Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2
Identifieur interne : 000240 ( Main/Exploration ); précédent : 000239; suivant : 000241Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2
Auteurs : Nina Schultz ; Henrietta M. Nielsen ; Lennart Minthon ; Malin WennströmSource :
- Journal of Neuropathology and Experimental Neurology [ 0022-3069 ] ; 2014.
Abstract
Supplemental digital content is available in the text.
Url:
DOI: 10.1097/NEN.0000000000000084
PubMed: 24918635
PubMed Central: 4072439
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000392
- to stream Pmc, to step Curation: 000392
- to stream Pmc, to step Checkpoint: 000202
- to stream Ncbi, to step Merge: 000246
- to stream Ncbi, to step Curation: 000246
- to stream Ncbi, to step Checkpoint: 000246
- to stream Main, to step Merge: 000240
- to stream Main, to step Curation: 000240
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2</title><author><name sortKey="Schultz, Nina" sort="Schultz, Nina" uniqKey="Schultz N" first="Nina" last="Schultz">Nina Schultz</name></author><author><name sortKey="Nielsen, Henrietta M" sort="Nielsen, Henrietta M" uniqKey="Nielsen H" first="Henrietta M." last="Nielsen">Henrietta M. Nielsen</name></author><author><name sortKey="Minthon, Lennart" sort="Minthon, Lennart" uniqKey="Minthon L" first="Lennart" last="Minthon">Lennart Minthon</name></author><author><name sortKey="Wennstrom, Malin" sort="Wennstrom, Malin" uniqKey="Wennstrom M" first="Malin" last="Wennström">Malin Wennström</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24918635</idno><idno type="pmc">4072439</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4072439</idno><idno type="RBID">PMC:4072439</idno><idno type="doi">10.1097/NEN.0000000000000084</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000392</idno><idno type="wicri:Area/Pmc/Curation">000392</idno><idno type="wicri:Area/Pmc/Checkpoint">000202</idno><idno type="wicri:Area/Ncbi/Merge">000246</idno><idno type="wicri:Area/Ncbi/Curation">000246</idno><idno type="wicri:Area/Ncbi/Checkpoint">000246</idno><idno type="wicri:doubleKey">0022-3069:2014:Schultz N:involvement:of:matrix</idno><idno type="wicri:Area/Main/Merge">000240</idno><idno type="wicri:Area/Main/Curation">000240</idno><idno type="wicri:Area/Main/Exploration">000240</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2</title><author><name sortKey="Schultz, Nina" sort="Schultz, Nina" uniqKey="Schultz N" first="Nina" last="Schultz">Nina Schultz</name></author><author><name sortKey="Nielsen, Henrietta M" sort="Nielsen, Henrietta M" uniqKey="Nielsen H" first="Henrietta M." last="Nielsen">Henrietta M. Nielsen</name></author><author><name sortKey="Minthon, Lennart" sort="Minthon, Lennart" uniqKey="Minthon L" first="Lennart" last="Minthon">Lennart Minthon</name></author><author><name sortKey="Wennstrom, Malin" sort="Wennstrom, Malin" uniqKey="Wennstrom M" first="Malin" last="Wennström">Malin Wennström</name></author></analytic><series><title level="j">Journal of Neuropathology and Experimental Neurology</title><idno type="ISSN">0022-3069</idno><idno type="eISSN">1554-6578</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Supplemental digital content is available in the text.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Winkler, Ea" uniqKey="Winkler E">EA Winkler</name></author><author><name sortKey="Bell, Rd" uniqKey="Bell R">RD Bell</name></author><author><name sortKey="Zlokovic, Bv" uniqKey="Zlokovic B">BV Zlokovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armulik, A" uniqKey="Armulik A">A Armulik</name></author><author><name sortKey="Genove, G" uniqKey="Genove G">G Genove</name></author><author><name sortKey="Mae, M" uniqKey="Mae M">M Mae</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, Rd" uniqKey="Bell R">RD Bell</name></author><author><name sortKey="Winkler, Ea" uniqKey="Winkler E">EA Winkler</name></author><author><name sortKey="Sagare, Ap" uniqKey="Sagare A">AP Sagare</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Shimizu, F" uniqKey="Shimizu F">F Shimizu</name></author><author><name sortKey="Sano, Y" uniqKey="Sano Y">Y Sano</name></author><author><name sortKey="Maeda, T" uniqKey="Maeda T">T Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vagnucci, Ah" uniqKey="Vagnucci A">AH Vagnucci</name></author><author><name sortKey="Li, Ww" uniqKey="Li W">WW Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thomas, We" uniqKey="Thomas