Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment
Identifieur interne : 002334 ( Main/Curation ); précédent : 002333; suivant : 002335Sex differences in endocrine and psychological responses to psychosocial stress in healthy elderly subjects and the impact of a 2-week dehydroepiandrosterone treatment
Auteurs : B. M. Kudielka [Allemagne] ; J. Hellhammer [Allemagne] ; D. H. Hellhammer [Allemagne] ; O. T. Wolf [Allemagne] ; K.-M. Pirke [Allemagne] ; E. Varadi [Hongrie] ; J. Pilz [Allemagne] ; C. Kirschbaum [Allemagne]Source :
- The Journal of clinical endocrinology and metabolism [ 0021-972X ] ; 1998.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adrenocorticotropic Hormone (blood), Age, Aged, Behavior, Chemotherapy, Comparative study, Dehydroepiandrosterone, Elderly, Epinephrine (blood), Female, Heart Rate, Hormonodependence, Humans, Hydrocortisone (blood), Hydrocortisone (metabolism), Hypothalamohypophysoadrenal axis, Kinetics, Male, Norepinephrine (blood), Psychological effect, Saliva (metabolism), Sex, Sex Characteristics, Stress, Stress, Physiological (physiopathology), Treatment.
- MESH :
- chemical , blood : Adrenocorticotropic Hormone, Epinephrine, Hydrocortisone, Norepinephrine.
- chemical , metabolism : Hydrocortisone.
- metabolism : Saliva.
- physiopathology : Stress, Physiological.
- Aged, Dehydroepiandrosterone, Female, Heart Rate, Humans, Kinetics, Male, Sex Characteristics.
Abstract
Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.
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Pascal:98-0276698Le document en format XML
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<series><title level="j" type="main">The Journal of clinical endocrinology and metabolism</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (blood)</term>
<term>Age</term>
<term>Aged</term>
<term>Behavior</term>
<term>Chemotherapy</term>
<term>Comparative study</term>
<term>Dehydroepiandrosterone</term>
<term>Elderly</term>
<term>Epinephrine (blood)</term>
<term>Female</term>
<term>Heart Rate</term>
<term>Hormonodependence</term>
<term>Humans</term>
<term>Hydrocortisone (blood)</term>
<term>Hydrocortisone (metabolism)</term>
<term>Hypothalamohypophysoadrenal axis</term>
<term>Kinetics</term>
<term>Male</term>
<term>Norepinephrine (blood)</term>
<term>Psychological effect</term>
<term>Saliva (metabolism)</term>
<term>Sex</term>
<term>Sex Characteristics</term>
<term>Stress</term>
<term>Stress, Physiological (physiopathology)</term>
<term>Treatment</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term>
<term>Epinephrine</term>
<term>Hydrocortisone</term>
<term>Norepinephrine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saliva</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Physiological</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Dehydroepiandrosterone</term>
<term>Female</term>
<term>Heart Rate</term>
<term>Humans</term>
<term>Kinetics</term>
<term>Male</term>
<term>Sex Characteristics</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Comportement</term>
<term>Effet psychologique</term>
<term>Stress</term>
<term>Système hypothalamohypophysosurrénalien</term>
<term>Déhydroépiandrostérone</term>
<term>Chimiothérapie</term>
<term>Traitement</term>
<term>Sexe</term>
<term>Hormonodépendance</term>
<term>Age</term>
<term>Etude comparative</term>
<term>Vieillard</term>
<term>Mâle</term>
<term>Femelle</term>
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<front><div type="abstract" xml:lang="en">Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.</div>
</front>
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<wicri:noRegion>Trier</wicri:noRegion>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Hellhammer, J" sort="Hellhammer, J" uniqKey="Hellhammer J" first="J." last="Hellhammer">J. Hellhammer</name>
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</placeName>
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</author>
<author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H." last="Hellhammer">D. H. Hellhammer</name>
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</placeName>
<orgName type="university">Université de Trèves</orgName>
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</author>
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</placeName>
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</placeName>
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</placeName>
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<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychobiological and Psychosomatic Research, University of Trier</s1>
<s2>Trier</s2>
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<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
