[Synovialitis of the arthrofibrotic type: criteria of a new synovialitis type for the diagnosis of arthrofibrosis].
Identifieur interne : 000393 ( PubMed/Checkpoint ); précédent : 000392; suivant : 000394[Synovialitis of the arthrofibrotic type: criteria of a new synovialitis type for the diagnosis of arthrofibrosis].
Auteurs : V. Krenn [Allemagne] ; M. Ruppert ; P. Knö ; D. Kendoff ; C. Poremba ; M. Thomsen ; M. Skutek ; J. Hassenpflug ; R. Ascherl ; M G Krukemeyer ; G. Matziolis ; P. Thomas ; T. GehrkeSource :
- Zeitschrift fur Rheumatologie [ 1435-1250 ] ; 2013.
English descriptors
- KwdEn :
- MESH :
- adverse effects : Joint Prosthesis.
- complications : Arthritis, Rheumatoid.
- etiology : Fibrosis, Synovitis.
- pathology : Fibrosis, Synovitis.
- surgery : Arthritis, Rheumatoid.
- Aged, Diagnosis, Differential, Female, Humans, Male, Middle Aged, Terminology as Topic.
Abstract
After rheumatologic conservative medical therapy has been exhausted in degenerative and inflammatory joint diseases, arthroplastic operations are an important option to restore quality of life. Endoprosthesis-associated arthrofibrosis is a severe fibrosing disease of the synovial membrane after endoprosthetic operations. Neither the morphological substrate nor histopathological criteria have been described. The aim was to describe the histopathological substrate of arthrofibrosis and to define histological and immunohistochemical criteria of arthrofibrosis on the basis of tissue samples derived from revision. In histopathological analyses arthrofibrosis revealed a synovialitis with varying fibrosis, without detectable ossification and without minimal wear particle reaction (so-called synovialitis of arthrofibrotic type, SAT). A 3-stage grading was determined based on the cellular density of the fibrous tissue (fibroblast cellularity). In 191 cases with SAT, grade 1 was found in 24.1 % (n = 46), grade 2 was found in 51.8 % (n = 99) and grade 3 was found in 24.1 % (n = 46). The control group consisted of 29 cases with synovialitis of indifferent type (type IV membrane). If SAT grades 2 and 3 are summed together, i.e. the distance between the fibroblasts was less than two cell lengths, the difference of the fibroblast cellularity compared with the type IV membrane was significant (p < 0.001). Above SAT grade 2 the diagnosis of arthrofibrosis could be made with a sensitivity 0.7592 and specificity 0.8276. The SM-alpha-actin cytoplasmic positivity of fibroblasts indicates a myofibroblast phenotype and the β-catenin positivity suggests a resemblance to fibromatosis or a keloid-like process. In the quantitative evaluation of the β-catenin positive fibroblasts, there was a significant difference (p < 0.001) between type IV membrane and SAT. A threshold value of 20 beta-catenin positive cells per microscopic high power field (HPF) was determined, which represents in conjunction with the clinical information a new histopathological diagnosis component (sensitivity 0.720, specificity 0.867).
