Interrelationships of interleukin‐8 with interleukin‐1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women
Identifieur interne : 000607 ( Istex/Curation ); précédent : 000606; suivant : 000608Interrelationships of interleukin‐8 with interleukin‐1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women
Auteurs : Sabina Cauci [Italie] ; Secondo Guaschino ; Domenico De Aloysio ; Silvia Driussi [Italie] ; Davide De Santo ; Paola Penacchioni ; Franco QuadrifoglioSource :
- Molecular Human Reproduction [ 1360-9947 ] ; 2003-01.
English descriptors
- KwdEn :
- Teeft :
- Bacterial vaginosis, Cauci, Chemokines, Cytokine, Eld, Eschenbach, Gynecol, Healthy controls, Healthy women, High concentrations, High levels, High neutrophil counts, High neutrophils, High number, High numbers, Hillier, Immune, Innate factors, Innate immunity, Leukocyte, Median, Median value, Microbial, Mucosal, Neutrophil, Neutrophil recruitment, Obstet, Percentile, Positive women, Quadrifoglio, Reprod, Subgroup, Such differences, Udine, Vaginal, Vaginal neutrophils, Vaginalis, Vaginosis.
Abstract
Vaginal innate immunity in response to microbial perturbation is still poorly understood and could be crucial for protection from adverse outcomes. We investigated the relationship between interleukin (IL)‐8, IL‐1β and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis (BV) positive. Concentrations of IL‐8 and IL‐1β were highly correlated with counts of neutrophils in vaginal fluid of the entire population examined (111 subjects). Vaginal IL‐1β concentrations were significantly higher (P < 0.001) in BV positive women. There was no significant difference in IL‐8 levels or number of neutrophils between healthy controls and BV positive women. None of the healthy controls with high neutrophil counts (≥75th percentile, 14 average count per field) had high concentrations of IL‐1β (≥75th percentile, 220 pg/ml), whereas 84% of BV positive women with high neutrophil counts had high IL‐1β concentrations (P < 0.001). On the contrary, no difference in the percentage of subjects with elevated concentrations of IL‐8 (≥75th percentile, 2842 pg/ml) was found between healthy and BV positive women with high numbers of neutrophils (55.5% of healthy versus 53% of BV positive women). Our findings show that BV causes a large increase in IL‐1β concentrations which is not paralleled by an increase in IL‐8 concentrations in vaginal fluid, suggesting that BV‐associated factors more specifically dampen IL‐8 rather than IL‐1β. The lack of an increase in IL‐8 may explain the absence of an increase in neutrophil numbers in most women exposed to abnormal vaginal colonization (BV).
Url:
DOI: 10.1093/molehr/gag003
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000639
Links to Exploration step
ISTEX:3CDA555FAA9725714F8C4A9958181E4ED93AFF10Curation
No country items
Secondo Guaschino<affiliation><mods:affiliation>Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, School of Medicine, University of Trieste, Via dell’Istria 65/1, 34100 Trieste,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Sant’Orsola Hospital, School of Medicine, University of Bologna,Via Massarenti, 40138 Bologna and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, School of Medicine, University of Trieste, Via dell’Istria 65/1, 34100 Trieste,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Sant’Orsola Hospital, School of Medicine, University of Bologna,Via Massarenti, 40138 Bologna and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation><affiliation><mods:affiliation>Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Piazzale Kolbe 4, 33100 Udine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation>Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Interrelationships of interleukin‐8 with interleukin‐1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women</title><author><name sortKey="Cauci, Sabina" sort="Cauci, Sabina" uniqKey="Cauci S" first="Sabina" last="Cauci">Sabina Cauci</name><affiliation><mods:affiliation>Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Piazzale Kolbe 4, 33100 Udine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>To whom correspondence should be addressed. e‐mail: scauci@mail.dstb.uniud.it</mods:affiliation><country wicri:rule="url">Italie</country></affiliation></author><author><name sortKey="Guaschino, Secondo" sort="Guaschino, Secondo" uniqKey="Guaschino S" first="Secondo" last="Guaschino">Secondo Guaschino</name><affiliation><mods:affiliation>Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, School of Medicine, University of Trieste, Via dell’Istria 65/1, 34100 