Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation.
Identifieur interne : 000365 ( PubMed/Corpus ); précédent : 000364; suivant : 000366Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation.
Auteurs : Thomas M. Schilling ; Diana S. Ferreira De Sá ; René Westerhausen ; Florian Strelzyk ; Mauro F. Larra ; Manfred Hallschmid ; Egemen Savaskan ; Melly S. Oitzl ; Hans-Peter Busch ; Ewald Naumann ; Hartmut Sch ChingerSource :
- Human brain mapping [ 1097-0193 ] ; 2014.
English descriptors
- KwdEn :
- Administration, Oral, Adult, Analysis of Variance, Cerebral Cortex (drug effects), Cerebrovascular Circulation (drug effects), Dose-Response Relationship, Drug, Double-Blind Method, Fasting, Humans, Hydrocortisone (administration & dosage), Hydrocortisone (metabolism), Hypoglycemic Agents (administration & dosage), Insulin (administration & dosage), Magnetic Resonance Imaging, Male, Saliva (metabolism), Spin Labels, Time Factors, Visual Analog Scale, Young Adult.
- MESH :
- chemical , administration & dosage : Hydrocortisone, Hypoglycemic Agents, Insulin.
- drug effects : Cerebral Cortex, Cerebrovascular Circulation.
- chemical , metabolism : Hydrocortisone, Saliva.
- Administration, Oral, Adult, Analysis of Variance, Dose-Response Relationship, Drug, Double-Blind Method, Fasting, Humans, Magnetic Resonance Imaging, Male, Spin Labels, Time Factors, Visual Analog Scale, Young Adult.
Abstract
Insulin and cortisol play a key role in the regulation of energy homeostasis, appetite, and satiety. Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this study, we assessed the impact of single and combined application of insulin and cortisol on resting regional cerebral blood flow (rCBF) in the insular cortex. After standardized periods of food restriction, 48 male volunteers were randomly assigned to receive either 40 IU intranasal insulin, 30 mg oral cortisol, both, or neither (placebo). Continuous arterial spin labeling (CASL) sequences were acquired before and after pharmacological treatment. We observed a bilateral, locally distinct rCBF increase after insulin administration in the insular cortex and the putamen. Insulin effects on rCBF were present regardless of whether participants had received cortisol or not. Our results indicate that insulin, but not cortisol, affects blood flow in human brain structures involved in the regulation of eating behavior.
DOI: 10.1002/hbm.22304
PubMed: 23907764
Links to Exploration step
pubmed:23907764Le document en format XML
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Ferreira De Sá</name></author><author><name sortKey="Westerhausen, Rene" sort="Westerhausen, Rene" uniqKey="Westerhausen R" first="René" last="Westerhausen">René Westerhausen</name></author><author><name sortKey="Strelzyk, Florian" sort="Strelzyk, Florian" uniqKey="Strelzyk F" first="Florian" last="Strelzyk">Florian Strelzyk</name></author><author><name sortKey="Larra, Mauro F" sort="Larra, Mauro F" uniqKey="Larra M" first="Mauro F" last="Larra">Mauro F. Larra</name></author><author><name sortKey="Hallschmid, Manfred" sort="Hallschmid, Manfred" uniqKey="Hallschmid M" first="Manfred" last="Hallschmid">Manfred Hallschmid</name></author><author><name sortKey="Savaskan, Egemen" sort="Savaskan, Egemen" uniqKey="Savaskan E" first="Egemen" last="Savaskan">Egemen Savaskan</name></author><author><name sortKey="Oitzl, Melly S" sort="Oitzl, Melly S" uniqKey="Oitzl M" first="Melly S" last="Oitzl">Melly S. Oitzl</name></author><author><name sortKey="Busch, Hans Peter" sort="Busch, Hans Peter" uniqKey="Busch H" first="Hans-Peter" last="Busch">Hans-Peter Busch</name></author><author><name sortKey="Naumann, Ewald" sort="Naumann, Ewald" uniqKey="Naumann E" first="Ewald" last="Naumann">Ewald Naumann</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2014">2014</date><idno type="RBID">pubmed:23907764</idno><idno type="pmid">23907764</idno><idno type="doi">10.1002/hbm.22304</idno><idno type="wicri:Area/PubMed/Corpus">000365</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000365</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation.