POLYMODE

POLYMODE
Titre :	Novel polysaccharide modifying enzymes to optimise the potential of hydrocolloids for food and medical applications
Budget :	8 226 k€
Subventions :	FP7-KBBE (5 999 k€)
Sous-programme :	KBBE-2007-3-2-07 NOVEL ENZYMES
Type de contrat :	LARGE
Début :	1er mai 2009
Fin :	30 avril 2013
Site officiel :	http://www.polymode.eu/
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POLYMODE est l'acronyme du projet européen Novel polysaccharide modifying enzymes to optimise the potential of hydrocolloids for food and medical applications, qui a pour référence sur le service CORDIS 222628.

English description

Note : Les objectifs suivants sont repris de la fiche du projet sur Cordis

Objective

The PolyModE project convenes an international, interdisciplinary, and intersectorial consortium to identify, characterise, and optimise novel polysaccharide modifying enzymes, and to develop robust fermentation strategies for their large-scale production, to exploit the potential of biopolymers for food, pharmaceutical, cosmetic, and technical applications. We have selected the six complex carbohydrates with the highest current market share or expected future market potential, namely alginate, carrageenan, chitosan, glycosaminoglycan, pectin, and xanthan gum.

For each of these, the industrial partners have identified those enzymes which will answer to the most pressing needs or offer the most promising potential for improved production of polysaccharides with novel physico-chemical properties and biological functionalities. Primary targets will be alginate epimerases, carrageenan sulfatases, chitosan de-acetylases, glycosaminoglycan sulfatases, pectin de-acetylases, and xanthan gum de-acetylases. These enzymes together with secondary target enzymes, e.g. sequence specific lyases and hydrolases, will allow the generation and analysis of polymers and oligomers with novel, non-random patterns of modification. Two parallel approaches will be followed for each type of polysaccharide modifying enzyme, namely a knowledge-based genomic approach and a broad, un-biased metagenomic approach, e.g. using soil or sludge samples with a history of contact with the polysaccharide in question.

A pipeline of three levels of fermentation systems will be established, ranging from lab-scale innovative expression systems with features shaped according to the specific characteristics of our target enzymes, through medium-scale, novel and unusual fermentation systems provided by a number of SME with highly specialised knowledge and expertise in developing and using such systems, to the established large-scale fermentation systems and facilities of market leaders in White Biotechnology.

 

Les partenaires du projet

Coordinateur du projet

• Université de Münster - Münster (Rhénanie-du-Nord-Westphalie - Allemagne)

Partenaires

• Gillet Chitosan EURL - Nancy (Lorraine, France) - Contact : Dominique Gillet
• GTP technology S.A. - Labege (Midi-Pyrénées, France)
• Lyon ingénierie projets - Villeurbanne (Rhône-Alpes, France)
• Centre national de la recherche scientifique (CNRS) - Paris (Île-de-France, France)
• Université de Wageningen - Wageningen (Pays-Bas)
• Petra Tewes-Schwarzer - Care sense consulting - Senden (Rhénanie-du-Nord-Westphalie - Allemagne)
• Libragen - Toulouse (Midi-Pyrénées, France)
• Sanofi-aventis recherche et développement - Chilly-Mazarin (Île-de-France, France)
• The Stephan Angeloff instituteof microbiology - Bulgarian academy of sciences - Sofia (Bulgarie)
• Sveriges lantbruksuniversitet - Uppsala (Suède)
• Danisco A/S - Copenhague (Danemark)
• Geneart AG - Ratisbonne (Bavière - Allemagne)
• Institut national de la recherche agronomique (INRA) - Paris (Île-de-France, France)
• Artes biotechnology GMBH - Langenfeld (Rhénanie-du-Nord-Westphalie - Allemagne)

Financement

• Coût total du projet : 8 226 733 €
• Subvention de la Commission européenne (programme FP7-KBBE) : 5 999 948 €

Dates importantes

• Date de début : 1^er mai 2009
• Date de fin : 30 avril 2013

Voir aussi

Liens externes

• Le site officiel du projet
• Le site officiel de l'Université de Münster