Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat
Identifieur interne : 001680 ( Istex/Corpus ); précédent : 001679; suivant : 001681Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat
Auteurs : T. Wilckens ; U. Schweiger ; K. M. PirkeSource :
- Psychopharmacology [ 0033-3158 ] ; 1992-10-01.
Abstract
Abstract: Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT1C receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT1C receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT1C agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT1C receptor activation.
Url:
DOI: 10.1007/BF02245483
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<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat</title><author><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name><affiliation><mods:affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name><affiliation><mods:affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><affiliation><mods:affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9</idno><date when="1992" year="1992">1992</date><idno type="doi">10.1007/BF02245483</idno><idno type="url">https://api.istex.fr/document/9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001680</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001680</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat</title><author><name sortKey="Wilckens, T" sort="Wilckens, T" uniqKey="Wilckens T" first="T." last="Wilckens">T. Wilckens</name><affiliation><mods:affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Schweiger, U" sort="Schweiger, U" uniqKey="Schweiger U" first="U." last="Schweiger">U. Schweiger</name><affiliation><mods:affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</mods:affiliation></affiliation></author><author><name sortKey="Pirke, K M" sort="Pirke, K M" uniqKey="Pirke K" first="K. M." last="Pirke">K. M. Pirke</name><affiliation><mods:affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Psychopharmacology</title><title level="j" type="abbrev">Psychopharmacology</title><idno type="ISSN">0033-3158</idno><idno type="eISSN">1432-2072</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1992-10-01">1992-10-01</date><biblScope unit="volume">109</biblScope><biblScope unit="issue">1-2</biblScope><biblScope unit="page" from="77">77</biblScope><biblScope unit="page" to="84">84</biblScope></imprint><idno type="ISSN">0033-3158</idno></series><idno type="istex">9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9</idno><idno type="DOI">10.1007/BF02245483</idno><idno type="ArticleID">BF02245483</idno><idno type="ArticleID">Art10</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0033-3158</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT1C receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT1C receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT1C agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT1C receptor activation.</div></front></TEI><istex><corpusName>springer</corpusName><author><json:item><name>T. Wilckens</name><affiliations><json:string>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</json:string></affiliations></json:item><json:item><name>U. Schweiger</name><affiliations><json:string>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</json:string></affiliations></json:item><json:item><name>K. M. Pirke</name><affiliations><json:string>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</json:string></affiliations></json:item></author><articleId><json:string>BF02245483</json:string><json:string>Art10</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>OriginalPaper</json:string></originalGenre><abstract>Abstract: Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT1C receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT1C receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT1C agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT1C receptor activation.</abstract><qualityIndicators><score>7.148</score><pdfVersion>1.3</pdfVersion><pdfPageSize>591 x 785 pts</pdfPageSize><refBibsNative>false</refBibsNative><keywordCount>0</keywordCount><abstractCharCount>1129</abstractCharCount><pdfWordCount>5762</pdfWordCount><pdfCharCount>31989</pdfCharCount><pdfPageCount>8</pdfPageCount><abstractWordCount>179</abstractWordCount></qualityIndicators><title>Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat</title><refBibs><json:item><author><json:item><name>Li Backus</name></json:item><json:item><name>T Sharp</name></json:item><json:item><name>Dg Grahame-Smith</name></json:item></author><host><volume>100</volume><pages><last>799</last><first>793</first></pages><author></author><title>Br J Pharmacol</title><publicationDate>1990</publicationDate></host><title>Behavioural evidence for a functional interaction between central 5-HT 2 and 5- HT1A receptors</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>C Bendotti</name></json:item><json:item><name>R Samanin</name></json:item></author><host><volume>41</volume><pages><last>642</last><first>635</first></pages><issue>t987</issue><author></author><title>Life