Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
Identifieur interne : 001084 ( Main/Exploration ); précédent : 001083; suivant : 001085Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
Auteurs : M. Coburn [Allemagne] ; O. Kunitz [Allemagne] ; C. C. Apfel [États-Unis] ; M. Hein [Allemagne] ; M. Fries [Allemagne] ; R. Rossaint [Allemagne]Source :
- British Journal of Anaesthesia [ 0007-0912 ] ; 2008-06.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P<0.001 and P<0.021). Conclusion Despite knowing the 5-HT3 antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.
Url:
DOI: 10.1093/bja/aen077
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001841
- to stream Istex, to step Curation: 001725
- to stream Istex, to step Checkpoint: 000497
- to stream Main, to step Merge: 001185
- to stream PascalFrancis, to step Corpus: 000828
- to stream PascalFrancis, to step Curation: 000609
- to stream PascalFrancis, to step Checkpoint: 000615
- to stream Main, to step Merge: 001328
- to stream Main, to step Curation: 001084
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia</title><author><name sortKey="Coburn, M" sort="Coburn, M" uniqKey="Coburn M" first="M." last="Coburn">M. Coburn</name></author><author><name sortKey="Kunitz, O" sort="Kunitz, O" uniqKey="Kunitz O" first="O." last="Kunitz">O. Kunitz</name></author><author><name sortKey="Apfel, C C" sort="Apfel, C C" uniqKey="Apfel C" first="C. C." last="Apfel">C. C. Apfel</name></author><author><name sortKey="Hein, M" sort="Hein, M" uniqKey="Hein M" first="M." last="Hein">M. Hein</name></author><author><name sortKey="Fries, M" sort="Fries, M" uniqKey="Fries M" first="M." last="Fries">M. Fries</name></author><author><name sortKey="Rossaint, R" sort="Rossaint, R" uniqKey="Rossaint R" first="R." last="Rossaint">R. Rossaint</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F962B1DF9EA9DF7E2865CC8DA44771B993696118</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1093/bja/aen077</idno><idno type="url">https://api.istex.fr/document/F962B1DF9EA9DF7E2865CC8DA44771B993696118/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001841</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001841</idno><idno type="wicri:Area/Istex/Curation">001725</idno><idno type="wicri:Area/Istex/Checkpoint">000497</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000497</idno><idno type="wicri:doubleKey">0007-0912:2008:Coburn M:incidence:of:postoperative</idno><idno type="wicri:Area/Main/Merge">001185</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:08-0281710</idno><idno type="wicri:Area/PascalFrancis/Corpus">000828</idno><idno type="wicri:Area/PascalFrancis/Curation">000609</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000615</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000615</idno><idno type="wicri:doubleKey">0007-0912:2008:Coburn M:incidence:of:postoperative</idno><idno type="wicri:Area/Main/Merge">001328</idno><idno type="wicri:Area/Main/Curation">001084</idno><idno type="wicri:Area/Main/Exploration">001084</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia</title><author><name sortKey="Coburn, M" sort="Coburn, M" uniqKey="Coburn M" first="M." last="Coburn">M. Coburn</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation></author><author><name sortKey="Kunitz, O" sort="Kunitz, O" uniqKey="Kunitz O" first="O." last="Kunitz">O. Kunitz</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anaesthesia and Intensive Care Medicine, Mutterhaus der Borromerinnen Medical Centre, Trier</wicri:regionArea><wicri:noRegion>Trier</wicri:noRegion><wicri:noRegion>Trier</wicri:noRegion></affiliation></author><author><name sortKey="Apfel, C C" sort="Apfel, C C" uniqKey="Apfel C" first="C. C." last="Apfel">C. C. Apfel</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Hein, M" sort="Hein, M" uniqKey="Hein M" first="M." last="Hein">M. Hein</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Fries, M" sort="Fries, M" uniqKey="Fries M" first="M." last="Fries">M. Fries</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author><author><name sortKey="Rossaint, R" sort="Rossaint, R" uniqKey="Rossaint R" first="R." last="Rossaint">R. Rossaint</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Cologne</region><settlement type="city">Aix-la-Chapelle</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">British Journal of Anaesthesia</title><title level="j" type="abbrev">Br J Anaesth</title><idno type="ISSN">0007-0912</idno><idno type="eISSN">1471-6771</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-06">2008-06</date><biblScope unit="volume">100</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="787">787</biblScope><biblScope unit="page" to="791">791</biblScope></imprint><idno type="ISSN">0007-0912</idno></series><idno type="istex">F962B1DF9EA9DF7E2865CC8DA44771B993696118</idno><idno type="DOI">10.1093/bja/aen077</idno><idno type="ArticleID">aen077</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-0912</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Anesthesia</term><term>Emetic</term><term>General anesthetic</term><term>Incidence</term><term>Nausea</term><term>Postoperative</term><term>Propofol</term><term>Vomiting</term><term>Xenon</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anesthésie</term><term>Anesthésique général</term><term>Emétique</term><term>Incidence</term><term>Nausée</term><term>Postopératoire</term><term>Propofol</term><term>Vomissement</term><term>Xénon</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P<0.001 and P<0.021). Conclusion Despite knowing the 5-HT3 antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>États-Unis</li></country><region><li>Californie</li><li>District de Cologne</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Aix-la-Chapelle</li></settlement></list><tree><country name="Allemagne"><region name="Rhénanie-du-Nord-Westphalie"><name sortKey="Coburn, M" sort="Coburn, M" uniqKey="Coburn M" first="M." last="Coburn">M. Coburn</name></region><name sortKey="Coburn, M" sort="Coburn, M" uniqKey="Coburn M" first="M." last="Coburn">M. Coburn</name><name sortKey="Fries, M" sort="Fries, M" uniqKey="Fries M" first="M." last="Fries">M. Fries</name><name sortKey="Hein, M" sort="Hein, M" uniqKey="Hein M" first="M." last="Hein">M. Hein</name><name sortKey="Kunitz, O" sort="Kunitz, O" uniqKey="Kunitz O" first="O." last="Kunitz">O. Kunitz</name><name sortKey="Rossaint, R" sort="Rossaint, R" uniqKey="Rossaint R" first="R." last="Rossaint">R. Rossaint</name></country><country name="États-Unis"><region name="Californie"><name sortKey="Apfel, C C" sort="Apfel, C C" uniqKey="Apfel C" first="C. C." last="Apfel">C. C. Apfel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001084 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001084 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:F962B1DF9EA9DF7E2865CC8DA44771B993696118
|texte= Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
}}
| This area was generated with Dilib version V0.6.31. |  |