Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
Identifieur interne : 001841 ( Istex/Corpus ); précédent : 001840; suivant : 001842Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia
Auteurs : M. Coburn ; O. Kunitz ; C. C. Apfel ; M. Hein ; M. Fries ; R. RossaintSource :
- British Journal of Anaesthesia [ 0007-0912 ] ; 2008-06.
Abstract
Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P<0.001 and P<0.021). Conclusion Despite knowing the 5-HT3 antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.
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DOI: 10.1093/bja/aen077
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C." last="Apfel">C. C. Apfel</name><affiliation><mods:affiliation>Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Hein, M" sort="Hein, M" uniqKey="Hein M" first="M." last="Hein">M. Hein</name><affiliation><mods:affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Fries, M" sort="Fries, M" uniqKey="Fries M" first="M." last="Fries">M. Fries</name><affiliation><mods:affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rossaint, R" sort="Rossaint, R" uniqKey="Rossaint R" first="R." last="Rossaint">R. Rossaint</name><affiliation><mods:affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:F962B1DF9EA9DF7E2865CC8DA44771B993696118</idno><date when="2008" year="2008">2008</date><idno type="doi">10.1093/bja/aen077</idno><idno type="url">https://api.istex.fr/document/F962B1DF9EA9DF7E2865CC8DA44771B993696118/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001841</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001841</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia</title><author><name sortKey="Coburn, M" sort="Coburn, M" uniqKey="Coburn M" first="M." last="Coburn">M. Coburn</name><affiliation><mods:affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: mcoburn@ukaachen.de</mods:affiliation></affiliation></author><author><name sortKey="Kunitz, O" sort="Kunitz, O" uniqKey="Kunitz O" first="O." last="Kunitz">O. Kunitz</name><affiliation><mods:affiliation>Department of Anaesthesia and Intensive Care Medicine, Mutterhaus der Borromerinnen Medical Centre, Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Apfel, C C" sort="Apfel, C C" uniqKey="Apfel C" first="C. C." last="Apfel">C. C. Apfel</name><affiliation><mods:affiliation>Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, CA, USA</mods:affiliation></affiliation></author><author><name sortKey="Hein, M" sort="Hein, M" uniqKey="Hein M" first="M." last="Hein">M. Hein</name><affiliation><mods:affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Fries, M" sort="Fries, M" uniqKey="Fries M" first="M." last="Fries">M. Fries</name><affiliation><mods:affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rossaint, R" sort="Rossaint, R" uniqKey="Rossaint R" first="R." last="Rossaint">R. Rossaint</name><affiliation><mods:affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">British Journal of Anaesthesia</title><title level="j" type="abbrev">Br J Anaesth</title><idno type="ISSN">0007-0912</idno><idno type="eISSN">1471-6771</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-06">2008-06</date><biblScope unit="volume">100</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="787">787</biblScope><biblScope unit="page" to="791">791</biblScope></imprint><idno type="ISSN">0007-0912</idno></series><idno type="istex">F962B1DF9EA9DF7E2865CC8DA44771B993696118</idno><idno type="DOI">10.1093/bja/aen077</idno><idno type="ArticleID">aen077</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0007-0912</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract">Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P<0.001 and P<0.021). Conclusion Despite knowing the 5-HT3 antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>M. Coburn</name><affiliations><json:string>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</json:string><json:string>E-mail: mcoburn@ukaachen.de</json:string></affiliations></json:item><json:item><name>O. Kunitz</name><affiliations><json:string>Department of Anaesthesia and Intensive Care Medicine, Mutterhaus der Borromerinnen Medical Centre, Trier, Germany</json:string></affiliations></json:item><json:item><name>C. C. Apfel</name><affiliations><json:string>Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, CA, USA</json:string></affiliations></json:item><json:item><name>M. Hein</name><affiliations><json:string>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</json:string></affiliations></json:item><json:item><name>M. Fries</name><affiliations><json:string>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</json:string></affiliations></json:item><json:item><name>R. Rossaint</name><affiliations><json:string>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</json:string></affiliations></json:item></author><subject><json:item><value>anaesthetics, xenon</value></json:item><json:item><value>anaesthetics, i.v., propofol</value></json:item><json:item><value>recovery, postoperative</value></json:item><json:item><value>vomiting, nausea, anaesthetic factors</value></json:item></subject><articleId><json:string>aen077</json:string></articleId><language><json:string>unknown</json:string></language><originalGenre><json:string>research-article</json:string></originalGenre><abstract>Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P>0.001 and P>0.021). 