Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa
Identifieur interne : 001122 ( Istex/Corpus ); précédent : 001121; suivant : 001123Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa
Auteurs : A. Hinney ; N. Barth ; A. Ziegler ; S. Von Prittwitz ; A. Hamann ; K. Hennighausen ; K. M. Pirke ; A. Heils ; K. Rosenkranz ; H. Roth ; H. Coners ; H. Mayer ; W. Herzog ; A. Siegfried ; G. Lehmkuhl ; F. Poustka ; M. H. Schmidt ; H. Sch Fer ; K.-H. Grzeschik ; K.-P. Lesch ; K.-U. Lentes ; H. Remschmidt ; J. HebebrandSource :
- Life Sciences [ 0024-3205 ] ; 1997.
Abstract
Several lines of evidence implicate a role for the serotonergic system in body weight regulation and eating disorders. The magnitude and duration of postsynaptic responses to serotonin (5-HT) is directed by the transport into and release from the presynaptic neuron. Recently, a common polymorphism of a repetitive element in the region of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) was identified that results in a system of two common alleles. The activity of the 5-HTT, as measured in in vitro assays and in human lymphoblastoid cell lines, is dependent on the respective genotype. We thus hypothesized that this polymorphism is relevant for weight regulation in general and is possibly involved in the etiology of anorexia nervosa (AN). Allele frequencies and genotypes were determined in a total of 385 unrelated obese children, adolescents and adults, 112 underweight subjects and 96 patients with AN. Furthermore, both parents of 98 obese children and adolescents and of 55 patients with AN, respectively, were genotyped, thus allowing to test for both association and linkage. The comparison of allele frequencies between obese and underweight probands provided no evidence for a major role of the 5-HTTLPR in weight regulation. Patients with AN had allele frequencies not significantly different to those observed for obese and underweight individuals.
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DOI: 10.1016/S0024-3205(97)00888-6
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Sch Fer</name><affiliation><mods:affiliation>Institute of Medical Biometry of the University of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Grzeschik, K H" sort="Grzeschik, K H" uniqKey="Grzeschik K" first="K.-H." last="Grzeschik">K.-H. Grzeschik</name><affiliation><mods:affiliation>Institute of Human Genetics of the University of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lesch, K P" sort="Lesch, K P" uniqKey="Lesch K" first="K.-P." last="Lesch">K.-P. Lesch</name><affiliation><mods:affiliation>Department of Psychiatry of the University of Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lentes, K U" sort="Lentes, K U" uniqKey="Lentes K" first="K.-U." last="Lentes">K.-U. Lentes</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Remschmidt, H" sort="Remschmidt, H" uniqKey="Remschmidt H" first="H." last="Remschmidt">H. Remschmidt</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hebebrand, J" sort="Hebebrand, J" uniqKey="Hebebrand J" first="J." last="Hebebrand">J. 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Hinney</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Barth, N" sort="Barth, N" uniqKey="Barth N" first="N." last="Barth">N. Barth</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Ziegler, A" sort="Ziegler, A" uniqKey="Ziegler A" first="A." last="Ziegler">A. Ziegler</name><affiliation><mods:affiliation>Institute of Medical Biometry of the University of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Von Prittwitz, S" sort="Von Prittwitz, S" uniqKey="Von Prittwitz S" first="S." last="Von Prittwitz">S. Von Prittwitz</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hamann, A" sort="Hamann, A" uniqKey="Hamann A" first="A." last="Hamann">A. Hamann</name><affiliation><mods:affiliation>Department of Medicine, University-Hospital Eppendorf, Hamburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hennighausen, K" sort="Hennighausen, K" uniqKey="Hennighausen K" first="K." last="Hennighausen">K. Hennighausen</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Heils, A" sort="Heils, A" uniqKey="Heils A" first="A." last="Heils">A. Heils</name><affiliation><mods:affiliation>Department of Psychiatry of the University of Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Rosenkranz, K" sort="Rosenkranz, K" uniqKey="Rosenkranz K" first="K." last="Rosenkranz">K. Rosenkranz</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Roth, H" sort="Roth, H" uniqKey="Roth H" first="H." last="Roth">H. Roth</name><affiliation><mods:affiliation>Institute of Human Genetics of the University of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Coners, H" sort="Coners, H" uniqKey="Coners H" first="H." last="Coners">H. Coners</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Mayer, H" sort="Mayer, H" uniqKey="Mayer H" first="H." last="Mayer">H. Mayer</name><affiliation><mods:affiliation>Children's Hospital Hochried, Murnau, Germany</mods:affiliation></affiliation></author><author><name sortKey="Herzog, W" sort="Herzog, W" uniqKey="Herzog W" first="W." last="Herzog">W. Herzog</name><affiliation><mods:affiliation>Department