Effect of methionine on the fatty acid composition of cellular membranes in rats with chronic ethanol consumption and jejunoileal bypass.
Identifieur interne : 000951 ( PubMed/Corpus ); précédent : 000950; suivant : 000952Effect of methionine on the fatty acid composition of cellular membranes in rats with chronic ethanol consumption and jejunoileal bypass.
Auteurs : A R Waladkhani ; M R Clemens ; J C Bode ; C. BodeSource :
- Alcohol and alcoholism (Oxford, Oxfordshire) [ 0735-0414 ] ; 1996.
English descriptors
- KwdEn :
- Alcoholism (enzymology), Animals, Cell Membrane (drug effects), Cell Membrane (metabolism), Dose-Response Relationship, Drug, Fatty Acid Desaturases (physiology), Fatty Acids (metabolism), Fatty Acids, Unsaturated (metabolism), Jejunoileal Bypass, Jejunum (drug effects), Jejunum (enzymology), Liver (drug effects), Liver (enzymology), Male, Membrane Lipids (metabolism), Methionine (pharmacology), Rats, Rats, Wistar.
- MESH :
- chemical , metabolism : Fatty Acids, Fatty Acids, Unsaturated, Membrane Lipids.
- chemical , pharmacology : Methionine.
- chemical , physiology : Fatty Acid Desaturases.
- drug effects : Cell Membrane, Jejunum, Liver.
- enzymology : Alcoholism, Jejunum, Liver.
- metabolism : Cell Membrane.
- Animals, Dose-Response Relationship, Drug, Jejunoileal Bypass, Male, Rats, Rats, Wistar.
Abstract
The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32, 160 and 224 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group. A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of delta 6-and delta 5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid and higher proportions of docosahexaenoic acid, appeared. A possible explanation for this increase of PUFA in tissue may be increased activities of delta 6- and delta 5-desaturases.
PubMed: 8949962
Links to Exploration step
pubmed:8949962Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of methionine on the fatty acid composition of cellular membranes in rats with chronic ethanol consumption and jejunoileal bypass.</title><author><name sortKey="Waladkhani, A R" sort="Waladkhani, A R" uniqKey="Waladkhani A" first="A R" last="Waladkhani">A R Waladkhani</name><affiliation><nlm:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Clemens, M R" sort="Clemens, M R" uniqKey="Clemens M" first="M R" last="Clemens">M R Clemens</name></author><author><name sortKey="Bode, J C" sort="Bode, J C" uniqKey="Bode J" first="J C" last="Bode">J C Bode</name></author><author><name sortKey="Bode, C" sort="Bode, C" uniqKey="Bode C" first="C" last="Bode">C. Bode</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="1996">1996</date><idno type="RBID">pubmed:8949962</idno><idno type="pmid">8949962</idno><idno type="wicri:Area/PubMed/Corpus">000951</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000951</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Effect of methionine on the fatty acid composition of cellular membranes in rats with chronic ethanol consumption and jejunoileal bypass.</title><author><name sortKey="Waladkhani, A R" sort="Waladkhani, A R" uniqKey="Waladkhani A" first="A R" last="Waladkhani">A R Waladkhani</name><affiliation><nlm:affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Clemens, M R" sort="Clemens, M R" uniqKey="Clemens M" first="M R" last="Clemens">M R Clemens</name></author><author><name sortKey="Bode, J C" sort="Bode, J C" uniqKey="Bode J" first="J C" last="Bode">J C Bode</name></author><author><name sortKey="Bode, C" sort="Bode, C" uniqKey="Bode C" first="C" last="Bode">C. Bode</name></author></analytic><series><title level="j">Alcohol and alcoholism (Oxford, Oxfordshire)</title><idno type="ISSN">0735-0414</idno><imprint><date when="1996" type="published">1996</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Alcoholism (enzymology)</term><term>Animals</term><term>Cell Membrane (drug effects)</term><term>Cell Membrane (metabolism)</term><term>Dose-Response Relationship, Drug</term><term>Fatty Acid Desaturases (physiology)</term><term>Fatty Acids (metabolism)</term><term>Fatty Acids, Unsaturated (metabolism)</term><term>Jejunoileal Bypass</term><term>Jejunum (drug effects)</term><term>Jejunum (enzymology)</term><term>Liver (drug effects)</term><term>Liver (enzymology)</term><term>Male</term><term>Membrane Lipids (metabolism)</term><term>Methionine (pharmacology)</term><term>Rats</term><term>Rats, Wistar</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Fatty Acids</term><term>Fatty Acids, Unsaturated</term><term>Membrane Lipids</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Methionine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Fatty Acid Desaturases</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cell Membrane</term><term>Jejunum</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Alcoholism</term><term>Jejunum</term><term>Liver</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Cell Membrane</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dose-Response Relationship, Drug</term><term>Jejunoileal Bypass</term><term>Male</term><term>Rats</term><term>Rats, Wistar</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32, 160 and 224 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group. A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of delta 6-and delta 5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid and higher proportions of docosahexaenoic acid, appeared. A possible explanation for this increase of PUFA in tissue may be increased activities of delta 6- and delta 5-desaturases.