W">WE Thomas</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Darland, Dc" uniqKey="Darland D">DC Darland</name></author><author><name sortKey="Massingham, Lj" uniqKey="Massingham L">LJ Massingham</name></author><author><name sortKey="Smith, Sr" uniqKey="Smith S">SR Smith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Arihiro, S" uniqKey="Arihiro S">S Arihiro</name></author><author><name sortKey="Ohtani, H" uniqKey="Ohtani H">H Ohtani</name></author><author><name sortKey="Hiwatashi, N" uniqKey="Hiwatashi N">N Hiwatashi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takata, F" uniqKey="Takata F">F Takata</name></author><author><name sortKey="Dohgu, S" uniqKey="Dohgu S">S Dohgu</name></author><author><name sortKey="Matsumoto, J" uniqKey="Matsumoto J">J Matsumoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Q" uniqKey="Chen Q">Q Chen</name></author><author><name sortKey="Jin, M" uniqKey="Jin M">M Jin</name></author><author><name sortKey="Yang, F" uniqKey="Yang F">F Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sagare, Ap" uniqKey="Sagare A">AP Sagare</name></author><author><name sortKey="Bell, Rd" uniqKey="Bell R">RD Bell</name></author><author><name sortKey="Zhao, Z" uniqKey="Zhao Z">Z Zhao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zlokovic, Bv" uniqKey="Zlokovic B">BV Zlokovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zlokovic, Bv" uniqKey="Zlokovic B">BV Zlokovic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Blennow, K" uniqKey="Blennow K">K Blennow</name></author><author><name sortKey="De Leon, Mj" uniqKey="De Leon M">MJ de Leon</name></author><author><name sortKey="Zetterberg, H" uniqKey="Zetterberg H">H Zetterberg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lee, Yj" uniqKey="Lee Y">YJ Lee</name></author><author><name sortKey="Han, Sb" uniqKey="Han S">SB Han</name></author><author><name sortKey="Nam, Sy" uniqKey="Nam S">SY Nam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Brun, A" uniqKey="Brun A">A Brun</name></author><author><name sortKey="Englund, E" uniqKey="Englund E">E Englund</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Englund, E" uniqKey="Englund E">E Englund</name></author><author><name sortKey="Brun, A" uniqKey="Brun A">A Brun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farkas, E" uniqKey="Farkas E">E Farkas</name></author><author><name sortKey="Luiten, Pg" uniqKey="Luiten P">PG Luiten</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kalaria, Rn" uniqKey="Kalaria R">RN Kalaria</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Marchesi, Vt" uniqKey="Marchesi V">VT Marchesi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iadecola, C" uniqKey="Iadecola C">C Iadecola</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sengillo, Jd" uniqKey="Sengillo J">JD Sengillo</name></author><author><name sortKey="Winkler, Ea" uniqKey="Winkler E">EA Winkler</name></author><author><name sortKey="Walker, Ct" uniqKey="Walker C">CT Walker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeek, Mm" uniqKey="Verbeek M">MM Verbeek</name></author><author><name sortKey="De Waal, Rm" uniqKey="De Waal R">RM de Waal</name></author><author><name sortKey="Schipper, Jj" uniqKey="Schipper J">JJ Schipper</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wilhelmus, Mm" uniqKey="Wilhelmus M">MM Wilhelmus</name></author><author><name sortKey="Otte Holler, I" uniqKey="Otte Holler I">I Otte-Holler</name></author><author><name sortKey="Van Triel, Jj" uniqKey="Van Triel J">JJ van Triel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozerdem, U" uniqKey="Ozerdem U">U Ozerdem</name></author><author><name sortKey="Grako, Ka" uniqKey="Grako K">KA Grako</name></author><author><name sortKey="Dahlin Huppe, K" uniqKey="Dahlin Huppe K">K Dahlin-Huppe</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author><author><name sortKey="Huang, Fj" uniqKey="Huang F">FJ Huang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ozerdem, U" uniqKey="Ozerdem U">U Ozerdem</name></author><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="You, Wk" uniqKey="You W">WK You</name></author><author><name sortKey="Yotsumoto, F" uniqKey="Yotsumoto F">F Yotsumoto</name></author><author><name sortKey="Sakimura, K" uniqKey="Sakimura K">K Sakimura</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fukushi, J" uniqKey="Fukushi J">J Fukushi</name></author><author><name sortKey="Makagiansar, It" uniqKey="Makagiansar