Sci</title></host><title>The role of putative 5-HT1A and 5- HT1B receptors in the control of feeding in rats</title></json:item><json:item><author><json:item><name>Hhg Berendsen</name></json:item><json:item><name>Cle Broekkamp</name></json:item></author><host><volume>101</volume><pages><last>673</last><first>667</first></pages><author></author><title>Br J Pharmacol</title><publicationDate>1990</publicationDate></host><title>Behavioural evidence for functional interactions between 5-HT-receptors subtypes in rats and mice</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>Hhg Berendsen</name></json:item><json:item><name>Cle Broekkamp</name></json:item></author><host><volume>105</volume><pages><last>224</last><first>219</first></pages><author></author><title>Psychopharmacology</title><publicationDate>1991</publicationDate></host><title>Attenuation of 5-HT~^ and 5-HT2 but not 5-HTlc receptor mediated behaviour in rats following chronic treatment with 5-HT receptor agonists, antagonists or anti-depressants</title><publicationDate>1991</publicationDate></json:item><json:item><author><json:item><name>Hhg Berendsen</name></json:item><json:item><name>F Jenck</name></json:item><json:item><name>Cle Broekkamp</name></json:item></author><host><volume>101</volume><pages><last>61</last><first>57</first></pages><author></author><title>Psychopharmacology</title><publicationDate>1990</publicationDate></host><title>Involvement of 5-HTlc-receptors in drug-induced penile erections in the rat</title><publicationDate>1990</publicationDate></json:item><json:item><author><json:item><name>K Bervoets</name></json:item><json:item><name>M,J Millan</name></json:item><json:item><name>Fc Colpaert</name></json:item></author><host><volume>01</volume><pages><first>124</first></pages><issue>113</issue><author></author><title>Psychopharmacology Behavioural/pharmacology of 5-HT. 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rats</title><publicationDate>1990</publicationDate></json:item></refBibs><genre><json:string>research-article</json:string></genre><host><volume>109</volume><pages><last>84</last><first>77</first></pages><issn><json:string>0033-3158</json:string></issn><issue>1-2</issue><subject><json:item><value>Pharmacology/Toxicology</value></json:item><json:item><value>Psychiatry</value></json:item></subject><journalId><json:string>213</json:string></journalId><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1432-2072</json:string></eissn><title>Psychopharmacology</title><publicationDate>1992</publicationDate><copyrightDate>1992</copyrightDate></host><categories><wos><json:string>social science</json:string><json:string>psychiatry</json:string><json:string>science</json:string><json:string>pharmacology & pharmacy</json:string><json:string>neurosciences</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>psychiatry</json:string></scienceMetrix></categories><publicationDate>1992</publicationDate><copyrightDate>1992</copyrightDate><doi><json:string>10.1007/BF02245483</json:string></doi><id>9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9</id><score>0.019345682</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat</title><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt><respStmt><resp>Références bibliographiques récupérées via GROBID</resp><name resp="ISTEX-API">ISTEX-API (INIST-CNRS)</name></respStmt></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><availability><p>Springer-Verlag, 1992</p></availability><date>1990-08-15</date></publicationStmt><notesStmt><note>Original Investigations</note></notesStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat</title><author xml:id="author-1"><persName><forename type="first">T.</forename><surname>Wilckens</surname></persName><affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">U.</forename><surname>Schweiger</surname></persName><affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</affiliation></author><author xml:id="author-3" corresp="yes"><persName><forename type="first">K.</forename><surname>Pirke</surname></persName><affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</affiliation></author></analytic><monogr><title level="j">Psychopharmacology</title><title level="j" type="abbrev">Psychopharmacology</title><idno type="journal-ID">213</idno><idno type="pISSN">0033-3158</idno><idno type="eISSN">1432-2072</idno><idno type="issue-article-count">39</idno><idno type="volume-issue-count">4</idno><imprint><publisher>Springer-Verlag</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="1992-10-01"></date><biblScope unit="volume">109</biblScope><biblScope unit="issue">1-2</biblScope><biblScope unit="page" from="77">77</biblScope><biblScope unit="page" to="84">84</biblScope></imprint></monogr><idno type="istex">9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9</idno><idno type="DOI">10.1007/BF02245483</idno><idno type="ArticleID">BF02245483</idno><idno type="ArticleID">Art10</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>1990-08-15</date></creation><langUsage><language ident="en">en</language></langUsage><abstract xml:lang="en"><p>Abstract: Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT1C receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT1C receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT1C agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT1C receptor activation.