Clinical and pathological characteristics of melanoma: a population‐based study in a French regional population
Identifieur interne : 001658 ( Istex/Corpus ); précédent : 001657; suivant : 001659Clinical and pathological characteristics of melanoma: a population‐based study in a French regional population
Auteurs : C. Barbe ; E. Hibon ; F. Vitry ; A. Le Clainche ; F. GrangeSource :
- Journal of the European Academy of Dermatology and Venereology [ 0926-9959 ] ; 2012-02.
English descriptors
- Teeft :
- Acad dermatol venereol, Acral lentiginous, Ajcc, Ajcc stage, Arch dermatol, Authors journal, Breslow, Breslow thickness, Clark level, Cutaneous, Cutaneous melanoma, Dermatol, Dermatologist, Dermatology, Early diagnosis, Epidemiology, European academy, Gender, Higher breslow thickness, Higher proportion, Histological, Histological type, Inhabitant, Invasive, Invasive melanomas, Jeadv, Lentigo, Lentigo maligna melanomas, Lower limb, Maligna, Median, Melanoma, Melanoma characteristics, Melanoma incidence, Nodular, Older patients, Omecha registry, Pathological characteristics, Standard deviation, Study area, Thick melanomas, Tumour, Tumour characteristics, Ulceration, Ulceration status, Upper limb, Venereology, Venereology barbe.
Abstract
Background Although incidence and mortality data are numerous, population‐based studies including clinical and pathological characteristics of melanoma are rare.
Objectives To describe the characteristics of melanoma in a rural French region during 2004–2008 and to identify differences according to age, gender and geographical areas.
Methods Pathology reports of cutaneous melanomas diagnosed in residents from the Champagne‐Ardenne region during 2004–2008 were anonymously collected from pathology laboratories. Demographic, clinical and pathological data were extracted and analysed by experts, including dermatologists, pathologists and epidemiologists.
Results One hundred and seventy‐seven in situ melanomas were diagnosed in 177 patients (female/male ratio : 1.72). Patients with head and neck in situ melanomas were older than patients with melanomas in other locations (72 vs. 54 years; P < 0.0001). Six hundred and sixty‐one invasive melanomas were diagnosed (female/male ratio : 1.26), corresponding to an annual incidence rate of 6.3/100 000. Male patients had thicker and more frequently ulcerated tumours. The location widely varied between genders, involving the trunk in 47% of male patients and the lower limb in 48% of female patients. Older patients had thicker and more advanced melanomas, with a more frequent head and neck location. Nodular, acral lentiginous and unclassified melanomas were much thicker than superficial spreading and lentigo maligna melanomas (4.37 vs. 1.33 mm, P < 0.0001). Primary melanomas of advanced stages were more frequent in one of the four districts of the study area. Overall, the mean Breslow thickness (2.02 mm) was much higher than that previously observed in other regions of north‐eastern France (1.59 mm).
Conclusions Information and screening campaigns should particularly target rural areas, males, older people and focus on nodular, acrolentiginous and unclassified subtypes.
Url:
DOI: 10.1111/j.1468-3083.2011.04021.x
Links to Exploration step
ISTEX:61050CA8356F61F40F209097C574FAC5F035A0A6Le document en format XML
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Vitry</name><affiliation><mods:affiliation>Centre de Recherche, d’Investigation Clinique et d’Aide Méthodologique, Hôpital Maison Blanche, Reims, France</mods:affiliation></affiliation></author><author><name sortKey="Le Clainche, A" sort="Le Clainche, A" uniqKey="Le Clainche A" first="A." last="Le Clainche">A. Le Clainche</name><affiliation><mods:affiliation>Centre de Recherche, d’Investigation Clinique et d’Aide Méthodologique, Hôpital Maison Blanche, Reims, France</mods:affiliation></affiliation></author><author><name sortKey="Grange, F" sort="Grange, F" uniqKey="Grange F" first="F." last="Grange">F. 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Barbe</name><affiliation><mods:affiliation>Coordination de la Recherche Clinique, Hôpital Robert Debré, Reims, France</mods:affiliation></affiliation></author><author><name sortKey="Hibon, E" sort="Hibon, E" uniqKey="Hibon E" first="E." last="Hibon">E. Hibon</name><affiliation><mods:affiliation>Laboratoire de pathologie, Centre de Regroupement Informatique des Statistiques Anatomo‐pathologiques de Champagne‐Ardenne, Reims, France</mods:affiliation></affiliation></author><author><name sortKey="Vitry, F" sort="Vitry, F" uniqKey="Vitry F" first="F." last="Vitry">F. Vitry</name><affiliation><mods:affiliation>Centre de Recherche, d’Investigation Clinique et d’Aide Méthodologique, Hôpital Maison Blanche, Reims, France</mods:affiliation></affiliation></author><author><name sortKey="Le Clainche, A" sort="Le Clainche, A" uniqKey="Le Clainche A" first="A." last="Le Clainche">A. 