DOI: 10.1007/s00393-012-1076-7
PubMed: 23223892
Affiliations:
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Ruppert</name></author><author><name sortKey="Kno, P" sort="Kno, P" uniqKey="Kno P" first="P" last="Knö">P. Knö</name></author><author><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name></author><author><name sortKey="Poremba, C" sort="Poremba, C" uniqKey="Poremba C" first="C" last="Poremba">C. Poremba</name></author><author><name sortKey="Thomsen, M" sort="Thomsen, M" uniqKey="Thomsen M" first="M" last="Thomsen">M. Thomsen</name></author><author><name sortKey="Skutek, M" sort="Skutek, M" uniqKey="Skutek M" first="M" last="Skutek">M. Skutek</name></author><author><name sortKey="Hassenpflug, J" sort="Hassenpflug, J" uniqKey="Hassenpflug J" first="J" last="Hassenpflug">J. Hassenpflug</name></author><author><name sortKey="Ascherl, R" sort="Ascherl, R" uniqKey="Ascherl R" first="R" last="Ascherl">R. 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Gehrke</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2013">2013</date><idno type="RBID">pubmed:23223892</idno><idno type="pmid">23223892</idno><idno type="doi">10.1007/s00393-012-1076-7</idno><idno type="wicri:Area/PubMed/Corpus">000437</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000437</idno><idno type="wicri:Area/PubMed/Curation">000437</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000437</idno><idno type="wicri:Area/PubMed/Checkpoint">000437</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000437</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Synovialitis of the arthrofibrotic type: criteria of a new synovialitis type for the diagnosis of arthrofibrosis].</title><author><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name><affiliation wicri:level="1"><nlm:affiliation>Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Str. 18+20, 54296 Trier, Deutschland. krenn@patho-trier.de</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Str. 18+20, 54296 Trier</wicri:regionArea><wicri:noRegion>54296 Trier</wicri:noRegion><wicri:noRegion>54296 Trier</wicri:noRegion><wicri:noRegion>54296 Trier</wicri:noRegion></affiliation></author><author><name sortKey="Ruppert, M" sort="Ruppert, M" uniqKey="Ruppert M" first="M" last="Ruppert">M. Ruppert</name></author><author><name sortKey="Kno, P" sort="Kno, P" uniqKey="Kno P" first="P" last="Knö">P. Knö</name></author><author><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name></author><author><name sortKey="Poremba, C" sort="Poremba, C" uniqKey="Poremba C" first="C" last="Poremba">C. Poremba</name></author><author><name sortKey="Thomsen, M" sort="Thomsen, M" uniqKey="Thomsen M" first="M" last="Thomsen">M. Thomsen</name></author><author><name sortKey="Skutek, M" sort="Skutek, M" uniqKey="Skutek M" first="M" last="Skutek">M. Skutek</name></author><author><name sortKey="Hassenpflug, J" sort="Hassenpflug, J" uniqKey="Hassenpflug J" first="J" last="Hassenpflug">J. Hassenpflug</name></author><author><name sortKey="Ascherl, R" sort="Ascherl, R" uniqKey="Ascherl R" first="R" last="Ascherl">R. Ascherl</name></author><author><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name></author><author><name sortKey="Matziolis, G" sort="Matziolis, G" uniqKey="Matziolis G" first="G" last="Matziolis">G. Matziolis</name></author><author><name sortKey="Thomas, P" sort="Thomas, P" uniqKey="Thomas P" first="P" last="Thomas">P. Thomas</name></author><author><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name></author></analytic><series><title level="j">Zeitschrift fur Rheumatologie</title><idno type="eISSN">1435-1250</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aged</term><term>Arthritis, Rheumatoid (complications)</term><term>Arthritis, Rheumatoid (surgery)</term><term>Diagnosis, Differential</term><term>Female</term><term>Fibrosis (etiology)</term><term>Fibrosis (pathology)</term><term>Humans</term><term>Joint Prosthesis (adverse effects)</term><term>Male</term><term>Middle Aged</term><term>Synovitis (etiology)</term><term>Synovitis (pathology)</term><term>Terminology as Topic</term></keywords><keywords scheme="MESH" qualifier="adverse effects" xml:lang="en"><term>Joint Prosthesis</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Fibrosis</term><term>Synovitis</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Fibrosis</term><term>Synovitis</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Arthritis, Rheumatoid</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Aged</term><term>Diagnosis, Differential</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Terminology as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">After rheumatologic conservative medical therapy has been exhausted in degenerative and inflammatory joint