</p></abstract><textClass><keywords scheme="Journal Subject"><list><head>Biomedicine</head><item><term>Pharmacology/Toxicology</term></item><item><term>Psychiatry</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="1990-08-15">Created</change><change when="1992-10-01">Published</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2016-11-22">References added</change><change xml:id="refBibs-istex" who="#ISTEX-API" when="2017-01-20">References added</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Springer, Publisher found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0" encoding="UTF-8"</istex:xmlDeclaration><istex:docType PUBLIC="-//Springer-Verlag//DTD A++ V2.4//EN" URI="http://devel.springer.de/A++/V2.4/DTD/A++V2.4.dtd" name="istex:docType"></istex:docType><istex:document><Publisher><PublisherInfo><PublisherName>Springer-Verlag</PublisherName><PublisherLocation>Berlin/Heidelberg</PublisherLocation></PublisherInfo><Journal><JournalInfo JournalProductType="ArchiveJournal" NumberingStyle="Unnumbered"><JournalID>213</JournalID><JournalPrintISSN>0033-3158</JournalPrintISSN><JournalElectronicISSN>1432-2072</JournalElectronicISSN><JournalTitle>Psychopharmacology</JournalTitle><JournalAbbreviatedTitle>Psychopharmacology</JournalAbbreviatedTitle><JournalSubjectGroup><JournalSubject Type="Primary">Biomedicine</JournalSubject><JournalSubject Type="Secondary">Pharmacology/Toxicology</JournalSubject><JournalSubject Type="Secondary">Psychiatry</JournalSubject></JournalSubjectGroup></JournalInfo><Volume><VolumeInfo VolumeType="Regular" TocLevels="0"><VolumeIDStart>109</VolumeIDStart><VolumeIDEnd>109</VolumeIDEnd><VolumeIssueCount>4</VolumeIssueCount></VolumeInfo><Issue IssueType="Combined"><IssueInfo TocLevels="0"><IssueIDStart>1</IssueIDStart><IssueIDEnd>2</IssueIDEnd><IssueArticleCount>39</IssueArticleCount><IssueHistory><CoverDate><Year>1992</Year><Month>10</Month></CoverDate></IssueHistory><IssueCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1992</CopyrightYear></IssueCopyright></IssueInfo><Article ID="Art10"><ArticleInfo Language="En" ArticleType="OriginalPaper" NumberingStyle="Unnumbered" TocLevels="0" ContainsESM="No"><ArticleID>BF02245483</ArticleID><ArticleDOI>10.1007/BF02245483</ArticleDOI><ArticleSequenceNumber>10</ArticleSequenceNumber><ArticleTitle Language="En">Activation of 5-HT<Subscript>1C</Subscript>-receptors suppresses excessive wheel running induced by semi-starvation in the rat</ArticleTitle><ArticleCategory>Original Investigations</ArticleCategory><ArticleFirstPage>77</ArticleFirstPage><ArticleLastPage>84</ArticleLastPage><ArticleHistory><RegistrationDate><Year>2005</Year><Month>10</Month><Day>21</Day></RegistrationDate><Received><Year>1990</Year><Month>8</Month><Day>15</Day></Received><Revised><Year>1992</Year><Month>5</Month><Day>7</Day></Revised></ArticleHistory><ArticleCopyright><CopyrightHolderName>Springer-Verlag</CopyrightHolderName><CopyrightYear>1992</CopyrightYear></ArticleCopyright><ArticleGrants Type="Regular"><MetadataGrant Grant="OpenAccess"></MetadataGrant><AbstractGrant Grant="OpenAccess"></AbstractGrant><BodyPDFGrant Grant="Restricted"></BodyPDFGrant><BodyHTMLGrant Grant="Restricted"></BodyHTMLGrant><BibliographyGrant Grant="Restricted"></BibliographyGrant><ESMGrant Grant="Restricted"></ESMGrant></ArticleGrants><ArticleContext><JournalID>213</JournalID><VolumeIDStart>109</VolumeIDStart><VolumeIDEnd>109</VolumeIDEnd><IssueIDStart>1</IssueIDStart><IssueIDEnd>2</IssueIDEnd></ArticleContext></ArticleInfo><ArticleHeader><AuthorGroup><Author AffiliationIDS="Aff1" PresentAffiliationID="Aff2"><AuthorName DisplayOrder="Western"><GivenName>T.</GivenName><FamilyName>Wilckens</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1"><AuthorName DisplayOrder="Western"><GivenName>U.</GivenName><FamilyName>Schweiger</FamilyName></AuthorName></Author><Author AffiliationIDS="Aff1" CorrespondingAffiliationID="Aff3"><AuthorName DisplayOrder="Western"><GivenName>K.</GivenName><GivenName>M.</GivenName><FamilyName>Pirke</FamilyName></AuthorName></Author><Affiliation ID="Aff1"><OrgName>Max Planck Institut für Psychiatrie</OrgName><OrgAddress><Street>Kraepelinstrasse 10</Street><Postcode>W-8000</Postcode><City>München 40</City><Country>Federal Republic of Germany</Country></OrgAddress></Affiliation><Affiliation ID="Aff2"><OrgDivision>Department of Medicine</OrgDivision><OrgName>Division of Geographic Medicine and Infectious Disease</OrgName><OrgAddress><Street>750 Washington Street, NEMCH# 68</Street><Postcode>02111</Postcode><City>Boston</City><State>MA</State><Country>USA</Country></OrgAddress></Affiliation><Affiliation ID="Aff3"><OrgDivision>Department of Psychoendocrinology, Building D</OrgDivision><OrgName>Center for Psychobiology and Psychosomatic Research at the University of Trier</OrgName><OrgAddress><Postbox>Box 3825</Postbox><Postcode>W-5500</Postcode><City>Trier</City><Country>Federal Republic of Germany</Country></OrgAddress></Affiliation></AuthorGroup><Abstract ID="Abs1" Language="En"><Heading>Abstract</Heading><Para>Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT<Subscript>1C</Subscript> receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT<Subscript>1C</Subscript> receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT<Subscript>1C</Subscript> agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT<Subscript>1C</Subscript> receptor activation.