UnivTrevesV1, Main, Curation, bibRecord, 000C09

Quantitative determination of the diagnostic accuracy of the synovitis score and its components

Identifieur interne : 000C09 ( Main/Curation ); précédent : 000C08; suivant : 000C10

Quantitative determination of the diagnostic accuracy of the synovitis score and its components

Auteurs : Elisabeth Slansky [Allemagne] ; Jialiang Li [Singapour] ; Thomas H Upl ; Lars Morawietz [Allemagne] ; Veit Krenn ; Frank Pessler [Allemagne]

Source :

Histopathology [ 0309-0167 ] ; 2010-09.

RBID : ISTEX:553D6B5A3C6FE12706F58F81E88ACF989200BBBE

Descripteurs français

Pascal (Inist)
- Analyse quantitative, Anatomopathologie, Arthrose, Chronique, Diagnostic, Polyarthrite rhumatoïde, Précision, Récepteur, Score, Synovite.
Wicri :
- topic : Analyse quantitative.

English descriptors

KwdEn :
- Accuracy, Anatomic pathology, Chronic, Diagnosis, Osteoarthritis, Quantitative analysis, Receiver, Rheumatoid arthritis, Score, Synovitis, osteoarthritis, receiver operating characteristic analysis, rheumatoid arthritis, synovitis.

Abstract

Slansky E, Li J, Häupl T, Morawietz L, Krenn V & Pessler F (2010) Histopathology 57, 436–443 Quantitative determination of the diagnostic accuracy of the synovitis score and its components

Url:

https://api.istex.fr/document/553D6B5A3C6FE12706F58F81E88ACF989200BBBE/fulltext/pdf

DOI: 10.1111/j.1365-2559.2010.03641.x

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Thomas H Upl

<affiliation><wicri:noCountry code="no comma">Department of Rheumatology</wicri:noCountry>
</affiliation>

Veit Krenn

<affiliation><wicri:noCountry code="subField">Trier</wicri:noCountry>
</affiliation>

Le document en format XML

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<term>Diagnosis</term>
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<term>Quantitative analysis</term>
<term>Receiver</term>
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<term>Synovitis</term>
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<front><div type="abstract" xml:lang="en">Aims: To assess the diagnostic accuracy of a three-component synovitis score and to determine the relative contribution of each of its components to its overall discriminatory power. Methods and results: The synovitis score was determined in 666 synovial specimens: normal synovium, n = 33; post-traumatic arthropathy (PtA), n = 29; osteoarthritis (OA), n = 221; psoriatic arthritis (PsA), n = 42; and rheumatoid arthritis (RA), n = 341. The discriminatory abilities of the score and its components were quantified with binary and multicategory receiver operating characteristic (ROC) analysis. The score differentiated all arthropathies accurately from normal tissue (area under the ROC curve, AUC: 0.87-0.98) and RA from OA or PtA (AUC: 0.85 for both), but could not distinguish well within pairs of inflammatory or degenerative arthropathies. AUCs of the intimal hyperplasia and stromal cellularity components correlated with the AUCs of the complete score markedly more strongly (r = 0.94 and 0.91, respectively) than the inflammatory infiltration component (r = 0.60). Multicategory ROC analysis ranked the score several-fold higher than any of its components, and the components in the order stromal cellularity>intimal hyperplasia>infiltration. Conclusion: Combining three distinct histological parameters into a three-component score produces greatly increased overall diagnostic power. The discriminatory ability of the score stems more from measuring proliferative than infiltrative aspects of synovitis.</div>
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<front><div type="abstract">Slansky E, Li J, Häupl T, Morawietz L, Krenn V & Pessler F (2010) Histopathology 57, 436–443 Quantitative determination of the diagnostic accuracy of the synovitis score and its components</div>
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Quantitative determination of the diagnostic accuracy of the synovitis score and its components

Quantitative determination of the diagnostic accuracy of the synovitis score and its components

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