of Internal Medicine of the University of Heidelberg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Siegfried, A" sort="Siegfried, A" uniqKey="Siegfried A" first="A." last="Siegfried">A. Siegfried</name><affiliation><mods:affiliation>Obesity Treatment Center Insula (Adipositas Rehabilitationszentrum Insula), Berchtesgaden, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lehmkuhl, G" sort="Lehmkuhl, G" uniqKey="Lehmkuhl G" first="G." last="Lehmkuhl">G. Lehmkuhl</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Cologne, Germany</mods:affiliation></affiliation></author><author><name sortKey="Poustka, F" sort="Poustka, F" uniqKey="Poustka F" first="F." last="Poustka">F. Poustka</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Frankfurt, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schmidt, M H" sort="Schmidt, M H" uniqKey="Schmidt M" first="M. H." last="Schmidt">M. H. Schmidt</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Heidelberg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Sch Fer, H" sort="Sch Fer, H" uniqKey="Sch Fer H" first="H." last="Sch Fer">H. Sch Fer</name><affiliation><mods:affiliation>Institute of Medical Biometry of the University of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Grzeschik, K H" sort="Grzeschik, K H" uniqKey="Grzeschik K" first="K.-H." last="Grzeschik">K.-H. Grzeschik</name><affiliation><mods:affiliation>Institute of Human Genetics of the University of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lesch, K P" sort="Lesch, K P" uniqKey="Lesch K" first="K.-P." last="Lesch">K.-P. Lesch</name><affiliation><mods:affiliation>Department of Psychiatry of the University of Würzburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Lentes, K U" sort="Lentes, K U" uniqKey="Lentes K" first="K.-U." last="Lentes">K.-U. Lentes</name><affiliation><mods:affiliation>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Remschmidt, H" sort="Remschmidt, H" uniqKey="Remschmidt H" first="H." last="Remschmidt">H. Remschmidt</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hebebrand, J" sort="Hebebrand, J" uniqKey="Hebebrand J" first="J." last="Hebebrand">J. Hebebrand</name><affiliation><mods:affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="ISSN">0024-3205</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997">1997</date><biblScope unit="volume">61</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="page" from="PL295">PL295</biblScope><biblScope unit="page" to="PL303">PL303</biblScope></imprint><idno type="ISSN">0024-3205</idno></series><idno type="istex">BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0</idno><idno type="DOI">10.1016/S0024-3205(97)00888-6</idno><idno type="PII">S0024-3205(97)00888-6</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0024-3205</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Several lines of evidence implicate a role for the serotonergic system in body weight regulation and eating disorders. The magnitude and duration of postsynaptic responses to serotonin (5-HT) is directed by the transport into and release from the presynaptic neuron. Recently, a common polymorphism of a repetitive element in the region of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) was identified that results in a system of two common alleles. The activity of the 5-HTT, as measured in in vitro assays and in human lymphoblastoid cell lines, is dependent on the respective genotype. We thus hypothesized that this polymorphism is relevant for weight regulation in general and is possibly involved in the etiology of anorexia nervosa (AN). Allele frequencies and genotypes were determined in a total of 385 unrelated obese children, adolescents and adults, 112 underweight subjects and 96 patients with AN. Furthermore, both parents of 98 obese children and adolescents and of 55 patients with AN, respectively, were genotyped, thus allowing to test for both association and linkage. The comparison of allele frequencies between obese and underweight probands provided no evidence for a major role of the 5-HTTLPR in weight regulation. Patients with AN had allele frequencies not significantly different to those observed for obese and underweight individuals.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>A. Hinney</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</json:string></affiliations></json:item><json:item><name>N. Barth</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</json:string></affiliations></json:item><json:item><name>A. Ziegler</name><affiliations><json:string>Institute of Medical Biometry of the University of Marburg, Germany</json:string></affiliations></json:item><json:item><name>S. Von Prittwitz</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</json:string></affiliations></json:item><json:item><name>A. Hamann</name><affiliations><json:string>Department of Medicine, University-Hospital Eppendorf, Hamburg, Germany</json:string></affiliations></json:item><json:item><name>K. Hennighausen</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</json:string></affiliations></json:item><json:item><name>K.M. Pirke</name><affiliations><json:string>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</json:string></affiliations></json:item><json:item><name>A. Heils</name><affiliations><json:string>Department