[Life threatening hypercalcemia in a young man with ALL].
Identifieur interne : 000833 ( PubMed/Corpus ); précédent : 000832; suivant : 000834[Life threatening hypercalcemia in a young man with ALL].
Auteurs : T. Schneider ; F. Seydlitz ; U. Zimmermann ; B. Sontag ; W H BoeskenSource :
- Deutsche medizinische Wochenschrift (1946) [ 0012-0472 ] ; 2001.
English descriptors
- KwdEn :
- Adolescent, Biopsy, Needle, Bone Marrow (pathology), Calcitonin (administration & dosage), Combined Modality Therapy, Diagnosis, Differential, Fluid Therapy, Humans, Hypercalcemia (diagnosis), Hypercalcemia (etiology), Male, Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis), Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy), Prednisone (administration & dosage).
- MESH :
- chemical , administration & dosage : Calcitonin, Prednisone.
- diagnosis : Hypercalcemia, Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- etiology : Hypercalcemia.
- pathology : Bone Marrow.
- therapy : Precursor Cell Lymphoblastic Leukemia-Lymphoma.
- Adolescent, Biopsy, Needle, Combined Modality Therapy, Diagnosis, Differential, Fluid Therapy, Humans, Male.
Abstract
A 16-year-old man experienced fatigue, vomiting and diffuse abdominal pain. Since 4 days he had myalgia in both arms and legs. On examination only a tachycardia of 110/min was noticed.
DOI: 10.1055/s-2001-9883
PubMed: 11200666
Links to Exploration step
pubmed:11200666Le document en format XML
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Sontag</name></author><author><name sortKey="Boesken, W H" sort="Boesken, W H" uniqKey="Boesken W" first="W H" last="Boesken">W H Boesken</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2001">2001</date><idno type="RBID">pubmed:11200666</idno><idno type="pmid">11200666</idno><idno type="doi">10.1055/s-2001-9883</idno><idno type="wicri:Area/PubMed/Corpus">000833</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000833</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Life threatening hypercalcemia in a young man with ALL].</title><author><name sortKey="Schneider, T" sort="Schneider, T" uniqKey="Schneider T" first="T" last="Schneider">T. Schneider</name><affiliation><nlm:affiliation>II. Med. Abteilung, Brüderkrankenhaus, Trier. BKT-Med2@T-Online.de</nlm:affiliation></affiliation></author><author><name sortKey="Seydlitz, F" sort="Seydlitz, F" uniqKey="Seydlitz F" first="F" last="Seydlitz">F. Seydlitz</name></author><author><name sortKey="Zimmermann, U" sort="Zimmermann, U" uniqKey="Zimmermann U" first="U" last="Zimmermann">U. Zimmermann</name></author><author><name sortKey="Sontag, B" sort="Sontag, B" uniqKey="Sontag B" first="B" last="Sontag">B. Sontag</name></author><author><name sortKey="Boesken, W H" sort="Boesken, W H" uniqKey="Boesken W" first="W H" last="Boesken">W H Boesken</name></author></analytic><series><title level="j">Deutsche medizinische Wochenschrift (1946)</title><idno type="ISSN">0012-0472</idno><imprint><date when="2001" type="published">2001</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term><term>Biopsy, Needle</term><term>Bone Marrow (pathology)</term><term>Calcitonin (administration & dosage)</term><term>Combined Modality Therapy</term><term>Diagnosis, Differential</term><term>Fluid Therapy</term><term>Humans</term><term>Hypercalcemia (diagnosis)</term><term>Hypercalcemia (etiology)</term><term>Male</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (diagnosis)</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma (therapy)</term><term>Prednisone (administration & dosage)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Calcitonin</term><term>Prednisone</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Hypercalcemia</term><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Hypercalcemia</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone Marrow</term></keywords><keywords scheme="MESH" qualifier="therapy" xml:lang="en"><term>Precursor Cell Lymphoblastic Leukemia-Lymphoma</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adolescent</term><term>Biopsy, Needle</term><term>Combined Modality Therapy</term><term>Diagnosis, Differential</term><term>Fluid Therapy</term><term>Humans</term><term>Male</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">A 16-year-old man experienced fatigue, vomiting and diffuse abdominal pain. Since 4 days he had myalgia in both arms and legs. On examination only a tachycardia of 110/min was noticed.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">11200666</PMID><DateCreated><Year>2001</Year><Month>01</Month><Day>30</Day></DateCreated><DateCompleted><Year>2001</Year><Month>02</Month><Day>15</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0012-0472</ISSN><JournalIssue CitedMedium="Print"><Volume>126</Volume><Issue>1-2</Issue><PubDate><Year>2001</Year><Month>Jan</Month><Day>05</Day></PubDate></JournalIssue><Title>Deutsche medizinische Wochenschrift (1946)</Title><ISOAbbreviation>Dtsch. Med. Wochenschr.