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Grange</name><affiliation><mods:affiliation>Service de Dermatologie, Hôpital Robert Debré, Reims, France</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: fgrange@chu‐reims.fr</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Journal of the European Academy of Dermatology and Venereology</title><title level="j" type="alt">JOURNAL OF EUROPEAN ACADEMY DERMATOLOGY VENEREOLOGY</title><idno type="ISSN">0926-9959</idno><idno type="eISSN">1468-3083</idno><imprint><biblScope unit="vol">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="159">159</biblScope><biblScope unit="page" to="164">164</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-02">2012-02</date></imprint><idno type="ISSN">0926-9959</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0926-9959</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="Teeft" xml:lang="en"><term>Acad dermatol venereol</term><term>Acral lentiginous</term><term>Ajcc</term><term>Ajcc stage</term><term>Arch dermatol</term><term>Authors journal</term><term>Breslow</term><term>Breslow thickness</term><term>Clark level</term><term>Cutaneous</term><term>Cutaneous melanoma</term><term>Dermatol</term><term>Dermatologist</term><term>Dermatology</term><term>Early diagnosis</term><term>Epidemiology</term><term>European academy</term><term>Gender</term><term>Higher breslow thickness</term><term>Higher proportion</term><term>Histological</term><term>Histological type</term><term>Inhabitant</term><term>Invasive</term><term>Invasive melanomas</term><term>Jeadv</term><term>Lentigo</term><term>Lentigo maligna melanomas</term><term>Lower limb</term><term>Maligna</term><term>Median</term><term>Melanoma</term><term>Melanoma characteristics</term><term>Melanoma incidence</term><term>Nodular</term><term>Older patients</term><term>Omecha registry</term><term>Pathological characteristics</term><term>Standard deviation</term><term>Study area</term><term>Thick melanomas</term><term>Tumour</term><term>Tumour characteristics</term><term>Ulceration</term><term>Ulceration status</term><term>Upper limb</term><term>Venereology</term><term>Venereology barbe</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background Although incidence and mortality data are numerous, population‐based studies including clinical and pathological characteristics of melanoma are rare.</div><div type="abstract">Objectives To describe the characteristics of melanoma in a rural French region during 2004–2008 and to identify differences according to age, gender and geographical areas.</div><div type="abstract">Methods Pathology reports of cutaneous melanomas diagnosed in residents from the Champagne‐Ardenne region during 2004–2008 were anonymously collected from pathology laboratories. Demographic, clinical and pathological data were extracted and analysed by experts, including dermatologists, pathologists and epidemiologists.</div><div type="abstract">Results One hundred and seventy‐seven in situ melanomas were diagnosed in 177 patients (female/male ratio : 1.72). Patients with head and neck in situ melanomas were older than patients with melanomas in other locations (72 vs. 54 years; P < 0.0001). Six hundred and sixty‐one invasive melanomas were diagnosed (female/male ratio : 1.26), corresponding to an annual incidence rate of 6.3/100 000. Male patients had thicker and more frequently ulcerated tumours. The location widely varied between genders, involving the trunk in 47% of male patients and the lower limb in 48% of female patients. Older patients had thicker and more advanced melanomas, with a more frequent head and neck location. Nodular, acral lentiginous and unclassified melanomas were much thicker than superficial spreading and lentigo maligna melanomas (4.37 vs. 1.33 mm, P < 0.0001). Primary melanomas of advanced stages were more frequent in one of the four districts of the study area. Overall, the mean Breslow thickness (2.02 mm) was much higher than that previously observed in other regions of north‐eastern France (1.59 mm).</div><div type="abstract">Conclusions Information and screening campaigns should particularly target rural areas, males, older people and focus on nodular, acrolentiginous and unclassified subtypes.