of Psychiatry of the University of Würzburg, Germany</json:string></affiliations></json:item><json:item><name>K. Rosenkranz</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</json:string></affiliations></json:item><json:item><name>H. Roth</name><affiliations><json:string>Institute of Human Genetics of the University of Marburg, Germany</json:string></affiliations></json:item><json:item><name>H. Coners</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</json:string></affiliations></json:item><json:item><name>H. Mayer</name><affiliations><json:string>Children's Hospital Hochried, Murnau, Germany</json:string></affiliations></json:item><json:item><name>W. Herzog</name><affiliations><json:string>Department of Internal Medicine of the University of Heidelberg, Germany</json:string></affiliations></json:item><json:item><name>A. Siegfried</name><affiliations><json:string>Obesity Treatment Center Insula (Adipositas Rehabilitationszentrum Insula), Berchtesgaden, Germany</json:string></affiliations></json:item><json:item><name>G. Lehmkuhl</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Cologne, Germany</json:string></affiliations></json:item><json:item><name>F. Poustka</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Frankfurt, Germany</json:string></affiliations></json:item><json:item><name>M.H. Schmidt</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Heidelberg, Germany</json:string></affiliations></json:item><json:item><name>H. Schäfer</name><affiliations><json:string>Institute of Medical Biometry of the University of Marburg, Germany</json:string></affiliations></json:item><json:item><name>K.-H. Grzeschik</name><affiliations><json:string>Institute of Human Genetics of the University of Marburg, Germany</json:string></affiliations></json:item><json:item><name>K.-P. Lesch</name><affiliations><json:string>Department of Psychiatry of the University of Würzburg, Germany</json:string></affiliations></json:item><json:item><name>K.-U. Lentes</name><affiliations><json:string>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</json:string></affiliations></json:item><json:item><name>H. Remschmidt</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</json:string></affiliations></json:item><json:item><name>J. Hebebrand</name><affiliations><json:string>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>serotonin transporter gene-linked polymorphic region</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>obesity</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>anorexia nervosa</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>underweight</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>serotonergic system</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>body weight</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Short communication</json:string></originalGenre><abstract>Several lines of evidence implicate a role for the serotonergic system in body weight regulation and eating disorders. The magnitude and duration of postsynaptic responses to serotonin (5-HT) is directed by the transport into and release from the presynaptic neuron. Recently, a common polymorphism of a repetitive element in the region of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) was identified that results in a system of two common alleles. The activity of the 5-HTT, as measured in in vitro assays and in human lymphoblastoid cell lines, is dependent on the respective genotype. We thus hypothesized that this polymorphism is relevant for weight regulation in general and is possibly involved in the etiology of anorexia nervosa (AN). Allele frequencies and genotypes were determined in a total of 385 unrelated obese children, adolescents and adults, 112 underweight subjects and 96 patients with AN. Furthermore, both parents of 98 obese children and adolescents and of 55 patients with AN, respectively, were genotyped, thus allowing to test for both association and linkage. The comparison of allele frequencies between obese and underweight probands provided no evidence for a major role of the 5-HTTLPR in weight regulation. Patients with AN had allele frequencies not significantly different to those observed for obese and underweight individuals.</abstract><qualityIndicators><score>6.005</score><pdfVersion>1.2</pdfVersion><pdfPageSize>468 x 720 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>6</keywordCount><abstractCharCount>1394</abstractCharCount><pdfWordCount>3485</pdfWordCount><pdfCharCount>21586</pdfCharCount><pdfPageCount>9</pdfPageCount><abstractWordCount>210</abstractWordCount></qualityIndicators><title>Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa</title><pii><json:string>S0024-3205(97)00888-6</json:string></pii><refBibs><json:item><host><volume>55:</volume><pages><last>159</last><first>155</first></pages><author></author><title>Am. J. Clin. 