UnivTrevesV1, PascalFrancis, Curation, bibRecord, 000295

Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases

Identifieur interne : 000295 ( PascalFrancis/Curation ); précédent : 000294; suivant : 000296

Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases

Auteurs : J.-J. Body [Belgique] ; I. J. Diel [Allemagne] ; M. R. Lichinitser [Russie] ; E. D. Kreuser [Allemagne] ; W. Dornoff [Allemagne] ; V. A. Gorbunova [Russie] ; M. Budde [Suisse] ; B. Bergström [États-Unis]

Source :

Annals of oncology [ 0923-7534 ] ; 2003.

RBID : Pascal:03-0511102

Descripteurs français

Pascal (Inist)
- Acide ibandronique, Homme, Femelle, Tumeur maligne, Glande mammaire, Métastatique, Métastase, Os, Essai clinique phase III, Traitement, Anticancéreux, Chimiothérapie, Voie intraveineuse, Antimétastatique, Complication, Lésion, Bisphosphonates, Diphosphonique acide dérivé, Squelette.
Wicri :
- topic : Homme.

English descriptors

KwdEn :
- Antimetastatic agent, Antineoplastic agent, Bisphosphonates, Bone, Chemotherapy, Complication, Diphosphonic acid derivatives, Female, Human, Ibandronic acid, Intravenous administration, Lesion, Malignant tumor, Mammary gland, Metastasis, Metastatic, Phase III trial, Skeleton, Treatment.

Abstract

Background: This phase III study compared the efficacy of the new potent bisphosphonate, ibandronate, with placebo as intravenous (i.v.) therapy in metastatic bone disease due to breast cancer. Patients and methods: A total of 466 patients were randomised to receive placebo (n = 158), or 2 mg (n = 154) or 6 mg (n = 154) ibandronate every 3-4 weeks for up to 2 years. The primary efficacy parameter was the number of 12-week periods with new bone complications, expressed as the skeletal morbidity period rate (SMPR). Bone pain, analgesic use and safety were evaluated monthly. Results: SMPR was lower in both ibandronate groups compared with the placebo group; the difference was statistically significant for the ibandronate 6 mg group (P = 0.004 versus placebo). Consistent with the SMPR, ibandronate 6 mg significantly reduced the number of new bone events (by 38%) and increased time to first new bone event. Patients on ibandronate 6 mg also experienced decreased bone pain scores and analgesic use. Treatment with ibandronate was well tolerated. Conclusions: These results indicate that 6 mg i.v. ibandronate is effective and safe in the treatment of bone metastases from breast cancer.