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Anaesthesia</title></host><categories><wos><json:string>science</json:string><json:string>anesthesiology</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>anesthesiology</json:string></scienceMetrix></categories><publicationDate>2008</publicationDate><copyrightDate>2008</copyrightDate><doi><json:string>10.1093/bja/aen077</json:string></doi><id>F962B1DF9EA9DF7E2865CC8DA44771B993696118</id><score>0.20304762</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/F962B1DF9EA9DF7E2865CC8DA44771B993696118/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/F962B1DF9EA9DF7E2865CC8DA44771B993696118/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/F962B1DF9EA9DF7E2865CC8DA44771B993696118/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Oxford University Press</publisher><availability><p>The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissionsoxfordjournals.org</p></availability><date>2008-04-08</date></publicationStmt><notesStmt><note>Drs M. Coburn and O. Kunitz contributed equally to this study.</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia</title><author xml:id="author-1"><persName><forename type="first">M.</forename><surname>Coburn</surname></persName><email>mcoburn@ukaachen.de</email><note type="biography">Drs M. Coburn and O. Kunitz contributed equally to this study.</note><note type="biography">Declaration of interest. Dr M. Coburn and Professor R. Rossaint are paid consultants of Air Liquide Sant International, a company interested in developing clinical applications for medical gases, including xenon.</note><affiliation>Drs M. Coburn and O. Kunitz contributed equally to this study.</affiliation><affiliation>Declaration of interest. Dr M. Coburn and Professor R. Rossaint are paid consultants of Air Liquide Sant International, a company interested in developing clinical applications for medical gases, including xenon.</affiliation><affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">O.</forename><surname>Kunitz</surname></persName><note type="biography">Drs M. Coburn and O. Kunitz contributed equally to this study.</note><affiliation>Drs M. Coburn and O. Kunitz contributed equally to this study.</affiliation><affiliation>Department of Anaesthesia and Intensive Care Medicine, Mutterhaus der Borromerinnen Medical Centre, Trier, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">C. C.</forename><surname>Apfel</surname></persName><affiliation>Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, CA, USA</affiliation></author><author xml:id="author-4"><persName><forename type="first">M.</forename><surname>Hein</surname></persName><affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">M.</forename><surname>Fries</surname></persName><affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</affiliation></author><author xml:id="author-6"><persName><forename type="first">R.</forename><surname>Rossaint</surname></persName><note type="biography">Declaration of interest. Dr M. Coburn and Professor R. Rossaint are paid consultants of Air Liquide Sant International, a company interested in developing clinical applications for medical gases, including xenon.</note><affiliation>Declaration of interest. Dr M. Coburn and Professor R. Rossaint are paid consultants of Air Liquide Sant International, a company interested in developing clinical applications for medical gases, including xenon.</affiliation><affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</affiliation></author></analytic><monogr><title level="j">British Journal of Anaesthesia</title><title level="j" type="abbrev">Br J Anaesth</title><idno type="pISSN">0007-0912</idno><idno type="eISSN">1471-6771</idno><imprint><publisher>Oxford University Press</publisher><date type="published" when="2008-06"></date><biblScope unit="volume">100</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="787">787</biblScope><biblScope unit="page" to="791">791</biblScope></imprint></monogr><idno type="istex">F962B1DF9EA9DF7E2865CC8DA44771B993696118</idno><idno type="DOI">10.1093/bja/aen077</idno><idno type="ArticleID">aen077</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2008-04-08</date></creation><abstract><p>Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P<0.001 and P<0.021). Conclusion Despite knowing the 5-HT3 antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>anaesthetics, xenon</term></item><item><term>anaesthetics, i.v., propofol</term></item><item><term>recovery, postoperative</term></item><item><term>vomiting, nausea, anaesthetic factors</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2008-04-08">Created</change><change when="2008-06">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/F962B1DF9EA9DF7E2865CC8DA44771B993696118/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="research-article"><front><journal-meta><journal-id journal-id-type="hwp">brjana</journal-id><journal-id journal-id-type="publisher-id">bjaint</journal-id><journal-title>British Journal of Anaesthesia</journal-title><abbrev-journal-title>Br J Anaesth</abbrev-journal-title><issn pub-type="ppub">0007-0912</issn><issn pub-type="epub">1471-6771</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.1093/bja/aen077</article-id><article-id pub-id-type="publisher-id">aen077</article-id><article-categories><subj-group subj-group-type="heading"><subject>CLINICAL PRACTICE</subject></subj-group></article-categories><title-group><article-title>Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Coburn</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="corresp" rid="cor1">*</xref><xref ref-type="author-notes" rid="FN1">†</xref><xref ref-type="author-notes" rid="FN2">‡</xref></contrib><contrib contrib-type="author"><name><surname>Kunitz</surname><given-names>O.</given-names></name><xref ref-type="aff" rid="af2">2</xref><xref ref-type="author-notes" rid="FN1">†</xref></contrib><contrib contrib-type="author"><name><surname>Apfel</surname><given-names>C. C.</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Hein</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Fries</surname><given-names>M.</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Rossaint</surname><given-names>R.</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="author-notes" rid="FN2">‡</xref></contrib></contrib-group><aff id="af1"><label>1</label><addr-line>Department of Anaesthesiology</addr-line>, <institution>University Hospital Aachen of the RWTH Aachen</institution>, <addr-line>Pauwelsstreet 30, D-52072 Aachen</addr-line>, <country>Germany</country></aff><aff id="af2"><label>2</label><addr-line>Department of Anaesthesia and Intensive Care Medicine, Mutterhaus der Borromäerinnen Medical Centre</addr-line>, <addr-line>Trier</addr-line>, <country>Germany</country></aff><aff id="af3"><label>3</label><addr-line>Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care</addr-line>, <institution>University of California</institution>, <addr-line>San Francisco, CA</addr-line>, <country>USA</country></aff><author-notes><fn id="FN1"><label>†</label><p>Drs M. Coburn and O. Kunitz contributed equally to this study.</p></fn><fn id="FN2"><label>‡</label><p><italic>Declaration of interest</italic>. Dr M. Coburn and Professor R. Rossaint are paid consultants of Air Liquide Santé International, a company interested in developing clinical applications for medical gases, including xenon.</p></fn><corresp id="cor1"><label>*</label>Corresponding author. E-mail: <email>mcoburn@ukaachen.de</email></corresp></author-notes><pub-date pub-type="ppub"><month>6</month><year>2008</year></pub-date><pub-date pub-type="epub"><day>8</day><month>4</month><year>2008</year></pub-date><volume>100</volume><issue>6</issue><fpage>787</fpage><lpage>791</lpage><history><date date-type="accepted"><day>2</day><month>3</month><year>2008</year></date></history><copyright-statement>© The Board of Management and Trustees of the British Journal of Anaesthesia 2008. All rights reserved. For Permissions, please e-mail: journals.permissions@oxfordjournals.org</copyright-statement><copyright-year>2008</copyright-year><abstract><sec><title>Background</title><p>Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT<sub>3</sub>) receptor. As 5-HT<sub>3</sub> receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia.</p></sec><sec><title>Methods</title><p>After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia.</p></sec><sec><title>Results</title><p>A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (<sc>sd</sc>) concentrations of either xenon 61 (2)% or propofol 100 (20) µg kg<sup>−1</sup> min<sup>−1</sup>. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2% and 35.2% in the xenon group and 26.8% and 16.9% in the TIVA group (<italic>P</italic><0.001 and <italic>P</italic><0.021).</p></sec><sec><title>Conclusion</title><p>Despite knowing the 5-HT<sub>3</sub> antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>anaesthetics, xenon</kwd><kwd>anaesthetics, i.v., propofol</kwd><kwd>recovery, postoperative</kwd><kwd>vomiting, nausea, anaesthetic factors</kwd></kwd-group></article-meta></front></article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Incidence of postoperative nausea and emetic episodes after xenon anaesthesia compared with propofol-based anaesthesia</title></titleInfo><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Coburn</namePart><affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</affiliation><affiliation>E-mail: mcoburn@ukaachen.de</affiliation><description>Drs M. Coburn and O. Kunitz contributed equally to this study.