Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa
Identifieur interne : 002433 ( Main/Exploration ); précédent : 002432; suivant : 002434Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa
Auteurs : A. Hinney [Allemagne] ; N. Barth [Allemagne] ; A. Ziegler [Allemagne] ; S. Von Prittwitz [Allemagne] ; A. Hamann [Allemagne] ; K. Hennighausen [Allemagne] ; K. M. Pirke [Allemagne] ; A. Heils [Allemagne] ; K. Rosenkranz [Allemagne] ; H. Roth [Allemagne] ; H. Coners [Allemagne] ; H. Mayer [Allemagne] ; W. Herzog [Allemagne] ; A. Siegfried [Allemagne] ; G. Lehmkuhl [Allemagne] ; F. Poustka [Allemagne] ; M. H. Schmidt [Allemagne] ; H. Sch Fer [Allemagne] ; K.-H. Grzeschik [Allemagne] ; K.-P. Lesch [Allemagne] ; K.-U. Lentes [Allemagne] ; H. Remschmidt [Allemagne] ; J. Hebebrand [Allemagne]Source :
- Life Sciences [ 0024-3205 ] ; 1997.
Abstract
Several lines of evidence implicate a role for the serotonergic system in body weight regulation and eating disorders. The magnitude and duration of postsynaptic responses to serotonin (5-HT) is directed by the transport into and release from the presynaptic neuron. Recently, a common polymorphism of a repetitive element in the region of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) was identified that results in a system of two common alleles. The activity of the 5-HTT, as measured in in vitro assays and in human lymphoblastoid cell lines, is dependent on the respective genotype. We thus hypothesized that this polymorphism is relevant for weight regulation in general and is possibly involved in the etiology of anorexia nervosa (AN). Allele frequencies and genotypes were determined in a total of 385 unrelated obese children, adolescents and adults, 112 underweight subjects and 96 patients with AN. Furthermore, both parents of 98 obese children and adolescents and of 55 patients with AN, respectively, were genotyped, thus allowing to test for both association and linkage. The comparison of allele frequencies between obese and underweight probands provided no evidence for a major role of the 5-HTTLPR in weight regulation. Patients with AN had allele frequencies not significantly different to those observed for obese and underweight individuals.
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DOI: 10.1016/S0024-3205(97)00888-6
Affiliations:
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Hinney</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Barth, N" sort="Barth, N" uniqKey="Barth N" first="N." last="Barth">N. Barth</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Ziegler, A" sort="Ziegler, A" uniqKey="Ziegler A" first="A." last="Ziegler">A. Ziegler</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry of the University of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Von Prittwitz, S" sort="Von Prittwitz, S" uniqKey="Von Prittwitz S" first="S." last="Von Prittwitz">S. 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Hennighausen</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Psychobiological and Psychosomatic Research of the University of Trier</wicri:regionArea></affiliation></author><author><name sortKey="Heils, A" sort="Heils, A" uniqKey="Heils A" first="A." last="Heils">A. Heils</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry of the University of Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Rosenkranz, K" sort="Rosenkranz, K" uniqKey="Rosenkranz K" first="K." last="Rosenkranz">K. Rosenkranz</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Roth, H" sort="Roth, H" uniqKey="Roth H" first="H." last="Roth">H. Roth</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics of the University of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Coners, H" sort="Coners, H" uniqKey="Coners H" first="H." last="Coners">H. Coners</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Mayer, H" sort="Mayer, H" uniqKey="Mayer H" first="H." last="Mayer">H. Mayer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Children's Hospital Hochried, Murnau</wicri:regionArea><wicri:noRegion>Murnau</wicri:noRegion><wicri:noRegion>Murnau</wicri:noRegion></affiliation></author><author><name sortKey="Herzog, W" sort="Herzog, W" uniqKey="Herzog W" first="W." last="Herzog">W. Herzog</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Internal Medicine of the University of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Siegfried, A" sort="Siegfried, A" uniqKey="Siegfried A" first="A." last="Siegfried">A. Siegfried</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Obesity Treatment Center Insula (Adipositas Rehabilitationszentrum Insula), Berchtesgaden</wicri:regionArea><wicri:noRegion>Berchtesgaden</wicri:noRegion><wicri:noRegion>Berchtesgaden</wicri:noRegion></affiliation></author><author><name sortKey="Lehmkuhl, G" sort="Lehmkuhl, G" uniqKey="Lehmkuhl G" first="G." last="Lehmkuhl">G. Lehmkuhl</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Cologne</wicri:regionArea></affiliation></author><author><name sortKey="Poustka, F" sort="Poustka, F" uniqKey="Poustka F" first="F." last="Poustka">F. Poustka</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Frankfurt</wicri:regionArea></affiliation></author><author><name sortKey="Schmidt, M H" sort="Schmidt, M H" uniqKey="Schmidt M" first="M. H." last="Schmidt">M. H. Schmidt</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Heidelberg</wicri:regionArea></affiliation></author><author><name sortKey="Sch Fer, H" sort="Sch Fer, H" uniqKey="Sch Fer H" first="H." last="Sch Fer">H. Sch Fer</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Biometry of the University of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Grzeschik, K H" sort="Grzeschik, K H" uniqKey="Grzeschik K" first="K.