[Wear particles: key to aseptic prosthetic loosening?].
Identifieur interne : 000648 ( PubMed/Checkpoint ); précédent : 000647; suivant : 000649[Wear particles: key to aseptic prosthetic loosening?].
Auteurs : M. Otto [Allemagne] ; J. Kriegsmann ; T. Gehrke ; S. BertzSource :
- Der Pathologe [ 0172-8113 ] ; 2006.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Arthroplasty, Replacement, Hip, Knee Prosthesis.
- pathology : Bone Resorption, Inflammation, Synovial Membrane.
- Humans, Prosthesis Failure.
Abstract
The aseptic prosthetic loosening of hip and knee prosthesis is the most important cause of implant insufficiency. Bone loss as a result of the biological effect of wear particles is the main cause of such loosening. Wear particles develop their biological activity along different cellular pathways, above all via macrophages, foreign body giant cells as well as fibroblasts of the periprosthetic membrane. These cells induce particle-dependent bone resorption by means of proinflammatory cytokines, such as IL-1beta, TNF-alpha, IL-6 and PGE2. These factors induce the activation of osteoclasts as well as the suppression of osteoblasts. Neutrophil granulocytes and lymphocytes do not play an important role in the process of aseptic loosening. The different wear particles, such as ultra-high molecular weight polyethylene, metal particles, ceramic particles and polymethylmethacrylate can be morphologically recognized very easily. From the clinical point of view, the differentiation between acute or chronic implant infection and particle induced prosthetic loosening is very important, with the histomorphological differential diagnosis between septic and aseptic loosening and their combination being the key clinicopathological factor.
DOI: 10.1007/s00292-006-0868-4
PubMed: 17024444
Affiliations:
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pubmed:17024444Le document en format XML
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Bertz</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2006">2006</date><idno type="RBID">pubmed:17024444</idno><idno type="pmid">17024444</idno><idno type="doi">10.1007/s00292-006-0868-4</idno><idno type="wicri:Area/PubMed/Corpus">000671</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000671</idno><idno type="wicri:Area/PubMed/Curation">000671</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000671</idno><idno type="wicri:Area/PubMed/Checkpoint">000671</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000671</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Wear particles: key to aseptic prosthetic loosening?].</title><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name><affiliation wicri:level="1"><nlm:affiliation>Institut für Pathologie Trier und Referenzzentrum für Implantatpathologie/Biomaterialien. otto@patho-trier.de</nlm:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J" last="Kriegsmann">J. Kriegsmann</name></author><author><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name></author><author><name sortKey="Bertz, S" sort="Bertz, S" uniqKey="Bertz S" first="S" last="Bertz">S. Bertz</name></author></analytic><series><title level="j">Der Pathologe</title><idno type="ISSN">0172-8113</idno><imprint><date when="2006" type="published">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Arthroplasty, Replacement, Hip (adverse effects)</term><term>Bone Resorption (pathology)</term><term>Humans</term><term>Inflammation (pathology)</term><term>Knee Prosthesis (adverse effects)</term><term>Prosthesis Failure</term><term>Synovial Membrane (pathology)</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Arthroplasty, Replacement, Hip</term><term>Knee Prosthesis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Bone Resorption</term><term>Inflammation</term><term>Synovial Membrane</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Humans</term><term>Prosthesis Failure</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The aseptic prosthetic loosening of hip and knee prosthesis is the most important cause of implant insufficiency. Bone loss as a result of the biological effect of wear particles is the main cause of such loosening. Wear particles develop their biological activity along different cellular pathways, above all via macrophages, foreign body giant cells as well as fibroblasts of the periprosthetic membrane. These cells induce particle-dependent bone resorption by means of proinflammatory cytokines, such as IL-1beta, TNF-alpha, IL-6 and PGE2. These factors induce the activation of osteoclasts as well as the suppression of osteoblasts. Neutrophil granulocytes and lymphocytes do not play an important role in the process of aseptic loosening. The different wear particles, such as ultra-high molecular weight polyethylene, metal particles, ceramic particles and polymethylmethacrylate can be morphologically recognized very easily. From the clinical point of view, the differentiation between acute or chronic implant infection and particle induced prosthetic loosening is very important, with the histomorphological differential diagnosis between septic and aseptic loosening and their combination being the key clinicopathological factor.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17024444</PMID><DateCreated><Year>2006</Year><Month>11</Month><Day>30</Day></DateCreated><DateCompleted><Year>2007</Year><Month>09</Month><Day>17</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>30</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0172-8113</ISSN><JournalIssue CitedMedium="Print"><Volume>27</Volume><Issue>6</Issue><PubDate><Year>2006</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Der Pathologe</Title><ISOAbbreviation>Pathologe</ISOAbbreviation></Journal><ArticleTitle>[Wear particles: key to aseptic prosthetic loosening?].</ArticleTitle><Pagination><MedlinePgn>447-60</MedlinePgn></Pagination><Abstract><AbstractText>The aseptic prosthetic loosening of hip and knee prosthesis is the most important cause of implant insufficiency. Bone loss as a result of the biological effect of wear particles is the main cause of such loosening. Wear particles develop their biological activity along different cellular pathways, above all via macrophages, foreign body giant cells as well as fibroblasts of the periprosthetic membrane. These cells induce particle-dependent bone resorption by means of proinflammatory cytokines, such as IL-1beta, TNF-alpha, IL-6 and PGE2. These factors induce the activation of osteoclasts as well as the suppression of osteoblasts. Neutrophil granulocytes and lymphocytes do not play an important role in the process of aseptic loosening. The different wear particles, such as ultra-high molecular weight polyethylene, metal particles, ceramic particles and polymethylmethacrylate can be morphologically recognized very easily. From the clinical point of view, the differentiation between acute or chronic implant infection and particle induced prosthetic loosening is very important, with the histomorphological differential diagnosis between septic and aseptic loosening and their combination being the key clinicopathological factor.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Otto</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Institut für Pathologie Trier und Referenzzentrum für Implantatpathologie/Biomaterialien. otto@patho-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kriegsmann</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Gehrke</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Bertz</LastName><ForeName>S</ForeName><Initials>S</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList><VernacularTitle>Abriebpartikel. Schlüssel der aseptischen Prothesenlockerung?</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Pathologe</MedlineTA><NlmUniqueID>8006541</NlmUniqueID><ISSNLinking>0172-8113</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D019644" MajorTopicYN="N">Arthroplasty, Replacement, Hip</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D001862" MajorTopicYN="N">Bone Resorption</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007249" MajorTopicYN="N">Inflammation</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D007720" MajorTopicYN="N">Knee Prosthesis</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011475" MajorTopicYN="Y">Prosthesis Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013583" MajorTopicYN="N">Synovial Membrane</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading></MeshHeadingList><NumberOfReferences>67</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2006</Year><Month>10</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2007</Year><Month>9</Month><Day>18</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2006</Year><Month>10</Month><Day>7</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17024444</ArticleId><ArticleId IdType="doi">10.1007/s00292-006-0868-4</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Bertz, S" sort="Bertz, S" uniqKey="Bertz S" first="S" last="Bertz">S. Bertz</name><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J" last="Kriegsmann">J. Kriegsmann</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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