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<wicri:noRegion>Trier</wicri:noRegion>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Hellhammer, J" sort="Hellhammer, J" uniqKey="Hellhammer J" first="J." last="Hellhammer">J. Hellhammer</name>
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</placeName>
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<author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D. H." last="Hellhammer">D. H. Hellhammer</name>
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<author><name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O. T." last="Wolf">O. T. Wolf</name>
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<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
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</author>
<author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K.-M." last="Pirke">K.-M. Pirke</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychobiological and Psychosomatic Research, University of Trier</s1>
<s2>Trier</s2>
<s3>DEU</s3>
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<country>Allemagne</country>
<wicri:noRegion>Trier</wicri:noRegion>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Varadi, E" sort="Varadi, E" uniqKey="Varadi E" first="E." last="Varadi">E. Varadi</name>
<affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Department of Psychiatry and Psychotherapy, Semmelweis University of the Medical Sciences</s1>
<s2>Budapest</s2>
<s3>HUN</s3>
<sZ>6 aut.</sZ>
</inist:fA14>
<country>Hongrie</country>
<placeName><settlement type="city">Budapest</settlement>
<region nuts="2">Hongrie centrale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Pilz, J" sort="Pilz, J" uniqKey="Pilz J" first="J." last="Pilz">J. Pilz</name>
<affiliation wicri:level="3"><inist:fA14 i1="03"><s1>Department of Psychiatry, University of Göttingen</s1>
<s2>Göttingen</s2>
<s3>DEU</s3>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<placeName><region type="land" nuts="2">Basse-Saxe</region>
<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C." last="Kirschbaum">C. Kirschbaum</name>
<affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Center for Psychobiological and Psychosomatic Research, University of Trier</s1>
<s2>Trier</s2>
<s3>DEU</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
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</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Trier</wicri:noRegion>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of clinical endocrinology and metabolism</title>
<title level="j" type="abbreviated">J. clin. endocrinol. metab.</title>
<idno type="ISSN">0021-972X</idno>
<imprint><date when="1998">1998</date>
</imprint>
</series>
</biblStruct>
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<seriesStmt><title level="j" type="main">The Journal of clinical endocrinology and metabolism</title>
<title level="j" type="abbreviated">J. clin. endocrinol. metab.</title>
<idno type="ISSN">0021-972X</idno>
</seriesStmt>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term>
<term>Behavior</term>
<term>Chemotherapy</term>
<term>Comparative study</term>
<term>Dehydroepiandrosterone</term>
<term>Elderly</term>
<term>Female</term>
<term>Hormonodependence</term>
<term>Hypothalamohypophysoadrenal axis</term>
<term>Male</term>
<term>Psychological effect</term>
<term>Sex</term>
<term>Stress</term>
<term>Treatment</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Comportement</term>
<term>Effet psychologique</term>
<term>Stress</term>
<term>Système hypothalamohypophysosurrénalien</term>
<term>Déhydroépiandrostérone</term>
<term>Chimiothérapie</term>
<term>Traitement</term>
<term>Sexe</term>
<term>Hormonodépendance</term>
<term>Age</term>
<term>Etude comparative</term>
<term>Vieillard</term>
<term>Mâle</term>
<term>Femelle</term>
</keywords>
</textClass>
</profileDesc>
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<front><div type="abstract" xml:lang="en">Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.</div>
</front>
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<author><name sortKey="Kudielka, B M" sort="Kudielka, B M" uniqKey="Kudielka B" first="B M" last="Kudielka">B M Kudielka</name>
<affiliation wicri:level="4"><nlm:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Hellhammer, J" sort="Hellhammer, J" uniqKey="Hellhammer J" first="J" last="Hellhammer">J. Hellhammer</name>
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<author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D H" last="Hellhammer">D H Hellhammer</name>
</author>
<author><name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O T" last="Wolf">O T Wolf</name>