</title><author><name sortKey="Schilling, Thomas M" sort="Schilling, Thomas M" uniqKey="Schilling T" first="Thomas M" last="Schilling">Thomas M. Schilling</name><affiliation><nlm:affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Ferreira De Sa, Diana S" sort="Ferreira De Sa, Diana S" uniqKey="Ferreira De Sa D" first="Diana S" last="Ferreira De Sá">Diana S. Ferreira De Sá</name></author><author><name sortKey="Westerhausen, Rene" sort="Westerhausen, Rene" uniqKey="Westerhausen R" first="René" last="Westerhausen">René Westerhausen</name></author><author><name sortKey="Strelzyk, Florian" sort="Strelzyk, Florian" uniqKey="Strelzyk F" first="Florian" last="Strelzyk">Florian Strelzyk</name></author><author><name sortKey="Larra, Mauro F" sort="Larra, Mauro F" uniqKey="Larra M" first="Mauro F" last="Larra">Mauro F. Larra</name></author><author><name sortKey="Hallschmid, Manfred" sort="Hallschmid, Manfred" uniqKey="Hallschmid M" first="Manfred" last="Hallschmid">Manfred Hallschmid</name></author><author><name sortKey="Savaskan, Egemen" sort="Savaskan, Egemen" uniqKey="Savaskan E" first="Egemen" last="Savaskan">Egemen Savaskan</name></author><author><name sortKey="Oitzl, Melly S" sort="Oitzl, Melly S" uniqKey="Oitzl M" first="Melly S" last="Oitzl">Melly S. Oitzl</name></author><author><name sortKey="Busch, Hans Peter" sort="Busch, Hans Peter" uniqKey="Busch H" first="Hans-Peter" last="Busch">Hans-Peter Busch</name></author><author><name sortKey="Naumann, Ewald" sort="Naumann, Ewald" uniqKey="Naumann E" first="Ewald" last="Naumann">Ewald Naumann</name></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name></author></analytic><series><title level="j">Human brain mapping</title><idno type="eISSN">1097-0193</idno><imprint><date when="2014" type="published">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Analysis of Variance</term><term>Cerebral Cortex (drug effects)</term><term>Cerebrovascular Circulation (drug effects)</term><term>Dose-Response Relationship, Drug</term><term>Double-Blind Method</term><term>Fasting</term><term>Humans</term><term>Hydrocortisone (administration & dosage)</term><term>Hydrocortisone (metabolism)</term><term>Hypoglycemic Agents (administration & dosage)</term><term>Insulin (administration & dosage)</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Saliva (metabolism)</term><term>Spin Labels</term><term>Time Factors</term><term>Visual Analog Scale</term><term>Young Adult</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Hydrocortisone</term><term>Hypoglycemic Agents</term><term>Insulin</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Cerebral Cortex</term><term>Cerebrovascular Circulation</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term><term>Saliva</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Administration, Oral</term><term>Adult</term><term>Analysis of Variance</term><term>Dose-Response Relationship, Drug</term><term>Double-Blind Method</term><term>Fasting</term><term>Humans</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Spin Labels</term><term>Time Factors</term><term>Visual Analog Scale</term><term>Young Adult</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Insulin and cortisol play a key role in the regulation of energy homeostasis, appetite, and satiety. Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this study, we assessed the impact of single and combined application of insulin and cortisol on resting regional cerebral blood flow (rCBF) in the insular cortex. After standardized periods of food restriction, 48 male volunteers were randomly assigned to receive either 40 IU intranasal insulin, 30 mg oral cortisol, both, or neither (placebo). Continuous arterial spin labeling (CASL) sequences were acquired before and after pharmacological treatment. We observed a bilateral, locally distinct rCBF increase after insulin administration in the insular cortex and the putamen. Insulin effects on rCBF were present regardless of whether participants had received cortisol or not. Our results indicate that insulin, but not cortisol, affects blood flow in human brain structures involved in the regulation of eating behavior.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23907764</PMID><DateCreated><Year>2014</Year><Month>04</Month><Day>11</Day></DateCreated><DateCompleted><Year>2014</Year><Month>12</Month><Day>01</Day></DateCompleted><DateRevised><Year>2014</Year><Month>04</Month><Day>11</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1097-0193</ISSN><JournalIssue CitedMedium="Internet"><Volume>35</Volume><Issue>5</Issue><PubDate><Year>2014</Year><Month>May</Month></PubDate></JournalIssue><Title>Human brain mapping</Title><ISOAbbreviation>Hum Brain Mapp</ISOAbbreviation></Journal><ArticleTitle>Intranasal insulin increases regional cerebral blood flow in the insular cortex in men independently of cortisol manipulation.