UnivTrevesV1, Main, Exploration, bibRecordById, PMC:3130089

Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging

Identifieur interne : 000B03 ( Main/Exploration ); précédent : 000B02; suivant : 000B04

Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging

Auteurs : Carol E. Franz [États-Unis] ; Robert C. O'Brien [États-Unis] ; Richard L. Hauger [États-Unis] ; Sally P. Mendoza [États-Unis] ; Matthew S. Panizzon [États-Unis] ; Elizabeth Prom-Wormley [États-Unis] ; Lindon J. Eaves [États-Unis] ; Kristen Jacobson [États-Unis] ; Michael J. Lyons [États-Unis] ; Sonia Lupien [Canada] ; Dirk Hellhammer [Allemagne] ; HONG XIAN [États-Unis] ; William S. Kremen [États-Unis]

Source :

Psychoneuroendocrinology [ 0306-4530 ] ; 2011.

RBID : Pascal:11-0360823

Descripteurs français

Pascal (Inist)
- Etude longitudinale, Hydrocortisone, Cognition, Etude familiale, Jumeau, Sénescence, Système hypothalamohypophysosurrénalien, Antiinflammatoire.

English descriptors

KwdEn :
- Antiinflammatory agent, Cognition, Family study, Follow up study, Hydrocortisone, Hypothalamohypophysoadrenal axis, Senescence, Twin.

Abstract

High levels of cortisol, a sign of potential hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes in older adults. Most cortisol research has focused on hippocampal-related abilities such as episodic memory; however, the presence of glucocorticoid receptors in the human prefrontal cortex suggests that cortisol regulation is likely to be associated with prefrontally-mediated executive function abilities. We hypothesized that elevated cortisol levels would be associated with poorer frontal-executive function in addition to episodic memory. We assessed cortisol from 15 saliva samples paralleling individual diurnal rhythms across three non-consecutive days in a group of 778 middle-aged twin men ages 51-60. Cognitive domains created from 24 standard measures included: general cognitive ability, verbal and visual-spatial ability, verbal and visual-spatial memory, short-term/immediate memory, working memory, executive function, verbal fluency, abstract reasoning, and psychomotor processing speed. Adjusting for general cognitive ability at age 20, age, race, and multiple health and lifestyle indicators, higher levels of average area-under-the-curve cortisol output across three days were significantly associated with poorer performance in three domains: executive (primarily set-shifting) measures, processing speed, and visual-spatial memory. In a 35-year longitudinal component of the study, we also found that general cognitive ability at age 20 was a significant predictor of midlife cortisol levels. These results possibly support the notion that glucocorticoid exposure is associated with cognitive functions that are mediated by frontal-striatal systems, and is not specific to hippocampal-dependent memory. The results also suggest that the direction of effect is complex.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130089

