Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging
Identifieur interne : 000398 ( PascalFrancis/Corpus ); précédent : 000397; suivant : 000399Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging
Auteurs : Carol E. Franz ; Robert C. O'Brien ; Richard L. Hauger ; Sally P. Mendoza ; Matthew S. Panizzon ; Elizabeth Prom-Wormley ; Lindon J. Eaves ; Kristen Jacobson ; Michael J. Lyons ; Sonia Lupien ; Dirk Hellhammer ; HONG XIAN ; William S. KremenSource :
- Psychoneuroendocrinology [ 0306-4530 ] ; 2011.
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- Pascal (Inist)
English descriptors
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Abstract
High levels of cortisol, a sign of potential hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes in older adults. Most cortisol research has focused on hippocampal-related abilities such as episodic memory; however, the presence of glucocorticoid receptors in the human prefrontal cortex suggests that cortisol regulation is likely to be associated with prefrontally-mediated executive function abilities. We hypothesized that elevated cortisol levels would be associated with poorer frontal-executive function in addition to episodic memory. We assessed cortisol from 15 saliva samples paralleling individual diurnal rhythms across three non-consecutive days in a group of 778 middle-aged twin men ages 51-60. Cognitive domains created from 24 standard measures included: general cognitive ability, verbal and visual-spatial ability, verbal and visual-spatial memory, short-term/immediate memory, working memory, executive function, verbal fluency, abstract reasoning, and psychomotor processing speed. Adjusting for general cognitive ability at age 20, age, race, and multiple health and lifestyle indicators, higher levels of average area-under-the-curve cortisol output across three days were significantly associated with poorer performance in three domains: executive (primarily set-shifting) measures, processing speed, and visual-spatial memory. In a 35-year longitudinal component of the study, we also found that general cognitive ability at age 20 was a significant predictor of midlife cortisol levels. These results possibly support the notion that glucocorticoid exposure is associated with cognitive functions that are mediated by frontal-striatal systems, and is not specific to hippocampal-dependent memory. The results also suggest that the direction of effect is complex.
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Format Inist (serveur)
| NO : | PASCAL 11-0360823 INIST |
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| ET : | Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging |
| AU : | FRANZ (Carol E.); O'BRIEN (Robert C.); HAUGER (Richard L.); MENDOZA (Sally P.); PANIZZON (Matthew S.); PROM-WORMLEY (Elizabeth); EAVES (Lindon J.); JACOBSON (Kristen); LYONS (Michael J.); LUPIEN (Sonia); HELLHAMMER (Dirk); HONG XIAN; KREMEN (William S.) |
| AF : | University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738/La Jolla, CA 92093/Etats-Unis (1 aut., 2 aut., 3 aut., 5 aut., 13 aut.); VA San Diego Healthcare System/Etats-Unis (3 aut., 13 aut.); University of California Davis, California National Primate Research Center, 1 Shields Ave/Davis, CA 95616/Etats-Unis (4 aut.); Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics/Richmond, VA 23298/Etats-Unis (6 aut., 7 aut.); University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S. Maryland Ave/Chicago, IL 60637/Etats-Unis (8 aut.); Boston University, Department of Psychology, 648 Beacon St./Boston, MA 02215/Etats-Unis (9 aut.); University of Montreal, Mental Health Research Centre Fernand Seguin, Hopital Louis-H Lafontaine/Montreal/Canada (10 aut.); University of Trier, Department of Psychobiology, Johanniterufer 15/Trier/Allemagne (11 aut.); Washington University, Department of Internal Medicine, 915 North Grand Blvd/St. Louis, MO 63106/Etats-Unis (12 aut.) |
| DT : | Publication en série; Niveau analytique |
| SO : | Psychoneuroendocrinology; ISSN 0306-4530; Coden PSYCDE; Royaume-Uni; Da. 2011; Vol. 36; No. 7; Pp. 1040-1052; Bibl. 2 p. |
| LA : | Anglais |