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<author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K M" last="Pirke">K M Pirke</name>
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<author><name sortKey="Pilz, J" sort="Pilz, J" uniqKey="Pilz J" first="J" last="Pilz">J. Pilz</name>
</author>
<author><name sortKey="Kirschbaum, C" sort="Kirschbaum, C" uniqKey="Kirschbaum C" first="C" last="Kirschbaum">C. Kirschbaum</name>
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<affiliation wicri:level="4"><nlm:affiliation>Center for Psychobiological and Psychosomatic Research, University of Trier, Germany.</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier</wicri:regionArea>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
<orgName type="university">Université de Trèves</orgName>
</affiliation>
</author>
<author><name sortKey="Hellhammer, J" sort="Hellhammer, J" uniqKey="Hellhammer J" first="J" last="Hellhammer">J. Hellhammer</name>
</author>
<author><name sortKey="Hellhammer, D H" sort="Hellhammer, D H" uniqKey="Hellhammer D" first="D H" last="Hellhammer">D H Hellhammer</name>
</author>
<author><name sortKey="Wolf, O T" sort="Wolf, O T" uniqKey="Wolf O" first="O T" last="Wolf">O T Wolf</name>
</author>
<author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K M" last="Pirke">K M Pirke</name>
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<author><name sortKey="Varadi, E" sort="Varadi, E" uniqKey="Varadi E" first="E" last="Varadi">E. Varadi</name>
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<series><title level="j">The Journal of clinical endocrinology and metabolism</title>
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<imprint><date when="1998" type="published">1998</date>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adrenocorticotropic Hormone (blood)</term>
<term>Aged</term>
<term>Dehydroepiandrosterone</term>
<term>Epinephrine (blood)</term>
<term>Female</term>
<term>Heart Rate</term>
<term>Humans</term>
<term>Hydrocortisone (blood)</term>
<term>Hydrocortisone (metabolism)</term>
<term>Kinetics</term>
<term>Male</term>
<term>Norepinephrine (blood)</term>
<term>Saliva (metabolism)</term>
<term>Sex Characteristics</term>
<term>Stress, Physiological (physiopathology)</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Adrenocorticotropic Hormone</term>
<term>Epinephrine</term>
<term>Hydrocortisone</term>
<term>Norepinephrine</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Hydrocortisone</term>
</keywords>
<keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Saliva</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Physiological</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Aged</term>
<term>Dehydroepiandrosterone</term>
<term>Female</term>
<term>Heart Rate</term>
<term>Humans</term>
<term>Kinetics</term>
<term>Male</term>
<term>Sex Characteristics</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Evidence from animal as well as human studies has suggested that significant sex differences exist in hypothalamus-pituitary-adrenal axis (HPA) activity. As gonadal steroids could be important modulators of HPA sex differences, stress responses were investigated in subjects of advanced age after dehydroepiandrosterone (DHEA) or placebo treatment. After a 2-week treatment with 50 mg DHEA daily or placebo, 75 men and women (mean age, 67.6 yr) were exposed to the Trier Social Stress Test (TSST). The TSST is a brief psychosocial stress that consists of a free speech and mental arithmetic task in front of an audience. The results show that the TSST induced significant increases in ACTH, salivary free cortisol, total plasma cortisol, norepinephrine, and heart rates (all P < 0.0001) as well as decreased positive affect in the elderly (P = 0.0009). Men showed larger stress responses in ACTH (P = 0.004), salivary free cortisol (P = 0.044), and plasma total cortisol (P = 0.076) compared to women. No sex differences were observed in norepinephrine, epinephrine, or heart rate responses. In contrast to ACTH and cortisol response differences, women reported that they were significantly more stressed by the TSST than men (P = 0.0051). Women treated with DHEA showed ACTH stress responses similar to those of men, but significantly enhanced compared to those of women taking placebos (P < 0.009). No other stress response differences emerged between DHEA and placebo groups. Finally, DHEA treatment did not result in an improvement of subjective well-being. We conclude that elderly men show larger HPA responses than women to psychosocial stress, as studied in the TSST. Estrogen effects on hypothalamic CRF-producing neurons might be responsible for these sex differences.</div>
</front>
</TEI>
</PubMed>
</double>
</record>
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