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging</title>
<author><name sortKey="Franz, Carol E" sort="Franz, Carol E" uniqKey="Franz C" first="Carol E." last="Franz">Carol E. Franz</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Brien, Robert C" sort="O Brien, Robert C" uniqKey="O Brien R" first="Robert C." last="O'Brien">Robert C. O'Brien</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>VA San Diego Healthcare System</s1>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mendoza, Sally P" sort="Mendoza, Sally P" uniqKey="Mendoza S" first="Sally P." last="Mendoza">Sally P. Mendoza</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>University of California Davis, California National Primate Research Center, 1 Shields Ave</s1>
<s2>Davis, CA 95616</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Panizzon, Matthew S" sort="Panizzon, Matthew S" uniqKey="Panizzon M" first="Matthew S." last="Panizzon">Matthew S. Panizzon</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prom Wormley, Elizabeth" sort="Prom Wormley, Elizabeth" uniqKey="Prom Wormley E" first="Elizabeth" last="Prom-Wormley">Elizabeth Prom-Wormley</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics</s1>
<s2>Richmond, VA 23298</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eaves, Lindon J" sort="Eaves, Lindon J" uniqKey="Eaves L" first="Lindon J." last="Eaves">Lindon J. Eaves</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics</s1>
<s2>Richmond, VA 23298</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jacobson, Kristen" sort="Jacobson, Kristen" uniqKey="Jacobson K" first="Kristen" last="Jacobson">Kristen Jacobson</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S. Maryland Ave</s1>
<s2>Chicago, IL 60637</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lyons, Michael J" sort="Lyons, Michael J" uniqKey="Lyons M" first="Michael J." last="Lyons">Michael J. Lyons</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Boston University, Department of Psychology, 648 Beacon St.</s1>
<s2>Boston, MA 02215</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lupien, Sonia" sort="Lupien, Sonia" uniqKey="Lupien S" first="Sonia" last="Lupien">Sonia Lupien</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>University of Montreal, Mental Health Research Centre Fernand Seguin, Hopital Louis-H Lafontaine</s1>
<s2>Montreal</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hellhammer, Dirk" sort="Hellhammer, Dirk" uniqKey="Hellhammer D" first="Dirk" last="Hellhammer">Dirk Hellhammer</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>University of Trier, Department of Psychobiology, Johanniterufer 15</s1>
<s2>Trier</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Trier</wicri:noRegion>
<wicri:noRegion>Johanniterufer 15</wicri:noRegion>
<wicri:noRegion>Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hong Xian" sort="Hong Xian" uniqKey="Hong Xian" last="Hong Xian">HONG XIAN</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Washington University, Department of Internal Medicine, 915 North Grand Blvd</s1>
<s2>St. Louis, MO 63106</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>VA San Diego Healthcare System</s1>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0360823</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0360823 INIST</idno>
<idno type="RBID">Pascal:11-0360823</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000398</idno>
<idno type="stanalyst">FRANCIS 11-0360823 INIST</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000480</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000951</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000317</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000317</idno>
<idno type="wicri:doubleKey">0306-4530:2011:Franz C:cross:sectional:and</idno>
<idno type="wicri:Area/Main/Merge">000B50</idno>
<idno type="wicri:source">PMC</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3130089</idno>
<idno type="RBID">PMC:3130089</idno>
<idno type="wicri:Area/Pmc/Corpus">000094</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000094</idno>
<idno type="wicri:Area/Pmc/Curation">000094</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000094</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000132</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000132</idno>
<idno type="wicri:Area/Ncbi/Merge">000452</idno>
<idno type="wicri:Area/Ncbi/Curation">000452</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000452</idno>
<idno type="wicri:doubleKey">0306-4530:2011:Franz C:cross:sectional:and</idno>
<idno type="wicri:Area/Main/Merge">000941</idno>
<idno type="wicri:Area/Main/Curation">000B03</idno>
<idno type="wicri:Area/Main/Exploration">000B03</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging</title>
