[Lupus nephritis with crystal structures in glomerulopathy ].
Identifieur interne : 000766 ( PubMed/Corpus ); précédent : 000765; suivant : 000767[Lupus nephritis with crystal structures in glomerulopathy ].
Auteurs : M. Otto ; T. Hansen ; S. Bertz ; E H Str M ; S H Brorson ; M J Mihatsch ; J. KriegsmannSource :
- Der Pathologe [ 0172-8113 ] ; 2003.
English descriptors
- KwdEn :
- MESH :
- pathology : Glomerulonephritis, Kidney Glomerulus, Lupus Nephritis.
- ultrastructure : Kidney Glomerulus.
- Adult, Crystallization, Female, Humans, Immunohistochemistry, Microscopy, Immunoelectron.
Abstract
Lupus nephritis is a common phenomenon in Systemic Lupus Erythematosus (SLE). We analyzed a renal biopsy of a 30-year-old woman with SLE. The clinical history showed a typical SLE with generalized symptoms without demonstrable lupus coagulant, positive for anti-nuclear antibodies and anti-ds-DNA antibodies but negative for rheumatoid factor, cryoglobulins and antiphospholipid antibodies. A paraproteinemia for IgA, IgG and IgM was not detectable. Using light, electron and immunoelectron microscopy electron-dense deposits were noted in subepithelial, subendothelial and mesangial position. Most remarkably, the electron-dense deposits and mesangial areas in the vicinity of deposits contained an electron-dense crystalline material. The crystalline structures were composed of IgG and kappa light chains, while they were negative for IgM, IgA and lambda light chains, as demonstrated by immunoelectron microscopy. As far as we know, this is the first case of lupus nephritis with crystalline structures. Since we could not detect cryoglobulinemia or paraproteinemia, other mechanisms possibly favor organization of macromolecular structures.
DOI: 10.1007/s00292-003-0658-1
PubMed: 14605847
Links to Exploration step
pubmed:14605847Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[Lupus nephritis with crystal structures in glomerulopathy ].</title><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name><affiliation><nlm:affiliation>Gemeinschaftspraxis für Pathologie, Trier. otto@patho-trier.de</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, T" sort="Hansen, T" uniqKey="Hansen T" first="T" last="Hansen">T. Hansen</name></author><author><name sortKey="Bertz, S" sort="Bertz, S" uniqKey="Bertz S" first="S" last="Bertz">S. Bertz</name></author><author><name sortKey="Str M, E H" sort="Str M, E H" uniqKey="Str M E" first="E H" last="Str M">E H Str M</name></author><author><name sortKey="Brorson, S H" sort="Brorson, S H" uniqKey="Brorson S" first="S H" last="Brorson">S H Brorson</name></author><author><name sortKey="Mihatsch, M J" sort="Mihatsch, M J" uniqKey="Mihatsch M" first="M J" last="Mihatsch">M J Mihatsch</name></author><author><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J" last="Kriegsmann">J. Kriegsmann</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2003">2003</date><idno type="RBID">pubmed:14605847</idno><idno type="pmid">14605847</idno><idno type="doi">10.1007/s00292-003-0658-1</idno><idno type="wicri:Area/PubMed/Corpus">000766</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000766</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">[Lupus nephritis with crystal structures in glomerulopathy ].</title><author><name sortKey="Otto, M" sort="Otto, M" uniqKey="Otto M" first="M" last="Otto">M. Otto</name><affiliation><nlm:affiliation>Gemeinschaftspraxis für Pathologie, Trier. otto@patho-trier.de</nlm:affiliation></affiliation></author><author><name sortKey="Hansen, T" sort="Hansen, T" uniqKey="Hansen T" first="T" last="Hansen">T. Hansen</name></author><author><name sortKey="Bertz, S" sort="Bertz, S" uniqKey="Bertz S" first="S" last="Bertz">S. Bertz</name></author><author><name sortKey="Str M, E H" sort="Str M, E H" uniqKey="Str M E" first="E H" last="Str M">E H Str M</name></author><author><name sortKey="Brorson, S H" sort="Brorson, S H" uniqKey="Brorson S" first="S H" last="Brorson">S H Brorson</name></author><author><name sortKey="Mihatsch, M J" sort="Mihatsch, M J" uniqKey="Mihatsch M" first="M J" last="Mihatsch">M J Mihatsch</name></author><author><name sortKey="Kriegsmann, J" sort="Kriegsmann, J" uniqKey="Kriegsmann J" first="J" last="Kriegsmann">J. Kriegsmann</name></author></analytic><series><title level="j">Der Pathologe</title><idno type="ISSN">0172-8113</idno><imprint><date when="2003" type="published">2003</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Crystallization</term><term>Female</term><term>Glomerulonephritis (pathology)</term><term>Humans</term><term>Immunohistochemistry</term><term>Kidney Glomerulus (pathology)</term><term>Kidney Glomerulus (ultrastructure)</term><term>Lupus Nephritis (pathology)</term><term>Microscopy, Immunoelectron</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Glomerulonephritis</term><term>Kidney Glomerulus</term><term>Lupus Nephritis</term></keywords><keywords scheme="MESH" qualifier="ultrastructure" xml:lang="en"><term>Kidney Glomerulus</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Crystallization</term><term>Female</term><term>Humans</term><term>Immunohistochemistry</term><term>Microscopy, Immunoelectron</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Lupus nephritis is a common phenomenon in Systemic Lupus Erythematosus (SLE). We analyzed a renal biopsy of a 30-year-old woman with