-H." last="Grzeschik">K.-H. Grzeschik</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Human Genetics of the University of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Lesch, K P" sort="Lesch, K P" uniqKey="Lesch K" first="K.-P." last="Lesch">K.-P. Lesch</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Psychiatry of the University of Würzburg</wicri:regionArea></affiliation></author><author><name sortKey="Lentes, K U" sort="Lentes, K U" uniqKey="Lentes K" first="K.-U." last="Lentes">K.-U. Lentes</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Psychobiological and Psychosomatic Research of the University of Trier</wicri:regionArea></affiliation></author><author><name sortKey="Remschmidt, H" sort="Remschmidt, H" uniqKey="Remschmidt H" first="H." last="Remschmidt">H. Remschmidt</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Marburg</wicri:regionArea></affiliation></author><author><name sortKey="Hebebrand, J" sort="Hebebrand, J" uniqKey="Hebebrand J" first="J." last="Hebebrand">J. Hebebrand</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Child and Adolescent Psychiatry of the Universities of Marburg</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="page" from="PL295">PL295</biblScope><biblScope unit="page" to="PL303">PL303</biblScope></imprint><idno type="ISSN">0024-3205</idno></series><idno type="istex">BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0</idno><idno type="DOI">10.1016/S0024-3205(97)00888-6</idno><idno type="PII">S0024-3205(97)00888-6</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several lines of evidence implicate a role for the serotonergic system in body weight regulation and eating disorders. The magnitude and duration of postsynaptic responses to serotonin (5-HT) is directed by the transport into and release from the presynaptic neuron. Recently, a common polymorphism of a repetitive element in the region of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) was identified that results in a system of two common alleles. The activity of the 5-HTT, as measured in in vitro assays and in human lymphoblastoid cell lines, is dependent on the respective genotype. We thus hypothesized that this polymorphism is relevant for weight regulation in general and is possibly involved in the etiology of anorexia nervosa (AN). Allele frequencies and genotypes were determined in a total of 385 unrelated obese children, adolescents and adults, 112 underweight subjects and 96 patients with AN. Furthermore, both parents of 98 obese children and adolescents and of 55 patients with AN, respectively, were genotyped, thus allowing to test for both association and linkage. The comparison of allele frequencies between obese and underweight probands provided no evidence for a major role of the 5-HTTLPR in weight regulation. Patients with AN had allele frequencies not significantly different to those observed for obese and underweight individuals.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Hambourg</li></region><settlement><li>Hambourg</li></settlement></list><tree><country name="Allemagne"><noRegion><name sortKey="Hinney, A" sort="Hinney, A" uniqKey="Hinney A" first="A." last="Hinney">A. Hinney</name></noRegion><name sortKey="Barth, N" sort="Barth, N" uniqKey="Barth N" first="N." last="Barth">N. Barth</name><name sortKey="Coners, H" sort="Coners, H" uniqKey="Coners H" first="H." last="Coners">H. Coners</name><name sortKey="Grzeschik, K H" sort="Grzeschik, K H" uniqKey="Grzeschik K" first="K.-H." last="Grzeschik">K.-H. Grzeschik</name><name sortKey="Hamann, A" sort="Hamann, A" uniqKey="Hamann A" first="A." last="Hamann">A. Hamann</name><name sortKey="Hebebrand, J" sort="Hebebrand, J" uniqKey="Hebebrand J" first="J." last="Hebebrand">J. Hebebrand</name><name sortKey="Heils, A" sort="Heils, A" uniqKey="Heils A" first="A." last="Heils">A. Heils</name><name sortKey="Hennighausen, K" sort="Hennighausen, K" uniqKey="Hennighausen K" first="K." last="Hennighausen">K. Hennighausen</name><name sortKey="Herzog, W" sort="Herzog, W" uniqKey="Herzog W" first="W." last="Herzog">W. Herzog</name><name sortKey="Lehmkuhl, G" sort="Lehmkuhl, G" uniqKey="Lehmkuhl G" first="G." last="Lehmkuhl">G. Lehmkuhl</name><name sortKey="Lentes, K U" sort="Lentes, K U" uniqKey="Lentes K" first="K.-U." last="Lentes">K.-U. Lentes</name><name sortKey="Lesch, K P" sort="Lesch, K P" uniqKey="Lesch K" first="K.-P." last="Lesch">K.-P. Lesch</name><name sortKey="Mayer, H" sort="Mayer, H" uniqKey="Mayer H" first="H." last="Mayer">H. Mayer</name><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><name sortKey="Poustka, F" sort="Poustka, F" uniqKey="Poustka F" first="F." last="Poustka">F. Poustka</name><name sortKey="Remschmidt, H" sort="Remschmidt, H" uniqKey="Remschmidt H" first="H." last="Remschmidt">H. Remschmidt</name><name sortKey="Rosenkranz, K" sort="Rosenkranz, K" uniqKey="Rosenkranz K" first="K." last="Rosenkranz">K. Rosenkranz</name><name sortKey="Roth, H" sort="Roth, H" uniqKey="Roth H" first="H." last="Roth">H. Roth</name><name sortKey="Sch Fer, H" sort="Sch Fer, H" uniqKey="Sch Fer H" first="H." last="Sch Fer">H. Sch Fer</name><name sortKey="Schmidt, M H" sort="Schmidt, M H" uniqKey="Schmidt M" first="M. H." last="Schmidt">M. H. Schmidt</name><name sortKey="Siegfried, A" sort="Siegfried, A" uniqKey="Siegfried A" first="A." last="Siegfried">A. Siegfried</name><name sortKey="Von Prittwitz, S" sort="Von Prittwitz, S" uniqKey="Von Prittwitz S" first="S." last="Von Prittwitz">S. Von Prittwitz</name><name sortKey="Ziegler, A" sort="Ziegler, A" uniqKey="Ziegler A" first="A." last="Ziegler">A. Ziegler</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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