[Lupus nephritis with crystal structures in glomerulopathy ].
Identifieur interne : 001A25 ( Main/Exploration ); précédent : 001A24; suivant : 001A26[Lupus nephritis with crystal structures in glomerulopathy ].
Auteurs : M. Otto [Allemagne] ; T. Hansen ; S. Bertz ; E H Str M ; S H Brorson ; M J Mihatsch ; J. KriegsmannSource :
- Der Pathologe [ 0172-8113 ] ; 2003.
English descriptors
- KwdEn :
- MESH :
- pathology : Glomerulonephritis, Kidney Glomerulus, Lupus Nephritis.
- ultrastructure : Kidney Glomerulus.
- Adult, Crystallization, Female, Humans, Immunohistochemistry, Microscopy, Immunoelectron.
Abstract
Lupus nephritis is a common phenomenon in Systemic Lupus Erythematosus (SLE). We analyzed a renal biopsy of a 30-year-old woman with SLE. The clinical history showed a typical SLE with generalized symptoms without demonstrable lupus coagulant, positive for anti-nuclear antibodies and anti-ds-DNA antibodies but negative for rheumatoid factor, cryoglobulins and antiphospholipid antibodies. A paraproteinemia for IgA, IgG and IgM was not detectable. Using light, electron and immunoelectron microscopy electron-dense deposits were noted in subepithelial, subendothelial and mesangial position. Most remarkably, the electron-dense deposits and mesangial areas in the vicinity of deposits contained an electron-dense crystalline material. The crystalline structures were composed of IgG and kappa light chains, while they were negative for IgM, IgA and lambda light chains, as demonstrated by immunoelectron microscopy. As far as we know, this is the first case of lupus nephritis with crystalline structures. Since we could not detect cryoglobulinemia or paraproteinemia, other mechanisms possibly favor organization of macromolecular structures.
DOI: 10.1007/s00292-003-0658-1
PubMed: 14605847
Affiliations:
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Le document en format XML
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Bertz</name></author><author><name sortKey="Str M, E H" sort="Str M, E H" uniqKey="Str M E" first="E H" last="Str M">E H Str M</name></author><author><name sortKey="Brorson, S H" sort="Brorson, S H" uniqKey="Brorson S" first="S H" last="Brorson">S H Brorson</name></author><author><name sortKey="Mihatsch, M J" sort="Mihatsch, M J" uniqKey="Mihatsch M" first="M J" last="Mihatsch">M J Mihatsch</name></author><author><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J" last="Kriegsmann">J. Kriegsmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:14605847</idno><idno type="pmid">14605847</idno><idno type="doi">10.1007/s00292-003-0658-1</idno><idno type="wicri:Area/PubMed/Corpus">000766</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000766</idno><idno type="wicri:Area/PubMed/Curation">000766</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000766</idno><idno type="wicri:Area/PubMed/Checkpoint">000766</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000766</idno><idno type="wicri:Area/Ncbi/Merge">000136</idno><idno type="wicri:Area/Ncbi/Curation">000136</idno><idno type="wicri:Area/Ncbi/Checkpoint">000136</idno><idno type="wicri:doubleKey">0172-8113:2003:Otto M:lupus:nephritis:with</idno><idno type="wicri:Area/Main/Merge">001C34</idno><idno type="wicri:Area/Main/Curation">001A25</idno><idno type="wicri:Area/Main/Exploration">001A25</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Lupus nephritis with crystal structures in glomerulopathy ].</title><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name><affiliation wicri:level="1"><nlm:affiliation>Gemeinschaftspraxis für Pathologie, Trier. otto@patho-trier.de</nlm:affiliation><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Hansen, T" sort="Hansen, T" uniqKey="Hansen T" first="T" last="Hansen">T. Hansen</name></author><author><name sortKey="Bertz, S" sort="Bertz, S" uniqKey="Bertz S" first="S" last="Bertz">S. Bertz</name></author><author><name sortKey="Str M, E H" sort="Str M, E H" uniqKey="Str M E" first="E H" last="Str M">E H Str M</name></author><author><name sortKey="Brorson, S H" sort="Brorson, S H" uniqKey="Brorson S" first="S H" last="Brorson">S H Brorson</name></author><author><name sortKey="Mihatsch, M J" sort="Mihatsch, M J" uniqKey="Mihatsch M" first="M J" last="Mihatsch">M J Mihatsch</name></author><author><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J" last="Kriegsmann">J. Kriegsmann</name></author></analytic><series><title level="j">Der Pathologe</title><idno type="ISSN">0172-8113</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Crystallization</term><term>Female</term><term>Glomerulonephritis (pathology)</term><term>Humans</term><term>Immunohistochemistry</term><term>Kidney Glomerulus (pathology)</term><term>Kidney Glomerulus (ultrastructure)</term><term>Lupus Nephritis (pathology)</term><term>Microscopy, Immunoelectron</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Glomerulonephritis</term><term>Kidney Glomerulus</term><term>Lupus Nephritis</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Kidney Glomerulus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Crystallization</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Microscopy, Immunoelectron</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lupus nephritis is a common phenomenon in Systemic Lupus Erythematosus (SLE). We analyzed a renal biopsy of a 30-year-old woman with SLE. The clinical history showed a typical SLE with generalized symptoms without demonstrable lupus coagulant, positive for anti-nuclear antibodies and anti-ds-DNA antibodies but negative for rheumatoid factor, cryoglobulins and antiphospholipid antibodies. A paraproteinemia for IgA, IgG and IgM was not detectable. Using light, electron and immunoelectron microscopy electron-dense deposits were noted in subepithelial, subendothelial and mesangial position. Most remarkably, the electron-dense deposits and mesangial areas in the vicinity of deposits contained an electron-dense crystalline material. The crystalline structures were composed of IgG and kappa light chains, while they were negative for IgM, IgA and lambda light chains, as demonstrated by immunoelectron microscopy. As far as we know, this is the first case of lupus nephritis with crystalline structures. Since we could not detect cryoglobulinemia or paraproteinemia, other mechanisms possibly favor organization of macromolecular structures.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country></list><tree><noCountry><name sortKey="Bertz, S" sort="Bertz, S" uniqKey="Bertz S" first="S" last="Bertz">S. Bertz</name><name sortKey="Brorson, S H" sort="Brorson, S H" uniqKey="Brorson S" first="S H" last="Brorson">S H Brorson</name><name sortKey="Hansen, T" sort="Hansen, T" uniqKey="Hansen T" first="T" last="Hansen">T. Hansen</name><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J" last="Kriegsmann">J. Kriegsmann</name><name sortKey="Mihatsch, M J" sort="Mihatsch, M J" uniqKey="Mihatsch M" first="M J" last="Mihatsch">M J Mihatsch</name><name sortKey="Str M, E H" sort="Str M, E H" uniqKey="Str M E" first="E H" last="Str M">E H Str M</name></noCountry><country name="Allemagne"><noRegion><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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