SLE. The clinical history showed a typical SLE with generalized symptoms without demonstrable lupus coagulant, positive for anti-nuclear antibodies and anti-ds-DNA antibodies but negative for rheumatoid factor, cryoglobulins and antiphospholipid antibodies. A paraproteinemia for IgA, IgG and IgM was not detectable. Using light, electron and immunoelectron microscopy electron-dense deposits were noted in subepithelial, subendothelial and mesangial position. Most remarkably, the electron-dense deposits and mesangial areas in the vicinity of deposits contained an electron-dense crystalline material. The crystalline structures were composed of IgG and kappa light chains, while they were negative for IgM, IgA and lambda light chains, as demonstrated by immunoelectron microscopy. As far as we know, this is the first case of lupus nephritis with crystalline structures. Since we could not detect cryoglobulinemia or paraproteinemia, other mechanisms possibly favor organization of macromolecular structures.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">14605847</PMID><DateCreated><Year>2003</Year><Month>11</Month><Day>07</Day></DateCreated><DateCompleted><Year>2004</Year><Month>01</Month><Day>21</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0172-8113</ISSN><JournalIssue CitedMedium="Print"><Volume>24</Volume><Issue>6</Issue><PubDate><Year>2003</Year><Month>Oct</Month></PubDate></JournalIssue><Title>Der Pathologe</Title><ISOAbbreviation>Pathologe</ISOAbbreviation></Journal><ArticleTitle>[Lupus nephritis with crystal structures in glomerulopathy ].</ArticleTitle><Pagination><MedlinePgn>433-8</MedlinePgn></Pagination><Abstract><AbstractText>Lupus nephritis is a common phenomenon in Systemic Lupus Erythematosus (SLE). We analyzed a renal biopsy of a 30-year-old woman with SLE. The clinical history showed a typical SLE with generalized symptoms without demonstrable lupus coagulant, positive for anti-nuclear antibodies and anti-ds-DNA antibodies but negative for rheumatoid factor, cryoglobulins and antiphospholipid antibodies. A paraproteinemia for IgA, IgG and IgM was not detectable. Using light, electron and immunoelectron microscopy electron-dense deposits were noted in subepithelial, subendothelial and mesangial position. Most remarkably, the electron-dense deposits and mesangial areas in the vicinity of deposits contained an electron-dense crystalline material. The crystalline structures were composed of IgG and kappa light chains, while they were negative for IgM, IgA and lambda light chains, as demonstrated by immunoelectron microscopy. As far as we know, this is the first case of lupus nephritis with crystalline structures. Since we could not detect cryoglobulinemia or paraproteinemia, other mechanisms possibly favor organization of macromolecular structures.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Otto</LastName><ForeName>M</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Gemeinschaftspraxis für Pathologie, Trier. otto@patho-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Hansen</LastName><ForeName>T</ForeName><Initials>T</Initials></Author><Author ValidYN="Y"><LastName>Bertz</LastName><ForeName>S</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Strøm</LastName><ForeName>E H</ForeName><Initials>EH</Initials></Author><Author ValidYN="Y"><LastName>Brorson</LastName><ForeName>S H</ForeName><Initials>SH</Initials></Author><Author ValidYN="Y"><LastName>Mihatsch</LastName><ForeName>M J</ForeName><Initials>MJ</Initials></Author><Author ValidYN="Y"><LastName>Kriegsmann</LastName><ForeName>J</ForeName><Initials>J</Initials></Author></AuthorList><Language>ger</Language><PublicationTypeList><PublicationType UI="D002363">Case Reports</PublicationType><PublicationType UI="D004740">English Abstract</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><VernacularTitle>Lupusnephritis mit Kristallstrukturen in glomerulären Ablagerungen.</VernacularTitle></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Pathologe</MedlineTA><NlmUniqueID>8006541</NlmUniqueID><ISSNLinking>0172-8113</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D003460" MajorTopicYN="N">Crystallization</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005921" MajorTopicYN="N">Glomerulonephritis</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007150" MajorTopicYN="N">Immunohistochemistry</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007678" MajorTopicYN="N">Kidney Glomerulus</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName><QualifierName UI="Q000648" MajorTopicYN="N">ultrastructure</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D008181" MajorTopicYN="N">Lupus Nephritis</DescriptorName><QualifierName UI="Q000473" MajorTopicYN="Y">pathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D016253" MajorTopicYN="N">Microscopy, Immunoelectron</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2003</Year><Month>11</Month><Day>8</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2004</Year><Month>1</Month><Day>22</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2003</Year><Month>11</Month><Day>8</Day><Hour>5</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">14605847</ArticleId><ArticleId IdType="doi">10.1007/s00292-003-0658-1</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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