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>melanoma</json:string><json:string>breslow</json:string><json:string>breslow thickness</json:string><json:string>cutaneous</json:string><json:string>dermatol</json:string><json:string>dermatology</json:string><json:string>ajcc</json:string><json:string>european academy</json:string><json:string>invasive</json:string><json:string>ulceration</json:string><json:string>tumour</json:string><json:string>venereology</json:string><json:string>histological</json:string><json:string>lower limb</json:string><json:string>dermatologist</json:string><json:string>cutaneous melanoma</json:string><json:string>epidemiology</json:string><json:string>lentigo</json:string><json:string>maligna</json:string><json:string>ajcc stage</json:string><json:string>jeadv</json:string><json:string>inhabitant</json:string><json:string>authors journal</json:string><json:string>invasive melanomas</json:string><json:string>histological type</json:string><json:string>gender</json:string><json:string>melanoma characteristics</json:string><json:string>upper limb</json:string><json:string>arch dermatol</json:string><json:string>acral lentiginous</json:string><json:string>median</json:string><json:string>nodular</json:string><json:string>higher breslow thickness</json:string><json:string>older patients</json:string><json:string>venereology barbe</json:string><json:string>lentigo maligna melanomas</json:string><json:string>study area</json:string><json:string>early diagnosis</json:string><json:string>omecha registry</json:string><json:string>clark level</json:string><json:string>higher proportion</json:string><json:string>tumour characteristics</json:string><json:string>thick melanomas</json:string><json:string>ulceration status</json:string><json:string>melanoma incidence</json:string><json:string>pathological characteristics</json:string><json:string>acad dermatol venereol</json:string><json:string>standard deviation</json:string></teeft></keywords><author><json:item><name>C. Barbe</name><affiliations><json:string>Coordination de la Recherche Clinique, Hôpital Robert Debré, Reims, France</json:string></affiliations></json:item><json:item><name>E. Hibon</name><affiliations><json:string>Laboratoire de pathologie, Centre de Regroupement Informatique des Statistiques Anatomo‐pathologiques de Champagne‐Ardenne, Reims, France</json:string></affiliations></json:item><json:item><name>F. Vitry</name><affiliations><json:string>Centre de Recherche, d’Investigation Clinique et d’Aide Méthodologique, Hôpital Maison Blanche, Reims, France</json:string></affiliations></json:item><json:item><name>A. Le Clainche</name><affiliations><json:string>Centre de Recherche, d’Investigation Clinique et d’Aide Méthodologique, Hôpital Maison Blanche, Reims, France</json:string></affiliations></json:item><json:item><name>F. 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Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology</licence></availability><date type="published" when="2012-02"></date></publicationStmt><notesStmt><note type="content-type" subtype="article" source="article" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</note><note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note></notesStmt><sourceDesc><biblStruct type="article"><analytic><title level="a" type="main">Clinical and pathological characteristics of melanoma: a population‐based study in a French regional population</title><title level="a" type="short">Characteristics of melanoma in a French regional population</title><author xml:id="author-0000"><persName><forename type="first">C.</forename><surname>Barbe</surname></persName><affiliation><address><addrLine>Coordination de la Recherche Clinique</addrLine><addrLine>Hôpital Robert Debré</addrLine><addrLine>Reims</addrLine><country key="FR">FRANCE</country><country key="FR"></country></address></affiliation></author><author xml:id="author-0001"><persName><forename type="first">E.</forename><surname>Hibon</surname></persName><affiliation><orgName type="laboratory">Laboratoire de pathologie</orgName><address><addrLine>Centre de Regroupement Informatique des Statistiques Anatomo‐pathologiques de Champagne‐Ardenne</addrLine><addrLine>Reims</addrLine><country key="FR">FRANCE</country><country key="FR"></country></address></affiliation></author><author xml:id="author-0002"><persName><forename type="first">F.</forename><surname>Vitry</surname></persName><affiliation><address><addrLine>Centre de Recherche</addrLine><addrLine>d’Investigation Clinique et d’Aide Méthodologique</addrLine><addrLine>Hôpital Maison Blanche</addrLine><addrLine>Reims</addrLine><country key="FR">FRANCE</country><country key="FR"></country></address></affiliation></author><author xml:id="author-0003"><persName><forename type="first">A.</forename><surname>Le Clainche</surname></persName><affiliation><address><addrLine>Centre de Recherche</addrLine><addrLine>d’Investigation Clinique et d’Aide Méthodologique</addrLine><addrLine>Hôpital Maison Blanche</addrLine><addrLine>Reims</addrLine><country key="FR">FRANCE</country><country key="FR"></country></address></affiliation></author><author xml:id="author-0004" role="corresp"><persName><forename type="first">F.