| EA : | High levels of cortisol, a sign of potential hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes in older adults. Most cortisol research has focused on hippocampal-related abilities such as episodic memory; however, the presence of glucocorticoid receptors in the human prefrontal cortex suggests that cortisol regulation is likely to be associated with prefrontally-mediated executive function abilities. We hypothesized that elevated cortisol levels would be associated with poorer frontal-executive function in addition to episodic memory. We assessed cortisol from 15 saliva samples paralleling individual diurnal rhythms across three non-consecutive days in a group of 778 middle-aged twin men ages 51-60. Cognitive domains created from 24 standard measures included: general cognitive ability, verbal and visual-spatial ability, verbal and visual-spatial memory, short-term/immediate memory, working memory, executive function, verbal fluency, abstract reasoning, and psychomotor processing speed. Adjusting for general cognitive ability at age 20, age, race, and multiple health and lifestyle indicators, higher levels of average area-under-the-curve cortisol output across three days were significantly associated with poorer performance in three domains: executive (primarily set-shifting) measures, processing speed, and visual-spatial memory. In a 35-year longitudinal component of the study, we also found that general cognitive ability at age 20 was a significant predictor of midlife cortisol levels. These results possibly support the notion that glucocorticoid exposure is associated with cognitive functions that are mediated by frontal-striatal systems, and is not specific to hippocampal-dependent memory. The results also suggest that the direction of effect is complex. |
| CC : | 002A26C03 |
| FD : | Etude longitudinale; Hydrocortisone; Cognition; Etude familiale; Jumeau; Sénescence; Système hypothalamohypophysosurrénalien; Antiinflammatoire |
| FG : | Glucocorticoïde; Hormone surrénalienne; Corticostéroïde; Hormone stéroïde |
| ED : | Follow up study; Hydrocortisone; Cognition; Family study; Twin; Senescence; Hypothalamohypophysoadrenal axis; Antiinflammatory agent |
| EG : | Glucocorticoid; Adrenal hormone; Corticosteroid; Steroid hormone |
| SD : | Estudio longitudinal; Hidrocortisona; Cognición; Estudio familiar; Gemelo; Senescencia; Sistema hipotalamohipofisosuprarrenal; Antiinflamatorio |
| LO : | INIST-17200.354000508582410110 |
| ID : | 11-0360823 |
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Kremen</name><affiliation><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1><s2>La Jolla, CA 92093</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>VA San Diego Healthcare System</s1><s3>USA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0360823</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0360823 INIST</idno><idno type="RBID">Pascal:11-0360823</idno><idno type="wicri:Area/PascalFrancis/Corpus">000398</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging</title><author><name sortKey="Franz, Carol E" sort="Franz, Carol E" uniqKey="Franz C" first="Carol E." last="Franz">Carol E. Franz</name><affiliation><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1><s2>La Jolla, CA 92093</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="O Brien, Robert C" sort="O Brien, Robert C" uniqKey="O Brien R" first="Robert C." last="O'Brien">Robert C. O'Brien</name><affiliation><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1><s2>La Jolla, CA 92093</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hauger, Richard L" sort="Hauger, Richard L" uniqKey="Hauger R" first="Richard L." last="Hauger">Richard L. Hauger</name><affiliation><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1><s2>La Jolla, CA 92093</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>VA San Diego Healthcare System</s1><s3>USA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Mendoza, Sally P" sort="Mendoza, Sally P" uniqKey="Mendoza S" first="Sally P." last="Mendoza">Sally P. Mendoza</name><affiliation><inist:fA14 i1="03"><s1>University of California Davis, California National Primate Research Center, 1 Shields Ave</s1><s2>Davis, CA 95616</s2><s3>USA</s3><sZ>4 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Panizzon, Matthew S" sort="Panizzon, Matthew S" uniqKey="Panizzon M" first="Matthew S." last="Panizzon">Matthew S. Panizzon</name><affiliation><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1><s2>La Jolla, CA 