Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.
Identifieur interne : 000A58 ( PubMed/Checkpoint ); précédent : 000A57; suivant : 000A59Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.
Auteurs : Jens Gaab [Allemagne] ; Dominik Hüster ; Renate Peisen ; Veronika Engert ; Vera Heitz ; Tanja Schad ; Thomas H. Schürmeyer ; Ulrike EhlertSource :
- Psychosomatic medicine [ 0033-3174 ]
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Area Under Curve, Blood Glucose (drug effects), Endocrine Glands (physiopathology), Exercise Test (psychology), Fatigue Syndrome, Chronic (physiopathology), Fatigue Syndrome, Chronic (psychology), Female, Heart Rate (physiology), Humans, Hypothalamo-Hypophyseal System (physiopathology), Insulin (administration & dosage), Male, Middle Aged, Pituitary-Adrenal System (physiopathology), Psychometrics (statistics & numerical data), Stress, Physiological (physiopathology), Stress, Physiological (psychology), Stress, Psychological (physiopathology), Stress, Psychological (psychology), Time Factors.
- MESH :
- chemical , administration & dosage : Insulin.
- chemical , drug effects : Blood Glucose.
- physiology : Heart Rate.
- physiopathology : Endocrine Glands, Fatigue Syndrome, Chronic, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Stress, Physiological, Stress, Psychological.
- psychology : Exercise Test, Fatigue Syndrome, Chronic, Stress, Physiological, Stress, Psychological.
- statistics & numerical data : Psychometrics.
- Adult, Analysis of Variance, Area Under Curve, Female, Humans, Male, Middle Aged, Time Factors.
Abstract
Subtle alterations of the hypothalamic-pituitary-adrenal (HPA) axis in chronic fatigue syndrome (CFS) have been proposed as a shared pathway linking numerous etiological and perpetuating processes with symptoms and observed physiological abnormalities. Because the HPA axis is involved in the adaptive responses to stress and CFS patients experience a worsening of symptoms after physical and psychological stress, we tested HPA axis functioning with three centrally acting stress tests.
PubMed: 12461200
Affiliations:
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pubmed:12461200Le document en format XML
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Schürmeyer</name></author><author><name sortKey="Ehlert, Ulrike" sort="Ehlert, Ulrike" uniqKey="Ehlert U" first="Ulrike" last="Ehlert">Ulrike Ehlert</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="????"><PubDate><MedlineDate>2002 Nov-Dec</MedlineDate></PubDate></date><idno type="RBID">pubmed:12461200</idno><idno type="pmid">12461200</idno><idno type="wicri:Area/PubMed/Corpus">000794</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000794</idno><idno type="wicri:Area/PubMed/Curation">000794</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000794</idno><idno type="wicri:Area/PubMed/Checkpoint">000794</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000794</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.</title><author><name sortKey="Gaab, Jens" sort="Gaab, Jens" uniqKey="Gaab J" first="Jens" last="Gaab">Jens Gaab</name><affiliation wicri:level="4"><nlm:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany. jgaab@klipsy.unizh.ch</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Huster, Dominik" sort="Huster, Dominik" uniqKey="Huster D" first="Dominik" last="Hüster">Dominik Hüster</name></author><author><name sortKey="Peisen, Renate" sort="Peisen, Renate" uniqKey="Peisen R" first="Renate" last="Peisen">Renate Peisen</name></author><author><name sortKey="Engert, Veronika" sort="Engert, Veronika" uniqKey="Engert V" first="Veronika" last="Engert">Veronika Engert</name></author><author><name sortKey="Heitz, Vera" sort="Heitz, Vera" uniqKey="Heitz V" first="Vera" last="Heitz">Vera Heitz</name></author><author><name sortKey="Schad, Tanja" sort="Schad, Tanja" uniqKey="Schad T" first="Tanja" last="Schad">Tanja Schad</name></author><author><name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H" last="Schürmeyer">Thomas H. Schürmeyer</name></author><author><name sortKey="Ehlert, Ulrike" sort="Ehlert, Ulrike" uniqKey="Ehlert U" first="Ulrike" last="Ehlert">Ulrike Ehlert</name></author></analytic><series><title level="j">Psychosomatic medicine</title><idno type="ISSN">0033-3174</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Area Under Curve</term><term>Blood Glucose (drug effects)</term><term>Endocrine Glands (physiopathology)</term><term>Exercise Test (psychology)</term><term>Fatigue Syndrome, Chronic (physiopathology)</term><term>Fatigue Syndrome, Chronic (psychology)</term><term>Female</term><term>Heart Rate (physiology)</term><term>Humans</term><term>Hypothalamo-Hypophyseal System (physiopathology)</term><term>Insulin (administration & dosage)</term><term>Male</term><term>Middle Aged</term><term>Pituitary-Adrenal System (physiopathology)</term><term>Psychometrics (statistics & numerical data)</term><term>Stress, Physiological (physiopathology)</term><term>Stress, Physiological (psychology)</term><term>Stress, Psychological (physiopathology)</term><term>Stress, Psychological (psychology)</term><term>Time Factors</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Insulin</term></keywords><keywords scheme="MESH" type="chemical" qualifier="drug effects" xml:lang="en"><term>Blood Glucose</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Heart Rate</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Endocrine Glands</term><term>Fatigue Syndrome, Chronic</term><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term><term>Stress, Physiological</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="psychology" xml:lang="en"><term>Exercise Test</term><term>Fatigue Syndrome, Chronic</term><term>Stress, Physiological</term><term>Stress, Psychological</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Psychometrics</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Area Under Curve</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Time Factors</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Subtle alterations of the hypothalamic-pituitary-adrenal (HPA) axis in chronic fatigue syndrome (CFS) have been proposed as a shared pathway linking numerous etiological and perpetuating processes with symptoms and observed physiological abnormalities. Because the HPA axis is involved in the adaptive responses to stress and CFS patients experience a worsening of symptoms after physical and psychological stress, we tested HPA axis functioning with three centrally acting stress tests.