</ArticleTitle><Pagination><MedlinePgn>1944-56</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1002/hbm.22304</ELocationID><Abstract><AbstractText>Insulin and cortisol play a key role in the regulation of energy homeostasis, appetite, and satiety. Little is known about the action and interaction of both hormones in brain structures controlling food intake and the processing of neurovisceral signals from the gastrointestinal tract. In this study, we assessed the impact of single and combined application of insulin and cortisol on resting regional cerebral blood flow (rCBF) in the insular cortex. After standardized periods of food restriction, 48 male volunteers were randomly assigned to receive either 40 IU intranasal insulin, 30 mg oral cortisol, both, or neither (placebo). Continuous arterial spin labeling (CASL) sequences were acquired before and after pharmacological treatment. We observed a bilateral, locally distinct rCBF increase after insulin administration in the insular cortex and the putamen. Insulin effects on rCBF were present regardless of whether participants had received cortisol or not. Our results indicate that insulin, but not cortisol, affects blood flow in human brain structures involved in the regulation of eating behavior.</AbstractText><CopyrightInformation>Copyright © 2013 Wiley Periodicals, Inc.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Schilling</LastName><ForeName>Thomas M</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ferreira de Sá</LastName><ForeName>Diana S</ForeName><Initials>DS</Initials></Author><Author ValidYN="Y"><LastName>Westerhausen</LastName><ForeName>René</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Strelzyk</LastName><ForeName>Florian</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Larra</LastName><ForeName>Mauro F</ForeName><Initials>MF</Initials></Author><Author ValidYN="Y"><LastName>Hallschmid</LastName><ForeName>Manfred</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Savaskan</LastName><ForeName>Egemen</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Oitzl</LastName><ForeName>Melly S</ForeName><Initials>MS</Initials></Author><Author ValidYN="Y"><LastName>Busch</LastName><ForeName>Hans-Peter</ForeName><Initials>HP</Initials></Author><Author ValidYN="Y"><LastName>Naumann</LastName><ForeName>Ewald</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Schächinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016449">Randomized Controlled Trial</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2013</Year><Month>08</Month><Day>01</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Hum Brain Mapp</MedlineTA><NlmUniqueID>9419065</NlmUniqueID><ISSNLinking>1065-9471</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007004">Hypoglycemic Agents</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007328">Insulin</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D013113">Spin Labels</NameOfSubstance></Chemical><Chemical><RegistryNumber>WI4X0X7BPJ</RegistryNumber><NameOfSubstance UI="D006854">Hydrocortisone</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000284" MajorTopicYN="N">Administration, Oral</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D002540" MajorTopicYN="N">Cerebral Cortex</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D002560" MajorTopicYN="N">Cerebrovascular Circulation</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004305" MajorTopicYN="N">Dose-Response Relationship, Drug</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D004311" MajorTopicYN="N">Double-Blind Method</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005215" MajorTopicYN="N">Fasting</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006854" MajorTopicYN="N">Hydrocortisone</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007004" MajorTopicYN="N">Hypoglycemic Agents</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007328" MajorTopicYN="N">Insulin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008279" MajorTopicYN="N">Magnetic Resonance Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012463" MajorTopicYN="N">Saliva</DescriptorName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013113" MajorTopicYN="N">Spin Labels</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D064232" MajorTopicYN="N">Visual Analog Scale</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D055815" MajorTopicYN="N">Young Adult</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">basal ganglia</Keyword><Keyword MajorTopicYN="N">cerebral cortex</Keyword><Keyword MajorTopicYN="N">glucocorticoids</Keyword><Keyword MajorTopicYN="N">hippocampus</Keyword><Keyword MajorTopicYN="N">metabolism</Keyword><Keyword MajorTopicYN="N">pancreatic hormones</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2012</Year><Month>08</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2013</Year><Month>02</Month><Day>22</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2013</Year><Month>03</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2013</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2013</Year><Month>8</Month><Day>3</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2014</Year><Month>12</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23907764</ArticleId><ArticleId IdType="doi">10.1002/hbm.22304</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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