A01	`01`	`1`		`@0 0923-7534`
A03		`1`		`@0 Ann. oncol.`
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A06				`@2 9`
A08	`01`	`1`	`ENG`	`@1 Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases`
A11	`01`	`1`		`@1 BODY (J.-J.)`
A11	`02`	`1`		`@1 DIEL (I. J.)`
A11	`03`	`1`		`@1 LICHINITSER (M. R.)`
A11	`04`	`1`		`@1 KREUSER (E. D.)`
A11	`05`	`1`		`@1 DORNOFF (W.)`
A11	`06`	`1`		`@1 GORBUNOVA (V. A.)`
A11	`07`	`1`		`@1 BUDDE (M.)`
A11	`08`	`1`		`@1 BERGSTRÖM (B.)`
A14	`01`			`@1 Université Libre de Bruxelles, Institut Jules Bordet @2 Brussels @3 BEL @Z 1 aut.`
A14	`02`			`@1 Department of Obstetrics and Gynaecology, University Hospital @2 Heidelberg @3 DEU @Z 2 aut.`
A14	`03`			`@1 Department of Clinical Chemotherapy, Cancer Research Center @2 Moscow @3 RUS @Z 3 aut.`
A14	`04`			`@1 Krankenhaus der Barmherzigen Brueder, Onkologische Ambulanz @2 Regensburg @3 DEU @Z 4 aut.`
A14	`05`			`@1 Mutterhaus der Borromaeerinnen @2 Trier @3 DEU @Z 5 aut.`
A14	`06`			`@1 Cancer Research Center, Department of Chemotherapy @2 Moscow @3 RUS @Z 6 aut.`
A14	`07`			`@1 F. Hoffmann-La Roche Ltd @2 Basel @3 CHE @Z 7 aut.`
A14	`08`			`@1 F. Hoffmann-La Roche Inc. @2 Nutley, NJ @3 USA @Z 8 aut.`
A20				`@1 1399-1405`
A21				`@1 2003`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 22429 @5 354000114378040100`
A44				`@0 0000 @1 © 2003 INIST-CNRS. All rights reserved.`
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A47	`01`	`1`		`@0 03-0511102`
A60				`@1 P`
A61				`@0 A`
A64	`01`	`1`		`@0 Annals of oncology`
A66	`01`			`@0 GBR`
C01	`01`		`ENG`	@0 Background: This phase III study compared the efficacy of the new potent bisphosphonate, ibandronate, with placebo as intravenous (i.v.) therapy in metastatic bone disease due to breast cancer. Patients and methods: A total of 466 patients were randomised to receive placebo (n = 158), or 2 mg (n = 154) or 6 mg (n = 154) ibandronate every 3-4 weeks for up to 2 years. The primary efficacy parameter was the number of 12-week periods with new bone complications, expressed as the skeletal morbidity period rate (SMPR). Bone pain, analgesic use and safety were evaluated monthly. Results: SMPR was lower in both ibandronate groups compared with the placebo group; the difference was statistically significant for the ibandronate 6 mg group (P = 0.004 versus placebo). Consistent with the SMPR, ibandronate 6 mg significantly reduced the number of new bone events (by 38%) and increased time to first new bone event. Patients on ibandronate 6 mg also experienced decreased bone pain scores and analgesic use. Treatment with ibandronate was well tolerated. Conclusions: These results indicate that 6 mg i.v. ibandronate is effective and safe in the treatment of bone metastases from breast cancer.
C02	`01`	`X`		`@0 002B02R02`