Trieste,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="De Aloysio, Domenico" sort="De Aloysio, Domenico" uniqKey="De Aloysio D" first="Domenico" last="De Aloysio">Domenico De Aloysio</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Sant’Orsola Hospital, School of Medicine, University of Bologna,Via Massarenti, 40138 Bologna and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Driussi, Silvia" sort="Driussi, Silvia" uniqKey="Driussi S" first="Silvia" last="Driussi">Silvia Driussi</name><affiliation><mods:affiliation>Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Piazzale Kolbe 4, 33100 Udine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation><affiliation wicri:level="1"><mods:affiliation>Azienda Servizi Sanitari N. 4 Medio Friuli, Via San Valentino, 33100 Udine, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Servizi Sanitari N. 4 Medio Friuli, Via San Valentino, 33100 Udine</wicri:regionArea></affiliation></author><author><name sortKey="De Santo, Davide" sort="De Santo, Davide" uniqKey="De Santo D" first="Davide" last="De Santo">Davide De Santo</name><affiliation><mods:affiliation>Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, School of Medicine, University of Trieste, Via dell’Istria 65/1, 34100 Trieste,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Penacchioni, Paola" sort="Penacchioni, Paola" uniqKey="Penacchioni P" first="Paola" last="Penacchioni">Paola Penacchioni</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Sant’Orsola Hospital, School of Medicine, University of Bologna,Via Massarenti, 40138 Bologna and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Quadrifoglio, Franco" sort="Quadrifoglio, Franco" uniqKey="Quadrifoglio F" first="Franco" last="Quadrifoglio">Franco Quadrifoglio</name><affiliation><mods:affiliation>Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Piazzale Kolbe 4, 33100 Udine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:3CDA555FAA9725714F8C4A9958181E4ED93AFF10</idno><date when="2003" year="2003">2003</date><idno type="doi">10.1093/molehr/gag003</idno><idno type="url">https://api.istex.fr/document/3CDA555FAA9725714F8C4A9958181E4ED93AFF10/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000639</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000639</idno><idno type="wicri:Area/Istex/Curation">000607</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Interrelationships of interleukin‐8 with interleukin‐1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women</title><author><name sortKey="Cauci, Sabina" sort="Cauci, Sabina" uniqKey="Cauci S" first="Sabina" last="Cauci">Sabina Cauci</name><affiliation><mods:affiliation>Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Piazzale Kolbe 4, 33100 Udine,</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>To whom correspondence should be addressed. e‐mail: scauci@mail.dstb.uniud.it</mods:affiliation><country wicri:rule="url">Italie</country></affiliation></author><author><name sortKey="Guaschino, Secondo" sort="Guaschino, Secondo" uniqKey="Guaschino S" first="Secondo" last="Guaschino">Secondo Guaschino</name><affiliation><mods:affiliation>Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, School of Medicine, University of Trieste, Via dell’Istria 65/1, 34100 Trieste,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="De Aloysio, Domenico" sort="De Aloysio, Domenico" uniqKey="De Aloysio D" first="Domenico" last="De Aloysio">Domenico De Aloysio</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Sant’Orsola Hospital, School of Medicine, University of Bologna,Via Massarenti, 40138 Bologna and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Driussi, Silvia" sort="Driussi, Silvia" uniqKey="Driussi S" first="Silvia" last="Driussi">Silvia Driussi</name><affiliation><mods:affiliation>Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Piazzale Kolbe 4, 33100 Udine,</mods:affiliation></affiliation><affiliation wicri:level="1"><mods:affiliation>Azienda Servizi Sanitari N. 4 Medio Friuli, Via San Valentino, 33100 Udine, Italy</mods:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Azienda Servizi Sanitari N. 4 Medio Friuli, Via San Valentino, 33100 Udine</wicri:regionArea></affiliation></author><author><name sortKey="De Santo, Davide" sort="De Santo, Davide" uniqKey="De Santo D" first="Davide" last="De Santo">Davide De Santo</name><affiliation><mods:affiliation>Obstetric and Gynecologic Unit, Department of Reproductive and Development Sciences, IRCCS Burlo Garofolo Hospital, School of Medicine, University of Trieste, Via dell’Istria 65/1, 34100 Trieste,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author><author><name