Description and removal of background activity in EEG power spectra under general anesthesia using the Lorentzian curve
Identifieur interne : 000031 ( Pmc/Corpus ); précédent : 000030; suivant : 000032Description and removal of background activity in EEG power spectra under general anesthesia using the Lorentzian curve
Auteurs : Mariia Fedotenkova ; Axel Hutt ; James W. SleighSource :
- BMC Neuroscience [ 1471-2202 ] ; 2015.
Url:
DOI: 10.1186/1471-2202-16-S1-P233
PubMed: NONE
PubMed Central: 4698763
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Description and removal of background activity in EEG power spectra under general anesthesia using the Lorentzian curve</title><author><name sortKey="Fedotenkova, Mariia" sort="Fedotenkova, Mariia" uniqKey="Fedotenkova M" first="Mariia" last="Fedotenkova">Mariia Fedotenkova</name><affiliation><nlm:aff id="I1">CNRS, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, F-54500, France</nlm:aff></affiliation><affiliation><nlm:aff id="I2">NEUROSYS team, Inria, Villers-lès-Nancy, F-54600, France</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Université de Lorraine, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Hutt, Axel" sort="Hutt, Axel" uniqKey="Hutt A" first="Axel" last="Hutt">Axel Hutt</name><affiliation><nlm:aff id="I1">CNRS, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, F-54500, France</nlm:aff></affiliation><affiliation><nlm:aff id="I2">NEUROSYS team, Inria, Villers-lès-Nancy, F-54600, France</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Université de Lorraine, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Sleigh, James W" sort="Sleigh, James W" uniqKey="Sleigh J" first="James W" last="Sleigh">James W. Sleigh</name><affiliation><nlm:aff id="I4">Department of Anesthesia, Waikato Clinical School of the University of Auckland, Waikato Hospital, Hamilton 3206, New Zealand</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmc">4698763</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4698763</idno><idno type="RBID">PMC:4698763</idno><idno type="doi">10.1186/1471-2202-16-S1-P233</idno><idno type="pmid">NONE</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000031</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000031</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Description and removal of background activity in EEG power spectra under general anesthesia using the Lorentzian curve</title><author><name sortKey="Fedotenkova, Mariia" sort="Fedotenkova, Mariia" uniqKey="Fedotenkova M" first="Mariia" last="Fedotenkova">Mariia Fedotenkova</name><affiliation><nlm:aff id="I1">CNRS, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, F-54500, France</nlm:aff></affiliation><affiliation><nlm:aff id="I2">NEUROSYS team, Inria, Villers-lès-Nancy, F-54600, France</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Université de Lorraine, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Hutt, Axel" sort="Hutt, Axel" uniqKey="Hutt A" first="Axel" last="Hutt">Axel Hutt</name><affiliation><nlm:aff id="I1">CNRS, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, F-54500, France</nlm:aff></affiliation><affiliation><nlm:aff id="I2">NEUROSYS team, Inria, Villers-lès-Nancy, F-54600, France</nlm:aff></affiliation><affiliation><nlm:aff id="I3">Université de Lorraine, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, France</nlm:aff></affiliation></author><author><name sortKey="Sleigh, James W" sort="Sleigh, James W" uniqKey="Sleigh J" first="James W" last="Sleigh">James W. Sleigh</name><affiliation><nlm:aff id="I4">Department of Anesthesia, Waikato Clinical School of the University of Auckland, Waikato Hospital, Hamilton 3206, New Zealand</nlm:aff></affiliation></author></analytic><series><title level="j">BMC Neuroscience</title><idno type="eISSN">1471-2202</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Sleigh, Jw" uniqKey="Sleigh J">JW Sleigh</name></author><author><name sortKey="Leslie, K" uniqKey="Leslie K">K Leslie</name></author><author><name sortKey="Voss, L" uniqKey="Voss L">L Voss</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bedard, C" uniqKey="Bedard C">C Bédard</name></author><author><name sortKey="Destexhe, A" uniqKey="Destexhe A">A Destexhe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hutt, A" uniqKey="Hutt A">A Hutt</name></author><author><name sortKey="Frank, Td" uniqKey="Frank T">TD Frank</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Demanuele, C" uniqKey="Demanuele C">C Demanuele</name></author><author><name sortKey="James, Cj" uniqKey="James C">CJ James</name></author><author><name sortKey="Sonuga Barke, Ej" uniqKey="Sonuga Barke E">EJ Sonuga-Barke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Freeman, Wj" uniqKey="Freeman W">WJ Freeman</name></author><author><name