Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat
Identifieur interne : 002D41 ( Main/Exploration ); précédent : 002D40; suivant : 002D42Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat
Auteurs : T. Wilckens [Allemagne] ; U. Schweiger [Allemagne] ; K. M. Pirke [Allemagne]Source :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1992.
Abstract
Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different α-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the α2-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for α2-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by α2-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.
Url:
DOI: 10.1016/0091-3057(92)90402-2
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000B83
- to stream Istex, to step Curation: 000B15
- to stream Istex, to step Checkpoint: 001387
- to stream Main, to step Merge: 003318
- to stream Main, to step Curation: 002D41
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat</title><author><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name></author><author><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:A239F35498E78F70872E587DD494A613D64C622F</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1016/0091-3057(92)90402-2</idno><idno type="url">https://api.istex.fr/document/A239F35498E78F70872E587DD494A613D64C622F/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000B83</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000B83</idno><idno type="wicri:Area/Istex/Curation">000B15</idno><idno type="wicri:Area/Istex/Checkpoint">001387</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001387</idno><idno type="wicri:doubleKey">0091-3057:1992:Wilckens T:activation:of:adrenoceptors</idno><idno type="wicri:Area/Main/Merge">003318</idno><idno type="wicri:Area/Main/Curation">002D41</idno><idno type="wicri:Area/Main/Exploration">002D41</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat</title><author><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck-Institut for Psychiatry, D-8000 München 40</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck-Institut for Psychiatry, D-8000 München 40</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Max-Planck-Institut for Psychiatry, D-8000 München 40</wicri:regionArea><placeName><region type="land" nuts="1">Bavière</region><region type="district" nuts="2">District de Haute-Bavière</region><settlement type="city">Munich</settlement></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">43</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="733">733</biblScope><biblScope unit="page" to="738">738</biblScope></imprint><idno type="ISSN">0091-3057</idno></series><idno type="istex">A239F35498E78F70872E587DD494A613D64C622F</idno><idno type="DOI">10.1016/0091-3057(92)90402-2</idno><idno type="PII">0091-3057(92)90402-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different α-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the α2-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for α2-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by α2-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name></region><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002D41 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002D41 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:A239F35498E78F70872E587DD494A613D64C622F
|texte= Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat
}}
| This area was generated with Dilib version V0.6.31. |  |