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">8949962</PMID><DateCreated><Year>1997</Year><Month>03</Month><Day>19</Day></DateCreated><DateCompleted><Year>1997</Year><Month>03</Month><Day>19</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0735-0414</ISSN><JournalIssue CitedMedium="Print"><Volume>31</Volume><Issue>5</Issue><PubDate><Year>1996</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Alcohol and alcoholism (Oxford, Oxfordshire)</Title><ISOAbbreviation>Alcohol Alcohol.</ISOAbbreviation></Journal><ArticleTitle>Effect of methionine on the fatty acid composition of cellular membranes in rats with chronic ethanol consumption and jejunoileal bypass.</ArticleTitle><Pagination><MedlinePgn>463-9</MedlinePgn></Pagination><Abstract><AbstractText>The objective of this study was to investigate the effect of alcohol administration on jejunoileal bypass (JIB)-induced liver dysfunction in rats resulting in abnormalities of fatty acid composition of cell membranes, and whether methionine is able to reverse these changes. Male Wistar rats were subjected to a jejunoileal bypass operation. For 12 weeks, all groups were pair-fed either an alcohol-containing (36% of total calories) liquid diet or a liquid diet in which alcohol was replaced isocalorically by starch. Methionine supplementation in three control groups was 0, 32, 160 and 224 mg/kg body weight/day and the rats in the four alcohol feeding groups received 0, 32, 160 and 224 mg/kg body weight/day. In the alcohol group without any methionine supplementation, higher proportions of oleic and linoleic acid and lower proportions of docosahexaenoic and arachidonic acid became evident in tissue samples of liver and jejunum, in comparison with the other alcohol group. A possible explanation for this reduction in tissue polyunsaturated fatty acid (PUFA) may be a decrease in the activities of delta 6-and delta 5-desaturases, and subsequently a displacement of PUFA from lipid fractions by other fatty acids. Interestingly, in the alcohol group with the highest methionine supplementation, compared to all other alcohol groups, lower proportions of oleic acid and higher proportions of docosahexaenoic acid, appeared. A possible explanation for this increase of PUFA in tissue may be increased activities of delta 6- and delta 5-desaturases.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Waladkhani</LastName><ForeName>A R</ForeName><Initials>AR</Initials><AffiliationInfo><Affiliation>Krankenanstalt Mutterhaus der Borromäerinnen, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Clemens</LastName><ForeName>M R</ForeName><Initials>MR</Initials></Author><Author ValidYN="Y"><LastName>Bode</LastName><ForeName>J C</ForeName><Initials>JC</Initials></Author><Author ValidYN="Y"><LastName>Bode</LastName><ForeName>C</ForeName><Initials>C</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Alcohol Alcohol</MedlineTA><NlmUniqueID>8310684</NlmUniqueID><ISSNLinking>0735-0414</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005227">Fatty Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005231">Fatty Acids, Unsaturated</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D008563">Membrane Lipids</NameOfSubstance></Chemical><Chemical><RegistryNumber>AE28F7PNPL</RegistryNumber><NameOfSubstance UI="D008715">Methionine</NameOfSubstance></Chemical><Chemical><RegistryNumber>EC 1.14.19.-</RegistryNumber><NameOfSubstance UI="D044943">Fatty Acid Desaturases</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000437" MajorTopicYN="N">Alcoholism</DescriptorName><QualifierName UI="Q000201" MajorTopicYN="Y">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002462" MajorTopicYN="N">Cell Membrane</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D044943" MajorTopicYN="N">Fatty Acid Desaturases</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005227" MajorTopicYN="N">Fatty Acids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005231" MajorTopicYN="N">Fatty Acids, Unsaturated</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007581" MajorTopicYN="Y">Jejunoileal Bypass</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007583" MajorTopicYN="N">Jejunum</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008099" MajorTopicYN="N">Liver</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName><QualifierName UI="Q000201" MajorTopicYN="N">enzymology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008563" MajorTopicYN="N">Membrane Lipids</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008715" MajorTopicYN="N">Methionine</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D051381" MajorTopicYN="N">Rats</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017208" MajorTopicYN="N">Rats, Wistar</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1996</Year><Month>9</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1996</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1996</Year><Month>9</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8949962</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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