sortKey="Zhai, J" uniqKey="Zhai J">J Zhai</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="abstract" xml:lang="en"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">BMC Neurosci</journal-id><journal-id journal-id-type="iso-abbrev">BMC Neurosci</journal-id><journal-title-group><journal-title>BMC Neuroscience</journal-title></journal-title-group><issn pub-type="epub">1471-2202</issn><publisher><publisher-name>BioMed Central</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmc">4698763</article-id><article-id pub-id-type="publisher-id">1471-2202-16-S1-P233</article-id><article-id pub-id-type="doi">10.1186/1471-2202-16-S1-P233</article-id><article-categories><subj-group subj-group-type="heading"><subject>Poster Presentation</subject></subj-group></article-categories><title-group><article-title>Description and removal of background activity in EEG power spectra under general anesthesia using the Lorentzian curve</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes" id="A1"><name><surname>Fedotenkova</surname><given-names>Mariia</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref><email>mariia.fedotenkova@inria.fr</email></contrib><contrib contrib-type="author" id="A2"><name><surname>Hutt</surname><given-names>Axel</given-names></name><xref ref-type="aff" rid="I1">1</xref><xref ref-type="aff" rid="I2">2</xref><xref ref-type="aff" rid="I3">3</xref></contrib><contrib contrib-type="author" id="A3"><name><surname>Sleigh</surname><given-names>James W</given-names></name><xref ref-type="aff" rid="I4">4</xref></contrib></contrib-group><aff id="I1"><label>1</label>CNRS, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, F-54500, France</aff><aff id="I2"><label>2</label>NEUROSYS team, Inria, Villers-lès-Nancy, F-54600, France</aff><aff id="I3"><label>3</label>Université de Lorraine, Loria, UMR nº 7503, Vandœuvre-lès-Nancy, France</aff><aff id="I4"><label>4</label>Department of Anesthesia, Waikato Clinical School of the University of Auckland, Waikato Hospital, Hamilton 3206, New Zealand</aff><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>18</day><month>12</month><year>2015</year></pub-date><volume>16</volume><issue>Suppl 1</issue><supplement><named-content content-type="supplement-title">24th Annual Computational Neuroscience Meeting: CNS*2015</named-content><named-content content-type="supplement-editor">Gennady Cymbalyuk and Anthony Burkitt</named-content><named-content content-type="supplement-sponsor">The publication charges for this supplement were funded by the Organization for Computational Neurosciences. The Supplement Editors declare that they have no competing interests.</named-content></supplement><fpage>P233</fpage><lpage>P233</lpage><permissions><copyright-statement>Copyright © 2015 Fedotenkova et al.</copyright-statement><copyright-year>2015</copyright-year><copyright-holder>Fedotenkova et al.</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0">http://creativecommons.org/licenses/by/4.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. The Creative Commons Public Domain Dedication waiver (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/publicdomain/zero/1.0/">http://creativecommons.org/publicdomain/zero/1.0/</ext-link>) applies to the data made available in this article, unless otherwise stated.</license-p></license></permissions><self-uri xlink:href="http://www.biomedcentral.com/1471-2202/16/S1/P233"></self-uri><conference><conf-date>18-23 July 2015</conf-date><conf-name>24th Annual Computational Neuroscience Meeting: CNS*2015</conf-name><conf-loc>Prague, Czech Republic</conf-loc></conference></article-meta></front><body><sec><title></title><p>General anesthesia is an important medical procedure in today's hospital practice and comprises loss of consciousness, analgesia, amnesia and immobility. Our current work analyzes patient reaction on nociception stimuli during a surgical operation and differences in this reaction provided different anesthetic drugs, propofol and desflurane. The studied dataset comprises EEG-recordings before and after incision obtained from 115 patients [<xref ref-type="bibr" rid="B1">1</xref>]. The task is the identification of spectral EEG signal features reflecting the incision. This analysis will reveal a possible new marker of pain during deep anesthesia.