</forename><surname>Grange</surname></persName><affiliation><orgName type="laboratory">Service de Dermatologie</orgName><address><addrLine>Hôpital Robert Debré</addrLine><addrLine>Reims</addrLine><country key="FR">FRANCE</country><country key="FR"></country></address></affiliation><affiliation>F Grange. E‐mail:fgrange@chu‐reims.fr</affiliation></author><idno type="istex">61050CA8356F61F40F209097C574FAC5F035A0A6</idno><idno type="ark">ark:/67375/WNG-D09Z6V5N-X</idno><idno type="DOI">10.1111/j.1468-3083.2011.04021.x</idno><idno type="unit">JDV4021</idno><idno type="toTypesetVersion">file:JDV.JDV4021.pdf</idno></analytic><monogr><title level="j" type="main">Journal of the European Academy of Dermatology and Venereology</title><title level="j" type="alt">JOURNAL OF EUROPEAN ACADEMY DERMATOLOGY VENEREOLOGY</title><idno type="pISSN">0926-9959</idno><idno type="eISSN">1468-3083</idno><idno type="book-DOI">10.1111/(ISSN)1468-3083</idno><idno type="book-part-DOI">10.1111/jdv.2012.26.issue-2</idno><idno type="product">JDV</idno><idno type="publisherDivision">ST</idno><imprint><biblScope unit="vol">26</biblScope><biblScope unit="issue">2</biblScope><biblScope unit="page" from="159">159</biblScope><biblScope unit="page" to="164">164</biblScope><biblScope unit="page-count">6</biblScope><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2012-02"></date></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head><p><hi rend="italic">Background </hi> Although incidence and mortality data are numerous, population‐based studies including clinical and pathological characteristics of melanoma are rare.</p><p><hi rend="italic">Objectives </hi> To describe the characteristics of melanoma in a rural French region during 2004–2008 and to identify differences according to age, gender and geographical areas.</p><p><hi rend="italic">Methods </hi> Pathology reports of cutaneous melanomas diagnosed in residents from the Champagne‐Ardenne region during 2004–2008 were anonymously collected from pathology laboratories. Demographic, clinical and pathological data were extracted and analysed by experts, including dermatologists, pathologists and epidemiologists.</p><p><hi rend="italic">Results </hi> One hundred and seventy‐seven <hi rend="italic">in situ</hi> melanomas were diagnosed in 177 patients (female/male ratio : 1.72). Patients with head and neck <hi rend="italic">in situ</hi> melanomas were older than patients with melanomas in other locations (72 vs. 54 years; <hi rend="italic">P</hi> < 0.0001). Six hundred and sixty‐one invasive melanomas were diagnosed (female/male ratio : 1.26), corresponding to an annual incidence rate of 6.3/100 000. Male patients had thicker and more frequently ulcerated tumours. The location widely varied between genders, involving the trunk in 47% of male patients and the lower limb in 48% of female patients. Older patients had thicker and more advanced melanomas, with a more frequent head and neck location. Nodular, acral lentiginous and unclassified melanomas were much thicker than superficial spreading and lentigo maligna melanomas (4.37 vs. 1.33 mm, <hi rend="italic">P</hi> < 0.0001). Primary melanomas of advanced stages were more frequent in one of the four districts of the study area. Overall, the mean Breslow thickness (2.02 mm) was much higher than that previously observed in other regions of north‐eastern France (1.59 mm).</p><p><hi rend="italic">Conclusions </hi> Information and screening campaigns should particularly target rural areas, males, older people and focus on nodular, acrolentiginous and unclassified subtypes.</p></abstract><textClass><keywords rend="tocHeading1"><term>ORIGINAL ARTICLES</term></keywords><keywords rend="articleCategory"><term>ORIGINAL ARTICLE</term></keywords></textClass><langUsage><language ident="en"></language></langUsage></profileDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/ark:/67375/WNG-D09Z6V5N-X/fulltext.txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1468-3083</doi><issn type="print">0926-9959</issn><issn type="electronic">1468-3083</issn><idGroup><id type="product" value="JDV"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="JOURNAL OF EUROPEAN ACADEMY DERMATOLOGY VENEREOLOGY">Journal of the European Academy of Dermatology and Venereology</title></titleGroup></publicationMeta><publicationMeta level="part" position="02102"><doi origin="wiley">10.1111/jdv.2012.26.issue-2</doi><numberingGroup><numbering type="journalVolume" number="26">26</numbering><numbering type="journalIssue" number="2">2</numbering></numberingGroup><coverDate startDate="2012-02">February 2012</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="4" status="forIssue"><doi origin="wiley">10.1111/j.1468-3083.2011.04021.x</doi><idGroup><id type="unit" value="JDV4021"></id></idGroup><countGroup><count type="pageTotal" number="6"></count></countGroup><titleGroup><title type="tocHeading1">ORIGINAL ARTICLES</title><title type="articleCategory">ORIGINAL ARTICLE</title></titleGroup><copyright>© 2011 The Authors. Journal of the European Academy of Dermatology and Venereology © 2011 European Academy of Dermatology and Venereology</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.0.1 mode:FullText" date="2012-01-26"></event><event type="publishedOnlineEarlyUnpaginated" date="2011-04-06"></event><event type="firstOnline" date="2011-04-06"></event><event type="publishedOnlineFinalForm" date="2012-01-26"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="159">159</numbering><numbering type="pageLast" number="164">164</numbering></numberingGroup><correspondenceTo>