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Sciences</title><publicationDate>1997</publicationDate></host><categories><wos><json:string>science</json:string><json:string>pharmacology & pharmacy</json:string><json:string>medicine, research & experimental</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>pharmacology & pharmacy</json:string></scienceMetrix></categories><publicationDate>1997</publicationDate><copyrightDate>1997</copyrightDate><doi><json:string>10.1016/S0024-3205(97)00888-6</json:string></doi><id>BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0</id><score>0.4876415</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>ELSEVIER</publisher><availability><p>ELSEVIER</p></availability><date>1997</date></publicationStmt><notesStmt><note type="content">Section title: Pharmacology letter Accelerated communication</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa</title><author xml:id="author-1"><persName><forename type="first">A.</forename><surname>Hinney</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">N.</forename><surname>Barth</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">A.</forename><surname>Ziegler</surname></persName><affiliation>Institute of Medical Biometry of the University of Marburg, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">S.</forename><surname>Von Prittwitz</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">A.</forename><surname>Hamann</surname></persName><affiliation>Department of Medicine, University-Hospital Eppendorf, Hamburg, Germany</affiliation></author><author xml:id="author-6"><persName><forename type="first">K.</forename><surname>Hennighausen</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation></author><author xml:id="author-7"><persName><forename type="first">K.M.</forename><surname>Pirke</surname></persName><affiliation>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</affiliation></author><author xml:id="author-8"><persName><forename type="first">A.</forename><surname>Heils</surname></persName><affiliation>Department of Psychiatry of the University of Würzburg, Germany</affiliation></author><author xml:id="author-9"><persName><forename type="first">K.</forename><surname>Rosenkranz</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation></author><author xml:id="author-10"><persName><forename type="first">H.</forename><surname>Roth</surname></persName><affiliation>Institute of Human Genetics of the University of Marburg, Germany</affiliation></author><author xml:id="author-11"><persName><forename type="first">H.</forename><surname>Coners</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation></author><author xml:id="author-12"><persName><forename type="first">H.</forename><surname>Mayer</surname></persName><affiliation>Children's Hospital Hochried, Murnau, Germany</affiliation></author><author xml:id="author-13"><persName><forename type="first">W.</forename><surname>Herzog</surname></persName><affiliation>Department of Internal Medicine of the University of Heidelberg, Germany</affiliation></author><author xml:id="author-14"><persName><forename type="first">A.</forename><surname>Siegfried</surname></persName><affiliation>Obesity Treatment Center Insula (Adipositas Rehabilitationszentrum Insula), Berchtesgaden, Germany</affiliation></author><author xml:id="author-15"><persName><forename type="first">G.</forename><surname>Lehmkuhl</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Cologne, Germany</affiliation></author><author xml:id="author-16"><persName><forename type="first">F.</forename><surname>Poustka</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Frankfurt, Germany</affiliation></author><author xml:id="author-17"><persName><forename type="first">M.H.</forename><surname>Schmidt</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Heidelberg, Germany</affiliation></author><author xml:id="author-18"><persName><forename type="first">H.</forename><surname>Schäfer</surname></persName><affiliation>Institute of Medical Biometry of the University of Marburg, Germany</affiliation></author><author xml:id="author-19"><persName><forename type="first">K.-H.</forename><surname>Grzeschik</surname></persName><affiliation>Institute of Human Genetics of the University of Marburg, Germany</affiliation></author><author xml:id="author-20"><persName><forename type="first">K.-P.</forename><surname>Lesch</surname></persName><affiliation>Department of Psychiatry of the University of Würzburg, Germany</affiliation></author><author xml:id="author-21"><persName><forename type="first">K.-U.</forename><surname>Lentes</surname></persName><affiliation>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</affiliation></author><author xml:id="author-22"><persName><forename type="first">H.</forename><surname>Remschmidt</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation></author><author xml:id="author-23"><persName><forename type="first">J.