</p><p>This work considers one of the approaches to the problem, namely spectral analysis. First, power spectral density (PSD) estimates were obtained using Welch's method. It is well known that EEG power spectrum decays with higher frequencies following <italic>~1/f </italic>scaling [<xref ref-type="bibr" rid="B2">2</xref>-<xref ref-type="bibr" rid="B4">4</xref>]. We attribute this behavior to background activity [<xref ref-type="bibr" rid="B5">5</xref>], which takes place in the brain when no other activity is present. Background activity was describe by fitting regression curve <italic>P(f)~a/f <sup>b </sup></italic>to each PSD estimate. However, the resulting goodness of fit was not satisfactory. It is due to rise of power in delta peak, which becomes prominent under general anesthesia and makes the process of curve fitting less reliable. Thus, the original model was substituted by the Lorentzian function <italic>P(f)=a/(f <sup>b </sup>+ c)</italic>, which resembles the shape of actual power spectrum quite well. Afterwards, regression curves were subtracted from each power spectrum to normalize it [<xref ref-type="bibr" rid="B3">3</xref>] and to analyze spectral power contained in delta and alpha peaks regardless of distinctions in patients.</p><p>The results of this work revealed small differences between propofol and desflurane. Power spectra of patients receiving desflurane have more regular shape than the ones from propofol group. It can also be seen that delta power remains more consistent, while alpha power varies greatly from patient to patient. Another result of this work is a trend in the distribution of Lorentzian curve parameters: the set of parameters remains compact for small values of <italic>b</italic>, but <italic>a </italic>and <italic>c </italic>scatters significantly when <italic>b </italic>(which corresponds to steepness of curve) is larger than three. Results of this work provide insights on underlying background activity. However, they do not allow to distinguish between pre- and post-incision and poorly between propofol and desflurane. This problem requires more complicated techniques. Future work will expand spectral analysis with time information (time-frequency representations) and investigate time structure by means of recurrence analysis.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p><bold>Example of power spectrum density estimate (solid black), with fitted Lorentzian curve (dashed orange), goodness of fit (R2), delta (green circle) and alpha peaks (blue circle)</bold>.</p></caption><graphic xlink:href="1471-2202-16-S1-P233-1"></graphic></fig></sec></body><back><ref-list><ref id="B1"><mixed-citation publication-type="journal"><name><surname>Sleigh</surname><given-names>JW</given-names></name><name><surname>Leslie</surname><given-names>K</given-names></name><name><surname>Voss</surname><given-names>L</given-names></name><article-title>The effect of skin incision on the electroencephalogram during general anesthesia maintained with propofol or desflurane</article-title><source>Journal of Clinical Monitoring and Computing</source><year>2010</year><volume>24</volume><issue>4</issue><fpage>307</fpage><lpage>318</lpage><pub-id pub-id-type="pmid">20680669</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><name><surname>Bédard</surname><given-names>C</given-names></name><name><surname>Destexhe</surname><given-names>A</given-names></name><article-title>Macroscopic Models of Local Field Potentials and the Apparent 1/f Noise in Brain Activity</article-title><source>Biophysical Journal</source><year>2009</year><volume>96</volume><issue>7</issue><fpage>2589</fpage><lpage>2603</lpage><pub-id pub-id-type="pmid">19348744</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><name><surname>Hutt</surname><given-names>A</given-names></name><name><surname>Frank</surname><given-names>TD</given-names></name><article-title>Critical fluctuations and 1/f α-activity of neural fields involving transmission delays</article-title><source>Acta Phys Pol A</source><year>2005</year><volume>108</volume><fpage>1021</fpage><lpage>1040</lpage></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><name><surname>Demanuele</surname><given-names>C</given-names></name><name><surname>James</surname><given-names>CJ</given-names></name><name><surname>Sonuga-Barke</surname><given-names>EJ</given-names></name><article-title>Distinguishing low frequency oscillations within the 1/f spectral behaviour of electromagnetic brain signals</article-title><source>Behavioral and Brain Functions</source><year>2007</year><volume>3</volume><fpage>62</fpage><pub-id pub-id-type="pmid">18070337</pub-id></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><name><surname>Freeman</surname><given-names>WJ</given-names></name><name><surname>Zhai</surname><given-names>J</given-names></name><article-title>Simulated power spectral density (PSD) of background electrocorticogram (ECoG)</article-title><source>Cognitive Neurodynamics</source><year>2009</year><volume>3</volume><issue>1</issue><fpage>97</fpage><lpage>103</lpage><pub-id pub-id-type="pmid">19003455</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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