I">IT Makagiansar</name></author><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, H" uniqKey="Nielsen H">H Nielsen</name></author><author><name sortKey="Ek, D" uniqKey="Ek D">D Ek</name></author><author><name sortKey="Avdic, U" uniqKey="Avdic U">U Avdic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nielsen, Hm" uniqKey="Nielsen H">HM Nielsen</name></author><author><name sortKey="Hall, S" uniqKey="Hall S">S Hall</name></author><author><name sortKey="Surova, Y" uniqKey="Surova Y">Y Surova</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibb, Wr" uniqKey="Gibb W">WR Gibb</name></author><author><name sortKey="Luthert, Pj" uniqKey="Luthert P">PJ Luthert</name></author><author><name sortKey="Janota, I" uniqKey="Janota I">I Janota</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nishiyama, A" uniqKey="Nishiyama A">A Nishiyama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Asher, Ra" uniqKey="Asher R">RA Asher</name></author><author><name sortKey="Morgenstern, Da" uniqKey="Morgenstern D">DA Morgenstern</name></author><author><name sortKey="Properzi, F" uniqKey="Properzi F">F Properzi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, H" uniqKey="Liu H">H Liu</name></author><author><name sortKey="Shubayev, Vi" uniqKey="Shubayev V">VI Shubayev</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Larsen, Ph" uniqKey="Larsen P">PH Larsen</name></author><author><name sortKey="Wells, Je" uniqKey="Wells J">JE Wells</name></author><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dreier, R" uniqKey="Dreier R">R Dreier</name></author><author><name sortKey="Wallace, S" uniqKey="Wallace S">S Wallace</name></author><author><name sortKey="Fuchs, S" uniqKey="Fuchs S">S Fuchs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogata, Y" uniqKey="Ogata Y">Y Ogata</name></author><author><name sortKey="Itoh, Y" uniqKey="Itoh Y">Y Itoh</name></author><author><name sortKey="Nagase, H" uniqKey="Nagase H">H Nagase</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Steenport, M" uniqKey="Steenport M">M Steenport</name></author><author><name sortKey="Khan, Km" uniqKey="Khan K">KM Khan</name></author><author><name sortKey="Du, B" uniqKey="Du B">B Du</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bouchard, Ba" uniqKey="Bouchard B">BA Bouchard</name></author><author><name sortKey="Shatos, Ma" uniqKey="Shatos M">MA Shatos</name></author><author><name sortKey="Tracy, Pb" uniqKey="Tracy P">PB Tracy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeek, Mm" uniqKey="Verbeek M">MM Verbeek</name></author><author><name sortKey="Otte Holler, I" uniqKey="Otte Holler I">I Otte-Holler</name></author><author><name sortKey="Wesseling, P" uniqKey="Wesseling P">P Wesseling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tigges, U" uniqKey="Tigges U">U Tigges</name></author><author><name sortKey="Welser Alves, Jv" uniqKey="Welser Alves J">JV Welser-Alves</name></author><author><name sortKey="Boroujerdi, A" uniqKey="Boroujerdi A">A Boroujerdi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Verbeek, Mm" uniqKey="Verbeek M">MM Verbeek</name></author><author><name sortKey="Otte Holler, I" uniqKey="Otte Holler I">I Otte-Holler</name></author><author><name sortKey="Wesseling, P" uniqKey="Wesseling P">P Wesseling</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Korzeniewski, C" uniqKey="Korzeniewski C">C Korzeniewski</name></author><author><name sortKey="Callewaert, Dm" uniqKey="Callewaert D">DM Callewaert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ramos Desimone, N" uniqKey="Ramos Desimone N">N Ramos-DeSimone</name></author><author><name sortKey="Hahn Dantona, E" uniqKey="Hahn Dantona E">E Hahn-Dantona</name></author><author><name sortKey="Sipley, J" uniqKey="Sipley J">J Sipley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Horstmann, S" uniqKey="Horstmann S">S Horstmann</name></author><author><name sortKey="Budig, L" uniqKey="Budig L">L Budig</name></author><author><name sortKey="Gardner, H" uniqKey="Gardner H">H Gardner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klein, Wl" uniqKey="Klein W">WL Klein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stefani, M" uniqKey="Stefani M">M Stefani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biron, Ke" uniqKey="Biron K">KE Biron</name></author><author><name sortKey="Dickstein, Dl" uniqKey="Dickstein D">DL Dickstein</name></author><author><name