F Grange. <b>E‐mail:</b><email normalForm="fgrange@chu-reims.fr">fgrange@chu‐reims.fr</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:JDV.JDV4021.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received: 29 September 2010; Accepted: 31 January 2011</unparsedEditorialHistory><countGroup><count type="figureTotal" number="1"></count><count type="tableTotal" number="3"></count></countGroup><titleGroup><title type="main">Clinical and pathological characteristics of melanoma: a population‐based study in a French regional population</title><title type="shortAuthors">Barbe <i>et al</i>.</title><title type="short">Characteristics of melanoma in a French regional population</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1"><personName><givenNames>C.</givenNames><familyName>Barbe</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a2"><personName><givenNames>E.</givenNames><familyName>Hibon</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a3"><personName><givenNames>F.</givenNames><familyName>Vitry</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a3"><personName><givenNames>A.</givenNames><familyName>Le Clainche</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a4" corresponding="yes"><personName><givenNames>F.</givenNames><familyName>Grange</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="FR"><unparsedAffiliation>Coordination de la Recherche Clinique, Hôpital Robert Debré, Reims, France</unparsedAffiliation></affiliation><affiliation xml:id="a2" countryCode="FR"><unparsedAffiliation>Laboratoire de pathologie, Centre de Regroupement Informatique des Statistiques Anatomo‐pathologiques de Champagne‐Ardenne, Reims, France</unparsedAffiliation></affiliation><affiliation xml:id="a3" countryCode="FR"><unparsedAffiliation>Centre de Recherche, d’Investigation Clinique et d’Aide Méthodologique, Hôpital Maison Blanche, Reims, France</unparsedAffiliation></affiliation><affiliation xml:id="a4" countryCode="FR"><unparsedAffiliation>Service de Dermatologie, Hôpital Robert Debré, Reims, France</unparsedAffiliation></affiliation></affiliationGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p><b>Background </b> Although incidence and mortality data are numerous, population‐based studies including clinical and pathological characteristics of melanoma are rare.</p><p><b>Objectives </b> To describe the characteristics of melanoma in a rural French region during 2004–2008 and to identify differences according to age, gender and geographical areas.</p><p><b>Methods </b> Pathology reports of cutaneous melanomas diagnosed in residents from the Champagne‐Ardenne region during 2004–2008 were anonymously collected from pathology laboratories. Demographic, clinical and pathological data were extracted and analysed by experts, including dermatologists, pathologists and epidemiologists.</p><p><b>Results </b> One hundred and seventy‐seven <i>in situ</i> melanomas were diagnosed in 177 patients (female/male ratio : 1.72). Patients with head and neck <i>in situ</i> melanomas were older than patients with melanomas in other locations (72 vs. 54 years; <i>P</i> < 0.0001). Six hundred and sixty‐one invasive melanomas were diagnosed (female/male ratio : 1.26), corresponding to an annual incidence rate of 6.3/100 000. Male patients had thicker and more frequently ulcerated tumours. The location widely varied between genders, involving the trunk in 47% of male patients and the lower limb in 48% of female patients. Older patients had thicker and more advanced melanomas, with a more frequent head and neck location. Nodular, acral lentiginous and unclassified melanomas were much thicker than superficial spreading and lentigo maligna melanomas (4.37 vs. 1.33 mm, <i>P</i> < 0.0001). Primary melanomas of advanced stages were more frequent in one of the four districts of the study area. Overall, the mean Breslow thickness (2.02 mm) was much higher than that previously observed in other regions of north‐eastern France (1.59 mm).</p><p><b>Conclusions </b> Information and screening campaigns should particularly target rural areas, males, older people and focus on nodular, acrolentiginous and unclassified subtypes.</p></abstract></abstractGroup></contentMeta><noteGroup><note xml:id="fn1"><p>Conflict of interest
None declared.</p></note><note xml:id="fn2"><p>Funding sources
