Pavlovian conditioning of immune function: animal investigation and the challenge of human application
Identifieur interne : 001F50 ( Main/Exploration ); précédent : 001F49; suivant : 001F51Pavlovian conditioning of immune function: animal investigation and the challenge of human application
Auteurs : Michael S. Exton [Allemagne] ; Anne Kristin Von Auer [Allemagne] ; Angelika Buske-Kirschbaum [Allemagne] ; Ursula Stockhorst [Allemagne] ; Ulrich Göbel [Allemagne] ; Manfred Schedlowski [Allemagne]Source :
- Behavioural Brain Research [ 0166-4328 ] ; 2000.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Pavlovian conditioning of immune functions provided early impetus to the rapidly expanding knowledge of bi-directional communication among the immune, endocrine, and central nervous systems. Since these early investigations, the phenomenology of this response has been well characterized. However the neural mechanisms and biological relevance of conditioned immunomodulation remain unclear. To this end, we present here data from our laboratories that have: (1) revealed some of the neural mechanisms and biological relevance of an animal model of conditioned immunomodulation; (2) demonstrated the conditionability and potential mechanisms of conditioned immune responses in healthy humans, and (3) investigated conditioned immunomodulation in a clinical sample. Together, these data demonstrate that animal models provide a basis for investigating mechanisms whereby conditioned changes in immune function may modulate health status in a clinical realm.
Url:
DOI: 10.1016/S0166-4328(99)00191-6
Affiliations:
- Allemagne
- District de Düsseldorf, Rhénanie-Palatinat, Rhénanie-du-Nord-Westphalie
- Düsseldorf, Trèves (Allemagne)
- Université de Trèves
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001372
- to stream Istex, to step Curation: 001260
- to stream Istex, to step Checkpoint: 000C87
- to stream Main, to step Merge: 002263
- to stream PascalFrancis, to step Corpus: 000F19
- to stream PascalFrancis, to step Curation: 000050
- to stream PascalFrancis, to step Checkpoint: 000C70
- to stream Main, to step Merge: 002316
- to stream Main, to step Curation: 001F50
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Pavlovian conditioning of immune function: animal investigation and the challenge of human application</title><author><name sortKey="Exton, Michael S" sort="Exton, Michael S" uniqKey="Exton M" first="Michael S." last="Exton">Michael S. Exton</name></author><author><name sortKey="Von Auer, Anne Kristin" sort="Von Auer, Anne Kristin" uniqKey="Von Auer A" first="Anne Kristin" last="Von Auer">Anne Kristin Von Auer</name></author><author><name sortKey="Buske Kirschbaum, Angelika" sort="Buske Kirschbaum, Angelika" uniqKey="Buske Kirschbaum A" first="Angelika" last="Buske-Kirschbaum">Angelika Buske-Kirschbaum</name></author><author><name sortKey="Stockhorst, Ursula" sort="Stockhorst, Ursula" uniqKey="Stockhorst U" first="Ursula" last="Stockhorst">Ursula Stockhorst</name></author><author><name sortKey="Gobel, Ulrich" sort="Gobel, Ulrich" uniqKey="Gobel U" first="Ulrich" last="Göbel">Ulrich Göbel</name></author><author><name sortKey="Schedlowski, Manfred" sort="Schedlowski, Manfred" uniqKey="Schedlowski M" first="Manfred" last="Schedlowski">Manfred Schedlowski</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:1461CF819CB8832BA9C0AB1104B0F9386F240C89</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1016/S0166-4328(99)00191-6</idno><idno type="url">https://api.istex.fr/document/1461CF819CB8832BA9C0AB1104B0F9386F240C89/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001372</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001372</idno><idno type="wicri:Area/Istex/Curation">001260</idno><idno type="wicri:Area/Istex/Checkpoint">000C87</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000C87</idno><idno type="wicri:doubleKey">0166-4328:2000:Exton M:pavlovian:conditioning:of</idno><idno type="wicri:Area/Main/Merge">002263</idno><idno type="wicri:source">INIST</idno><idno type="RBID">Pascal:00-0398388</idno><idno type="wicri:Area/PascalFrancis/Corpus">000F19</idno><idno type="wicri:Area/PascalFrancis/Curation">000050</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000C70</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000C70</idno><idno type="wicri:doubleKey">0166-4328:2000:Exton M:pavlovian:conditioning:of</idno><idno type="wicri:Area/Main/Merge">002316</idno><idno type="wicri:Area/Main/Curation">001F50</idno><idno type="wicri:Area/Main/Exploration">001F50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Pavlovian conditioning of immune function: animal investigation and the challenge of human application</title><author><name sortKey="Exton, Michael S" sort="Exton, Michael S" uniqKey="Exton M" first="Michael S." last="Exton">Michael S. Exton</name><affiliation wicri:level="1"><country wicri:rule="url">Allemagne</country></affiliation><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Psychology, University of Essen, Hufelandstraße 55, 45122, Essen</wicri:regionArea><wicri:noRegion>45122, Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author><author><name sortKey="Von Auer, Anne Kristin" sort="Von Auer, Anne Kristin" uniqKey="Von Auer A" first="Anne Kristin" last="Von Auer">Anne Kristin Von Auer</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstraße 10-11, 54290, Trier</wicri:regionArea><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Buske Kirschbaum, Angelika" sort="Buske Kirschbaum, Angelika" uniqKey="Buske Kirschbaum A" first="Angelika" last="Buske-Kirschbaum">Angelika Buske-Kirschbaum</name><affiliation wicri:level="4"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Center for Psychobiological