</description><description>Declaration of interest. Dr M. Coburn and Professor R. Rossaint are paid consultants of Air Liquide Sant International, a company interested in developing clinical applications for medical gases, including xenon.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">O.</namePart><namePart type="family">Kunitz</namePart><affiliation>Department of Anaesthesia and Intensive Care Medicine, Mutterhaus der Borromerinnen Medical Centre, Trier, Germany</affiliation><description>Drs M. Coburn and O. Kunitz contributed equally to this study.</description><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">C. C.</namePart><namePart type="family">Apfel</namePart><affiliation>Perioperative Clinical Research Core, Department of Anaesthesia and Perioperative Care, University of California, San Francisco, CA, USA</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Hein</namePart><affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.</namePart><namePart type="family">Fries</namePart><affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">R.</namePart><namePart type="family">Rossaint</namePart><affiliation>Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D-52072 Aachen, Germany</affiliation><description>Declaration of interest. Dr M. Coburn and Professor R. Rossaint are paid consultants of Air Liquide Sant International, a company interested in developing clinical applications for medical gases, including xenon.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="research-article"></genre><originInfo><publisher>Oxford University Press</publisher><dateIssued encoding="w3cdtf">2008-06</dateIssued><dateCreated encoding="w3cdtf">2008-04-08</dateCreated><copyrightDate encoding="w3cdtf">2008</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>Background Xenon has been proved to be safe and efficacious for general anaesthesia in numerous trials. In addition, experimental studies demonstrate that xenon inhibits the 5-hydroxytryptamine type 3 (5-HT3) receptor. As 5-HT3 receptor antagonists are known to decrease postoperative nausea and vomiting (PONV) to an extent comparable with a propofol-based total i.v. technique, we tested the hypothesis that general anaesthesia with xenon would result in a reduced incidence of PONV similar to that observed with propofol-based anaesthesia. Methods After obtaining approval from the local ethics committee and written informed consent, 142 patients were randomized to receive xenon anaesthesia or propofol-based total i.v. anaesthesia (TIVA), both supplemented with remifentanil. The incidence of postoperative nausea and emetic episodes was recorded in the post-anaesthesia care unit and on the ward more than 24 h after anaesthesia. Results A total of 142 patients were equally distributed between the xenon and TIVA groups. Anaesthesia was maintained with mean (sd) concentrations of either xenon 61 (2) or propofol 100 (20) g kg1 min1. Incidences of nausea and emetic episodes over the whole 24-h period were 66.2 and 35.2 in the xenon group and 26.8 and 16.9 in the TIVA group (P<0.001 and P<0.021). Conclusion Despite knowing the 5-HT3 antagonistic properties of xenon, its use is associated with a higher incidence of nausea and emetic episodes compared with TIVA with propofol.</abstract><note type="footnotes">Drs M. Coburn and O. Kunitz contributed equally to this study.</note><subject><genre>Keywords</genre><topic>anaesthetics, xenon</topic><topic>anaesthetics, i.v., propofol</topic><topic>recovery, postoperative</topic><topic>vomiting, nausea, anaesthetic factors</topic></subject><relatedItem type="host"><titleInfo><title>British Journal of Anaesthesia</title></titleInfo><titleInfo type="abbreviated"><title>Br J Anaesth</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0007-0912</identifier><identifier type="eISSN">1471-6771</identifier><identifier type="PublisherID">bjaint</identifier><identifier type="PublisherID-hwp">brjana</identifier><part><date>2008</date><detail type="volume"><caption>vol.</caption><number>100</number></detail><detail type="issue"><caption>no.</caption><number>6</number></detail><extent unit="pages"><start>787</start><end>791</end></extent></part></relatedItem><identifier type="istex">F962B1DF9EA9DF7E2865CC8DA44771B993696118</identifier><identifier type="DOI">10.1093/bja/aen077</identifier><identifier type="ArticleID">aen077</identifier><accessCondition type="use and reproduction" contentType="copyright">The Board of Management and Trustees of the British Journal of Anaesthesia 2008. 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