Ligue contre le Cancer, Comité de la Marne.</p></note></noteGroup></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Clinical and pathological characteristics of melanoma: a population‐based study in a French regional population</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Characteristics of melanoma in a French regional population</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Clinical and pathological characteristics of melanoma: a population‐based study in a French regional population</title></titleInfo><name type="personal"><namePart type="given">C.</namePart><namePart type="family">Barbe</namePart><affiliation>Coordination de la Recherche Clinique, Hôpital Robert Debré, Reims, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">E.</namePart><namePart type="family">Hibon</namePart><affiliation>Laboratoire de pathologie, Centre de Regroupement Informatique des Statistiques Anatomo‐pathologiques de Champagne‐Ardenne, Reims, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Vitry</namePart><affiliation>Centre de Recherche, d’Investigation Clinique et d’Aide Méthodologique, Hôpital Maison Blanche, Reims, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Le Clainche</namePart><affiliation>Centre de Recherche, d’Investigation Clinique et d’Aide Méthodologique, Hôpital Maison Blanche, Reims, France</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Grange</namePart><affiliation>Service de Dermatologie, Hôpital Robert Debré, Reims, France</affiliation><affiliation>E-mail: fgrange@chu‐reims.fr</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-6N5SZHKN-D">article</genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2012-02</dateIssued><edition>Received: 29 September 2010; Accepted: 31 January 2011</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">1</extent><extent unit="tables">3</extent></physicalDescription><abstract>Background Although incidence and mortality data are numerous, population‐based studies including clinical and pathological characteristics of melanoma are rare.</abstract><abstract>Objectives To describe the characteristics of melanoma in a rural French region during 2004–2008 and to identify differences according to age, gender and geographical areas.</abstract><abstract>Methods Pathology reports of cutaneous melanomas diagnosed in residents from the Champagne‐Ardenne region during 2004–2008 were anonymously collected from pathology laboratories. Demographic, clinical and pathological data were extracted and analysed by experts, including dermatologists, pathologists and epidemiologists.</abstract><abstract>Results One hundred and seventy‐seven in situ melanomas were diagnosed in 177 patients (female/male ratio : 1.72). Patients with head and neck in situ melanomas were older than patients with melanomas in other locations (72 vs. 54 years; P < 0.0001). Six hundred and sixty‐one invasive melanomas were diagnosed (female/male ratio : 1.26), corresponding to an annual incidence rate of 6.3/100 000. Male patients had thicker and more frequently ulcerated tumours. The location widely varied between genders, involving the trunk in 47% of male patients and the lower limb in 48% of female patients. Older patients had thicker and more advanced melanomas, with a more frequent head and neck location. Nodular, acral lentiginous and unclassified melanomas were much thicker than superficial spreading and lentigo maligna melanomas (4.37 vs. 1.33 mm, P < 0.0001). Primary melanomas of advanced stages were more frequent in one of the four districts of the study area. Overall, the mean Breslow thickness (2.02 mm) was much higher than that previously observed in other regions of north‐eastern France (1.59 mm).</abstract><abstract>Conclusions Information and screening campaigns should particularly target rural areas, males, older people and focus on nodular, acrolentiginous and unclassified subtypes.</abstract><relatedItem type="host"><titleInfo><title>Journal of the European Academy of Dermatology and Venereology</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><subject><genre>article-category</genre><topic>ORIGINAL ARTICLE</topic></subject><identifier type="ISSN">0926-9959</identifier><identifier type="eISSN">1468-3083</identifier><identifier type="DOI">10.1111/(ISSN)1468-3083</identifier><identifier type="PublisherID">JDV</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>26</number></detail><detail type="issue"><caption>no.</caption><number>2</number></detail><extent unit="pages"><start>159</start><end>164</end><total>6</total></extent></part></relatedItem><identifier type="istex">61050CA8356F61F40F209097C574FAC5F035A0A6</identifier><identifier type="ark">ark:/67375/WNG-D09Z6V5N-X</identifier><identifier type="DOI">10.1111/j.1468-3083.2011.04021.x</identifier><identifier type="ArticleID">JDV4021</identifier><accessCondition type="use and reproduction" contentType="copyright">© 2011 The Authors. 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