Anion-exchange chromatography-electrospray ionization mass spectrometry method development for the environmental analysis of aliphatic polyhydroxy carboxylic acids.
Identifieur interne : 000647 ( PubMed/Checkpoint ); précédent : 000646; suivant : 000648Anion-exchange chromatography-electrospray ionization mass spectrometry method development for the environmental analysis of aliphatic polyhydroxy carboxylic acids.
Auteurs : Axel Meyer [Allemagne] ; Susanne Höffler ; Klaus FischerSource :
- Journal of chromatography. A [ 0021-9673 ] ; 2007.
English descriptors
- KwdEn :
- Anions, Carbohydrates (analysis), Carbohydrates (chemistry), Carboxylic Acids (analysis), Carboxylic Acids (chemistry), Chromatography, Ion Exchange (instrumentation), Chromatography, Ion Exchange (methods), Fatty Acids (analysis), Fatty Acids (chemistry), Hydroxides, Potassium Compounds, Reference Standards, Reproducibility of Results, Sensitivity and Specificity, Solvents, Spectrometry, Mass, Electrospray Ionization (methods), Uronic Acids (analysis), Uronic Acids (chemistry), Water Pollutants, Chemical (analysis).
- MESH :
- chemical , analysis : Carbohydrates, Carboxylic Acids, Fatty Acids, Uronic Acids, Water Pollutants, Chemical.
- chemical , chemistry : Carbohydrates, Carboxylic Acids, Fatty Acids, Uronic Acids.
- chemical : Anions, Hydroxides, Potassium Compounds, Solvents.
- instrumentation : Chromatography, Ion Exchange.
- methods : Chromatography, Ion Exchange, Spectrometry, Mass, Electrospray Ionization.
- Reference Standards, Reproducibility of Results, Sensitivity and Specificity.
Abstract
For environmental analytical purposes, an anion-exchange chromatography-electrospray ionization MS method was developed enabling the identification and quantification of 18 aliphatic (poly)hydroxy (poly)carboxylic acids including sugar and uronic acids. The initially incomplete separation could be partially improved for specific analyte combinations adding borate, the zwitter ionic MES, or an alkylglycoside to the NaOH gradient supplied with the Dionex IonPac AS-11 HC column. Despite the incomplete separation, reproducible and sensitive identification and quantification is possible with MS detection in the selected ion-monitoring mode. Applying an internal standard for the compensation of the sensitivity drift of the detector, linear calibration functions were calculated for all analytes. Limits of detection spanned between 18 and 71 microgL(-1) which could be further improved for some more hydrophobic analytes by post-column addition of MeOH.
DOI: 10.1016/j.chroma.2007.09.016
PubMed: 17915229
Affiliations:
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A</title><idno type="ISSN">0021-9673</idno><imprint><date when="2007" type="published">2007</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anions</term><term>Carbohydrates (analysis)</term><term>Carbohydrates (chemistry)</term><term>Carboxylic Acids (analysis)</term><term>Carboxylic Acids (chemistry)</term><term>Chromatography, Ion Exchange (instrumentation)</term><term>Chromatography, Ion Exchange (methods)</term><term>Fatty Acids (analysis)</term><term>Fatty Acids (chemistry)</term><term>Hydroxides</term><term>Potassium Compounds</term><term>Reference Standards</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term><term>Solvents</term><term>Spectrometry, Mass, Electrospray Ionization (methods)</term><term>Uronic Acids (analysis)</term><term>Uronic Acids (chemistry)</term><term>Water Pollutants, Chemical (analysis)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Carbohydrates</term><term>Carboxylic Acids</term><term>Fatty Acids</term><term>Uronic Acids</term><term>Water Pollutants, Chemical</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Carbohydrates</term><term>Carboxylic Acids</term><term>Fatty Acids</term><term>Uronic Acids</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Anions</term><term>Hydroxides</term><term>Potassium Compounds</term><term>Solvents</term></keywords><keywords scheme="MESH" qualifier="instrumentation" xml:lang="en"><term>Chromatography, Ion Exchange</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Chromatography, Ion Exchange</term><term>Spectrometry, Mass, Electrospray Ionization</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Reference Standards</term><term>Reproducibility of Results</term><term>Sensitivity and Specificity</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">For environmental analytical purposes, an anion-exchange chromatography-electrospray ionization MS method was developed enabling the identification and quantification of 18 aliphatic (poly)hydroxy (poly)carboxylic acids including sugar and uronic acids. The initially incomplete separation could be partially improved for specific analyte combinations adding borate, the zwitter ionic MES, or an alkylglycoside to the NaOH gradient supplied with the Dionex IonPac AS-11 HC column. Despite the incomplete separation, reproducible and sensitive identification and quantification is possible with MS detection in the selected ion-monitoring mode. Applying an internal standard for the compensation of the sensitivity drift of the detector, linear calibration functions were calculated for all analytes. Limits of detection spanned between 18 and 71 microgL(-1) which could be further improved for some more hydrophobic analytes by post-column addition of MeOH.