</Para></Abstract><KeywordGroup Language="En"><Heading>Key words</Heading><Keyword>Serotonin</Keyword><Keyword>5-HT</Keyword><Keyword>5-HT receptors</Keyword><Keyword>5-HT<Subscript>1C</Subscript> receptors</Keyword><Keyword>5-HT agonists</Keyword><Keyword>mCPP</Keyword><Keyword>Exercise</Keyword><Keyword>Anorexia</Keyword><Keyword>Stress</Keyword><Keyword>Hyperactivity</Keyword><Keyword>Food intake</Keyword><Keyword>Starvation</Keyword></KeywordGroup></ArticleHeader><NoBody></NoBody></Article></Issue></Volume></Journal></Publisher></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>Activation of 5-HT1C-receptors suppresses excessive wheel running induced by semi-starvation in the rat</title></titleInfo><name type="personal"><namePart type="given">T.</namePart><namePart type="family">Wilckens</namePart><affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">U.</namePart><namePart type="family">Schweiger</namePart><affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal" displayLabel="corresp"><namePart type="given">K.</namePart><namePart type="given">M.</namePart><namePart type="family">Pirke</namePart><affiliation>Max Planck Institut für Psychiatrie, Kraepelinstrasse 10, W-8000, München 40, Federal Republic of Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="research-article" displayLabel="OriginalPaper"></genre><originInfo><publisher>Springer-Verlag</publisher><place><placeTerm type="text">Berlin/Heidelberg</placeTerm></place><dateCreated encoding="w3cdtf">1990-08-15</dateCreated><dateIssued encoding="w3cdtf">1992-10-01</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract lang="en">Abstract: Male Wistar rats were housed in cages linked to running wheels and fed on a schedule designed to reduce their body weight by 20–30%. During this period of semistarvation the rats increased their daily running wheel activity (RWA) by up to 30 km/day. RWA could be kept at this level provided that body weight was kept constant. Different serotonin receptor (5-HT) agonists and antagonists were tested for their effects on RWA and it was found that RWA could be suppressed only by agonists with high affinity for the 5-HT1C receptor (TFMPP, mCPP, DOI and quipazine). Serotonin receptor agonists, which do not pass the blood-brain barrier, and 5-HT itself had no effect on RWA. The inhibitory effect of the agonists on RWA was prevented by pretreatment with antagonists that also had high affinity for 5-HT1C receptors (mianserin, metergoline and mesulergine). From these results we conclude that semi-starvation-induced hyperactivity can be blocked by 5-HT1C agonists. Furthermore we suggest that the animal model presented in this study might be a useful tool for in vivo studies on selective 5-HT1C receptor activation.</abstract><note>Original Investigations</note><relatedItem type="host"><titleInfo><title>Psychopharmacology</title></titleInfo><titleInfo type="abbreviated"><title>Psychopharmacology</title></titleInfo><genre type="journal" displayLabel="Archive Journal"></genre><originInfo><dateIssued encoding="w3cdtf">1992-10-01</dateIssued><copyrightDate encoding="w3cdtf">1992</copyrightDate></originInfo><subject><genre>Biomedicine</genre><topic>Pharmacology/Toxicology</topic><topic>Psychiatry</topic></subject><identifier type="ISSN">0033-3158</identifier><identifier type="eISSN">1432-2072</identifier><identifier type="JournalID">213</identifier><identifier type="IssueArticleCount">39</identifier><identifier type="VolumeIssueCount">4</identifier><part><date>1992</date><detail type="volume"><number>109</number><caption>vol.</caption></detail><detail type="issue"><number>1-2</number><caption>no.</caption></detail><extent unit="pages"><start>77</start><end>84</end></extent></part><recordInfo><recordOrigin>Springer-Verlag, 1992</recordOrigin></recordInfo></relatedItem><identifier type="istex">9BB1BEC71B4FC4CC84B756C253B883119C9AA6C9</identifier><identifier type="DOI">10.1007/BF02245483</identifier><identifier type="ArticleID">BF02245483</identifier><identifier type="ArticleID">Art10</identifier><accessCondition type="use and reproduction" contentType="copyright">Springer-Verlag, 1992</accessCondition><recordInfo><recordContentSource>SPRINGER</recordContentSource><recordOrigin>Springer-Verlag, 1992</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
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