sortKey="Gopaul, R" uniqKey="Gopaul R">R Gopaul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ujiie, M" uniqKey="Ujiie M">M Ujiie</name></author><author><name sortKey="Dickstein, Dl" uniqKey="Dickstein D">DL Dickstein</name></author><author><name sortKey="Carlow, Da" uniqKey="Carlow D">DA Carlow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biron, Ke" uniqKey="Biron K">KE Biron</name></author><author><name sortKey="Dickstein, Dl" uniqKey="Dickstein D">DL Dickstein</name></author><author><name sortKey="Gopaul, R" uniqKey="Gopaul R">R Gopaul</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dickstein, Dl" uniqKey="Dickstein D">DL Dickstein</name></author><author><name sortKey="Biron, Ke" uniqKey="Biron K">KE Biron</name></author><author><name sortKey="Ujiie, M" uniqKey="Ujiie M">M Ujiie</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pieper, C" uniqKey="Pieper C">C Pieper</name></author><author><name sortKey="Pieloch, P" uniqKey="Pieloch P">P Pieloch</name></author><author><name sortKey="Galla, Hj" uniqKey="Galla H">HJ Galla</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, Y" uniqKey="Yang Y">Y Yang</name></author><author><name sortKey="Estrada, Ey" uniqKey="Estrada E">EY Estrada</name></author><author><name sortKey="Thompson, Jf" uniqKey="Thompson J">JF Thompson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Virgintino, D" uniqKey="Virgintino D">D Virgintino</name></author><author><name sortKey="Errede, M" uniqKey="Errede M">M Errede</name></author><author><name sortKey="Girolamo, F" uniqKey="Girolamo F">F Girolamo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Farrall, Aj" uniqKey="Farrall A">AJ Farrall</name></author><author><name sortKey="Wardlaw, Jm" uniqKey="Wardlaw J">JM Wardlaw</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wang, H" uniqKey="Wang H">H Wang</name></author><author><name sortKey="Golob, Ej" uniqKey="Golob E">EJ Golob</name></author><author><name sortKey="Su, My" uniqKey="Su M">MY Su</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baloyannis, Sj" uniqKey="Baloyannis S">SJ Baloyannis</name></author><author><name sortKey="Baloyannis, Is" uniqKey="Baloyannis I">IS Baloyannis</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buee, L" uniqKey="Buee L">L Buee</name></author><author><name sortKey="Hof, Pr" uniqKey="Hof P">PR Hof</name></author><author><name sortKey="Bouras, C" uniqKey="Bouras C">C Bouras</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cordonnier, C" uniqKey="Cordonnier C">C Cordonnier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stallcup, Wb" uniqKey="Stallcup W">WB Stallcup</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stomrud, E" uniqKey="Stomrud E">E Stomrud</name></author><author><name sortKey="Bjorkqvist, M" uniqKey="Bjorkqvist M">M Bjorkqvist</name></author><author><name sortKey="Janciauskiene, S" uniqKey="Janciauskiene S">S Janciauskiene</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bell, Rd" uniqKey="Bell R">RD Bell</name></author><author><name sortKey="Winkler, Ea" uniqKey="Winkler E">EA Winkler</name></author><author><name sortKey="Singh, I" uniqKey="Singh I">I Singh</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list></list><tree><noCountry><name sortKey="Minthon, Lennart" sort="Minthon, Lennart" uniqKey="Minthon L" first="Lennart" last="Minthon">Lennart Minthon</name><name sortKey="Nielsen, Henrietta M" sort="Nielsen, Henrietta M" uniqKey="Nielsen H" first="Henrietta M." last="Nielsen">Henrietta M. Nielsen</name><name sortKey="Schultz, Nina" sort="Schultz, Nina" uniqKey="Schultz N" first="Nina" last="Schultz">Nina Schultz</name><name sortKey="Wennstrom, Malin" sort="Wennstrom, Malin" uniqKey="Wennstrom M" first="Malin" last="Wennström">Malin Wennström</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Belgique/explor/OpenAccessBelV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000240 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000240 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Belgique
|area= OpenAccessBelV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= PMC:4072439
|texte= Involvement of Matrix Metalloproteinase-9 in Amyloid-β 1–42–Induced Shedding of the Pericyte Proteoglycan NG2
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i -Sk "pubmed:24918635" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd \
| NlmPubMed2Wicri -a OpenAccessBelV2
| This area was generated with Dilib version V0.6.25. |  |