Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment
Identifieur interne : 002334 ( Main/Exploration ); précédent : 002333; suivant : 002335Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment
Auteurs : B. M. Kudielka [Allemagne] ; J. Hellhammer [Allemagne] ; D. H. Hellhammer [Allemagne] ; O. T. Wolf [Allemagne] ; K.-M. Pirke [Allemagne] ; E. Varadi [Hongrie] ; J. Pilz [Allemagne] ; C. Kirschbaum [Allemagne]Source :
- The Journal of clinical endocrinology and metabolism [ 0021-972X ] ; 1998.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adrenocorticotropic Hormone (blood), Age, Aged, Behavior, Chemotherapy, Comparative study, Dehydroepiandrosterone, Elderly, Epinephrine (blood), Female, Heart Rate, Hormonodependence, Humans, Hydrocortisone (blood), Hydrocortisone (metabolism), Hypothalamohypophysoadrenal axis, Kinetics, Male, Norepinephrine (blood), Psychological effect, Saliva (metabolism), Sex, Sex Characteristics, Stress, Stress, Physiological (physiopathology), Treatment.
- MESH :
- chemical , blood : Adrenocorticotropic Hormone, Epinephrine, Hydrocortisone, Norepinephrine.
- chemical , metabolism : Hydrocortisone.
- metabolism : Saliva.
- physiopathology : Stress, Physiological.
- Aged, Dehydroepiandrosterone, Female, Heart Rate, Humans, Kinetics, Male, Sex Characteristics.
Abstract
Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.
Affiliations:
- Allemagne, Hongrie
- Basse-Saxe, Hongrie centrale, Rhénanie-Palatinat
- Budapest, Göttingen, Trèves (Allemagne)
- Université de Trèves
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Le document en format XML
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<term>Age</term>
<term>Aged</term>
<term>Behavior</term>
<term>Chemotherapy</term>
<term>Comparative study</term>
<term>Dehydroepiandrosterone</term>
<term>Elderly</term>
<term>Epinephrine (blood)</term>
<term>Female</term>
<term>Heart Rate</term>
<term>Hormonodependence</term>
<term>Humans</term>
<term>Hydrocortisone (blood)</term>
<term>Hydrocortisone (metabolism)</term>
<term>Hypothalamohypophysoadrenal axis</term>
<term>Kinetics</term>
<term>Male</term>
<term>Norepinephrine (blood)</term>
<term>Psychological effect</term>
<term>Saliva (metabolism)</term>
<term>Sex</term>
<term>Sex Characteristics</term>
<term>Stress</term>
<term>Stress, Physiological (physiopathology)</term>
<term>Treatment</term>
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<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term>
<term>Epinephrine</term>
<term>Hydrocortisone</term>
<term>Norepinephrine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term>
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<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saliva</term>
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<term>Dehydroepiandrosterone</term>
<term>Female</term>
<term>Heart Rate</term>
<term>Humans</term>
<term>Kinetics</term>
<term>Male</term>
<term>Sex Characteristics</term>
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<term>Effet psychologique</term>
<term>Stress</term>
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<term>Déhydroépiandrostérone</term>
<term>Chimiothérapie</term>
<term>Traitement</term>
<term>Sexe</term>
<term>Hormonodépendance</term>
<term>Age</term>
<term>Etude comparative</term>
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<front><div type="abstract" xml:lang="en">Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.</div>
</front>
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</orgName>
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<tree><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Kudielka, B M" sort="Kudielka, B M" uniqKey="Kudielka B" first="B. M." last="Kudielka">B. M. Kudielka</name>
</region>
<name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H." last="Hellhammer">D. H. Hellhammer</name>
<name sortKey="Hellhammer, J" sort="Hellhammer, J" uniqKey="Hellhammer J" first="J." last="Hellhammer">J. Hellhammer</name>
<name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name>
<name sortKey="Pilz, J" sort="Pilz, J" uniqKey="Pilz J" first="J." last="Pilz">J. Pilz</name>
<name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K.-M." last="Pirke">K.-M. Pirke</name>
<name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O. T." last="Wolf">O. T. Wolf</name>
</country>
<country name="Hongrie"><region name="Hongrie centrale"><name sortKey="Varadi, E" sort="Varadi, E" uniqKey="Varadi E" first="E." last="Varadi">E. Varadi</name>
</region>
</country>
</tree>
</affiliations>
</record>
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