92093</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Prom Wormley, Elizabeth" sort="Prom Wormley, Elizabeth" uniqKey="Prom Wormley E" first="Elizabeth" last="Prom-Wormley">Elizabeth Prom-Wormley</name><affiliation><inist:fA14 i1="04"><s1>Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics</s1><s2>Richmond, VA 23298</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Eaves, Lindon J" sort="Eaves, Lindon J" uniqKey="Eaves L" first="Lindon J." last="Eaves">Lindon J. Eaves</name><affiliation><inist:fA14 i1="04"><s1>Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics</s1><s2>Richmond, VA 23298</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Jacobson, Kristen" sort="Jacobson, Kristen" uniqKey="Jacobson K" first="Kristen" last="Jacobson">Kristen Jacobson</name><affiliation><inist:fA14 i1="05"><s1>University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S. Maryland Ave</s1><s2>Chicago, IL 60637</s2><s3>USA</s3><sZ>8 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lyons, Michael J" sort="Lyons, Michael J" uniqKey="Lyons M" first="Michael J." last="Lyons">Michael J. Lyons</name><affiliation><inist:fA14 i1="06"><s1>Boston University, Department of Psychology, 648 Beacon St.</s1><s2>Boston, MA 02215</s2><s3>USA</s3><sZ>9 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Lupien, Sonia" sort="Lupien, Sonia" uniqKey="Lupien S" first="Sonia" last="Lupien">Sonia Lupien</name><affiliation><inist:fA14 i1="07"><s1>University of Montreal, Mental Health Research Centre Fernand Seguin, Hopital Louis-H Lafontaine</s1><s2>Montreal</s2><s3>CAN</s3><sZ>10 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hellhammer, Dirk" sort="Hellhammer, Dirk" uniqKey="Hellhammer D" first="Dirk" last="Hellhammer">Dirk Hellhammer</name><affiliation><inist:fA14 i1="08"><s1>University of Trier, Department of Psychobiology, Johanniterufer 15</s1><s2>Trier</s2><s3>DEU</s3><sZ>11 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Hong Xian" sort="Hong Xian" uniqKey="Hong Xian" last="Hong Xian">HONG XIAN</name><affiliation><inist:fA14 i1="09"><s1>Washington University, Department of Internal Medicine, 915 North Grand Blvd</s1><s2>St. Louis, MO 63106</s2><s3>USA</s3><sZ>12 aut.</sZ></inist:fA14></affiliation></author><author><name sortKey="Kremen, William S" sort="Kremen, William S" uniqKey="Kremen W" first="William S." last="Kremen">William S. Kremen</name><affiliation><inist:fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1><s2>La Jolla, CA 92093</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation><affiliation><inist:fA14 i1="02"><s1>VA San Diego Healthcare System</s1><s3>USA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></inist:fA14></affiliation></author></analytic><series><title level="j" type="main">Psychoneuroendocrinology</title><title level="j" type="abbreviated">Psychoneuroendocrinology</title><idno type="ISSN">0306-4530</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Psychoneuroendocrinology</title><title level="j" type="abbreviated">Psychoneuroendocrinology</title><idno type="ISSN">0306-4530</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Antiinflammatory agent</term><term>Cognition</term><term>Family study</term><term>Follow up study</term><term>Hydrocortisone</term><term>Hypothalamohypophysoadrenal axis</term><term>Senescence</term><term>Twin</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Etude longitudinale</term><term>Hydrocortisone</term><term>Cognition</term><term>Etude familiale</term><term>Jumeau</term><term>Sénescence</term><term>Système hypothalamohypophysosurrénalien</term><term>Antiinflammatoire</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">High levels of cortisol, a sign of potential hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes in older adults. Most cortisol research has focused on hippocampal-related abilities such as episodic memory; however, the presence of glucocorticoid receptors in the human prefrontal cortex suggests that cortisol regulation is likely to be associated with prefrontally-mediated executive function abilities. We hypothesized that elevated cortisol levels would be associated with poorer frontal-executive function in addition to episodic memory. We assessed cortisol from 15 saliva samples paralleling individual diurnal rhythms across three non-consecutive