Skin surgery under local anesthesia leads to stress-induced alterations of psychological, physical, and immune functions
Identifieur interne : 002515 ( Main/Merge ); précédent : 002514; suivant : 002516Skin surgery under local anesthesia leads to stress-induced alterations of psychological, physical, and immune functions
Auteurs : M. Augustin [Allemagne] ; I. Zschocke [Allemagne] ; N. Godau [Allemagne] ; A. Buske-Kirschbaum [Allemagne] ; M. Peschen [Allemagne] ; B. Sommer [Allemagne] ; G. Sattler [Allemagne]Source :
- Dermatologic surgery [ 1076-0512 ] ; 1999.
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Abstract
BACKGROUND. Although excision of nevi under local anesthesia is a frequent and harmless operation, it apparently causes increased stress in many patients. However, thus far no studies have focused on the question of whether there are measurable effects on psychological, physiological, and immunological parameters. OBJECTIVE. To assess the perioperative stress reactions of patients undergoing skin surgery under local anesthesia for nevo-cellular nevi. METHODS. Fifty consecutive patients with pigmented nevi were examined at five points of measurement: 1 week and 30 minutes before the operation, during the operation, 30 minutes and 1 week after the operation. Somatic parameters included blood pressure, pulse, respiratory rate, and the level of pain. Lymphocyte subpopulations, white blood cell count, and cortisol in saliva were determined. Anxiety and general psychological distress were evaluated with validated questionnaires. RESULTS. There was a significant increase in anxiety at the time of surgery. In parallel, the physiological parameters as well as the CD56+ lymphocytes changed significantly. Preoperation anxiety and intraoperation pain were significantly higher in women (P <.001), but did not depend on age. CONCLUSION. There appears to be an interaction between physiological and emotional components in the operative stress reaction under local anesthesia. In patients with skin cancer, the perioperative stress may lead to transient impairment of immune function.
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Augustin</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, University Clinics of Freiburg</s1><s2>Freiburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Zschocke, I" sort="Zschocke, I" uniqKey="Zschocke I" first="I." last="Zschocke">I. Zschocke</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, University Clinics of Freiburg</s1><s2>Freiburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Godau, N" sort="Godau, N" uniqKey="Godau N" first="N." last="Godau">N. Godau</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, University Clinics of Freiburg</s1><s2>Freiburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Buske Kirschbaum, A" sort="Buske Kirschbaum, A" uniqKey="Buske Kirschbaum A" first="A." last="Buske-Kirschbaum">A. Buske-Kirschbaum</name><affiliation wicri:level="4"><inist:fA14 i1="02"><s1>Department of Psychology, University of Trier</s1><s2>Trier</s2><s3>DEU</s3><sZ>4 aut.</sZ></inist:fA14><country>Allemagne</country><wicri:noRegion>Trier</wicri:noRegion><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName><orgName type="university">Université de Trèves</orgName></affiliation></author><author><name sortKey="Peschen, M" sort="Peschen, M" uniqKey="Peschen M" first="M." last="Peschen">M. Peschen</name><affiliation wicri:level="3"><inist:fA14 i1="01"><s1>Department of Dermatology, University Clinics of Freiburg</s1><s2>Freiburg</s2><s3>DEU</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Bade-Wurtemberg</region><region type="district" nuts="2">District de Fribourg-en-Brisgau</region><settlement type="city">Fribourg-en-Brisgau</settlement></placeName></affiliation></author><author><name sortKey="Sommer, B" sort="Sommer, B" uniqKey="Sommer B" first="B." last="Sommer">B. Sommer</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Clinic of Dermatology</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Rosenparkklinik</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author><author><name sortKey="Sattler, G" sort="Sattler, G" uniqKey="Sattler G" first="G." last="Sattler">G. Sattler</name><affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Clinic of Dermatology</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Rosenparkklinik</s1><s2>Darmstadt</s2><s3>DEU</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Allemagne</country><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Darmstadt</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Dermatologic surgery</title><title level="j" type="abbreviated">Dermatol. surg.</title><idno type="ISSN">1076-0512</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Dermatologic surgery</title><title level="j" type="abbreviated">Dermatol. surg.</title><idno type="ISSN">1076-0512</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anxiety</term><term>Emotional disorder</term><term>Human</term><term>Immunity</term><term>Local anesthesia</term><term>Psychosomatics</term><term>Skin</term><term>Statistical study</term><term>Stress</term><term>Surgery</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Peau</term><term>Chirurgie</term><term>Anesthésie locale</term><term>Stress</term><term>Immunité</term><term>Angoisse anxiété</term><term>Trouble émotion</term><term>Psychosomatique</term><term>Homme</term><term>Etude statistique</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Chirurgie</term><term>Homme</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND. Although excision of nevi under local anesthesia is a frequent and harmless operation, it apparently causes increased stress in many patients. However, thus far no studies have focused on the question of whether there are measurable effects on psychological, physiological, and immunological parameters. OBJECTIVE. To assess the perioperative stress reactions of patients undergoing skin surgery under local anesthesia for nevo-cellular nevi. METHODS. Fifty consecutive patients with pigmented nevi were examined at five points of measurement: 1 week and 30 minutes before the operation, during the operation, 30 minutes and 1 week after the operation. Somatic parameters included blood pressure, pulse, respiratory rate, and the level of pain. Lymphocyte subpopulations, white blood cell count, and cortisol in saliva were determined. Anxiety and general psychological distress were evaluated with validated questionnaires. RESULTS. There was a significant increase in anxiety at the time of surgery. In parallel, the physiological parameters as well as the CD56<sup>+</sup> lymphocytes changed significantly. Preoperation anxiety and intraoperation pain were significantly higher in women (P <.001), but did not depend on age. CONCLUSION. There appears to be an interaction between physiological and emotional components in the operative stress reaction under local anesthesia. In patients with skin cancer, the perioperative stress may lead to transient impairment of immune function.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bade-Wurtemberg</li><li>District de Darmstadt</li><li>District de Fribourg-en-Brisgau</li><li>Hesse (Land)</li><li>Rhénanie-Palatinat</li></region><settlement><li>Darmstadt</li><li>Fribourg-en-Brisgau</li><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><country name="Allemagne"><region name="Bade-Wurtemberg"><name sortKey="Augustin, M" sort="Augustin, M" uniqKey="Augustin M" first="M." last="Augustin">M. Augustin</name></region><name sortKey="Buske Kirschbaum, A" sort="Buske Kirschbaum, A" uniqKey="Buske Kirschbaum A" first="A." last="Buske-Kirschbaum">A. Buske-Kirschbaum</name><name sortKey="Godau, N" sort="Godau, N" uniqKey="Godau N" first="N." last="Godau">N. Godau</name><name sortKey="Peschen, M" sort="Peschen, M" uniqKey="Peschen M" first="M." last="Peschen">M. Peschen</name><name sortKey="Sattler, G" sort="Sattler, G" uniqKey="Sattler G" first="G." last="Sattler">G. Sattler</name><name sortKey="Sattler, G" sort="Sattler, G" uniqKey="Sattler G" first="G." last="Sattler">G. Sattler</name><name sortKey="Sommer, B" sort="Sommer, B" uniqKey="Sommer B" first="B." last="Sommer">B. Sommer</name><name sortKey="Sommer, B" sort="Sommer, B" uniqKey="Sommer B" first="B." last="Sommer">B. Sommer</name><name sortKey="Zschocke, I" sort="Zschocke, I" uniqKey="Zschocke I" first="I." last="Zschocke">I. Zschocke</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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