Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
Identifieur interne : 001084 ( Main/Exploration ); précédent : 001083; suivant : 001085Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
Auteurs : M. Coburn [Allemagne] ; O. Kunitz [Allemagne] ; C. C. Apfel [États-Unis] ; M. Hein [Allemagne] ; M. Fries [Allemagne] ; R. Rossaint [Allemagne]Source :
- British Journal of Anaesthesia [ 0007-0912 ] ; 2008-06.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P<0.001 and P<0.021). Conclusion Despite knowing the 5-HT3 antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.
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DOI: 10.1093/bja/aen077
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<front><div type="abstract">Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P<0.001 and P<0.021). Conclusion Despite knowing the 5-HT3 antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.</div>
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