diseases, arthroplastic operations are an important option to restore quality of life. Endoprosthesis-associated arthrofibrosis is a severe fibrosing disease of the synovial membrane after endoprosthetic operations. Neither the morphological substrate nor histopathological criteria have been described. The aim was to describe the histopathological substrate of arthrofibrosis and to define histological and immunohistochemical criteria of arthrofibrosis on the basis of tissue samples derived from revision. In histopathological analyses arthrofibrosis revealed a synovialitis with varying fibrosis, without detectable ossification and without minimal wear particle reaction (so-called synovialitis of arthrofibrotic type, SAT). A 3-stage grading was determined based on the cellular density of the fibrous tissue (fibroblast cellularity). In 191 cases with SAT, grade 1 was found in 24.1 % (n = 46), grade 2 was found in 51.8 % (n = 99) and grade 3 was found in 24.1 % (n = 46). The control group consisted of 29 cases with synovialitis of indifferent type (type IV membrane). If SAT grades 2 and 3 are summed together, i.e. the distance between the fibroblasts was less than two cell lengths, the difference of the fibroblast cellularity compared with the type IV membrane was significant (p < 0.001). Above SAT grade 2 the diagnosis of arthrofibrosis could be made with a sensitivity 0.7592 and specificity 0.8276. The SM-alpha-actin cytoplasmic positivity of fibroblasts indicates a myofibroblast phenotype and the β-catenin positivity suggests a resemblance to fibromatosis or a keloid-like process. In the quantitative evaluation of the β-catenin positive fibroblasts, there was a significant difference (p < 0.001) between type IV membrane and SAT. A threshold value of 20 beta-catenin positive cells per microscopic high power field (HPF) was determined, which represents in conjunction with the clinical information a new histopathological diagnosis component (sensitivity 0.720, specificity 0.867).</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">23223892</PMID><DateCreated><Year>2013</Year><Month>04</Month><Day>04</Day></DateCreated><DateCompleted><Year>2013</Year><Month>10</Month><Day>17</Day></DateCompleted><DateRevised><Year>2013</Year><Month>04</Month><Day>04</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1435-1250</ISSN><JournalIssue CitedMedium="Internet"><Volume>72</Volume><Issue>3</Issue><PubDate><Year>2013</Year><Month>Apr</Month></PubDate></JournalIssue><Title>Zeitschrift fur Rheumatologie</Title><ISOAbbreviation>Z Rheumatol</ISOAbbreviation></Journal><ArticleTitle>[Synovialitis of the arthrofibrotic type: criteria of a new synovialitis type for the diagnosis of arthrofibrosis].</ArticleTitle><Pagination><MedlinePgn>270-8</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00393-012-1076-7</ELocationID><Abstract><AbstractText>After rheumatologic conservative medical therapy has been exhausted in degenerative and inflammatory joint diseases, arthroplastic operations are an important option to restore quality of life. Endoprosthesis-associated arthrofibrosis is a severe fibrosing disease of the synovial membrane after endoprosthetic operations. Neither the morphological substrate nor histopathological criteria have been described. The aim was to describe the histopathological substrate of arthrofibrosis and to define histological and immunohistochemical criteria of arthrofibrosis on the basis of tissue samples derived from revision. In histopathological analyses arthrofibrosis revealed a synovialitis with varying fibrosis, without detectable ossification and without minimal wear particle reaction (so-called synovialitis of arthrofibrotic type, SAT). A 3-stage grading was determined based on the cellular density of the fibrous tissue (fibroblast cellularity). In 191 cases with SAT, grade 1 was found in 24.1 % (n = 46), grade 2 was found in 51.8 % (n = 99) and grade 3 was found in 24.1 % (n = 46). The control group consisted of 29 cases with synovialitis of indifferent type (type IV membrane). If SAT grades 2 and 3 are summed together, i.e. the distance between the fibroblasts was less than two cell lengths, the difference of the fibroblast cellularity compared with the type IV membrane was significant (p < 0.001). Above SAT grade 2 the diagnosis of arthrofibrosis could be made with a sensitivity 0.7592 and specificity 0.8276. The SM-alpha-actin cytoplasmic positivity of fibroblasts indicates a myofibroblast phenotype and the β-catenin positivity suggests a resemblance to fibromatosis or a keloid-like process. In the quantitative evaluation of the β-catenin positive fibroblasts, there was a significant difference (p < 0.001) between type IV membrane and SAT. A threshold value of 20 beta-catenin positive cells per microscopic high power field (HPF) was determined, which represents in conjunction with the clinical information a new histopathological diagnosis component (sensitivity 0.720, specificity 0.867).