Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence the cortisol awakening response as well as self-perceived stress.
Identifieur interne : 000092 ( PubMed/Corpus ); précédent : 000091; suivant : 000093Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence the cortisol awakening response as well as self-perceived stress.
Auteurs : Ting Li-Tempel ; Mauro F. Larra ; Ulrike Winnikes ; Tobias Tempel ; Roel H. Derijk ; André Schulz ; Hartmut Sch Chinger ; Jobst Meyer ; Andrea B. SchoteSource :
- Biological psychology [ 1873-6246 ] ; 2016.
Abstract
The hypothalamus-pituitary-adrenal (HPA) axis is a crucial endocrine system for coping with stress. A reliable and stable marker for the basal state of that system is the cortisol awakening response (CAR). We examined the influence of variants of four relevant candidate genes; the mineralocorticoid receptor gene (MR), the glucocorticoid receptor gene (GR), the serotonin transporter gene (5-HTT) and the gene encoding the brain-derived neurotrophic factor (BDNF) on CAR and self-perceived stress in 217 healthy subjects. We found that polymorphisms of GR influenced both, the basal state of the HPA axis as well as self-perceived stress. MR only associated with self-perceived stress and 5-HTT only with CAR. BDNF did not affected any of the investigated indices. In summary, we suggest that GR variants together with the CAR and supplemented with self reports on perceived stress might be useful indicators for the basal HPA axis activity.
DOI: 10.1016/j.biopsycho.2016.07.010
PubMed: 27427534
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Larra</name><affiliation><nlm:affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Winnikes, Ulrike" sort="Winnikes, Ulrike" uniqKey="Winnikes U" first="Ulrike" last="Winnikes">Ulrike Winnikes</name><affiliation><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tempel, Tobias" sort="Tempel, Tobias" uniqKey="Tempel T" first="Tobias" last="Tempel">Tobias Tempel</name><affiliation><nlm:affiliation>Department of Psychology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Derijk, Roel H" sort="Derijk, Roel H" uniqKey="Derijk R" first="Roel H" last="Derijk">Roel H. Derijk</name><affiliation><nlm:affiliation>Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name><affiliation><nlm:affiliation>Institute for Health and Behavior, Integrative Research Unit on Social and Individual Development (INSIDE), University of Luxembourg, Luxembourg.</nlm:affiliation></affiliation></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name><affiliation><nlm:affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schote, Andrea B" sort="Schote, Andrea B" uniqKey="Schote A" first="Andrea B" last="Schote">Andrea B. Schote</name><affiliation><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany. Electronic address: schotefrese@uni-trier.de.</nlm:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2016">2016</date><idno type="RBID">pubmed:27427534</idno><idno type="pmid">27427534</idno><idno type="doi">10.1016/j.biopsycho.2016.07.010</idno><idno type="wicri:Area/PubMed/Corpus">000092</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000092</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence the cortisol awakening response as well as self-perceived stress.</title><author><name sortKey="Li Tempel, Ting" sort="Li Tempel, Ting" uniqKey="Li Tempel T" first="Ting" last="Li-Tempel">Ting Li-Tempel</name><affiliation><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Larra, Mauro F" sort="Larra, Mauro F" uniqKey="Larra M" first="Mauro F" last="Larra">Mauro F. Larra</name><affiliation><nlm:affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Winnikes, Ulrike" sort="Winnikes, Ulrike" uniqKey="Winnikes U" first="Ulrike" last="Winnikes">Ulrike Winnikes</name><affiliation><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Tempel, Tobias" sort="Tempel, Tobias" uniqKey="Tempel T" first="Tobias" last="Tempel">Tobias Tempel</name><affiliation><nlm:affiliation>Department of Psychology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Derijk, Roel H" sort="Derijk, Roel H" uniqKey="Derijk R" first="Roel H" last="Derijk">Roel H. Derijk</name><affiliation><nlm:affiliation>Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.</nlm:affiliation></affiliation></author><author><name sortKey="Schulz, Andre" sort="Schulz, Andre" uniqKey="Schulz A" first="André" last="Schulz">André Schulz</name><affiliation><nlm:affiliation>Institute for Health and Behavior, Integrative Research Unit on Social and Individual Development (INSIDE), University of Luxembourg, Luxembourg.</nlm:affiliation></affiliation></author><author><name sortKey="Sch Chinger, Hartmut" sort="Sch Chinger, Hartmut" uniqKey="Sch Chinger H" first="Hartmut" last="Sch Chinger">Hartmut Sch Chinger</name><affiliation><nlm:affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Meyer, Jobst" sort="Meyer, Jobst" uniqKey="Meyer J" first="Jobst" last="Meyer">Jobst Meyer</name><affiliation><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</nlm:affiliation></affiliation></author><author><name sortKey="Schote, Andrea B" sort="Schote, Andrea B" uniqKey="Schote A" first="Andrea B" last="Schote">Andrea B. Schote</name><affiliation><nlm:affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany. Electronic address: schotefrese@uni-trier.de.