C03	`01`	`X`	`FRE`	`@0 Acide ibandronique @2 NK @2 FR @5 01`
C03	`01`	`X`	`ENG`	`@0 Ibandronic acid @2 NK @2 FR @5 01`
C03	`01`	`X`	`SPA`	`@0 Acido ibandrónico @2 NK @2 FR @5 01`
C03	`02`	`X`	`FRE`	`@0 Homme @5 04`
C03	`02`	`X`	`ENG`	`@0 Human @5 04`
C03	`02`	`X`	`SPA`	`@0 Hombre @5 04`
C03	`03`	`X`	`FRE`	`@0 Femelle @5 07`
C03	`03`	`X`	`ENG`	`@0 Female @5 07`
C03	`03`	`X`	`SPA`	`@0 Hembra @5 07`
C03	`04`	`X`	`FRE`	`@0 Tumeur maligne @5 10`
C03	`04`	`X`	`ENG`	`@0 Malignant tumor @5 10`
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C03	`05`	`X`	`FRE`	`@0 Glande mammaire @5 11`
C03	`05`	`X`	`ENG`	`@0 Mammary gland @5 11`
C03	`05`	`X`	`SPA`	`@0 Glándula mamaria @5 11`
C03	`06`	`X`	`FRE`	`@0 Métastatique @5 12`
C03	`06`	`X`	`ENG`	`@0 Metastatic @5 12`
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C03	`07`	`X`	`FRE`	`@0 Métastase @5 13`
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C03	`08`	`X`	`FRE`	`@0 Os @5 14`
C03	`08`	`X`	`ENG`	`@0 Bone @5 14`
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C03	`09`	`X`	`FRE`	`@0 Essai clinique phase III @5 15`
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C03	`10`	`X`	`FRE`	`@0 Traitement @5 16`
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C03	`11`	`X`	`FRE`	`@0 Anticancéreux @5 17`
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C03	`12`	`X`	`FRE`	`@0 Chimiothérapie @5 18`
C03	`12`	`X`	`ENG`	`@0 Chemotherapy @5 18`
C03	`12`	`X`	`SPA`	`@0 Quimioterapia @5 18`
C03	`13`	`X`	`FRE`	`@0 Voie intraveineuse @5 19`
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C03	`13`	`X`	`SPA`	`@0 Vía intravenosa @5 19`
C03	`14`	`X`	`FRE`	`@0 Antimétastatique @5 20`
C03	`14`	`X`	`ENG`	`@0 Antimetastatic agent @5 20`
C03	`14`	`X`	`SPA`	`@0 Antimetastásico @5 20`
C03	`15`	`X`	`FRE`	`@0 Complication @5 21`
C03	`15`	`X`	`ENG`	`@0 Complication @5 21`
C03	`15`	`X`	`SPA`	`@0 Complicación @5 21`
C03	`16`	`X`	`FRE`	`@0 Lésion @5 22`
C03	`16`	`X`	`ENG`	`@0 Lesion @5 22`
C03	`16`	`X`	`SPA`	`@0 Lesión @5 22`
C03	`17`	`X`	`FRE`	`@0 Bisphosphonates @5 25`
C03	`17`	`X`	`ENG`	`@0 Bisphosphonates @5 25`
C03	`17`	`X`	`SPA`	`@0 Bisfosfonatos @5 25`
C03	`18`	`X`	`FRE`	`@0 Diphosphonique acide dérivé @5 26`
C03	`18`	`X`	`ENG`	`@0 Diphosphonic acid derivatives @5 26`
C03	`18`	`X`	`SPA`	`@0 Difosfonico ácido derivado @5 26`
C03	`19`	`X`	`FRE`	`@0 Squelette @5 78`
C03	`19`	`X`	`ENG`	`@0 Skeleton @5 78`
C03	`19`	`X`	`SPA`	`@0 Esqueleto @5 78`
C07	`01`	`X`	`FRE`	`@0 Glande mammaire pathologie @2 NM @5 61`
C07	`01`	`X`	`ENG`	`@0 Mammary gland diseases @2 NM @5 61`
C07	`01`	`X`	`SPA`	`@0 Glándula mamaria patología @2 NM @5 61`
C07	`02`	`X`	`FRE`	`@0 Système ostéoarticulaire pathologie @5 62`
C07	`02`	`X`	`ENG`	`@0 Diseases of the osteoarticular system @5 62`
C07	`02`	`X`	`SPA`	`@0 Sistema osteoarticular patología @5 62`
N21				`@1 342`
N82				`@1 PSI`