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Krenn</LastName><ForeName>V</ForeName><Initials>V</Initials><AffiliationInfo><Affiliation>Zentrum für Histologie, Zytologie und Molekulare Diagnostik, Max-Planck-Str. 18+20, 54296 Trier, Deutschland. krenn@patho-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ruppert</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Knöß</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Kendoff</LastName><ForeName>D</ForeName><Initials>D</Initials></Author><Author ValidYN="Y"><LastName>Poremba</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Thomsen</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Skutek</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Hassenpflug</LastName><ForeName>J</ForeName><Initials>J</Initials></Author><Author ValidYN="Y"><LastName>Ascherl</LastName><ForeName>R</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Krukemeyer</LastName><ForeName>M G</ForeName><Initials>MG</Initials></Author><Author ValidYN="Y"><LastName>Matziolis</LastName><ForeName>G</ForeName><Initials>G</Initials></Author><Author ValidYN="Y"><LastName>Thomas</LastName><ForeName>P</ForeName><Initials>P</Initials></Author><Author ValidYN="Y"><LastName>Gehrke</LastName><ForeName>T</ForeName><Initials>T</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Synovialitis vom arthrofibrotischen Typ: Kriterien eines neuen Synovialitis-Typus für die Diagnose der Arthrofibrose.</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Z Rheumatol</MedlineTA><NlmUniqueID>0414162</NlmUniqueID><ISSNLinking>0340-1855</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001172" MajorTopicYN="N">Arthritis, Rheumatoid</DescriptorName><QualifierName UI="Q000150" MajorTopicYN="Y">complications</QualifierName><QualifierName UI="Q000601" MajorTopicYN="Y">surgery</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D003937" MajorTopicYN="N">Diagnosis, Differential</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005355" MajorTopicYN="N">Fibrosis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="N">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="N">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007595" MajorTopicYN="N">Joint Prosthesis</DescriptorName><QualifierName UI="Q000009" MajorTopicYN="Y">adverse effects</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D013585" MajorTopicYN="N">Synovitis</DescriptorName><QualifierName UI="Q000209" MajorTopicYN="Y">etiology</QualifierName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009626" MajorTopicYN="Y">Terminology as Topic</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="entrez"><Year>2012</Year><Month>12</Month><Day>11</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2012</Year><Month>12</Month><Day>12</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2013</Year><Month>10</Month><Day>18</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">23223892</ArticleId><ArticleId IdType="doi">10.1007/s00393-012-1076-7</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Ascherl, R" sort="Ascherl, R" uniqKey="Ascherl R" first="R" last="Ascherl">R. Ascherl</name><name sortKey="Gehrke, T" sort="Gehrke, T" uniqKey="Gehrke T" first="T" last="Gehrke">T. Gehrke</name><name sortKey="Hassenpflug, J" sort="Hassenpflug, J" uniqKey="Hassenpflug J" first="J" last="Hassenpflug">J. Hassenpflug</name><name sortKey="Kendoff, D" sort="Kendoff, D" uniqKey="Kendoff D" first="D" last="Kendoff">D. Kendoff</name><name sortKey="Kno, P" sort="Kno, P" uniqKey="Kno P" first="P" last="Knö">P. Knö</name><name sortKey="Krukemeyer, M G" sort="Krukemeyer, M G" uniqKey="Krukemeyer M" first="M G" last="Krukemeyer">M G Krukemeyer</name><name sortKey="Matziolis, G" sort="Matziolis, G" uniqKey="Matziolis G" first="G" last="Matziolis">G. Matziolis</name><name sortKey="Poremba, C" sort="Poremba, C" uniqKey="Poremba C" first="C" last="Poremba">C. Poremba</name><name sortKey="Ruppert, M" sort="Ruppert, M" uniqKey="Ruppert M" first="M" last="Ruppert">M. Ruppert</name><name sortKey="Skutek, M" sort="Skutek, M" uniqKey="Skutek M" first="M" last="Skutek">M. Skutek</name><name sortKey="Thomas, P" sort="Thomas, P" uniqKey="Thomas P" first="P" last="Thomas">P. Thomas</name><name sortKey="Thomsen, M" sort="Thomsen, M" uniqKey="Thomsen M" first="M" last="Thomsen">M. Thomsen</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Krenn, V" sort="Krenn, V" uniqKey="Krenn V" first="V" last="Krenn">V. Krenn</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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