Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat
Identifieur interne : 000B83 ( Istex/Corpus ); précédent : 000B82; suivant : 000B84Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat
Auteurs : T. Wilckens ; U. Schweiger ; K. M. PirkeSource :
- Pharmacology, Biochemistry and Behavior [ 0091-3057 ] ; 1992.
Abstract
Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different α-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the α2-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for α2-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by α2-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.
Url:
DOI: 10.1016/0091-3057(92)90402-2
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat</title><author><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name><affiliation><mods:affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name><affiliation><mods:affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</mods:affiliation></affiliation></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. 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Wilckens</name><affiliation><mods:affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</mods:affiliation></affiliation></author><author><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name><affiliation><mods:affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</mods:affiliation></affiliation></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><affiliation><mods:affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="ISSN">0091-3057</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992">1992</date><biblScope unit="volume">43</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="733">733</biblScope><biblScope unit="page" to="738">738</biblScope></imprint><idno type="ISSN">0091-3057</idno></series><idno type="istex">A239F35498E78F70872E587DD494A613D64C622F</idno><idno type="DOI">10.1016/0091-3057(92)90402-2</idno><idno type="PII">0091-3057(92)90402-2</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0091-3057</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different α-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the α2-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for α2-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by α2-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.</div></front></TEI><istex><corpusName>elsevier</corpusName><author><json:item><name>T. Wilckens</name><affiliations><json:string>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</json:string></affiliations></json:item><json:item><name>U. Schweiger</name><affiliations><json:string>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</json:string></affiliations></json:item><json:item><name>K.M. Pirke</name><affiliations><json:string>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>Clonidine</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Exercise</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Anorexia</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Stress</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>α2-receptors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>α2-adrenoceptors</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Subtypes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Food intake</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>Starvation</value></json:item></subject><language><json:string>eng</json:string></language><originalGenre><json:string>Full-length article</json:string></originalGenre><abstract>Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different α-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the α2-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for α2-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by α2-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.</abstract><qualityIndicators><score>4.715</score><pdfVersion>1.2</pdfVersion><pdfPageSize>612 x 792 pts (letter)</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>9</keywordCount><abstractCharCount>994</abstractCharCount><pdfWordCount>2879</pdfWordCount><pdfCharCount>17371</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>153</abstractWordCount></qualityIndicators><title>Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat</title><pii><json:string>0091-3057(92)90402-2</json:string></pii><refBibs><json:item><author><json:item><name>A. Broocks</name></json:item><json:item><name>J. Liu</name></json:item><json:item><name>K.M. 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M. Pirke at his current address: Department of Psychoendocrinology, Center for Psychobiology and Psychosomatic Research, University of Trier, Building D, Box 3825, D-5500 Trier, Germany.</note><affiliation>Requests for reprints should be addressed to Professor Dr. K. M. Pirke at his current address: Department of Psychoendocrinology, Center for Psychobiology and Psychosomatic Research, University of Trier, Building D, Box 3825, D-5500 Trier, Germany.</affiliation><affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</affiliation></author></analytic><monogr><title level="j">Pharmacology, Biochemistry and Behavior</title><title level="j" type="abbrev">PBB</title><idno type="pISSN">0091-3057</idno><idno type="PII">S0091-3057(00)X0287-0</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1992"></date><biblScope unit="volume">43</biblScope><biblScope unit="issue">3</biblScope><biblScope unit="page" from="733">733</biblScope><biblScope unit="page" to="738">738</biblScope></imprint></monogr><idno type="istex">A239F35498E78F70872E587DD494A613D64C622F</idno><idno type="DOI">10.1016/0091-3057(92)90402-2</idno><idno type="PII">0091-3057(92)90402-2</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1992</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different α-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the α2-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for α2-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by α2-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.