ADRENALINE INFUSION AND ADRENOCORTICOTROPHIN (ACTH) AND CORTISOL RELEASE IN NORMOTENSIVE AND HYPERTENSIVE MAN
Identifieur interne : 001390 ( Main/Exploration ); précédent : 001389; suivant : 001391ADRENALINE INFUSION AND ADRENOCORTICOTROPHIN (ACTH) AND CORTISOL RELEASE IN NORMOTENSIVE AND HYPERTENSIVE MAN
Auteurs : R. V. Jackson [Australie] ; A. J. Jackson [Australie] ; J. E. Grice [Australie] ; P. J. Penfold [Australie] ; M. B. Armour [Australie] ; A. W. Bachmann [Australie]Source :
- Clinical and Experimental Pharmacology and Physiology [ 0305-1870 ] ; 1987-03.
English descriptors
- KwdEn :
- Teeft :
- Acth, Acth release, Acth secretagog, Adrenaline, Adrenaline infusion, Adrenocorticotropin release, Arginine, Arginine vasopressin, Arginine vasopressin pressor, Arterial pressure, Axelrod, Axelrod reisine, Basal, Blood pressure, Cause acth, Clinical chemistry, Cortisol, Cortisol release, Cortisol response, Cortisol rise, Deltoid muscle, Dose adrenaline infusion, Endocrinology, Experimental pharmacology physiology, Greenslopes hospital, Heart rate, Hpaa, Infusion, Intravenous adrenaline infusion, Lower plasma cortisol response, Peak changes, Pituitary corticotrophs, Placebo, Plasma acth, Pressor, Reisine, Rivier, Secretagog, Significant changes, Significant difference, University department, Vasopressin.
Abstract
1. Adrenaline causes ACTH release from cultured rat pituitary corticotrophs (Vale et al. 1983) and there is evidence that it causes ACTH release in rats in vivo (Plotsky et al. 1985). 2. The present study examined the effects of intravenous adrenaline infusion with and without simultaneous administration of the known ACTH secretagog, arginine vasopressin, in normotensive and mild essential hypertensive men on their plasma ACTH and cortisol levels. 3. Low dose adrenaline infusion (0.013 μg/kg per min) does not cause ACTH or cortisol release, but appears to blunt the ACTH and cortisol rise caused by arginine vasopressin (0.14 pressor units/kg, i.m.).
Url:
DOI: 10.1111/j.1440-1681.1987.tb00376.x
Affiliations:
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Bachmann</name><affiliation wicri:level="1"><country xml:lang="fr">Australie</country><wicri:regionArea>Neuroendocrine Research Unit, University Department of Medicine, Greenslopes Hospital, Brisbane, Queensland</wicri:regionArea><wicri:noRegion>Queensland</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Clinical and Experimental Pharmacology and Physiology</title><idno type="ISSN">0305-1870</idno><idno type="eISSN">1440-1681</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="1987-03">1987-03</date><biblScope unit="volume">14</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="203">203</biblScope><biblScope unit="page" to="208">208</biblScope></imprint><idno type="ISSN">0305-1870</idno></series><idno type="istex">844717303AB9A9D13A621BD7044C159BCA5C5451</idno><idno type="DOI">10.1111/j.1440-1681.1987.tb00376.x</idno><idno type="ArticleID">CEP203</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0305-1870</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>adrenaline</term><term>adrenocorticotrophin</term><term>blood pressure</term><term>cortisol</term><term>man</term><term>pituitary</term><term>stress</term><term>sympathetic nervous system</term><term>vasopressin</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Acth</term><term>Acth release</term><term>Acth secretagog</term><term>Adrenaline</term><term>Adrenaline infusion</term><term>Adrenocorticotropin release</term><term>Arginine</term><term>Arginine vasopressin</term><term>Arginine vasopressin pressor</term><term>Arterial pressure</term><term>Axelrod</term><term>Axelrod reisine</term><term>Basal</term><term>Blood pressure</term><term>Cause acth</term><term>Clinical chemistry</term><term>Cortisol</term><term>Cortisol release</term><term>Cortisol response</term><term>Cortisol rise</term><term>Deltoid muscle</term><term>Dose adrenaline infusion</term><term>Endocrinology</term><term>Experimental pharmacology physiology</term><term>Greenslopes hospital</term><term>Heart rate</term><term>Hpaa</term><term>Infusion</term><term>Intravenous adrenaline infusion</term><term>Lower plasma cortisol response</term><term>Peak changes</term><term>Pituitary corticotrophs</term><term>Placebo</term><term>Plasma acth</term><term>Pressor</term><term>Reisine</term><term>Rivier</term><term>Secretagog</term><term>Significant changes</term><term>Significant difference</term><term>University department</term><term>Vasopressin</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">1. Adrenaline causes ACTH release from cultured rat pituitary corticotrophs (Vale et al. 1983) and there is evidence that it causes ACTH release in rats in vivo (Plotsky et al. 1985). 2. The present study examined the effects of intravenous adrenaline infusion with and without simultaneous administration of the known ACTH secretagog, arginine vasopressin, in normotensive and mild essential hypertensive men on their plasma ACTH and cortisol levels. 3. Low dose adrenaline infusion (0.013 μg/kg per min) does not cause ACTH or cortisol release, but appears to blunt the ACTH and cortisol rise caused by arginine vasopressin (0.14 pressor units/kg, i.m.).</div></front></TEI><affiliations><list><country><li>Australie</li></country></list><tree><country name="Australie"><noRegion><name sortKey="Jackson, R V" sort="Jackson, R V" uniqKey="Jackson R" first="R. V." last="Jackson">R. V. Jackson</name></noRegion><name sortKey="Armour, M B" sort="Armour, M B" uniqKey="Armour M" first="M. B." last="Armour">M. B. Armour</name><name sortKey="Bachmann, A W" sort="Bachmann, A W" uniqKey="Bachmann A" first="A. W." last="Bachmann">A. W. Bachmann</name><name sortKey="Grice, J E" sort="Grice, J E" uniqKey="Grice J" first="J. E." last="Grice">J. E. Grice</name><name sortKey="Jackson, A J" sort="Jackson, A J" uniqKey="Jackson A" first="A. J." last="Jackson">A. J. Jackson</name><name sortKey="Penfold, P J" sort="Penfold, P J" uniqKey="Penfold P" first="P. J." last="Penfold">P. J. Penfold</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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