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">17915229</PMID><DateCreated><Year>2007</Year><Month>10</Month><Day>15</Day></DateCreated><DateCompleted><Year>2008</Year><Month>02</Month><Day>26</Day></DateCompleted><DateRevised><Year>2012</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Print">0021-9673</ISSN><JournalIssue CitedMedium="Print"><Volume>1170</Volume><Issue>1-2</Issue><PubDate><Year>2007</Year><Month>Nov</Month><Day>02</Day></PubDate></JournalIssue><Title>Journal of chromatography. A</Title><ISOAbbreviation>J Chromatogr A</ISOAbbreviation></Journal><ArticleTitle>Anion-exchange chromatography-electrospray ionization mass spectrometry method development for the environmental analysis of aliphatic polyhydroxy carboxylic acids.</ArticleTitle><Pagination><MedlinePgn>62-72</MedlinePgn></Pagination><Abstract><AbstractText>For environmental analytical purposes, an anion-exchange chromatography-electrospray ionization MS method was developed enabling the identification and quantification of 18 aliphatic (poly)hydroxy (poly)carboxylic acids including sugar and uronic acids. The initially incomplete separation could be partially improved for specific analyte combinations adding borate, the zwitter ionic MES, or an alkylglycoside to the NaOH gradient supplied with the Dionex IonPac AS-11 HC column. Despite the incomplete separation, reproducible and sensitive identification and quantification is possible with MS detection in the selected ion-monitoring mode. Applying an internal standard for the compensation of the sensitivity drift of the detector, linear calibration functions were calculated for all analytes. Limits of detection spanned between 18 and 71 microgL(-1) which could be further improved for some more hydrophobic analytes by post-column addition of MeOH.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>Axel</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Analytical and Ecological Chemistry, Faculty VI - Geography/Geosciences, University of Trier, Campus II, Behringstrasse 21, D-54296 Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Höffler</LastName><ForeName>Susanne</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Fischer</LastName><ForeName>Klaus</ForeName><Initials>K</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D023362">Evaluation Studies</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2007</Year><Month>09</Month><Day>14</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>J Chromatogr A</MedlineTA><NlmUniqueID>9318488</NlmUniqueID><ISSNLinking>0021-9673</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D000838">Anions</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002241">Carbohydrates</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D002264">Carboxylic Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D005227">Fatty Acids</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D006878">Hydroxides</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D017680">Potassium 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MajorTopicYN="Y">analysis</QualifierName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2007</Year><Month>07</Month><Day>02</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2007</Year><Month>09</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2007</Year><Month>09</Month><Day>11</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2007</Year><Month>10</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2008</Year><Month>2</Month><Day>27</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2007</Year><Month>10</Month><Day>5</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">17915229</ArticleId><ArticleId IdType="pii">S0021-9673(07)01554-3</ArticleId><ArticleId IdType="doi">10.1016/j.chroma.2007.09.016</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Fischer, Klaus" sort="Fischer, Klaus" uniqKey="Fischer K" first="Klaus" last="Fischer">Klaus Fischer</name><name sortKey="Hoffler, Susanne" sort="Hoffler, Susanne" uniqKey="Hoffler S" first="Susanne" last="Höffler">Susanne Höffler</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Meyer, Axel" sort="Meyer, Axel" uniqKey="Meyer A" first="Axel" last="Meyer">Axel Meyer</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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