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Le document en format XML

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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antimetastatic agent</term>
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<term>Bisphosphonates</term>
<term>Bone</term>
<term>Chemotherapy</term>
<term>Complication</term>
<term>Diphosphonic acid derivatives</term>
<term>Female</term>
<term>Human</term>
<term>Ibandronic acid</term>
<term>Intravenous administration</term>
<term>Lesion</term>
<term>Malignant tumor</term>
<term>Mammary gland</term>
<term>Metastasis</term>
<term>Metastatic</term>
<term>Phase III trial</term>
<term>Skeleton</term>
<term>Treatment</term>
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<keywords scheme="Pascal" xml:lang="fr"><term>Acide ibandronique</term>
<term>Homme</term>
<term>Femelle</term>
<term>Tumeur maligne</term>
<term>Glande mammaire</term>
<term>Métastatique</term>
<term>Métastase</term>
<term>Os</term>
<term>Essai clinique phase III</term>
<term>Traitement</term>
<term>Anticancéreux</term>
<term>Chimiothérapie</term>
<term>Voie intraveineuse</term>
<term>Antimétastatique</term>
<term>Complication</term>
<term>Lésion</term>
<term>Bisphosphonates</term>
<term>Diphosphonique acide dérivé</term>
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<front><div type="abstract" xml:lang="en">Background: This phase III study compared the efficacy of the new potent bisphosphonate, ibandronate, with placebo as intravenous (i.v.) therapy in metastatic bone disease due to breast cancer. Patients and methods: A total of 466 patients were randomised to receive placebo (n = 158), or 2 mg (n = 154) or 6 mg (n = 154) ibandronate every 3-4 weeks for up to 2 years. The primary efficacy parameter was the number of 12-week periods with new bone complications, expressed as the skeletal morbidity period rate (SMPR). Bone pain, analgesic use and safety were evaluated monthly. Results: SMPR was lower in both ibandronate groups compared with the placebo group; the difference was statistically significant for the ibandronate 6 mg group (P = 0.004 versus placebo). Consistent with the SMPR, ibandronate 6 mg significantly reduced the number of new bone events (by 38%) and increased time to first new bone event. Patients on ibandronate 6 mg also experienced decreased bone pain scores and analgesic use. Treatment with ibandronate was well tolerated. Conclusions: These results indicate that 6 mg i.v. ibandronate is effective and safe in the treatment of bone metastases from breast cancer.</div>
</front>
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<fA11 i1="01" i2="1"><s1>BODY (J.-J.)</s1>
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<fA11 i1="08" i2="1"><s1>BERGSTRÖM (B.)</s1>
</fA11>
<fA14 i1="01"><s1>Université Libre de Bruxelles, Institut Jules Bordet</s1>
<s2>Brussels</s2>
<s3>BEL</s3>
<sZ>1 aut.</sZ>
</fA14>
<fA14 i1="02"><s1>Department of Obstetrics and Gynaecology, University Hospital</s1>
<s2>Heidelberg</s2>
<s3>DEU</s3>
<sZ>2 aut.</sZ>
</fA14>
<fA14 i1="03"><s1>Department of Clinical Chemotherapy, Cancer Research Center</s1>
<s2>Moscow</s2>
<s3>RUS</s3>
<sZ>3 aut.</sZ>
</fA14>
<fA14 i1="04"><s1>Krankenhaus der Barmherzigen Brueder, Onkologische Ambulanz</s1>
<s2>Regensburg</s2>
<s3>DEU</s3>
<sZ>4 aut.</sZ>
</fA14>
<fA14 i1="05"><s1>Mutterhaus der Borromaeerinnen</s1>
<s2>Trier</s2>
<s3>DEU</s3>
<sZ>5 aut.</sZ>
</fA14>
<fA14 i1="06"><s1>Cancer Research Center, Department of Chemotherapy</s1>
<s2>Moscow</s2>
<s3>RUS</s3>
<sZ>6 aut.</sZ>
</fA14>