days in a group of 778 middle-aged twin men ages 51-60. Cognitive domains created from 24 standard measures included: general cognitive ability, verbal and visual-spatial ability, verbal and visual-spatial memory, short-term/immediate memory, working memory, executive function, verbal fluency, abstract reasoning, and psychomotor processing speed. Adjusting for general cognitive ability at age 20, age, race, and multiple health and lifestyle indicators, higher levels of average area-under-the-curve cortisol output across three days were significantly associated with poorer performance in three domains: executive (primarily set-shifting) measures, processing speed, and visual-spatial memory. In a 35-year longitudinal component of the study, we also found that general cognitive ability at age 20 was a significant predictor of midlife cortisol levels. These results possibly support the notion that glucocorticoid exposure is associated with cognitive functions that are mediated by frontal-striatal systems, and is not specific to hippocampal-dependent memory. The results also suggest that the direction of effect is complex.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0306-4530</s0></fA01><fA02 i1="01"><s0>PSYCDE</s0></fA02><fA03 i2="1"><s0>Psychoneuroendocrinology</s0></fA03><fA05><s2>36</s2></fA05><fA06><s2>7</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging</s1></fA08><fA11 i1="01" i2="1"><s1>FRANZ (Carol E.)</s1></fA11><fA11 i1="02" i2="1"><s1>O'BRIEN (Robert C.)</s1></fA11><fA11 i1="03" i2="1"><s1>HAUGER (Richard L.)</s1></fA11><fA11 i1="04" i2="1"><s1>MENDOZA (Sally P.)</s1></fA11><fA11 i1="05" i2="1"><s1>PANIZZON (Matthew S.)</s1></fA11><fA11 i1="06" i2="1"><s1>PROM-WORMLEY (Elizabeth)</s1></fA11><fA11 i1="07" i2="1"><s1>EAVES (Lindon J.)</s1></fA11><fA11 i1="08" i2="1"><s1>JACOBSON (Kristen)</s1></fA11><fA11 i1="09" i2="1"><s1>LYONS (Michael J.)</s1></fA11><fA11 i1="10" i2="1"><s1>LUPIEN (Sonia)</s1></fA11><fA11 i1="11" i2="1"><s1>HELLHAMMER (Dirk)</s1></fA11><fA11 i1="12" i2="1"><s1>HONG XIAN</s1></fA11><fA11 i1="13" i2="1"><s1>KREMEN (William S.)</s1></fA11><fA14 i1="01"><s1>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738</s1><s2>La Jolla, CA 92093</s2><s3>USA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>3 aut.</sZ><sZ>5 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="02"><s1>VA San Diego Healthcare System</s1><s3>USA</s3><sZ>3 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="03"><s1>University of California Davis, California National Primate Research Center, 1 Shields Ave</s1><s2>Davis, CA 95616</s2><s3>USA</s3><sZ>4 aut.</sZ></fA14><fA14 i1="04"><s1>Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics</s1><s2>Richmond, VA 23298</s2><s3>USA</s3><sZ>6 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="05"><s1>University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S. Maryland Ave</s1><s2>Chicago, IL 60637</s2><s3>USA</s3><sZ>8 aut.</sZ></fA14><fA14 i1="06"><s1>Boston University, Department of Psychology, 648 Beacon St.</s1><s2>Boston, MA 02215</s2><s3>USA</s3><sZ>9 aut.</sZ></fA14><fA14 i1="07"><s1>University of Montreal, Mental Health Research Centre Fernand Seguin, Hopital Louis-H Lafontaine</s1><s2>Montreal</s2><s3>CAN</s3><sZ>10 aut.</sZ></fA14><fA14 i1="08"><s1>University of Trier, Department of Psychobiology, Johanniterufer 15</s1><s2>Trier</s2><s3>DEU</s3><sZ>11 aut.</sZ></fA14><fA14 i1="09"><s1>Washington University, Department of Internal Medicine, 915 North Grand Blvd</s1><s2>St. Louis, MO 63106</s2><s3>USA</s3><sZ>12 aut.</sZ></fA14><fA20><s1>1040-1052</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>17200</s2><s5>354000508582410110</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>2 p.