</ISOAbbreviation></Journal><ArticleTitle>[Life threatening hypercalcemia in a young man with ALL].</ArticleTitle><Pagination><MedlinePgn>7-11</MedlinePgn></Pagination><Abstract><AbstractText Label="HISTORY AND ADMISSION FINDINGS" NlmCategory="METHODS">A 16-year-old man experienced fatigue, vomiting and diffuse abdominal pain. Since 4 days he had myalgia in both arms and legs. On examination only a tachycardia of 110/min was noticed.</AbstractText><AbstractText Label="INVESTIGATIONS" NlmCategory="METHODS">Laboratory tests revealed hemoglobin 12.7 g/dl, leucocytes 10,300/microliter, platelets 89,000/microliter, LDH 191 U/l, sodium 134 mmol/l, potassium 2.76 mmol/l, calcium 4.52 mmol/l (I), creatinine 1.13 mg/dl, urea 72 mg/dl, uric acid 11.2 mg/dl. The levels of PTH (0 pg/ml), PTH-related peptide, vitamin D, vitamin A, IGF-1, STH, 5-HIES and interleukin 6 were within normal limits. TNF-alpha 25.9 pg/ml (< 8.1). The electrocardiography revealed a sinus rythm with a QT-time of 0.28 s (= 100%). Multiple osteolytic bone leasions were seen in thoracic CT-scan. Abdominal sonography showed normal liver structure, multiple subhepatic lymph nodes without splenomegaly. The cytologic examination of the bone marrow demonstrated a diffuse infiltration by a common acute leukemia.</AbstractText><AbstractText Label="TREATMENT AND COURSE" NlmCategory="METHODS">The rehydration with physiologic saline (3500 ml/d) was initiated in the ICU. Furosemide was added for further renal excretion. Additionally prednisone (100 mg/d) and calcitonin (300 I.E./d) were given. The calcium level fell within two days. No cardiac arrhythmia nor acute renal failure were seen. After definitive diagnosing the patient was treated corresponding to a specific protocol. One year later the relapsing ALL was diagnosed also by hypercalcemia (5.9 mmol/l). The level of TNF-alpha before and after correction of hypercalcemia was 20 pg/ml.</AbstractText><AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">The acute treatment of hypercalcemia is independent of the underlying cause (rehydration with physiologic saline, renal excretion with furosemide, inhibition of osteoclastic activity). The main causes are hyperparathyreoidism or malignancys (90%). We describe TNF-alpha as a possible marker of tumoral load of a common ALL but we are not able to reveal a correlation between TNF-alpha and the calcium level.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schneider</LastName><ForeName>T</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>II. Med. Abteilung, Brüderkrankenhaus, Trier. BKT-Med2@T-Online.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Seydlitz</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Zimmermann</LastName><ForeName>U</ForeName><Initials>U</Initials></Author><Author ValidYN="Y"><LastName>Sontag</LastName><ForeName>B</ForeName><Initials>B</Initials></Author><Author ValidYN="Y"><LastName>Boesken</LastName><ForeName>W H</ForeName><Initials>WH</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Lebensbedrohliche Hyperkalzämie bei einem jungen Mann mit ALL.</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Dtsch Med Wochenschr</MedlineTA><NlmUniqueID>0006723</NlmUniqueID><ISSNLinking>0012-0472</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>9007-12-9</RegistryNumber><NameOfSubstance UI="D002116">Calcitonin</NameOfSubstance></Chemical><Chemical><RegistryNumber>VB0R961HZT</RegistryNumber><NameOfSubstance UI="D011241">Prednisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000293" MajorTopicYN="N">Adolescent</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001707" MajorTopicYN="N">Biopsy, Needle</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001853" MajorTopicYN="N">Bone Marrow</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002116" MajorTopicYN="N">Calcitonin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003131" MajorTopicYN="N">Combined Modality Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005440" MajorTopicYN="N">Fluid Therapy</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006934" MajorTopicYN="N">Hypercalcemia</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D054198" MajorTopicYN="N">Precursor Cell Lymphoblastic Leukemia-Lymphoma</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="Y">diagnosis</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011241" MajorTopicYN="N">Prednisone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="N">administration & dosage</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2001</Year><Month>2</Month><Day>24</Day><Hour>12</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2001</Year><Month>3</Month><Day>3</Day><Hour>10</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2001</Year><Month>2</Month><Day>24</Day><Hour>12</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">11200666</ArticleId><ArticleId IdType="doi">10.1055/s-2001-9883</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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