<fA14 i1="07"><s1>F. Hoffmann-La Roche Ltd</s1>
<s2>Basel</s2>
<s3>CHE</s3>
<sZ>7 aut.</sZ>
</fA14>
<fA14 i1="08"><s1>F. Hoffmann-La Roche Inc.</s1>
<s2>Nutley, NJ</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</fA14>
<fA20><s1>1399-1405</s1>
</fA20>
<fA21><s1>2003</s1>
</fA21>
<fA23 i1="01"><s0>ENG</s0>
</fA23>
<fA43 i1="01"><s1>INIST</s1>
<s2>22429</s2>
<s5>354000114378040100</s5>
</fA43>
<fA44><s0>0000</s0>
<s1>© 2003 INIST-CNRS. All rights reserved.</s1>
</fA44>
<fA45><s0>22 ref.</s0>
</fA45>
<fA47 i1="01" i2="1"><s0>03-0511102</s0>
</fA47>
<fA60><s1>P</s1>
</fA60>
<fA61><s0>A</s0>
</fA61>
<fA64 i1="01" i2="1"><s0>Annals of oncology</s0>
</fA64>
<fA66 i1="01"><s0>GBR</s0>
</fA66>
<fC01 i1="01" l="ENG"><s0>Background: This phase III study compared the efficacy of the new potent bisphosphonate, ibandronate, with placebo as intravenous (i.v.) therapy in metastatic bone disease due to breast cancer. Patients and methods: A total of 466 patients were randomised to receive placebo (n = 158), or 2 mg (n = 154) or 6 mg (n = 154) ibandronate every 3-4 weeks for up to 2 years. The primary efficacy parameter was the number of 12-week periods with new bone complications, expressed as the skeletal morbidity period rate (SMPR). Bone pain, analgesic use and safety were evaluated monthly. Results: SMPR was lower in both ibandronate groups compared with the placebo group; the difference was statistically significant for the ibandronate 6 mg group (P = 0.004 versus placebo). Consistent with the SMPR, ibandronate 6 mg significantly reduced the number of new bone events (by 38%) and increased time to first new bone event. Patients on ibandronate 6 mg also experienced decreased bone pain scores and analgesic use. Treatment with ibandronate was well tolerated. Conclusions: These results indicate that 6 mg i.v. ibandronate is effective and safe in the treatment of bone metastases from breast cancer.</s0>
</fC01>
<fC02 i1="01" i2="X"><s0>002B02R02</s0>
</fC02>
<fC03 i1="01" i2="X" l="FRE"><s0>Acide ibandronique</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="ENG"><s0>Ibandronic acid</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="01" i2="X" l="SPA"><s0>Acido ibandrónico</s0>
<s2>NK</s2>
<s2>FR</s2>
<s5>01</s5>
</fC03>
<fC03 i1="02" i2="X" l="FRE"><s0>Homme</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="ENG"><s0>Human</s0>
<s5>04</s5>
</fC03>
<fC03 i1="02" i2="X" l="SPA"><s0>Hombre</s0>
<s5>04</s5>
</fC03>
<fC03 i1="03" i2="X" l="FRE"><s0>Femelle</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="ENG"><s0>Female</s0>
<s5>07</s5>
</fC03>
<fC03 i1="03" i2="X" l="SPA"><s0>Hembra</s0>
<s5>07</s5>
</fC03>
<fC03 i1="04" i2="X" l="FRE"><s0>Tumeur maligne</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="ENG"><s0>Malignant tumor</s0>
<s5>10</s5>
</fC03>
<fC03 i1="04" i2="X" l="SPA"><s0>Tumor maligno</s0>
<s5>10</s5>
</fC03>
<fC03 i1="05" i2="X" l="FRE"><s0>Glande mammaire</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="ENG"><s0>Mammary gland</s0>
<s5>11</s5>
</fC03>
<fC03 i1="05" i2="X" l="SPA"><s0>Glándula mamaria</s0>
<s5>11</s5>
</fC03>
<fC03 i1="06" i2="X" l="FRE"><s0>Métastatique</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="ENG"><s0>Metastatic</s0>
<s5>12</s5>
</fC03>
<fC03 i1="06" i2="X" l="SPA"><s0>Metastásico</s0>
<s5>12</s5>
</fC03>
<fC03 i1="07" i2="X" l="FRE"><s0>Métastase</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="ENG"><s0>Metastasis</s0>
<s5>13</s5>
</fC03>
<fC03 i1="07" i2="X" l="SPA"><s0>Metástasis</s0>
<s5>13</s5>
</fC03>
