Plasminogen activator inhibitor 1 gene polymorphisms and mirtazapine responses in Koreans with major depression
Identifieur interne : 000F39 ( Main/Merge ); précédent : 000F38; suivant : 000F40Plasminogen activator inhibitor 1 gene polymorphisms and mirtazapine responses in Koreans with major depression
Auteurs : Hun Soo Chang [Corée du Sud] ; Hwa-Young Lee [Corée du Sud] ; Byung-Joo Ham [Corée du Sud] ; Rhee-Hun Kang [Corée du Sud] ; Yoo-Jung Jeong [Corée du Sud] ; Hyang-Mi Kim [Corée du Sud] ; Sang-Woo Hahn [Corée du Sud] ; Min-Soo Lee [Corée du Sud]Source :
- Asia‐Pacific Psychiatry [ 1758-5864 ] ; 2009-12.
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- KwdEn :
Abstract
Introduction: Brain‐derived neurotrophic factor (BDNF) is involved in the pathophysiology of mental disorders and in the mechanism of action of antidepressant medications. The mature form of BDNF is derived from proBDNF through tissue type plasminogen activator (tPA) and the plasminogen system in the brain, which is regulated by an endogenous inhibitor, plasminogen activator inhibitor (PAI). Therefore, PAI may be involved in the development of major depressive disorder (MDD) and its response to antidepressant treatment. The present study determined the relationship between the 4G/5G polymorphism in the PAI1 gene and the clinical outcome of mirtazapine treatment in 271 Korean MDD patients.
Url:
DOI: 10.1111/j.1758-5872.2009.00025.x
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<front><div type="abstract">Introduction: Brain‐derived neurotrophic factor (BDNF) is involved in the pathophysiology of mental disorders and in the mechanism of action of antidepressant medications. The mature form of BDNF is derived from proBDNF through tissue type plasminogen activator (tPA) and the plasminogen system in the brain, which is regulated by an endogenous inhibitor, plasminogen activator inhibitor (PAI). Therefore, PAI may be involved in the development of major depressive disorder (MDD) and its response to antidepressant treatment. The present study determined the relationship between the 4G/5G polymorphism in the PAI1 gene and the clinical outcome of mirtazapine treatment in 271 Korean MDD patients.</div>
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