<author><name sortKey="Franz, Carol E" sort="Franz, Carol E" uniqKey="Franz C" first="Carol E." last="Franz">Carol E. Franz</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="O Brien, Robert C" sort="O Brien, Robert C" uniqKey="O Brien R" first="Robert C." last="O'Brien">Robert C. O'Brien</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>VA San Diego Healthcare System</s1>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Mendoza, Sally P" sort="Mendoza, Sally P" uniqKey="Mendoza S" first="Sally P." last="Mendoza">Sally P. Mendoza</name>
<affiliation wicri:level="2"><inist:fA14 i1="03"><s1>University of California Davis, California National Primate Research Center, 1 Shields Ave</s1>
<s2>Davis, CA 95616</s2>
<s3>USA</s3>
<sZ>4 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Panizzon, Matthew S" sort="Panizzon, Matthew S" uniqKey="Panizzon M" first="Matthew S." last="Panizzon">Matthew S. Panizzon</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prom Wormley, Elizabeth" sort="Prom Wormley, Elizabeth" uniqKey="Prom Wormley E" first="Elizabeth" last="Prom-Wormley">Elizabeth Prom-Wormley</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics</s1>
<s2>Richmond, VA 23298</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eaves, Lindon J" sort="Eaves, Lindon J" uniqKey="Eaves L" first="Lindon J." last="Eaves">Lindon J. Eaves</name>
<affiliation wicri:level="2"><inist:fA14 i1="04"><s1>Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics</s1>
<s2>Richmond, VA 23298</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Jacobson, Kristen" sort="Jacobson, Kristen" uniqKey="Jacobson K" first="Kristen" last="Jacobson">Kristen Jacobson</name>
<affiliation wicri:level="2"><inist:fA14 i1="05"><s1>University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S. Maryland Ave</s1>
<s2>Chicago, IL 60637</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lyons, Michael J" sort="Lyons, Michael J" uniqKey="Lyons M" first="Michael J." last="Lyons">Michael J. Lyons</name>
<affiliation wicri:level="2"><inist:fA14 i1="06"><s1>Boston University, Department of Psychology, 648 Beacon St.</s1>
<s2>Boston, MA 02215</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lupien, Sonia" sort="Lupien, Sonia" uniqKey="Lupien S" first="Sonia" last="Lupien">Sonia Lupien</name>
<affiliation wicri:level="3"><inist:fA14 i1="07"><s1>University of Montreal, Mental Health Research Centre Fernand Seguin, Hopital Louis-H Lafontaine</s1>
<s2>Montreal</s2>
<s3>CAN</s3>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<placeName><settlement type="city">Montréal</settlement>
<region type="state">Québec</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hellhammer, Dirk" sort="Hellhammer, Dirk" uniqKey="Hellhammer D" first="Dirk" last="Hellhammer">Dirk Hellhammer</name>
<affiliation wicri:level="4"><inist:fA14 i1="08"><s1>University of Trier, Department of Psychobiology, Johanniterufer 15</s1>
<s2>Trier</s2>
<s3>DEU</s3>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Allemagne</country>
<wicri:noRegion>Trier</wicri:noRegion>
<wicri:noRegion>Johanniterufer 15</wicri:noRegion>
<wicri:noRegion>Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hong Xian" sort="Hong Xian" uniqKey="Hong Xian" last="Hong Xian">HONG XIAN</name>
<affiliation wicri:level="2"><inist:fA14 i1="09"><s1>Washington University, Department of Internal Medicine, 915 North Grand Blvd</s1>
<s2>St. Louis, MO 63106</s2>
<s3>USA</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Missouri (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name>
<affiliation wicri:level="2"><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1>
<s2>La Jolla, CA 92093</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
<affiliation wicri:level="2"><inist:fA14 i1="02"><s1>VA San Diego Healthcare System</s1>
<s3>USA</s3>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<placeName><region type="state">Virginie</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Psychoneuroendocrinology</title>
<title level="j" type="abbreviated">Psychoneuroendocrinology</title>
<idno type="ISSN">0306-4530</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Psychoneuroendocrinology</title>
<title level="j" type="abbreviated">Psychoneuroendocrinology</title>
<idno type="ISSN">0306-4530</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiinflammatory agent</term>
<term>Cognition</term>
<term>Family study</term>
<term>Follow up study</term>
<term>Hydrocortisone</term>
<term>Hypothalamohypophysoadrenal axis</term>
<term>Senescence</term>
<term>Twin</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Etude longitudinale</term>
<term>Hydrocortisone</term>
<term>Cognition</term>
<term>Etude familiale</term>
<term>Jumeau</term>
<term>Sénescence</term>
<term>Système hypothalamohypophysosurrénalien</term>