<fC03 i1="08" i2="X" l="FRE"><s0>Os</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="ENG"><s0>Bone</s0>
<s5>14</s5>
</fC03>
<fC03 i1="08" i2="X" l="SPA"><s0>Hueso</s0>
<s5>14</s5>
</fC03>
<fC03 i1="09" i2="X" l="FRE"><s0>Essai clinique phase III</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="ENG"><s0>Phase III trial</s0>
<s5>15</s5>
</fC03>
<fC03 i1="09" i2="X" l="SPA"><s0>Ensayo clínico fase III</s0>
<s5>15</s5>
</fC03>
<fC03 i1="10" i2="X" l="FRE"><s0>Traitement</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="ENG"><s0>Treatment</s0>
<s5>16</s5>
</fC03>
<fC03 i1="10" i2="X" l="SPA"><s0>Tratamiento</s0>
<s5>16</s5>
</fC03>
<fC03 i1="11" i2="X" l="FRE"><s0>Anticancéreux</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="ENG"><s0>Antineoplastic agent</s0>
<s5>17</s5>
</fC03>
<fC03 i1="11" i2="X" l="SPA"><s0>Anticanceroso</s0>
<s5>17</s5>
</fC03>
<fC03 i1="12" i2="X" l="FRE"><s0>Chimiothérapie</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="ENG"><s0>Chemotherapy</s0>
<s5>18</s5>
</fC03>
<fC03 i1="12" i2="X" l="SPA"><s0>Quimioterapia</s0>
<s5>18</s5>
</fC03>
<fC03 i1="13" i2="X" l="FRE"><s0>Voie intraveineuse</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="ENG"><s0>Intravenous administration</s0>
<s5>19</s5>
</fC03>
<fC03 i1="13" i2="X" l="SPA"><s0>Vía intravenosa</s0>
<s5>19</s5>
</fC03>
<fC03 i1="14" i2="X" l="FRE"><s0>Antimétastatique</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="ENG"><s0>Antimetastatic agent</s0>
<s5>20</s5>
</fC03>
<fC03 i1="14" i2="X" l="SPA"><s0>Antimetastásico</s0>
<s5>20</s5>
</fC03>
<fC03 i1="15" i2="X" l="FRE"><s0>Complication</s0>
<s5>21</s5>
</fC03>
<fC03 i1="15" i2="X" l="ENG"><s0>Complication</s0>
<s5>21</s5>
</fC03>
<fC03 i1="15" i2="X" l="SPA"><s0>Complicación</s0>
<s5>21</s5>
</fC03>
<fC03 i1="16" i2="X" l="FRE"><s0>Lésion</s0>
<s5>22</s5>
</fC03>
<fC03 i1="16" i2="X" l="ENG"><s0>Lesion</s0>
<s5>22</s5>
</fC03>
<fC03 i1="16" i2="X" l="SPA"><s0>Lesión</s0>
<s5>22</s5>
</fC03>
<fC03 i1="17" i2="X" l="FRE"><s0>Bisphosphonates</s0>
<s5>25</s5>
</fC03>
<fC03 i1="17" i2="X" l="ENG"><s0>Bisphosphonates</s0>
<s5>25</s5>
</fC03>
<fC03 i1="17" i2="X" l="SPA"><s0>Bisfosfonatos</s0>
<s5>25</s5>
</fC03>
<fC03 i1="18" i2="X" l="FRE"><s0>Diphosphonique acide dérivé</s0>
<s5>26</s5>
</fC03>
<fC03 i1="18" i2="X" l="ENG"><s0>Diphosphonic acid derivatives</s0>
<s5>26</s5>
</fC03>
<fC03 i1="18" i2="X" l="SPA"><s0>Difosfonico ácido derivado</s0>
<s5>26</s5>
</fC03>
<fC03 i1="19" i2="X" l="FRE"><s0>Squelette</s0>
<s5>78</s5>
</fC03>
<fC03 i1="19" i2="X" l="ENG"><s0>Skeleton</s0>
<s5>78</s5>
</fC03>
<fC03 i1="19" i2="X" l="SPA"><s0>Esqueleto</s0>
<s5>78</s5>
</fC03>
<fC07 i1="01" i2="X" l="FRE"><s0>Glande mammaire pathologie</s0>
<s2>NM</s2>
<s5>61</s5>
</fC07>
<fC07 i1="01" i2="X" l="ENG"><s0>Mammary gland diseases</s0>
<s2>NM</s2>
<s5>61</s5>
</fC07>
<fC07 i1="01" i2="X" l="SPA"><s0>Glándula mamaria patología</s0>
<s2>NM</s2>
<s5>61</s5>
</fC07>
<fC07 i1="02" i2="X" l="FRE"><s0>Système ostéoarticulaire pathologie</s0>
<s5>62</s5>
</fC07>
<fC07 i1="02" i2="X" l="ENG"><s0>Diseases of the osteoarticular system</s0>
<s5>62</s5>
</fC07>
<fC07 i1="02" i2="X" l="SPA"><s0>Sistema osteoarticular patología</s0>
<s5>62</s5>
</fC07>
<fN21><s1>342</s1>
</fN21>
<fN82><s1>PSI</s1>
</fN82>
</pA>
</standard>
</inist>
</record>

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Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases

Intravenous ibandronate reduces the incidence of skeletal complications in patients with breast cancer and bone metastases

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