</p></abstract><textClass><keywords scheme="keyword"><list><head>Keywords</head><item><term>Clonidine</term></item><item><term>Exercise</term></item><item><term>Anorexia</term></item><item><term>Stress</term></item><item><term>α2-receptors</term></item><item><term>α2-adrenoceptors</term></item><item><term>Subtypes</term></item><item><term>Food intake</term></item><item><term>Starvation</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1992">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/A239F35498E78F70872E587DD494A613D64C622F/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Elsevier, elements deleted: tail"><istex:xmlDeclaration>version="1.0" encoding="utf-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//ES//DTD journal article DTD version 4.5.2//EN//XML" URI="art452.dtd" name="istex:docType"></istex:docType><istex:document><converted-article version="4.5.2" docsubtype="fla"><item-info><jid>PBB</jid><aid>92904022</aid><ce:pii>0091-3057(92)90402-2</ce:pii><ce:doi>10.1016/0091-3057(92)90402-2</ce:doi><ce:copyright type="unknown" year="1992"></ce:copyright></item-info><head><ce:title>Activation of <ce:italic>α</ce:italic><ce:inf>2</ce:inf>-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat</ce:title><ce:author-group><ce:author><ce:given-name>T.</ce:given-name><ce:surname>Wilckens</ce:surname></ce:author><ce:author><ce:given-name>U.</ce:given-name><ce:surname>Schweiger</ce:surname></ce:author><ce:author><ce:given-name>K.M.</ce:given-name><ce:surname>Pirke</ce:surname><ce:cross-ref refid="COR1"><ce:sup>1</ce:sup></ce:cross-ref></ce:author><ce:affiliation><ce:textfn>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</ce:textfn></ce:affiliation><ce:correspondence id="COR1"><ce:label>1</ce:label><ce:text>Requests for reprints should be addressed to Professor Dr. K. M. Pirke at his current address: Department of Psychoendocrinology, Center for Psychobiology and Psychosomatic Research, University of Trier, Building D, Box 3825, D-5500 Trier, Germany.</ce:text></ce:correspondence></ce:author-group><ce:date-received day="27" month="12" year="1991"></ce:date-received><ce:abstract><ce:section-title>Abstract</ce:section-title><ce:abstract-sec><ce:simple-para>Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different α-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the <ce:italic>α</ce:italic><ce:inf>2</ce:inf>-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for <ce:italic>α</ce:italic><ce:inf>2</ce:inf>-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by <ce:italic>α</ce:italic><ce:inf>2</ce:inf>-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.</ce:simple-para></ce:abstract-sec></ce:abstract><ce:keywords><ce:section-title>Keywords</ce:section-title><ce:keyword><ce:text>Clonidine</ce:text></ce:keyword><ce:keyword><ce:text>Exercise</ce:text></ce:keyword><ce:keyword><ce:text>Anorexia</ce:text></ce:keyword><ce:keyword><ce:text>Stress</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>α</ce:italic><ce:inf>2</ce:inf>-receptors</ce:text></ce:keyword><ce:keyword><ce:text><ce:italic>α</ce:italic><ce:inf>2</ce:inf>-adrenoceptors</ce:text></ce:keyword><ce:keyword><ce:text>Subtypes</ce:text></ce:keyword><ce:keyword><ce:text>Food intake</ce:text></ce:keyword><ce:keyword><ce:text>Starvation</ce:text></ce:keyword></ce:keywords></head></converted-article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Activation of α 2-adrenoceptors suppresses excessive wheel running in the semistarvation-induced hyperactive rat</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Activation of</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Wilckens</namePart><affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Schweiger</namePart><affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">K.M.</namePart><namePart type="family">Pirke</namePart><affiliation>Max-Planck-Institut for Psychiatry, D-8000 München 40, Germany</affiliation><description>Requests for reprints should be addressed to Professor Dr. K. M. Pirke at his current address: Department of Psychoendocrinology, Center for Psychobiology and Psychosomatic Research, University of Trier, Building D, Box 3825, D-5500 Trier, Germany.</description><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="Full-length article"></genre><originInfo><publisher>ELSEVIER</publisher><dateIssued encoding="w3cdtf">1992</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="iso639-2b">eng</languageTerm><languageTerm type="code" authority="rfc3066">en</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation, rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different α-adrenergic agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists that display high affinity for the α2-receptor (clonidine and guanfacine). Neither antagonist had an effect on RWA. Clonidine's inhibiting effect on RWA was prevented by pretreatment with yohimbine, which also has high affinity for α2-receptors. From these results, we conclude that semistarvation-induced hyperactivity can be blocked by α2-agonists. In view of this result and those that were obtained in previous studies, a theoretical model for the development of semistarvation-induced hyperactivity will be presented.</abstract><subject><genre>Keywords</genre><topic>Clonidine</topic><topic>Exercise</topic><topic>Anorexia</topic><topic>Stress</topic><topic>α2-receptors</topic><topic>α2-adrenoceptors</topic><topic>Subtypes</topic><topic>Food intake</topic><topic>Starvation</topic></subject><relatedItem type="host"><titleInfo><title>Pharmacology, Biochemistry and Behavior</title></titleInfo><titleInfo type="abbreviated"><title>PBB</title></titleInfo><genre type="journal">journal</genre><originInfo><dateIssued encoding="w3cdtf">199211</dateIssued></originInfo><identifier type="ISSN">0091-3057</identifier><identifier type="PII">S0091-3057(00)X0287-0</identifier><part><date>199211</date><detail type="volume"><number>43</number><caption>vol.</caption></detail><detail type="issue"><number>3</number><caption>no.</caption></detail><extent unit="issue pages"><start>661</start><end>977</end></extent><extent unit="pages"><start>733</start><end>738</end></extent></part></relatedItem><identifier type="istex">A239F35498E78F70872E587DD494A613D64C622F</identifier><identifier type="DOI">10.1016/0091-3057(92)90402-2</identifier><identifier type="PII">0091-3057(92)90402-2</identifier><recordInfo><recordContentSource>ELSEVIER</recordContentSource></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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