<term>Antiinflammatoire</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">High levels of cortisol, a sign of potential hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes in older adults. Most cortisol research has focused on hippocampal-related abilities such as episodic memory; however, the presence of glucocorticoid receptors in the human prefrontal cortex suggests that cortisol regulation is likely to be associated with prefrontally-mediated executive function abilities. We hypothesized that elevated cortisol levels would be associated with poorer frontal-executive function in addition to episodic memory. We assessed cortisol from 15 saliva samples paralleling individual diurnal rhythms across three non-consecutive days in a group of 778 middle-aged twin men ages 51-60. Cognitive domains created from 24 standard measures included: general cognitive ability, verbal and visual-spatial ability, verbal and visual-spatial memory, short-term/immediate memory, working memory, executive function, verbal fluency, abstract reasoning, and psychomotor processing speed. Adjusting for general cognitive ability at age 20, age, race, and multiple health and lifestyle indicators, higher levels of average area-under-the-curve cortisol output across three days were significantly associated with poorer performance in three domains: executive (primarily set-shifting) measures, processing speed, and visual-spatial memory. In a 35-year longitudinal component of the study, we also found that general cognitive ability at age 20 was a significant predictor of midlife cortisol levels. These results possibly support the notion that glucocorticoid exposure is associated with cognitive functions that are mediated by frontal-striatal systems, and is not specific to hippocampal-dependent memory. The results also suggest that the direction of effect is complex.</div>
</front>
</TEI>
<affiliations><list><country><li>Allemagne</li>
<li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Illinois</li>
<li>Massachusetts</li>
<li>Missouri (État)</li>
<li>Québec</li>
<li>Rhénanie-Palatinat</li>
<li>Virginie</li>
</region>
<settlement><li>Montréal</li>
<li>Trèves (Allemagne)</li>
</settlement>
<orgName><li>Université de Trèves</li>
</orgName>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Franz, Carol E" sort="Franz, Carol E" uniqKey="Franz C" first="Carol E." last="Franz">Carol E. Franz</name>
</region>
<name sortKey="Eaves, Lindon J" sort="Eaves, Lindon J" uniqKey="Eaves L" first="Lindon J." last="Eaves">Lindon J. Eaves</name>
<name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name>
<name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name>
<name sortKey="Hong Xian" sort="Hong Xian" uniqKey="Hong Xian" last="Hong Xian">HONG XIAN</name>
<name sortKey="Jacobson, Kristen" sort="Jacobson, Kristen" uniqKey="Jacobson K" first="Kristen" last="Jacobson">Kristen Jacobson</name>
<name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name>
<name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name>
<name sortKey="Lyons, Michael J" sort="Lyons, Michael J" uniqKey="Lyons M" first="Michael J." last="Lyons">Michael J. Lyons</name>
<name sortKey="Mendoza, Sally P" sort="Mendoza, Sally P" uniqKey="Mendoza S" first="Sally P." last="Mendoza">Sally P. Mendoza</name>
<name sortKey="O Brien, Robert C" sort="O Brien, Robert C" uniqKey="O Brien R" first="Robert C." last="O'Brien">Robert C. O'Brien</name>
<name sortKey="Panizzon, Matthew S" sort="Panizzon, Matthew S" uniqKey="Panizzon M" first="Matthew S." last="Panizzon">Matthew S. Panizzon</name>
<name sortKey="Prom Wormley, Elizabeth" sort="Prom Wormley, Elizabeth" uniqKey="Prom Wormley E" first="Elizabeth" last="Prom-Wormley">Elizabeth Prom-Wormley</name>
</country>
<country name="Canada"><region name="Québec"><name sortKey="Lupien, Sonia" sort="Lupien, Sonia" uniqKey="Lupien S" first="Sonia" last="Lupien">Sonia Lupien</name>
</region>
</country>
<country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Hellhammer, Dirk" sort="Hellhammer, Dirk" uniqKey="Hellhammer D" first="Dirk" last="Hellhammer">Dirk Hellhammer</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B03 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000B03 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Rhénanie
   |area=    UnivTrevesV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:11-0360823
   |texte=   Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging
}}

This area was generated with Dilib version V0.6.31.
Data generation: Sat Jul 22 16:29:01 2017. Site generation: Wed Feb 28 14:55:37 2024

Serveur d'exploration sur l'Université de Trèves

Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging

Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

	Serveur d'exploration sur l'Université de Trèves
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.