</forename><surname>Hebebrand</surname></persName><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation></author></analytic><monogr><title level="j">Life Sciences</title><title level="j" type="abbrev">LFS</title><idno type="pISSN">0024-3205</idno><idno type="PII">S0024-3205(00)X0138-5</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1997"></date><biblScope unit="volume">61</biblScope><biblScope unit="issue">21</biblScope><biblScope unit="page" from="PL295">PL295</biblScope><biblScope unit="page" to="PL303">PL303</biblScope></imprint></monogr><idno type="istex">BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0</idno><idno type="DOI">10.1016/S0024-3205(97)00888-6</idno><idno type="PII">S0024-3205(97)00888-6</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1997</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Several lines of evidence implicate a role for the serotonergic system in body weight regulation and eating disorders. The magnitude and duration of postsynaptic responses to serotonin (5-HT) is directed by the transport into and release from the presynaptic neuron. Recently, a common polymorphism of a repetitive element in the region of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) was identified that results in a system of two common alleles. The activity of the 5-HTT, as measured in in vitro assays and in human lymphoblastoid cell lines, is dependent on the respective genotype. We thus hypothesized that this polymorphism is relevant for weight regulation in general and is possibly involved in the etiology of anorexia nervosa (AN). Allele frequencies and genotypes were determined in a total of 385 unrelated obese children, adolescents and adults, 112 underweight subjects and 96 patients with AN. Furthermore, both parents of 98 obese children and adolescents and of 55 patients with AN, respectively, were genotyped, thus allowing to test for both association and linkage. The comparison of allele frequencies between obese and underweight probands provided no evidence for a major role of the 5-HTTLPR in weight regulation. Patients with AN had allele frequencies not significantly different to those observed for obese and underweight individuals.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>serotonin transporter gene-linked polymorphic region</term></item><item><term>obesity</term></item><item><term>anorexia nervosa</term></item><item><term>underweight</term></item><item><term>serotonergic system</term></item><item><term>body weight</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1996-08-19">Modified</change><change when="1997">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="sco"><item-info><jid>LFS</jid><aid>97008886</aid><ce:pii>S0024-3205(97)00888-6</ce:pii><ce:doi>10.1016/S0024-3205(97)00888-6</ce:doi><ce:copyright type="unknown" year="1997"></ce:copyright></item-info><head><ce:dochead><ce:textfn>Pharmacology letter Accelerated communication</ce:textfn></ce:dochead><ce:title>Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa</ce:title><ce:author-group><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Hinney</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>N.</ce:given-name><ce:surname>Barth</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Ziegler</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>S.</ce:given-name><ce:surname>Von Prittwitz</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Hamann</ce:surname><ce:cross-ref refid="AFF3"><ce:sup>3</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.</ce:given-name><ce:surname>Hennighausen</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.M.</ce:given-name><ce:surname>Pirke</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Heils</ce:surname><ce:cross-ref refid="AFF5"><ce:sup>5</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.</ce:given-name><ce:surname>Rosenkranz</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Roth</ce:surname><ce:cross-ref refid="AFF6"><ce:sup>6</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Coners</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Mayer</ce:surname><ce:cross-ref refid="AFF7"><ce:sup>7</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>W.</ce:given-name><ce:surname>Herzog</ce:surname><ce:cross-ref refid="AFF8"><ce:sup>8</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>A.</ce:given-name><ce:surname>Siegfried</ce:surname><ce:cross-ref refid="AFF9"><ce:sup>9</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>G.</ce:given-name><ce:surname>Lehmkuhl</ce:surname><ce:cross-ref refid="AFF10"><ce:sup>10</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>F.</ce:given-name><ce:surname>Poustka</ce:surname><ce:cross-ref refid="AFF11"><ce:sup>11</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>M.H.</ce:given-name><ce:surname>Schmidt</ce:surname><ce:cross-ref refid="AFF12"><ce:sup>12</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Schäfer</ce:surname><ce:cross-ref refid="AFF2"><ce:sup>2</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.-H.</ce:given-name><ce:surname>Grzeschik</ce:surname><ce:cross-ref refid="AFF6"><ce:sup>6</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.-P.</ce:given-name><ce:surname>Lesch</ce:surname><ce:cross-ref refid="AFF5"><ce:sup>5</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>K.-U.</ce:given-name><ce:surname>Lentes</ce:surname><ce:cross-ref refid="AFF4"><ce:sup>4</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>H.</ce:given-name><ce:surname>Remschmidt</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:author><ce:given-name>J.