</nlm:affiliation></affiliation></author></analytic><series><title level="j">Biological psychology</title><idno type="eISSN">1873-6246</idno><imprint><date when="2016" type="published">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The hypothalamus-pituitary-adrenal (HPA) axis is a crucial endocrine system for coping with stress. A reliable and stable marker for the basal state of that system is the cortisol awakening response (CAR). We examined the influence of variants of four relevant candidate genes; the mineralocorticoid receptor gene (MR), the glucocorticoid receptor gene (GR), the serotonin transporter gene (5-HTT) and the gene encoding the brain-derived neurotrophic factor (BDNF) on CAR and self-perceived stress in 217 healthy subjects. We found that polymorphisms of GR influenced both, the basal state of the HPA axis as well as self-perceived stress. MR only associated with self-perceived stress and 5-HTT only with CAR. BDNF did not affected any of the investigated indices. In summary, we suggest that GR variants together with the CAR and supplemented with self reports on perceived stress might be useful indicators for the basal HPA axis activity.</div></front></TEI><pubmed><MedlineCitation Status="In-Data-Review" Owner="NLM"><PMID Version="1">27427534</PMID><DateCreated><Year>2016</Year><Month>08</Month><Day>22</Day></DateCreated><DateRevised><Year>2016</Year><Month>08</Month><Day>22</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-6246</ISSN><JournalIssue CitedMedium="Internet"><Volume>119</Volume><PubDate><Year>2016</Year><Month>Sep</Month></PubDate></JournalIssue><Title>Biological psychology</Title><ISOAbbreviation>Biol Psychol</ISOAbbreviation></Journal><ArticleTitle>Polymorphisms of genes related to the hypothalamic-pituitary-adrenal axis influence the cortisol awakening response as well as self-perceived stress.</ArticleTitle><Pagination><MedlinePgn>112-21</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.biopsycho.2016.07.010</ELocationID><ELocationID EIdType="pii" ValidYN="Y">S0301-0511(16)30213-7</ELocationID><Abstract><AbstractText>The hypothalamus-pituitary-adrenal (HPA) axis is a crucial endocrine system for coping with stress. A reliable and stable marker for the basal state of that system is the cortisol awakening response (CAR). We examined the influence of variants of four relevant candidate genes; the mineralocorticoid receptor gene (MR), the glucocorticoid receptor gene (GR), the serotonin transporter gene (5-HTT) and the gene encoding the brain-derived neurotrophic factor (BDNF) on CAR and self-perceived stress in 217 healthy subjects. We found that polymorphisms of GR influenced both, the basal state of the HPA axis as well as self-perceived stress. MR only associated with self-perceived stress and 5-HTT only with CAR. BDNF did not affected any of the investigated indices. In summary, we suggest that GR variants together with the CAR and supplemented with self reports on perceived stress might be useful indicators for the basal HPA axis activity.</AbstractText><CopyrightInformation>Copyright © 2016 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Li-Tempel</LastName><ForeName>Ting</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Larra</LastName><ForeName>Mauro F</ForeName><Initials>MF</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Winnikes</LastName><ForeName>Ulrike</ForeName><Initials>U</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tempel</LastName><ForeName>Tobias</ForeName><Initials>T</Initials><AffiliationInfo><Affiliation>Department of Psychology, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>DeRijk</LastName><ForeName>Roel H</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>Department of Psychiatry, Leiden University Medical Center, Leiden, Netherlands.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schulz</LastName><ForeName>André</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Institute for Health and Behavior, Integrative Research Unit on Social and Individual Development (INSIDE), University of Luxembourg, Luxembourg.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schächinger</LastName><ForeName>Hartmut</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Division of Clinical Psychophysiology, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Meyer</LastName><ForeName>Jobst</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Schote</LastName><ForeName>Andrea B</ForeName><Initials>AB</Initials><AffiliationInfo><Affiliation>Institute of Psychobiology, Department of Neurobehavioral Genetics, University of Trier, Trier, Germany. Electronic address: schotefrese@uni-trier.de.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2016</Year><Month>07</Month><Day>15</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Biol Psychol</MedlineTA><NlmUniqueID>0375566</NlmUniqueID><ISSNLinking>0301-0511</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Brain-derived neurotrophic factor gene (BDNF)</Keyword><Keyword MajorTopicYN="N">Cortisol awaking response (CAR)</Keyword><Keyword MajorTopicYN="N">Glucocorticoid receptor gene (GR)</Keyword><Keyword MajorTopicYN="N">Mineralocorticoid receptor gene (MR)</Keyword><Keyword MajorTopicYN="N">Serotonin transporter gene (5-HTT)</Keyword><Keyword MajorTopicYN="N">Trier Inventory for Chronic Stress (TICS)</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2015</Year><Month>01</Month><Day>21</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2016</Year><Month>06</Month><Day>13</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2016</Year><Month>07</Month><Day>07</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2016</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2016</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2016</Year><Month>7</Month><Day>19</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">27427534</ArticleId><ArticleId IdType="pii">S0301-0511(16)30213-7</ArticleId><ArticleId IdType="doi">10.1016/j.biopsycho.2016.07.010</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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