and Psychosomatic Research, University of Trier, Dietrichstraße 10-11, 54290, Trier</wicri:regionArea><orgName type="university">Université de Trèves</orgName><placeName><settlement type="city">Trèves (Allemagne)</settlement><region type="land" nuts="1">Rhénanie-Palatinat</region></placeName></affiliation></author><author><name sortKey="Stockhorst, Ursula" sort="Stockhorst, Ursula" uniqKey="Stockhorst U" first="Ursula" last="Stockhorst">Ursula Stockhorst</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute of Medical Psychology, Heinrich-Heine-University Düsseldorf, PO Box 101007, 40001, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Gobel, Ulrich" sort="Gobel, Ulrich" uniqKey="Gobel U" first="Ulrich" last="Göbel">Ulrich Göbel</name><affiliation wicri:level="3"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Clinic of Pediatric Hematology and Oncology, Heinrich-Heine-University Düsseldorf, PO Box 101007, 40001, Düsseldorf</wicri:regionArea><placeName><region type="land" nuts="1">Rhénanie-du-Nord-Westphalie</region><region type="district" nuts="2">District de Düsseldorf</region><settlement type="city">Düsseldorf</settlement></placeName></affiliation></author><author><name sortKey="Schedlowski, Manfred" sort="Schedlowski, Manfred" uniqKey="Schedlowski M" first="Manfred" last="Schedlowski">Manfred Schedlowski</name><affiliation wicri:level="1"><country xml:lang="fr">Allemagne</country><wicri:regionArea>Institute for Medical Psychology, University of Essen, Hufelandstraße 55, 45122, Essen</wicri:regionArea><wicri:noRegion>45122, Essen</wicri:noRegion><wicri:noRegion>Essen</wicri:noRegion></affiliation></author></analytic><monogr></monogr><series><title level="j">Behavioural Brain Research</title><title level="j" type="abbrev">BBR</title><idno type="ISSN">0166-4328</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="2000">2000</date><biblScope unit="volume">110</biblScope><biblScope unit="issue">1–2</biblScope><biblScope unit="page" from="129">129</biblScope><biblScope unit="page" to="141">141</biblScope></imprint><idno type="ISSN">0166-4328</idno></series><idno type="istex">1461CF819CB8832BA9C0AB1104B0F9386F240C89</idno><idno type="DOI">10.1016/S0166-4328(99)00191-6</idno><idno type="PII">S0166-4328(99)00191-6</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0166-4328</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animal model</term><term>Behavioral conditioning</term><term>Classical conditioning</term><term>Clinical trial</term><term>Graft</term><term>Human</term><term>Immune system</term><term>Immunomodulation</term><term>Natural killer cell</term><term>Psychoneuroimmunology</term><term>Rat</term><term>Review</term><term>Sympathetic nervous system</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Article synthèse</term><term>Cellule NK</term><term>Conditionnement classique</term><term>Essai clinique</term><term>Greffe</term><term>Immunomodulation</term><term>Modèle animal</term><term>Système immunitaire</term><term>Système nerveux sympathique</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Pavlovian conditioning of immune functions provided early impetus to the rapidly expanding knowledge of bi-directional communication among the immune, endocrine, and central nervous systems. Since these early investigations, the phenomenology of this response has been well characterized. However the neural mechanisms and biological relevance of conditioned immunomodulation remain unclear. To this end, we present here data from our laboratories that have: (1) revealed some of the neural mechanisms and biological relevance of an animal model of conditioned immunomodulation; (2) demonstrated the conditionability and potential mechanisms of conditioned immune responses in healthy humans, and (3) investigated conditioned immunomodulation in a clinical sample. Together, these data demonstrate that animal models provide a basis for investigating mechanisms whereby conditioned changes in immune function may modulate health status in a clinical realm.</div></front></TEI><affiliations><list><country><li>Allemagne</li></country><region><li>District de Düsseldorf</li><li>Rhénanie-Palatinat</li><li>Rhénanie-du-Nord-Westphalie</li></region><settlement><li>Düsseldorf</li><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><country name="Allemagne"><noRegion><name sortKey="Exton, Michael S" sort="Exton, Michael S" uniqKey="Exton M" first="Michael S." last="Exton">Michael S. Exton</name></noRegion><name sortKey="Buske Kirschbaum, Angelika" sort="Buske Kirschbaum, Angelika" uniqKey="Buske Kirschbaum A" first="Angelika" last="Buske-Kirschbaum">Angelika Buske-Kirschbaum</name><name sortKey="Exton, Michael S" sort="Exton, Michael S" uniqKey="Exton M" first="Michael S." last="Exton">Michael S. Exton</name><name sortKey="Gobel, Ulrich" sort="Gobel, Ulrich" uniqKey="Gobel U" first="Ulrich" last="Göbel">Ulrich Göbel</name><name sortKey="Schedlowski, Manfred" sort="Schedlowski, Manfred" uniqKey="Schedlowski M" first="Manfred" last="Schedlowski">Manfred Schedlowski</name><name sortKey="Stockhorst, Ursula" sort="Stockhorst, Ursula" uniqKey="Stockhorst U" first="Ursula" last="Stockhorst">Ursula Stockhorst</name><name sortKey="Von Auer, Anne Kristin" sort="Von Auer, Anne Kristin" uniqKey="Von Auer A" first="Anne Kristin" last="Von Auer">Anne Kristin Von Auer</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001F50 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001F50 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:1461CF819CB8832BA9C0AB1104B0F9386F240C89
|texte= Pavlovian conditioning of immune function: animal investigation and the challenge of human application
}}
| This area was generated with Dilib version V0.6.31. |  |