</ce:given-name><ce:surname>Hebebrand</ce:surname><ce:cross-ref refid="AFF1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation id="AFF1"><ce:label>1</ce:label><ce:textfn>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF2"><ce:label>2</ce:label><ce:textfn>Institute of Medical Biometry of the University of Marburg, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF3"><ce:label>3</ce:label><ce:textfn>Department of Medicine, University-Hospital Eppendorf, Hamburg, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF4"><ce:label>4</ce:label><ce:textfn>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF5"><ce:label>5</ce:label><ce:textfn>Department of Psychiatry of the University of Würzburg, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF6"><ce:label>6</ce:label><ce:textfn>Institute of Human Genetics of the University of Marburg, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF7"><ce:label>7</ce:label><ce:textfn>Children's Hospital Hochried, Murnau, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF8"><ce:label>8</ce:label><ce:textfn>Department of Internal Medicine of the University of Heidelberg, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF9"><ce:label>9</ce:label><ce:textfn>Obesity Treatment Center Insula (Adipositas Rehabilitationszentrum Insula), Berchtesgaden, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF10"><ce:label>10</ce:label><ce:textfn>Department of Child and Adolescent Psychiatry of the Universities of Cologne, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF11"><ce:label>11</ce:label><ce:textfn>Department of Child and Adolescent Psychiatry of the Universities of Frankfurt, Germany</ce:textfn></ce:affiliation><ce:affiliation id="AFF12"><ce:label>12</ce:label><ce:textfn>Department of Child and Adolescent Psychiatry of the Universities of Heidelberg, Germany</ce:textfn></ce:affiliation></ce:author-group><ce:date-received day="27" month="3" year="1996"></ce:date-received><ce:date-revised day="19" month="8" year="1996"></ce:date-revised><ce:date-accepted day="7" month="7" year="1997"></ce:date-accepted><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Several lines of evidence implicate a role for the serotonergic system in body weight regulation and eating disorders. The magnitude and duration of postsynaptic responses to serotonin (5-HT) is directed by the transport into and release from the presynaptic neuron. Recently, a common polymorphism of a repetitive element in the region of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) was identified that results in a system of two common alleles. The activity of the 5-HTT, as measured in <ce:italic>in vitro</ce:italic> assays and in human lymphoblastoid cell lines, is dependent on the respective genotype. We thus hypothesized that this polymorphism is relevant for weight regulation in general and is possibly involved in the etiology of anorexia nervosa (AN). Allele frequencies and genotypes were determined in a total of 385 unrelated obese children, adolescents and adults, 112 underweight subjects and 96 patients with AN. Furthermore, both parents of 98 obese children and adolescents and of 55 patients with AN, respectively, were genotyped, thus allowing to test for both association and linkage. The comparison of allele frequencies between obese and underweight probands provided no evidence for a major role of the 5-HTTLPR in weight regulation. Patients with AN had allele frequencies not significantly different to those observed for obese and underweight individuals.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>serotonin transporter gene-linked polymorphic region</ce:text></ce:keyword><ce:keyword><ce:text>obesity</ce:text></ce:keyword><ce:keyword><ce:text>anorexia nervosa</ce:text></ce:keyword><ce:keyword><ce:text>underweight</ce:text></ce:keyword><ce:keyword><ce:text>serotonergic system</ce:text></ce:keyword><ce:keyword><ce:text>body weight</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Serotonin transporter gene-linked polymorphic region: Allele distributions in relationship to body weight and in anorexia nervosa</title></titleInfo><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Hinney</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">N.</namePart><namePart type="family">Barth</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Ziegler</namePart><affiliation>Institute of Medical Biometry of the University of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">S.</namePart><namePart type="family">Von Prittwitz</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Hamann</namePart><affiliation>Department of Medicine, University-Hospital Eppendorf, Hamburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Hennighausen</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.M.</namePart><namePart type="family">Pirke</namePart><affiliation>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Heils</namePart><affiliation>Department of Psychiatry of the University of Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.