Plasminogen activator inhibitor 1 gene polymorphisms and mirtazapine responses in Koreans with major depression
Identifieur interne : 000E65 ( Main/Exploration ); précédent : 000E64; suivant : 000E66Plasminogen activator inhibitor 1 gene polymorphisms and mirtazapine responses in Koreans with major depression
Auteurs : Hun Soo Chang [Corée du Sud] ; Hwa-Young Lee [Corée du Sud] ; Byung-Joo Ham [Corée du Sud] ; Rhee-Hun Kang [Corée du Sud] ; Yoo-Jung Jeong [Corée du Sud] ; Hyang-Mi Kim [Corée du Sud] ; Sang-Woo Hahn [Corée du Sud] ; Min-Soo Lee [Corée du Sud]Source :
- Asia‐Pacific Psychiatry [ 1758-5864 ] ; 2009-12.
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Abstract
Introduction: Brain‐derived neurotrophic factor (BDNF) is involved in the pathophysiology of mental disorders and in the mechanism of action of antidepressant medications. The mature form of BDNF is derived from proBDNF through tissue type plasminogen activator (tPA) and the plasminogen system in the brain, which is regulated by an endogenous inhibitor, plasminogen activator inhibitor (PAI). Therefore, PAI may be involved in the development of major depressive disorder (MDD) and its response to antidepressant treatment. The present study determined the relationship between the 4G/5G polymorphism in the PAI1 gene and the clinical outcome of mirtazapine treatment in 271 Korean MDD patients.
Url:
DOI: 10.1111/j.1758-5872.2009.00025.x
Affiliations:
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The mature form of BDNF is derived from proBDNF through tissue type plasminogen activator (tPA) and the plasminogen system in the brain, which is regulated by an endogenous inhibitor, plasminogen activator inhibitor (PAI). Therefore, PAI may be involved in the development of major depressive disorder (MDD) and its response to antidepressant treatment. The present study determined the relationship between the 4G/5G polymorphism in the PAI1 gene and the clinical outcome of mirtazapine treatment in 271 Korean MDD patients.</div></front></TEI><affiliations><list><country><li>Corée du Sud</li></country><settlement><li>Séoul</li></settlement></list><tree><country name="Corée du Sud"><noRegion><name sortKey="Chang, Hun Soo" sort="Chang, Hun Soo" uniqKey="Chang H" first="Hun Soo" last="Chang">Hun Soo Chang</name></noRegion><name sortKey="Chang, Hun Soo" sort="Chang, Hun Soo" uniqKey="Chang H" first="Hun Soo" last="Chang">Hun Soo Chang</name><name sortKey="Hahn, Sang Oo" sort="Hahn, Sang Oo" uniqKey="Hahn S" first="Sang-Woo" last="Hahn">Sang-Woo Hahn</name><name sortKey="Ham, Byung Oo" sort="Ham, Byung Oo" uniqKey="Ham B" first="Byung-Joo" last="Ham">Byung-Joo Ham</name><name sortKey="Jeong, Yoo Ung" sort="Jeong, Yoo Ung" uniqKey="Jeong Y" first="Yoo-Jung" last="Jeong">Yoo-Jung Jeong</name><name sortKey="Jeong, Yoo Ung" sort="Jeong, Yoo Ung" uniqKey="Jeong Y" first="Yoo-Jung" last="Jeong">Yoo-Jung Jeong</name><name sortKey="Kang, Rhee Un" sort="Kang, Rhee Un" uniqKey="Kang R" first="Rhee-Hun" last="Kang">Rhee-Hun Kang</name><name sortKey="Kang, Rhee Un" sort="Kang, Rhee Un" uniqKey="Kang R" first="Rhee-Hun" last="Kang">Rhee-Hun Kang</name><name sortKey="Kim, Hyang I" sort="Kim, Hyang I" uniqKey="Kim H" first="Hyang-Mi" last="Kim">Hyang-Mi Kim</name><name sortKey="Kim, Hyang I" sort="Kim, Hyang I" uniqKey="Kim H" first="Hyang-Mi" last="Kim">Hyang-Mi Kim</name><name sortKey="Lee, Hwa Oung" sort="Lee, Hwa Oung" uniqKey="Lee H" first="Hwa-Young" last="Lee">Hwa-Young Lee</name><name sortKey="Lee, Hwa Oung" sort="Lee, Hwa Oung" uniqKey="Lee H" first="Hwa-Young" last="Lee">Hwa-Young Lee</name><name sortKey="Lee, Min Oo" sort="Lee, Min Oo" uniqKey="Lee M" first="Min-Soo" last="Lee">Min-Soo Lee</name><name sortKey="Lee, Min Oo" sort="Lee, Min Oo" uniqKey="Lee M" first="Min-Soo" last="Lee">Min-Soo Lee</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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