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0360823</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>Psychoneuroendocrinology</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>High levels of cortisol, a sign of potential hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes in older adults. Most cortisol research has focused on hippocampal-related abilities such as episodic memory; however, the presence of glucocorticoid receptors in the human prefrontal cortex suggests that cortisol regulation is likely to be associated with prefrontally-mediated executive function abilities. We hypothesized that elevated cortisol levels would be associated with poorer frontal-executive function in addition to episodic memory. We assessed cortisol from 15 saliva samples paralleling individual diurnal rhythms across three non-consecutive days in a group of 778 middle-aged twin men ages 51-60. Cognitive domains created from 24 standard measures included: general cognitive ability, verbal and visual-spatial ability, verbal and visual-spatial memory, short-term/immediate memory, working memory, executive function, verbal fluency, abstract reasoning, and psychomotor processing speed. Adjusting for general cognitive ability at age 20, age, race, and multiple health and lifestyle indicators, higher levels of average area-under-the-curve cortisol output across three days were significantly associated with poorer performance in three domains: executive (primarily set-shifting) measures, processing speed, and visual-spatial memory. In a 35-year longitudinal component of the study, we also found that general cognitive ability at age 20 was a significant predictor of midlife cortisol levels. These results possibly support the notion that glucocorticoid exposure is associated with cognitive functions that are mediated by frontal-striatal systems, and is not specific to hippocampal-dependent memory. The results also suggest that the direction of effect is complex.</s0></fC01><fC02 i1="01" i2="X"><s0>002A26C03</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Etude longitudinale</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Follow up study</s0><s5>01</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Estudio longitudinal</s0><s5>01</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Hydrocortisone</s0><s2>NK</s2><s2>FR</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Hydrocortisone</s0><s2>NK</s2><s2>FR</s2><s5>02</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Hidrocortisona</s0><s2>NK</s2><s2>FR</s2><s5>02</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Cognition</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Cognition</s0><s5>03</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Cognición</s0><s5>03</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Etude familiale</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Family study</s0><s5>04</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Estudio familiar</s0><s5>04</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Jumeau</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Twin</s0><s5>05</s5></fC03><fC03 i1="05" i2="X" l="SPA"><s0>Gemelo</s0><s5>05</s5></fC03><fC03 i1="06" i2="X" l="FRE"><s0>Sénescence</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="ENG"><s0>Senescence</s0><s5>06</s5></fC03><fC03 i1="06" i2="X" l="SPA"><s0>Senescencia</s0><s5>06</s5></fC03><fC03 i1="07" i2="X" l="FRE"><s0>Système hypothalamohypophysosurrénalien</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="ENG"><s0>Hypothalamohypophysoadrenal axis</s0><s5>07</s5></fC03><fC03 i1="07" i2="X" l="SPA"><s0>Sistema hipotalamohipofisosuprarrenal</s0><s5>07</s5></fC03><fC03 i1="08" i2="X" l="FRE"><s0>Antiinflammatoire</s0><s5>31</s5></fC03><fC03 i1="08" i2="X" l="ENG"><s0>Antiinflammatory agent</s0><s5>31</s5></fC03><fC03 i1="08" i2="X" l="SPA"><s0>Antiinflamatorio</s0><s5>31</s5></fC03><fC07 i1="01" i2="X" l="FRE"><s0>Glucocorticoïde</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="ENG"><s0>Glucocorticoid</s0><s5>37</s5></fC07><fC07 i1="01" i2="X" l="SPA"><s0>Glucocorticoide</s0><s5>37</s5></fC07><fC07 i1="02" i2="X" l="FRE"><s0>Hormone surrénalienne</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="ENG"><s0>Adrenal hormone</s0><s5>38</s5></fC07><fC07 i1="02" i2="X" l="SPA"><s0>Hormona suprarrenal</s0><s5>38</s5></fC07><fC07 i1="03" i2="X" l="FRE"><s0>Corticostéroïde</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="ENG"><s0>Corticosteroid</s0><s5>39</s5></fC07><fC07 i1="03" i2="X" l="SPA"><s0>Corticoesteroide</s0><s5>39</s5></fC07><fC07 i1="04" i2="X" l="FRE"><s0>Hormone stéroïde</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="ENG"><s0>Steroid hormone</s0><s5>40</s5></fC07><fC07 i1="04" i2="X" l="SPA"><s0>Hormona esteroide</s0><s5>40</s5></fC07><fN21><s1>249</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard><server><NO>PASCAL 11-0360823 INIST</NO><ET>Cross-sectional and 35-year longitudinal assessment of salivary cortisol and cognitive functioning: The Vietnam Era Twin Study of Aging</ET><AU>FRANZ (Carol E.); O'BRIEN (Robert C.); HAUGER (Richard L.); MENDOZA (Sally P.); PANIZZON (Matthew S.); PROM-WORMLEY (Elizabeth); EAVES (Lindon J.); JACOBSON (Kristen); LYONS (Michael J.); LUPIEN (Sonia); HELLHAMMER (Dirk); HONG XIAN; KREMEN (William S.)