Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat
Identifieur interne : 002D75 ( Main/Exploration ); précédent : 002D74; suivant : 002D76Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat
Auteurs : T. Wilckens [Allemagne] ; U. Schweiger [Allemagne] ; K. M. Pirke [Allemagne]Source :
- Psychopharmacology [ 0033-3158 ] ; 1992-10-01.
Abstract
Abstract: Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT1C receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT1C receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT1C agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT1C receptor activation.
Url:
DOI: 10.1007/BF02245483
Affiliations:
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During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT1C receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT1C receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT1C agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT1C receptor activation.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>Bavière</li><li>District de Haute-Bavière</li></region><settlement><li>Munich</li></settlement></list><tree><country name="Allemagne"><region name="Bavière"><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name></region><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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