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">12461200</PMID><DateCreated><Year>2002</Year><Month>12</Month><Day>03</Day></DateCreated><DateCompleted><Year>2003</Year><Month>06</Month><Day>24</Day></DateCompleted><DateRevised><Year>2011</Year><Month>11</Month><Day>17</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0033-3174</ISSN><JournalIssue CitedMedium="Print"><Volume>64</Volume><Issue>6</Issue><PubDate><MedlineDate>2002 Nov-Dec</MedlineDate></PubDate></JournalIssue><Title>Psychosomatic medicine</Title><ISOAbbreviation>Psychosom Med</ISOAbbreviation></Journal><ArticleTitle>Hypothalamic-pituitary-adrenal axis reactivity in chronic fatigue syndrome and health under psychological, physiological, and pharmacological stimulation.</ArticleTitle><Pagination><MedlinePgn>951-62</MedlinePgn></Pagination><Abstract><AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">Subtle alterations of the hypothalamic-pituitary-adrenal (HPA) axis in chronic fatigue syndrome (CFS) have been proposed as a shared pathway linking numerous etiological and perpetuating processes with symptoms and observed physiological abnormalities. Because the HPA axis is involved in the adaptive responses to stress and CFS patients experience a worsening of symptoms after physical and psychological stress, we tested HPA axis functioning with three centrally acting stress tests.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">We used two procedures mimicking real-life stressors and compared them with a standardized pharmacological neuroendocrine challenge test. CFS patients were compared with healthy control subjects regarding their cardiovascular and endocrine reactivity in a psychosocial stress test and a standardized exercise test, and their endocrine response in the insulin tolerance test (ITT).</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">Controlling for possible confounding variables, we found significantly lower ACTH response levels in the psychosocial stress test and the exercise test, and significantly lower ACTH responses in the ITT, with no differences in plasma total cortisol responses. Also, salivary-free cortisol responses did not differ between the groups in the psychosocial stress test and the exercise test but were significantly higher for the CFS patients in the ITT. In all tests CFS patients had significantly reduced baseline ACTH levels.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">These results suggest that CFS patients are capable of mounting a sufficient cortisol response under different types of stress but that on a central level subtle dysregulations of the HPA axis exist.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gaab</LastName><ForeName>Jens</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Trier, Germany. jgaab@klipsy.unizh.ch</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hüster</LastName><ForeName>Dominik</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Peisen</LastName><ForeName>Renate</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Engert</LastName><ForeName>Veronika</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Heitz</LastName><ForeName>Vera</ForeName><Initials>V</Initials></Author><Author ValidYN="Y"><LastName>Schad</LastName><ForeName>Tanja</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Schürmeyer</LastName><ForeName>Thomas H</ForeName><Initials>TH</Initials></Author><Author ValidYN="Y"><LastName>Ehlert</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Psychosom Med</MedlineTA><NlmUniqueID>0376505</NlmUniqueID><ISSNLinking>0033-3174</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001786">Blood Glucose</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D007328">Insulin</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019540" MajorTopicYN="N">Area Under Curve</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001786" MajorTopicYN="N">Blood Glucose</DescriptorName><QualifierName UI="Q000187" MajorTopicYN="N">drug effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D004702" MajorTopicYN="N">Endocrine Glands</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005080" MajorTopicYN="N">Exercise Test</DescriptorName><QualifierName UI="Q000523" MajorTopicYN="N">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015673" MajorTopicYN="N">Fatigue Syndrome, Chronic</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006339" MajorTopicYN="N">Heart Rate</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007328" MajorTopicYN="N">Insulin</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011594" MajorTopicYN="N">Psychometrics</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics & numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013312" MajorTopicYN="N">Stress, Physiological</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="Y">physiopathology</QualifierName><QualifierName UI="Q000523" MajorTopicYN="Y">psychology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013997" MajorTopicYN="N">Time Factors</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2002</Year><Month>12</Month><Day>4</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2003</Year><Month>6</Month><Day>25</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2002</Year><Month>12</Month><Day>4</Day><Hour>4</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">12461200</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Ehlert, Ulrike" sort="Ehlert, Ulrike" uniqKey="Ehlert U" first="Ulrike" last="Ehlert">Ulrike Ehlert</name><name sortKey="Engert, Veronika" sort="Engert, Veronika" uniqKey="Engert V" first="Veronika" last="Engert">Veronika Engert</name><name sortKey="Heitz, Vera" sort="Heitz, Vera" uniqKey="Heitz V" first="Vera" last="Heitz">Vera Heitz</name><name sortKey="Huster, Dominik" sort="Huster, Dominik" uniqKey="Huster D" first="Dominik" last="Hüster">Dominik Hüster</name><name sortKey="Peisen, Renate" sort="Peisen, Renate" uniqKey="Peisen R" first="Renate" last="Peisen">Renate Peisen</name><name sortKey="Schad, Tanja" sort="Schad, Tanja" uniqKey="Schad T" first="Tanja" last="Schad">Tanja Schad</name><name sortKey="Schurmeyer, Thomas H" sort="Schurmeyer, Thomas H" uniqKey="Schurmeyer T" first="Thomas H" last="Schürmeyer">Thomas H. Schürmeyer</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Gaab, Jens" sort="Gaab, Jens" uniqKey="Gaab J" first="Jens" last="Gaab">Jens Gaab</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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