</namePart><namePart type="family">Rosenkranz</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Roth</namePart><affiliation>Institute of Human Genetics of the University of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Coners</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Mayer</namePart><affiliation>Children's Hospital Hochried, Murnau, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">W.</namePart><namePart type="family">Herzog</namePart><affiliation>Department of Internal Medicine of the University of Heidelberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">A.</namePart><namePart type="family">Siegfried</namePart><affiliation>Obesity Treatment Center Insula (Adipositas Rehabilitationszentrum Insula), Berchtesgaden, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">G.</namePart><namePart type="family">Lehmkuhl</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Cologne, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">F.</namePart><namePart type="family">Poustka</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Frankfurt, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M.H.</namePart><namePart type="family">Schmidt</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Heidelberg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Schäfer</namePart><affiliation>Institute of Medical Biometry of the University of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.-H.</namePart><namePart type="family">Grzeschik</namePart><affiliation>Institute of Human Genetics of the University of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.-P.</namePart><namePart type="family">Lesch</namePart><affiliation>Department of Psychiatry of the University of Würzburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.-U.</namePart><namePart type="family">Lentes</namePart><affiliation>Center for Psychobiological and Psychosomatic Research of the University of Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H.</namePart><namePart type="family">Remschmidt</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">J.</namePart><namePart type="family">Hebebrand</namePart><affiliation>Department of Child and Adolescent Psychiatry of the Universities of Marburg, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="brief-communication" displayLabel="Short communication"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1997</dateIssued><dateModified encoding="w3cdtf">1996-08-19</dateModified><copyrightDate encoding="w3cdtf">1997</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Several lines of evidence implicate a role for the serotonergic system in body weight regulation and eating disorders. The magnitude and duration of postsynaptic responses to serotonin (5-HT) is directed by the transport into and release from the presynaptic neuron. Recently, a common polymorphism of a repetitive element in the region of the serotonin transporter (5-HTT) gene-linked polymorphic region (5-HTTLPR) was identified that results in a system of two common alleles. The activity of the 5-HTT, as measured in in vitro assays and in human lymphoblastoid cell lines, is dependent on the respective genotype. We thus hypothesized that this polymorphism is relevant for weight regulation in general and is possibly involved in the etiology of anorexia nervosa (AN). Allele frequencies and genotypes were determined in a total of 385 unrelated obese children, adolescents and adults, 112 underweight subjects and 96 patients with AN. Furthermore, both parents of 98 obese children and adolescents and of 55 patients with AN, respectively, were genotyped, thus allowing to test for both association and linkage. The comparison of allele frequencies between obese and underweight probands provided no evidence for a major role of the 5-HTTLPR in weight regulation. Patients with AN had allele frequencies not significantly different to those observed for obese and underweight individuals.</abstract><note type="content">Section title: Pharmacology letter Accelerated communication</note><subject><genre>Keywords</genre><topic>serotonin transporter gene-linked polymorphic region</topic><topic>obesity</topic><topic>anorexia nervosa</topic><topic>underweight</topic><topic>serotonergic system</topic><topic>body weight</topic></subject><relatedItem type="host"><titleInfo><title>Life Sciences</title></titleInfo><titleInfo type="abbreviated"><title>LFS</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">19971017</dateIssued></originInfo><identifier type="ISSN">0024-3205</identifier><identifier type="PII">S0024-3205(00)X0138-5</identifier><part><date>19971017</date><detail type="volume"><number>61</number><caption>vol.</caption></detail><detail type="issue"><number>21</number><caption>no.</caption></detail><extent unit="issue pages"><start>PL295</start><end>PL326</end></extent><extent unit="issue pages"><start>2073</start><end>2142</end></extent><extent unit="pages"><start>PL295</start><end>PL303</end></extent></part></relatedItem><identifier type="istex">BE7C8AAB4C7B908585C1FE779720E3FEF8022DC0</identifier><identifier type="DOI">10.1016/S0024-3205(97)00888-6</identifier><identifier type="PII">S0024-3205(97)00888-6</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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