Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence the cortisol awakening response as well as self-perceived stress.
Identifieur interne : 000107 ( Main/Exploration ); précédent : 000106; suivant : 000108Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence the cortisol awakening response as well as self-perceived stress.
Auteurs : Ting Li-Tempel [Allemagne] ; Mauro F. Larra [Allemagne] ; Ulrike Winnikes [Allemagne] ; Tobias Tempel [Allemagne] ; Roel H. Derijk [Pays-Bas] ; André Schulz [Luxembourg (pays)] ; Hartmut Sch Chinger [Allemagne] ; Jobst Meyer [Allemagne] ; Andrea B. Schote [Allemagne]Source :
- Biological psychology [ 1873-6246 ] ; 2016.
Abstract
The hypothalamus-pituitary-adrenal (HPA) axis is a crucial endocrine system for coping with stress. A reliable and stable marker for the basal state of that system is the cortisol awakening response (CAR). We examined the influence of variants of four relevant candidate genes; the mineralocorticoid receptor gene (MR), the glucocorticoid receptor gene (GR), the serotonin transporter gene (5-HTT) and the gene encoding the brain-derived neurotrophic factor (BDNF) on CAR and self-perceived stress in 217 healthy subjects. We found that polymorphisms of GR influenced both, the basal state of the HPA axis as well as self-perceived stress. MR only associated with self-perceived stress and 5-HTT only with CAR. BDNF did not affected any of the investigated indices. In summary, we suggest that GR variants together with the CAR and supplemented with self reports on perceived stress might be useful indicators for the basal HPA axis activity.
DOI: 10.1016/j.biopsycho.2016.07.010
PubMed: 27427534
Affiliations:
- Allemagne, Luxembourg (pays), Pays-Bas
- Hollande-Méridionale, Rhénanie-Palatinat
- Leyde, Luxembourg, Trèves (Allemagne)
- Université de Trèves, Université du Luxembourg
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Larra</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Winnikes, Ulrike" sort="Winnikes, Ulrike" uniqKey="Winnikes U" first="Ulrike" last="Winnikes">Ulrike Winnikes</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Tempel, Tobias" sort="Tempel, Tobias" uniqKey="Tempel T" first="Tobias" last="Tempel">Tobias Tempel</name><affiliation wicri:level="4"><nlm:affiliation>Department of Psychology, University of Trier, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychology, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Derijk, Roel H" sort="Derijk, Roel H" uniqKey="Derijk R" first="Roel H" last="Derijk">Roel H. Derijk</name><affiliation wicri:level="3"><nlm:affiliation>Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Department of Psychiatry, Leiden University Medical Center, Leiden</wicri:regionArea><placeName><settlement type="city">Leyde</settlement><region nuts="2" type="province">Hollande-Méridionale</region></placeName></affiliation></author><author><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name><affiliation wicri:level="4"><nlm:affiliation>Institute for Health and Behavior, Integrative Research Unit on Social and Individual Development (INSIDE), University of Luxembourg, Luxembourg.</nlm:affiliation><country xml:lang="fr">Luxembourg (pays)</country><wicri:regionArea>Institute for Health and Behavior, Integrative Research Unit on Social and Individual Development (INSIDE), University of Luxembourg</wicri:regionArea><placeName><settlement type="city">Luxembourg</settlement></placeName><orgName type="university">Université du Luxembourg</orgName></affiliation></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Schote, Andrea B" sort="Schote, Andrea B" uniqKey="Schote A" first="Andrea B" last="Schote">Andrea B. Schote</name><affiliation wicri:level="4"><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany. Electronic address: schotefrese@uni-trier.de.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author></analytic><series><title level="j">Biological psychology</title><idno type="eISSN">1873-6246</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The hypothalamus-pituitary-adrenal (HPA) axis is a crucial endocrine system for coping with stress. A reliable and stable marker for the basal state of that system is the cortisol awakening response (CAR). We examined the influence of variants of four relevant candidate genes; the mineralocorticoid receptor gene (MR), the glucocorticoid receptor gene (GR), the serotonin transporter gene (5-HTT) and the gene encoding the brain-derived neurotrophic factor (BDNF) on CAR and self-perceived stress in 217 healthy subjects. We found that polymorphisms of GR influenced both, the basal state of the HPA axis as well as self-perceived stress. MR only associated with self-perceived stress and 5-HTT only with CAR. BDNF did not affected any of the investigated indices. In summary, we suggest that GR variants together with the CAR and supplemented with self reports on perceived stress might be useful indicators for the basal HPA axis activity.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Luxembourg (pays)</li><li>Pays-Bas</li></country><region><li>Hollande-Méridionale</li><li>Rhénanie-Palatinat</li></region><settlement><li>Leyde</li><li>Luxembourg</li><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li><li>Université du Luxembourg</li></orgName></list><tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Li Tempel, Ting" sort="Li Tempel, Ting" uniqKey="Li Tempel T" first="Ting" last="Li-Tempel">Ting Li-Tempel</name></region><name sortKey="Larra, Mauro F" sort="Larra, Mauro F" uniqKey="Larra M" first="Mauro F" last="Larra">Mauro F. Larra</name><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name><name sortKey="Schote, Andrea B" sort="Schote, Andrea B" uniqKey="Schote A" first="Andrea B" last="Schote">Andrea B. Schote</name><name sortKey="Tempel, Tobias" sort="Tempel, Tobias" uniqKey="Tempel T" first="Tobias" last="Tempel">Tobias Tempel</name><name sortKey="Winnikes, Ulrike" sort="Winnikes, Ulrike" uniqKey="Winnikes U" first="Ulrike" last="Winnikes">Ulrike Winnikes</name></country><country name="Pays-Bas"><region name="Hollande-Méridionale"><name sortKey="Derijk, Roel H" sort="Derijk, Roel H" uniqKey="Derijk R" first="Roel H" last="Derijk">Roel H. Derijk</name></region></country><country name="Luxembourg (pays)"><noRegion><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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