sortKey="Penacchioni, Paola" sort="Penacchioni, Paola" uniqKey="Penacchioni P" first="Paola" last="Penacchioni">Paola Penacchioni</name><affiliation><mods:affiliation>Department of Obstetrics and Gynecology, Sant’Orsola Hospital, School of Medicine, University of Bologna,Via Massarenti, 40138 Bologna and</mods:affiliation><wicri:noCountry code="subField">and</wicri:noCountry></affiliation></author><author><name sortKey="Quadrifoglio, Franco" sort="Quadrifoglio, Franco" uniqKey="Quadrifoglio F" first="Franco" last="Quadrifoglio">Franco Quadrifoglio</name><affiliation><mods:affiliation>Department of Biomedical Sciences and Technologies, School of Medicine, University of Udine, Piazzale Kolbe 4, 33100 Udine,</mods:affiliation><wicri:noCountry code="subField"></wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Molecular Human Reproduction</title><title level="j" type="abbrev">Mol. Hum. Reprod.</title><idno type="ISSN">1360-9947</idno><idno type="eISSN">1460-2407</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2003-01">2003-01</date><biblScope unit="volume">9</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="53">53</biblScope><biblScope unit="page" to="58">58</biblScope></imprint><idno type="ISSN">1360-9947</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1360-9947</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Key words: bacterial vaginosis/interleukin‐1β/interleukin‐8/mucosal innate immunity/vaginal leukocytes</term></keywords><keywords scheme="Teeft" xml:lang="en"><term>Bacterial vaginosis</term><term>Cauci</term><term>Chemokines</term><term>Cytokine</term><term>Eld</term><term>Eschenbach</term><term>Gynecol</term><term>Healthy controls</term><term>Healthy women</term><term>High concentrations</term><term>High levels</term><term>High neutrophil counts</term><term>High neutrophils</term><term>High number</term><term>High numbers</term><term>Hillier</term><term>Immune</term><term>Innate factors</term><term>Innate immunity</term><term>Leukocyte</term><term>Median</term><term>Median value</term><term>Microbial</term><term>Mucosal</term><term>Neutrophil</term><term>Neutrophil recruitment</term><term>Obstet</term><term>Percentile</term><term>Positive women</term><term>Quadrifoglio</term><term>Reprod</term><term>Subgroup</term><term>Such differences</term><term>Udine</term><term>Vaginal</term><term>Vaginal neutrophils</term><term>Vaginalis</term><term>Vaginosis</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Vaginal innate immunity in response to microbial perturbation is still poorly understood and could be crucial for protection from adverse outcomes. We investigated the relationship between interleukin (IL)‐8, IL‐1β and neutrophils in vaginal fluid obtained from 60 healthy women and 51 women who were bacterial vaginosis (BV) positive. Concentrations of IL‐8 and IL‐1β were highly correlated with counts of neutrophils in vaginal fluid of the entire population examined (111 subjects). Vaginal IL‐1β concentrations were significantly higher (P < 0.001) in BV positive women. There was no significant difference in IL‐8 levels or number of neutrophils between healthy controls and BV positive women. None of the healthy controls with high neutrophil counts (≥75th percentile, 14 average count per field) had high concentrations of IL‐1β (≥75th percentile, 220 pg/ml), whereas 84% of BV positive women with high neutrophil counts had high IL‐1β concentrations (P < 0.001). On the contrary, no difference in the percentage of subjects with elevated concentrations of IL‐8 (≥75th percentile, 2842 pg/ml) was found between healthy and BV positive women with high numbers of neutrophils (55.5% of healthy versus 53% of BV positive women). Our findings show that BV causes a large increase in IL‐1β concentrations which is not paralleled by an increase in IL‐8 concentrations in vaginal fluid, suggesting that BV‐associated factors more specifically dampen IL‐8 rather than IL‐1β. The lack of an increase in IL‐8 may explain the absence of an increase in neutrophil numbers in most women exposed to abnormal vaginal colonization (BV).</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sarre/explor/MusicSarreV3/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000607 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000607 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sarre
|area= MusicSarreV3
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:3CDA555FAA9725714F8C4A9958181E4ED93AFF10
|texte= Interrelationships of interleukin‐8 with interleukin‐1β and neutrophils in vaginal fluid of healthy and bacterial vaginosis positive women
}}
| This area was generated with Dilib version V0.6.33. |  |