</AU><AF>University of California San Diego, Department of Psychiatry, 9500 Gilman Drive, MC0738/La Jolla, CA 92093/Etats-Unis (1 aut., 2 aut., 3 aut., 5 aut., 13 aut.); VA San Diego Healthcare System/Etats-Unis (3 aut., 13 aut.); University of California Davis, California National Primate Research Center, 1 Shields Ave/Davis, CA 95616/Etats-Unis (4 aut.); Virginia Commonwealth University, Virginia Institute for Psychiatric and Behavioral Genetics/Richmond, VA 23298/Etats-Unis (6 aut., 7 aut.); University of Chicago, Department of Psychiatry and Behavioral Neuroscience, 5841 S. Maryland Ave/Chicago, IL 60637/Etats-Unis (8 aut.); Boston University, Department of Psychology, 648 Beacon St./Boston, MA 02215/Etats-Unis (9 aut.); University of Montreal, Mental Health Research Centre Fernand Seguin, Hopital Louis-H Lafontaine/Montreal/Canada (10 aut.); University of Trier, Department of Psychobiology, Johanniterufer 15/Trier/Allemagne (11 aut.); Washington University, Department of Internal Medicine, 915 North Grand Blvd/St. Louis, MO 63106/Etats-Unis (12 aut.)</AF><DT>Publication en série; Niveau analytique</DT><SO>Psychoneuroendocrinology; ISSN 0306-4530; Coden PSYCDE; Royaume-Uni; Da. 2011; Vol. 36; No. 7; Pp. 1040-1052; Bibl. 2 p.</SO><LA>Anglais</LA><EA>High levels of cortisol, a sign of potential hypothalamic-pituitary-adrenal (HPA) axis dysregulation, have been associated with poor cognitive outcomes in older adults. Most cortisol research has focused on hippocampal-related abilities such as episodic memory; however, the presence of glucocorticoid receptors in the human prefrontal cortex suggests that cortisol regulation is likely to be associated with prefrontally-mediated executive function abilities. We hypothesized that elevated cortisol levels would be associated with poorer frontal-executive function in addition to episodic memory. We assessed cortisol from 15 saliva samples paralleling individual diurnal rhythms across three non-consecutive days in a group of 778 middle-aged twin men ages 51-60. Cognitive domains created from 24 standard measures included: general cognitive ability, verbal and visual-spatial ability, verbal and visual-spatial memory, short-term/immediate memory, working memory, executive function, verbal fluency, abstract reasoning, and psychomotor processing speed. Adjusting for general cognitive ability at age 20, age, race, and multiple health and lifestyle indicators, higher levels of average area-under-the-curve cortisol output across three days were significantly associated with poorer performance in three domains: executive (primarily set-shifting) measures, processing speed, and visual-spatial memory. In a 35-year longitudinal component of the study, we also found that general cognitive ability at age 20 was a significant predictor of midlife cortisol levels. These results possibly support the notion that glucocorticoid exposure is associated with cognitive functions that are mediated by frontal-striatal systems, and is not specific to hippocampal-dependent memory. The results also suggest that the direction of effect is complex.</EA><CC>002A26C03</CC><FD>Etude longitudinale; Hydrocortisone; Cognition; Etude familiale; Jumeau; Sénescence; Système hypothalamohypophysosurrénalien; Antiinflammatoire</FD><FG>Glucocorticoïde; Hormone surrénalienne; Corticostéroïde; Hormone stéroïde</FG><ED>Follow up study; Hydrocortisone; Cognition; Family study; Twin; Senescence; Hypothalamohypophysoadrenal axis; Antiinflammatory agent</ED><EG>Glucocorticoid; Adrenal hormone; Corticosteroid; Steroid hormone</EG><SD>Estudio longitudinal; Hidrocortisona; Cognición; Estudio familiar; Gemelo; Senescencia; Sistema hipotalamohipofisosuprarrenal; Antiinflamatorio</SD><LO>INIST-17200.354000508582410110</LO><ID>11-0360823</ID></server></inist></record>Pour manipuler ce document sous Unix (Dilib)
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