content-type="supplement-title">24th Annual Computational Neuroscience Meeting: CNS*2015</named-content><named-content content-type="supplement-editor">Gennady Cymbalyuk and Anthony Burkitt</named-content><named-content content-type="supplement-sponsor">The publication charges for this supplement were funded by the Organization for Computational Neurosciences. The Supplement Editors declare that they have no competing interests.</named-content></supplement><fpage>P292</fpage><lpage>P292</lpage><permissions><copyright-statement>Copyright © 2015 Giovannini et al.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Giovannini et al.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><self-uri xlink:href="http://www.biomedcentral.com/1471-2202/16/S1/P292"></self-uri><conference><conf-date>18-23 July 2015</conf-date><conf-name>24th Annual Computational Neuroscience Meeting: CNS*2015</conf-name><conf-loc>Prague, Czech Republic</conf-loc></conference></article-meta></front><body><sec><title></title><p>Persistent neural activity has been the focus of neuroscientific research since it was first associated with complex cognitive behaviours. In particular, persistent firing has long been thought to be the neural mechanisms underlying short-term memory encoding and storage [<xref ref-type="bibr" rid="B1">1</xref>]. This activity is often elicited by short transient stimuli that have to be retained in memory for long delay periods, in the order of several seconds, after the original stimulus disappeared. In this scenario, the brain stores information for future execution of action depending on that information.</p><p>Persistent activity elicited in a recurrent network comprising strong excitation in the local circuit has been extensively described in the literature (for a review see [<xref ref-type="bibr" rid="B2">2</xref>]). However, recent findings have shown that memory can also be encoded in brain regions which do not display such recurrent connection topology, including the CA1 hippocampal area [<xref ref-type="bibr" rid="B3">3</xref>]. Emerging studies are pointing towards intrinsic neural mechanisms independent of synaptic connections, as a complementary mechanism for the maintenance of persistent activity in the hippocampus [<xref ref-type="bibr" rid="B4">4</xref>]. These include various cytoplasmic currents flowing through the membrane, characterised by slow ion channel kinetics, and particular neurotransmitter modulation. Our work investigates persistent firing activity in networks of hippocampal neurons, elicited by leveraging intrinsic currents rather than network dynamics.</p><p>Building on previous findings [<xref ref-type="bibr" rid="B5">5</xref>], we model a hippocampal pyramidal neuron using the Hodgkin-Huxley model, with low-threshold Ca<sup>2+ </sup>currents governing the inward flow of calcium ions in the cell membrane. The intracellular calcium concentration mediates the opening of calcium-activated non-specific (CAN) ion channels [<xref ref-type="bibr" rid="B6">6</xref>], which causes an increase in the ionic flow through the cell membrane. Therefore the CAN channels equip the neuron with an after-spike depolarisation mechanism, which enables it to emit action potentials in the absence of external stimulation. Given a transient 250<italic>ms </italic>200<italic>pA </italic>current injection, the neuron is capable of eliciting and maintaining persistent activity with a firing rate of 6<italic>Hz </italic>for long delay periods (<italic>~30s</italic>). Moreover, this behaviour is in accord with that displayed in neural recordings of hippocampal slice preparations [<xref ref-type="bibr" rid="B4">4</xref>]. Connecting these persistent firing neurons in a network comprising strong local excitation yields a wide range of behaviours depending on the interaction between CAN and synaptic currents. Indeed, our network model is capable of displaying rhythmic behaviour in the form of short synchronised bursts with intra-burst frequencies of <italic>20-40Hz </italic>and inter-burst frequencies of <italic>3Hz</italic>. These results hint towards a possible mechanism for the generation of memory-related oscillatory activity in the hippocampus.</p></sec></body><back><ref-list><ref id="B1"><mixed-citation publication-type="journal"><name><surname>Fuster</surname><given-names>J</given-names></name><name><surname>Alexander</surname><given-names>GE</given-names></name><article-title>Neuron Activity Related to Short-Term Memory</article-title><source>Science</source><year>1971</year><volume>173</volume><fpage>652</fpage><lpage>654</lpage><pub-id pub-id-type="pmid">4998337</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><name><surname>Wang</surname><given-names>X-J</given-names></name><article-title>Synaptic reverberation underlying mnemonic persistent activity</article-title><source>Trends Neurosci</source><year>2001</year><volume>24</volume><fpage>455</fpage><lpage>463</lpage><pub-id pub-id-type="pmid">11476885</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><name><surname>Amaral</surname><given-names>DG</given-names></name><article-title>Emerging principles of intrinsic hippocampal organization</article-title><source>Curr Opin Neurobiol</source><year>1993</year><volume>3</volume><fpage>225</fpage><lpage>229</lpage><pub-id pub-id-type="pmid">8390320</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><name><surname>Knauer</surname><given-names>B</given-names></name><name><surname>Jochems</surname><given-names>A</given-names></name><name><surname>Valero-Aracama</surname><given-names>MJ</given-names></name><name><surname>Yoshida</surname><given-names>M</given-names></name><article-title>Long-lasting intrinsic persistent firing in rat CA1 pyramidal cells: a possible mechanism for active maintenance of memory</article-title><source>Hippocampus</source><year>2013</year><volume>23</volume><fpage>820</fpage><lpage>831</lpage><pub-id pub-id-type="pmid">23609880</pub-id></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><name><surname>Destexhe</surname><given-names>A</given-names></name><name><surname>Contreras</surname><given-names>D</given-names></name><name><surname>Sejnowski</surname><given-names>TJ</given-names></name><name><surname>Steriade</surname><given-names>M</given-names></name><article-title>A model of spindle rhythmicity in the isolated thalamic reticular nucleus</article-title><source>J Neurophysiol</source><year>1994</year><volume>72</volume><fpage>803</fpage><lpage>818</lpage><pub-id pub-id-type="pmid">7527077</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="journal"><name><surname>Partridge</surname><given-names>LD</given-names></name><name><surname>Swandulla</surname><given-names>D</given-names></name><article-title>Calcium-activated non-specific cation channels</article-title><source>Trends Neurosci</source><year>1988</year><volume>11</volume><fpage>69</fpage><lpage>72</lpage><pub-id pub-id-type="pmid">2465602</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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