ADRENALINE INFUSION AND ADRENOCORTICOTROPHIN (ACTH) AND CORTISOL RELEASE IN NORMOTENSIVE AND HYPERTENSIVE MAN
Identifieur interne : 001390 ( Main/Exploration ); précédent : 001389; suivant : 001391ADRENALINE INFUSION AND ADRENOCORTICOTROPHIN (ACTH) AND CORTISOL RELEASE IN NORMOTENSIVE AND HYPERTENSIVE MAN
Auteurs : R. V. Jackson [Australie] ; A. J. Jackson [Australie] ; J. E. Grice [Australie] ; P. J. Penfold [Australie] ; M. B. Armour [Australie] ; A. W. Bachmann [Australie]Source :
- Clinical and Experimental Pharmacology and Physiology [ 0305-1870 ] ; 1987-03.
English descriptors
- KwdEn :
- Teeft :
- Acth, Acth release, Acth secretagog, Adrenaline, Adrenaline infusion, Adrenocorticotropin release, Arginine, Arginine vasopressin, Arginine vasopressin pressor, Arterial pressure, Axelrod, Axelrod reisine, Basal, Blood pressure, Cause acth, Clinical chemistry, Cortisol, Cortisol release, Cortisol response, Cortisol rise, Deltoid muscle, Dose adrenaline infusion, Endocrinology, Experimental pharmacology physiology, Greenslopes hospital, Heart rate, Hpaa, Infusion, Intravenous adrenaline infusion, Lower plasma cortisol response, Peak changes, Pituitary corticotrophs, Placebo, Plasma acth, Pressor, Reisine, Rivier, Secretagog, Significant changes, Significant difference, University department, Vasopressin.
Abstract
1. Adrenaline causes ACTH release from cultured rat pituitary corticotrophs (Vale et al. 1983) and there is evidence that it causes ACTH release in rats in vivo (Plotsky et al. 1985). 2. The present study examined the effects of intravenous adrenaline infusion with and without simultaneous administration of the known ACTH secretagog, arginine vasopressin, in normotensive and mild essential hypertensive men on their plasma ACTH and cortisol levels. 3. Low dose adrenaline infusion (0.013 μg/kg per min) does not cause ACTH or cortisol release, but appears to blunt the ACTH and cortisol rise caused by arginine vasopressin (0.14 pressor units/kg, i.m.).
Url:
DOI: 10.1111/j.1440-1681.1987.tb00376.x
Affiliations:
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Le document en format XML
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<term>Adrenaline infusion</term>
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<term>Blood pressure</term>
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<term>Clinical chemistry</term>
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<term>Cortisol response</term>
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<term>Dose adrenaline infusion</term>
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<term>Experimental pharmacology physiology</term>
<term>Greenslopes hospital</term>
<term>Heart rate</term>
<term>Hpaa</term>
<term>Infusion</term>
<term>Intravenous adrenaline infusion</term>
<term>Lower plasma cortisol response</term>
<term>Peak changes</term>
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<term>Placebo</term>
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<front><div type="abstract" xml:lang="en">1. Adrenaline causes ACTH release from cultured rat pituitary corticotrophs (Vale et al. 1983) and there is evidence that it causes ACTH release in rats in vivo (Plotsky et al. 1985). 2. The present study examined the effects of intravenous adrenaline infusion with and without simultaneous administration of the known ACTH secretagog, arginine vasopressin, in normotensive and mild essential hypertensive men on their plasma ACTH and cortisol levels. 3. Low dose adrenaline infusion (0.013 μg/kg per min) does not cause ACTH or cortisol release, but appears to blunt the ACTH and cortisol rise caused by arginine vasopressin (0.14 pressor units/kg, i.m.).</div>
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